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Searching for up to 100 curated homologs for AO353_06770 FitnessBrowser__pseudo3_N2E3:AO353_06770 (309 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

6wj9B / Q4KCF6 Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-glcnac (see paper)
    67% identity, 97% coverage of query (399 bits)

6wjaA Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-galnac
    67% identity, 97% coverage of query (399 bits)

F2NQX6 UDP-glucose 4-epimerase (EC 5.1.3.2) from Marinithermus hydrothermalis (see paper)
    41% identity, 98% coverage of query (205 bits)

Q9WYX9 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Thermotoga maritima (see paper)
4zrnA / Q9WYX9 Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
    37% identity, 96% coverage of query (202 bits)

6dntA / D3E402 Udp-n-acetylglucosamine 4-epimerase from methanobrevibacter ruminantium m1 in complex with udp-n-acetylmuramic acid (see paper)
    39% identity, 93% coverage of query (196 bits)

2p5uA / Q5SKQ2 Crystal structure of thermus thermophilus hb8 udp-glucose 4-epimerase complex with NAD
    42% identity, 92% coverage of query (194 bits)

F6DEY6 UDP-glucose 4-epimerase (EC 5.1.3.2) from Thermus thermophilus (see paper)
    41% identity, 92% coverage of query (192 bits)

UAE / Q868I5 UDP-N-acetylglucosamine 4'-epimerase (EC 5.1.3.7) from Giardia intestinalis (see 7 papers)
    34% identity, 98% coverage of query (176 bits)

3lu1A / Q7BJX9 Crystal structure analysis of wbgu: a udp-galnac 4-epimerase (see paper)
    34% identity, 96% coverage of query (168 bits)

3ruhA Alternative analogs as viable substrates of udp-hexose 4-epimerases
    34% identity, 96% coverage of query (168 bits)

3rufA Alternative analogs as viable substrates of udp-hexose 4-epimerases
    34% identity, 96% coverage of query (168 bits)

GALE_MYCS2 / A0R5C5 UDP-glucose 4-epimerase; UDP-galactose 4-epimerase; Uridine diphosphate galactose 4-epimerase; EC 5.1.3.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    39% identity, 98% coverage of query (164 bits)

wbgU / Q7BJX9 UDP-N-acetylglucosamine C4-epimerase subunit (EC 5.1.3.7) from Plesiomonas shigelloides (see paper)
GNE_PLESH / Q7BJX9 UDP-N-acetylglucosamine 4-epimerase; UDP-GalNAc 4-epimerase; EC 5.1.3.7 from Plesiomonas shigelloides (Aeromonas shigelloides) (see 3 papers)
Q7BJX9 UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Plesiomonas shigelloides (see 2 papers)
    33% identity, 96% coverage of query (163 bits)

Q8KN66 UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Pseudomonas aeruginosa (see paper)
1sb8A / Q8KN66 Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-n-acetylgalactosamine (see paper)
    34% identity, 96% coverage of query (155 bits)

1sb9A Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-glucose
    34% identity, 96% coverage of query (155 bits)

8vr2B / Q1QD53 Crystal structure of the pcryo_0617 oxidoreductase/decarboxylase from psychrobacter cryohalolentis k5 in the presence of NAD and udp
    35% identity, 97% coverage of query (154 bits)

wbpP / Q9RHD6 UDP-N-acetylglucosamine C4-epimerase subunit (EC 5.1.3.7) from Pseudomonas aeruginosa (see 8 papers)
    34% identity, 96% coverage of query (152 bits)

UXS1 / Q8VZC0 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see paper)
UXS1_ARATH / Q8VZC0 UDP-glucuronic acid decarboxylase 1; UDP-XYL synthase 1; UDP-glucuronate decarboxylase 1; UGD; UXS-1; EC 4.1.1.35 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q8VZC0 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see paper)
    33% identity, 98% coverage of query (147 bits)

galE1 / P9WN67 UDP-galactose/glucose 4-epimerase subunit (EC 5.1.3.7; EC 5.1.3.2) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
P9WN67 UDP-glucose 4-epimerase (EC 5.1.3.2) from Mycobacterium tuberculosis (see paper)
    38% identity, 89% coverage of query (145 bits)

7ystA / P9WN67 Crystal structure of udp-glucose 4-epimerase (rv3634c) in complex with both udp-glucose and udp-galactose in chain b from mycobacterium tuberculosis
    38% identity, 89% coverage of query (145 bits)

Q75PK6 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Oryza sativa (see paper)
UXS-1 / BAD12491.1 UDP-glucuronic acid decarboxylase from Oryza sativa Japonica Group (see paper)
    32% identity, 98% coverage of query (145 bits)

7ys9A Crystal structure of udp-glucose 4-epimerase (rv3634c) in complex with both udp-glucose and udp-galactose in chaina from mycobacterium tuberculosis
    38% identity, 89% coverage of query (145 bits)

7ysmA Crystal structure of udp-glucose 4-epimerase (rv3634c) co-crystallized with udp-n-acetylglucosamine from mycobacterium tuberculosis
    38% identity, 89% coverage of query (145 bits)

N0A0C4 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
    32% identity, 98% coverage of query (144 bits)

GALE_LACHE / Q7WTB1 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Lactobacillus helveticus (Lactobacillus suntoryeus) (see paper)
    33% identity, 88% coverage of query (142 bits)

N0A8N3 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
    35% identity, 88% coverage of query (142 bits)

Q75PK7 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Oryza sativa (see paper)
UXS-2 / BAD12490.1 UDP-glucuronic acid decarboxylase from Oryza sativa Japonica Group (see paper)
    32% identity, 96% coverage of query (141 bits)

uxs1 / Q92WA4 UDP-xylose synthase 1 subunit (EC 4.1.1.35) from Rhizobium meliloti (strain 1021) (see paper)
    33% identity, 98% coverage of query (140 bits)

O73960 UDP-glucose 4-epimerase (EC 5.1.3.2) from Pyrococcus horikoshii (see paper)
    32% identity, 88% coverage of query (140 bits)

Q8W3J1 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Oryza sativa (see paper)
UXS-4 / BAB84333.2 UDP-glucuronic acid decarboxylase from Oryza sativa Japonica Group (see paper)
    35% identity, 87% coverage of query (140 bits)

2b69A / Q8NBZ7 Crystal structure of human udp-glucoronic acid decarboxylase
    33% identity, 97% coverage of query (139 bits)

UXS1_RAT / Q5PQX0 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UGD; UXS-1; EC 4.1.1.35 from Rattus norvegicus (Rat) (see paper)
    36% identity, 83% coverage of query (139 bits)

UXS1_HUMAN / Q8NBZ7 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UGD; UXS-1; hUXS; hUXS1; EC 4.1.1.35 from Homo sapiens (Human) (see 3 papers)
    36% identity, 83% coverage of query (139 bits)

6bwlA / Q3ESA4 X-ray structure of pal from bacillus thuringiensis (see paper)
    37% identity, 72% coverage of query (138 bits)

A3MUJ4 UDP-glucose 4-epimerase (EC 5.1.3.2) from Pyrobaculum calidifontis (see paper)
    34% identity, 92% coverage of query (136 bits)

Build an alignment

Build an alignment for AO353_06770 and 35 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

2q1sA / O87989 Crystal structure of the bordetella bronchiseptica enzyme wbmf in complex with nadh (see paper)
    29% identity, 98% coverage of query (136 bits)

6zllA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-galacturonic acid and NAD (see paper)
    29% identity, 96% coverage of query (135 bits)

UXS2 / Q9LZI2 subunit of UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see 3 papers)
UXS2_ARATH / Q9LZI2 UDP-glucuronic acid decarboxylase 2; UDP-XYL synthase 2; UDP-glucuronate decarboxylase 2; UGD; UXS-2; dTDP-glucose 4-6-dehydratase homolog D18; EC 4.1.1.35 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LZI2 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see paper)
    33% identity, 88% coverage of query (135 bits)

tunF / E5KJ99 UDP-6-deoxy-5,6-ene-GlcNAc 4-epimerase (EC 5.1.3.7) from Streptomyces chartreusis (see paper)
    33% identity, 93% coverage of query (135 bits)

UGA4E_THEGP / F8C4X8 UDP-glucuronate 4-epimerase; UGA4E; TgUGAE; EC 5.1.3.6 from Thermodesulfobacterium geofontis (strain OPF15)
    29% identity, 98% coverage of query (135 bits)

6pnlA / O26475 Structure of epimerase mth375 from the thermophilic pseudomurein- containing methanogen methanothermobacter thermautotrophicus
    33% identity, 88% coverage of query (135 bits)

6zldA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-glucuronic acid and NAD
    29% identity, 96% coverage of query (135 bits)

6zl6A Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp and NAD
    29% identity, 96% coverage of query (135 bits)

Q8W3J0 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Oryza sativa (see paper)
UXS-3 / BAB84334.1 UDP-glucuronic acid decarboxylase from Oryza sativa Japonica Group (see paper)
    35% identity, 83% coverage of query (134 bits)

N0A414 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
    35% identity, 83% coverage of query (134 bits)

UXS1_DANRE / Q6GMI9 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UXS-1; EC 4.1.1.35 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
    32% identity, 98% coverage of query (134 bits)

galE / CAA89986.1 UDP-galactose 4-epimease from Corynebacterium glutamicum (see paper)
    33% identity, 95% coverage of query (134 bits)

6pmhA Structure of epimerase mth375 from the thermophilic pseudomurein- containing methanogen methanothermobacter thermautotrophicus
    33% identity, 88% coverage of query (134 bits)

2pzjA Crystal structure of the bordetella bronchiseptica enzyme wbmf in complex with NAD+
    30% identity, 89% coverage of query (134 bits)

2q1tA Crystal structure of the bordetella bronchiseptica enzyme wbmf in complex with NAD+ and udp
    30% identity, 89% coverage of query (134 bits)

6zljA Crystal structure of udp-glucuronic acid 4-epimerase y149f mutant from bacillus cereus in complex with udp-4-deoxy-4-fluoro-glucuronic acid and NAD
    29% identity, 96% coverage of query (134 bits)

6kv9A / A0A003 Moee5 in complex with udp-glucuronic acid and NAD (see paper)
    35% identity, 97% coverage of query (133 bits)

4lk3B / Q8NBZ7 Crystal structure of human udp-xylose synthase r236a substitution (see paper)
    34% identity, 89% coverage of query (133 bits)

N0A8N8 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
    35% identity, 83% coverage of query (132 bits)

epsS / BAC55147.1 UDP-glucose 4-epimerase EpsS from Methylobacillus sp. 12S (see paper)
    33% identity, 88% coverage of query (132 bits)

N0A422 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
    35% identity, 83% coverage of query (132 bits)

Q2LC83 UDP-arabinose 4-epimerase (EC 5.1.3.5) from Hordeum vulgare (see paper)
    32% identity, 94% coverage of query (132 bits)

1udaA Structure of udp-galactose-4-epimerase complexed with udp-4-deoxy-4- fluoro-alpha-d-galactose
    32% identity, 88% coverage of query (132 bits)

1naiA Udp-galactose 4-epimerase from escherichia coli, oxidized
    32% identity, 88% coverage of query (132 bits)

1lrjA Crystal structure of e. Coli udp-galactose 4-epimerase complexed with udp-n-acetylglucosamine
    32% identity, 88% coverage of query (132 bits)

6kvcA Moee5 in complex with udp-glucose and NAD
    34% identity, 97% coverage of query (132 bits)

4lk3C Crystal structure of human udp-xylose synthase r236a substitution
    35% identity, 85% coverage of query (131 bits)

uxe / Q92WA3 UDP-xylose 4-epimerase subunit (EC 5.1.3.5) from Rhizobium meliloti (strain 1021) (see paper)
Q92WA3 UDP-arabinose 4-epimerase (EC 5.1.3.5) from Sinorhizobium meliloti (see paper)
    34% identity, 88% coverage of query (130 bits)

N0A9U2 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
    34% identity, 88% coverage of query (130 bits)

4twrA / Q2YKG6 Structure of udp-glucose 4-epimerase from brucella abortus
    33% identity, 88% coverage of query (130 bits)

Q9AV98 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Pisum sativum (see paper)
uxs1 / BAB40967.1 UDP-D-glucuronate carboxy-lyase from Pisum sativum (see paper)
    35% identity, 83% coverage of query (130 bits)

GalD / b0759 UDP-glucose 4-epimerase (EC 5.1.3.2) from Escherichia coli K-12 substr. MG1655 (see 42 papers)
galE / P09147 UDP-glucose 4-epimerase (EC 5.1.3.2) from Escherichia coli (strain K12) (see 38 papers)
GALE_ECOLI / P09147 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Escherichia coli (strain K12) (see 13 papers)
    32% identity, 88% coverage of query (130 bits)

2udpA Udp-galactose 4-epimerase complexed with udp-phenol
    32% identity, 88% coverage of query (130 bits)

1udcA Structure of udp-galactose-4-epimerase complexed with udp-mannose
    32% identity, 88% coverage of query (130 bits)

UXS3 / Q9FIE8 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see 2 papers)
UXS3_ARATH / Q9FIE8 UDP-glucuronic acid decarboxylase 3; UDP-XYL synthase 3; UDP-glucuronate decarboxylase 3; UGD; UXS-3; EC 4.1.1.35 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9FIE8 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see paper)
    34% identity, 83% coverage of query (129 bits)

Q9SN95 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see paper)
    35% identity, 83% coverage of query (129 bits)

galE / P55180 UDP-glucose 4-epimerase (EC 5.1.3.7; EC 5.1.3.2) from Bacillus subtilis (strain 168) (see 5 papers)
galE / CAA67713.1 UDP-glucose 4-epimerase from Bacillus subtilis (see paper)
    32% identity, 88% coverage of query (129 bits)

1kvrA Udp-galactose 4-epimerase complexed with udp-phenol
    31% identity, 88% coverage of query (129 bits)

MUR4 / Q9SA77 UDP-D-xylose 4-epimerase (EC 5.1.3.5) from Arabidopsis thaliana (see 3 papers)
ARAE1_ARATH / Q9SA77 UDP-arabinose 4-epimerase 1; UDP-D-xylose 4-epimerase 1; EC 5.1.3.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9SA77 UDP-arabinose 4-epimerase (EC 5.1.3.5) from Arabidopsis thaliana (see paper)
    34% identity, 88% coverage of query (128 bits)

N0A0D3 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
    33% identity, 88% coverage of query (127 bits)

Q9ZV36 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see paper)
    34% identity, 83% coverage of query (127 bits)

1a9yA / P09147 Udp-galactose 4-epimerase mutant s124a/y149f complexed with udp- glucose (see paper)
    31% identity, 88% coverage of query (127 bits)

graE / AAA99939.1 dTDP-glucose dehydratase from Streptomyces violaceoruber (see paper)
    32% identity, 83% coverage of query (126 bits)

galE / CAB44218.1 UDP-galactose 4-epimerase from Lactococcus lactis (see paper)
    31% identity, 88% coverage of query (125 bits)

UDPGlcADCX1 / Q6IVK5 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Nicotiana tabacum (see paper)
    33% identity, 84% coverage of query (125 bits)

UGA4E_RHIR8 / B9J8R3 UDP-glucuronate 4-epimerase; UGA4E; ArUGAE; EC 5.1.3.6 from Rhizobium rhizogenes (strain K84 / ATCC BAA-868) (Agrobacterium radiobacter)
    29% identity, 97% coverage of query (125 bits)

2c20A / A0A6L8PTV5 Crystal structure of udp-glucose 4-epimerase
    30% identity, 93% coverage of query (122 bits)

3eheA / O29886 Crystal structure of udp-glucose 4 epimerase (gale-1) from archaeoglobus fulgidus
    30% identity, 84% coverage of query (120 bits)

8sk0B / A0A1C5ADV9 Crystal structure of evds6 decarboxylase in ligand bound state (see paper)
    32% identity, 97% coverage of query (119 bits)

8sk0A Crystal structure of evds6 decarboxylase in ligand bound state
    32% identity, 97% coverage of query (119 bits)

5u4qA 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
    29% identity, 97% coverage of query (118 bits)

3vpsA / E5KJ94 Structure of a novel NAD dependent-ndp-hexosamine 5,6-dehydratase, tuna, involved in tunicamycin biosynthesis
    34% identity, 82% coverage of query (116 bits)

7k3pA / Q0P9C3 The structure of the udp-glc/glcnac 4-epimerase from the human pathogen campylobacter jejuni
    30% identity, 88% coverage of query (115 bits)

7kn1A / B2FNY6 Crystal structure of udp-glucose-4-epimerase (gale) from stenotrophomonas maltophila with bound NAD and formylated udp- arabinopyranose
    30% identity, 95% coverage of query (114 bits)

3aw9A / A3MUJ4 Structure of udp-galactose 4-epimerase mutant
    31% identity, 92% coverage of query (112 bits)

2hunA / O58151 Crystal structure of hypothetical protein ph0414 from pyrococcus horikoshii ot3
    35% identity, 75% coverage of query (108 bits)

3enkA / Q3JPI3 1.9a crystal structure of udp-glucose 4-epimerase from burkholderia pseudomallei
    31% identity, 91% coverage of query (107 bits)

tyv / P14169 CDP-paratose 2-epimerase (EC 5.1.3.10) from Salmonella typhi (see paper)
RFBE_SALTI / P14169 CDP-paratose 2-epimerase; CDP-tyvelose 2-epimerase; EC 5.1.3.10 from Salmonella typhi (see paper)
    30% identity, 77% coverage of query (107 bits)

1orrA / P14169 Crystal structure of cdp-tyvelose 2-epimerase complexed with NAD and cdp (see paper)
    30% identity, 77% coverage of query (107 bits)

6k0iA Crystal structure of udp-glucose 4-epimerase from bifidobacterium longum in complex with NAD+ and udp-glc
    30% identity, 91% coverage of query (107 bits)

6k0hA Crystal structure of udp-glucose 4-epimerase from bifidobacterium longum in complex with NAD+ and udp-glcnac
    30% identity, 91% coverage of query (107 bits)

6k0gA / E8MF10 Crystal structure of udp-glucose 4-epimerase from bifidobacterium longum in complex with NAD+ and udp (see paper)
    30% identity, 91% coverage of query (107 bits)

5u4qB 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
    30% identity, 83% coverage of query (107 bits)

2cnbA Trypanosoma brucei udp-galactose-4-epimerase in ternary complex with NAD and the substrate analogue udp-4-deoxy-4- fluoro-alpha-d-galactose
    28% identity, 88% coverage of query (107 bits)

1ek6A Structure of human udp-galactose 4-epimerase complexed with nadh and udp-glucose
    30% identity, 90% coverage of query (107 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory