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Searching for up to 100 curated homologs for AO353_12260 FitnessBrowser__pseudo3_N2E3:AO353_12260 (283 a.a.)

Found high-coverage hits (≥70%) to 17 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AO356_09615 ABC transporter for L-Histidine, permease component from Pseudomonas fluorescens FW300-N2C3
    95% identity, 100% coverage of query (527 bits)

TC 3.A.1.12.6 / Q9KKE2 HutW aka HISW, component of Uptake system for hisitidine, proline, proline-betaine and glycine-betaine from Rhizobium meliloti (Sinorhizobium meliloti) (see paper)
    63% identity, 99% coverage of query (349 bits)

TC 3.A.1.12.9 / Q8U4S4 OtaB, component of The salt-induced glycine betaine OtaABC transporter from Methanosarcina mazei (see paper)
    51% identity, 93% coverage of query (241 bits)

OPUAB_BACSU / P46921 Glycine betaine transport system permease protein OpuAB from Bacillus subtilis (strain 168) (see 2 papers)
P46921 ABC-type quaternary amine transporter (EC 7.6.2.9) from Bacillus subtilis (see 2 papers)
TC 3.A.1.12.2 / P46921 OPAB aka OpuAB, component of Glycine betaine OpuAA/AB/AC porter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate) from Bacillus subtilis (see 3 papers)
    44% identity, 93% coverage of query (228 bits)

OUSW_DICD3 / E0SCY2 Glycine betaine/choline transport system permease protein OusW from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see paper)
    47% identity, 98% coverage of query (224 bits)

Q7DAU8 ABC-type quaternary amine transporter (EC 7.6.2.9) from Lactococcus lactis (see paper)
    46% identity, 90% coverage of query (219 bits)

TC 3.A.1.12.5 / Q9RQ05 BusAB aka OPUABC, component of Uptake system for glycine-betaine (high affinity) and proline (low affinity) (OpuAA-OpuABC) or BusAA-ABC of Lactococcus lactis). BusAA, the ATPase subunit, has a C-terminal tandem cystathionine β-synthase (CBS) domain which is the cytoplasmic K+ sensor for osmotic stress (osmotic strength)while the BusABC subunit has the membrane and receptor domains fused to each other (Biemans-Oldehinkel et al., 2006; Mahmood et al., 2006; Gul et al. 2012). An N-terminal amphipathic α-helix of OpuA is necessary for high activity but is not critical for biogenesis or the ionic regulation of transport from Lactococcus lactis (see 2 papers)
    46% identity, 90% coverage of query (218 bits)

OsrA / b2678 glycine betaine ABC transporter membrane subunit ProW (EC 7.6.2.9) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
proW / P14176 glycine betaine ABC transporter membrane subunit ProW (EC 7.6.2.9) from Escherichia coli (strain K12) (see paper)
PROW_ECOLI / P14176 Glycine betaine/proline betaine transport system permease protein ProW from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.1.12.1 / P14176 ProW aka B2678, component of Glycine betaine/proline porter, ProU or ProVWX (also transports proline betaine, carnitine, dimethyl proline, homobetaine, γ-butyrobetaine and choline with low affinity) from Escherichia coli (see 5 papers)
    48% identity, 92% coverage of query (214 bits)

TC 3.A.1.12.7 / Q92N36 ChoW, component of High affinity (3 μM) choline-specific uptake system from Rhizobium meliloti (Sinorhizobium meliloti) (see 2 papers)
    46% identity, 91% coverage of query (211 bits)

A0A077T980 ABC-type quaternary amine transporter (subunit 3/3) (EC 7.6.2.9) from Vibrio anguillarum serotype O1 (see paper)
    44% identity, 93% coverage of query (207 bits)

GBUB_LISM4 / Q9RR45 Glycine betaine/carnitine transport permease protein GbuB from Listeria monocytogenes serotype 1/2a (strain 10403S) (see 4 papers)
    44% identity, 92% coverage of query (202 bits)

AO353_07785 ABC transporter for Carnitine, permease component from Pseudomonas fluorescens FW300-N2E3
    50% identity, 72% coverage of query (197 bits)

AO356_13810 ABC transporter for Carnitine, permease component from Pseudomonas fluorescens FW300-N2C3
    50% identity, 72% coverage of query (196 bits)

Pf6N2E2_4682 ABC transporter for Carnitine, permease component from Pseudomonas fluorescens FW300-N2E2
    50% identity, 72% coverage of query (195 bits)

TC 3.A.1.12.12 / Q9HTI7 Probable permease of ABC transporter, component of The CbcWV/CbcX (choline)/CaiX (carnitine)/BetX (betaine) transporter with 3 binding receptors for distinct quaternary ammonium compounds. Only the ligand-bound receptor binds to the transporter with high affinity from Pseudomonas aeruginosa (see paper)
    43% identity, 96% coverage of query (190 bits)

TMOV_PELUB / Q4FL38 Trimethylamine N-oxide transport system permease protein TmoV; TMAO transport system permease protein TmoV from Pelagibacter ubique (strain HTCC1062) (see paper)
    40% identity, 72% coverage of query (150 bits)

TMOV_RUEPO / Q5LT64 Trimethylamine N-oxide transport system permease protein TmoV; TMAO transport system permease protein TmoV from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) (see paper)
    35% identity, 75% coverage of query (142 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory