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Searching for up to 100 curated homologs for AO353_12270 FitnessBrowser__pseudo3_N2E3:AO353_12270 (510 a.a.)

Found high-coverage hits (≥70%) to 79 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Pf6N2E2_3799 Histidine ammonia-lyase (EC 4.3.1.3) from Pseudomonas fluorescens FW300-N2E2
    95% identity, 100% coverage of query (982 bits)

PfGW456L13_320 Histidine ammonia-lyase (EC 4.3.1.3) from Pseudomonas fluorescens GW456-L13
    95% identity, 100% coverage of query (982 bits)

hutH / P21310 histidase subunit (EC 4.3.1.3) from Pseudomonas putida (see 5 papers)
HUTH_PSEPU / P21310 Histidine ammonia-lyase; Histidase; EC 4.3.1.3 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 4 papers)
    84% identity, 100% coverage of query (870 bits)

1gkmA / P21310 Histidine ammonia-lyase (hal) from pseudomonas putida inhibited with l-cysteine (see paper)
    84% identity, 100% coverage of query (858 bits)

BWI76_RS08740 Histidine ammonia-lyase (EC 4.3.1.3) from Klebsiella michiganensis M5al
    79% identity, 99% coverage of query (796 bits)

BPHYT_RS07555 Histidine ammonia-lyase (EC 4.3.1.3) from Burkholderia phytofirmans PsJN
    62% identity, 99% coverage of query (586 bits)

Ac3H11_2558 Histidine ammonia-lyase (EC 4.3.1.3) from Acidovorax sp. GW101-3H11
    59% identity, 95% coverage of query (535 bits)

SM_b21165 Histidine ammonia-lyase (EC 4.3.1.3) from Sinorhizobium meliloti 1021
    53% identity, 99% coverage of query (500 bits)

Ga0059261_3963 Histidine ammonia-lyase (EC 4.3.1.3) from Sphingomonas koreensis DSMZ 15582
    56% identity, 97% coverage of query (494 bits)

PGA1_c36340 Histidine ammonia-lyase (EC 4.3.1.3) from Phaeobacter inhibens BS107
    50% identity, 96% coverage of query (469 bits)

Q6AZU6 histidine ammonia-lyase (EC 4.3.1.3) from Xenopus tropicalis (see paper)
    42% identity, 98% coverage of query (409 bits)

HAL / P42357 histidase subunit (EC 4.3.1.3) from Homo sapiens (see 5 papers)
HUTH_HUMAN / P42357 Histidine ammonia-lyase; Histidase; EC 4.3.1.3 from Homo sapiens (Human) (see paper)
P42357 histidine ammonia-lyase (EC 4.3.1.3) from Homo sapiens (see paper)
    45% identity, 92% coverage of query (408 bits)

Q0VGW8 histidine ammonia-lyase (EC 4.3.1.3) from Xenopus laevis (see 2 papers)
    41% identity, 98% coverage of query (406 bits)

HUTH_RAT / P21213 Histidine ammonia-lyase; Histidase; EC 4.3.1.3 from Rattus norvegicus (Rat) (see paper)
    44% identity, 94% coverage of query (405 bits)

F6RBJ7 histidine ammonia-lyase (EC 4.3.1.3) from Xenopus tropicalis (see 2 papers)
    42% identity, 97% coverage of query (405 bits)

Sama_1631 Histidine ammonia-lyase (EC 4.3.1.3) from Shewanella amazonensis SB2B
    43% identity, 96% coverage of query (391 bits)

CA265_RS22270 Histidine ammonia-lyase (EC 4.3.1.3) from Pedobacter sp. GW460-11-11-14-LB5
    42% identity, 91% coverage of query (371 bits)

HUTH_DICDI / Q54JI7 Probable histidine ammonia-lyase; Histidase; EC 4.3.1.3 from Dictyostelium discoideum (Social amoeba) (see paper)
Q54JI7 phenylalanine ammonia-lyase (EC 4.3.1.24) from Dictyostelium discoideum (see paper)
    40% identity, 95% coverage of query (368 bits)

HUTH1_CAEEL / Q20502 Histidine ammonia-lyase; Histidase; EC 4.3.1.3 from Caenorhabditis elegans (see paper)
    42% identity, 94% coverage of query (359 bits)

AO356_09605 Histidine ammonia-lyase (EC 4.3.1.3) from Pseudomonas fluorescens FW300-N2C3
    40% identity, 95% coverage of query (309 bits)

Pf1N1B4_1582 Histidine ammonia-lyase (EC 4.3.1.3) from Pseudomonas fluorescens FW300-N1B4
    39% identity, 97% coverage of query (306 bits)

hutH / AAA26769.1 histidine ammonia-lyase from Streptomyces griseus (see paper)
    40% identity, 88% coverage of query (294 bits)

TAM_MYXSM / B8ZV94 Tyrosine 2,3-aminomutase; MxTAM; Tyrosine ammonia-lyase; EC 5.4.3.6; EC 4.3.1.23 from Myxococcus sp. (strain Mx-B0) (see paper)
B8ZV94 tyrosine 2,3-aminomutase (EC 5.4.3.6) from Myxococcus sp. Mx-B0 (see paper)
    37% identity, 90% coverage of query (286 bits)

TAM_MYXFU / B8ZV93 Tyrosine 2,3-aminomutase; MfTAM; Tyrosine ammonia-lyase; EC 5.4.3.6; EC 4.3.1.23 from Myxococcus fulvus (see paper)
B8ZV93 tyrosine 2,3-aminomutase (EC 5.4.3.6) from Myxococcus fulvus Mx f65 (see paper)
    37% identity, 90% coverage of query (286 bits)

A0A0F7R1D9 phenylalanine aminomutase (D-beta-phenylalanine forming) (EC 5.4.3.11) from Embleya scabrispora (see paper)
    36% identity, 92% coverage of query (281 bits)

TALY_CUPMC / Q1LRV9 Tyrosine ammonia-lyase; CmTAL; Tyrosine 2,3-aminomutase; EC 4.3.1.23; EC 5.4.3.6 from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans) (see paper)
    38% identity, 90% coverage of query (280 bits)

admH / Q84FL5 phenylalanine aminomutase [(S)-β-phenylalanine-forming] (EC 5.4.3.11) from Enterobacter agglomerans (see 3 papers)
Q84FL5 phenylalanine aminomutase (D-beta-phenylalanine forming) (EC 5.4.3.11) from Pantoea agglomerans (see 3 papers)
    33% identity, 93% coverage of query (279 bits)

TAM_CHOCO / Q0VZ68 Tyrosine 2,3-aminomutase; Tyrosine ammonia-lyase; EC 5.4.3.6; EC 4.3.1.23 from Chondromyces crocatus (see 3 papers)
Q0VZ68 tyrosine 2,3-aminomutase (EC 5.4.3.6) from Chondromyces crocatus (see paper)
    37% identity, 84% coverage of query (276 bits)

3unvA / Q84FL5 Pantoea agglomerans phenylalanine aminomutase (see paper)
    33% identity, 93% coverage of query (273 bits)

encP / Q9KHJ9 phenylalanine ammonia lyase (EC 4.3.1.25) from Streptomyces maritimus (see paper)
Q9KHJ9 phenylalanine aminomutase (D-beta-phenylalanine forming) (EC 5.4.3.11) from Streptomyces maritimus (see paper)
    34% identity, 92% coverage of query (270 bits)

TAM_STRGL / Q8GMG0 MIO-dependent tyrosine 2,3-aminomutase; Tyrosine ammonia-lyase; EC 5.4.3.6; EC 4.3.1.23 from Streptomyces globisporus (see 4 papers)
    36% identity, 95% coverage of query (265 bits)

2rjsA Sgtam bound to substrate mimic
    35% identity, 95% coverage of query (257 bits)

2rjrA Substrate mimic bound to sgtam
    35% identity, 95% coverage of query (257 bits)

2qveA Crystal structure of sgtam bound to mechanism based inhibitor
    35% identity, 95% coverage of query (257 bits)

3kdzA / Q8GMG0 X-ray crystal structure of a tyrosine aminomutase mutant construct with bound ligand (see paper)
    35% identity, 95% coverage of query (256 bits)

TALY_CERS4 / Q3IWB0 Tyrosine ammonia-lyase; EC 4.3.1.23 from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see paper)
Q3IWB0 tyrosine ammonia-lyase (EC 4.3.1.23) from Cereibacter sphaeroides (see 2 papers)
    37% identity, 95% coverage of query (245 bits)

2o7dA / Q3IWB0 Tyrosine ammonia-lyase from rhodobacter sphaeroides, complexed with caffeate (see paper)
    36% identity, 95% coverage of query (238 bits)

2o7eA Tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant), bound to 2-aminoindan-2-phosphonic acid
    36% identity, 95% coverage of query (237 bits)

Build an alignment

Build an alignment for AO353_12270 and 38 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

6s7qA / M2BPW8 Crystal structure of ergothioneine degrading enzyme ergothionase from treponema denticola in complex with desmethyl-ergothioneine sulfonic acid (see paper)
    29% identity, 97% coverage of query (218 bits)

PAL1_FRIUN / P0DO55 Phenylalanine/tyrosine ammonia-lyase 1; FuPAL1; EC 4.3.1.25 from Fritillaria unibracteata (Sichuan fritillary) (see paper)
    31% identity, 87% coverage of query (198 bits)

PAL1_PETHY / Q50EX7 Phenylalanine ammonia-lyase 1; PhPAL1; EC 4.3.1.24 from Petunia hybrida (Petunia) (see 4 papers)
    31% identity, 88% coverage of query (197 bits)

PAL1_ARATH / P35510 Phenylalanine ammonia-lyase 1; EC 4.3.1.24 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    31% identity, 88% coverage of query (197 bits)

C6ZIA5 phenylalanine ammonia-lyase (EC 4.3.1.24) from Nicotiana tabacum (see paper)
    32% identity, 86% coverage of query (197 bits)

PAL1_TOBAC / P25872 Phenylalanine ammonia-lyase; EC 4.3.1.24 from Nicotiana tabacum (Common tobacco) (see paper)
P25872 phenylalanine ammonia-lyase (EC 4.3.1.24) from Nicotiana tabacum (see paper)
    32% identity, 86% coverage of query (197 bits)

C0HJ40 phenylalanine ammonia-lyase (EC 4.3.1.24) from Zea mays (see paper)
    32% identity, 87% coverage of query (195 bits)

P45733 phenylalanine ammonia-lyase (EC 4.3.1.24) from Nicotiana tabacum (see paper)
    31% identity, 87% coverage of query (195 bits)

PAL3_ARATH / P45725 Phenylalanine ammonia-lyase 3; EC 4.3.1.24 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    32% identity, 87% coverage of query (195 bits)

PAL4_ARATH / Q9SS45 Phenylalanine ammonia-lyase 4; EC 4.3.1.24 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    32% identity, 84% coverage of query (194 bits)

P35511 phenylalanine ammonia-lyase (EC 4.3.1.24) from Solanum lycopersicum (see 3 papers)
    32% identity, 87% coverage of query (194 bits)

P35513 phenylalanine ammonia-lyase (EC 4.3.1.24) from Nicotiana tabacum (see paper)
TOBPAL1 / BAA22963.1 phenylalanine ammonia-lyase from Nicotiana tabacum (see paper)
    31% identity, 87% coverage of query (193 bits)

PAL1 / B5U983 phenylalanine ammonia-lyase 1 (EC 4.3.1.25) from Ephedra sinica (see paper)
B5U983 phenylalanine ammonia-lyase (EC 4.3.1.24) from Ephedra sinica (see paper)
    32% identity, 87% coverage of query (192 bits)

B9VU66 phenylalanine ammonia-lyase (EC 4.3.1.24) from Lycoris radiata (see 2 papers)
    31% identity, 88% coverage of query (192 bits)

PAL_TRIV2 / Q3M5Z3 Phenylalanine ammonia-lyase; EC 4.3.1.24 from Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis) (see 2 papers)
Q3M5Z3 phenylalanine ammonia-lyase (EC 4.3.1.24) from Trichormus variabilis (see 4 papers)
    32% identity, 83% coverage of query (192 bits)

C0LL35 phenylalanine ammonia-lyase (EC 4.3.1.24) from Bambusa oldhamii (see 2 papers)
    32% identity, 84% coverage of query (192 bits)

PAL2_ARATH / P45724 Phenylalanine ammonia-lyase 2; EC 4.3.1.24 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    31% identity, 88% coverage of query (191 bits)

PAL2_NARPS / A0A2H5AIY6 Phenylalanine ammonia-lyase 2; EC 4.3.1.24 from Narcissus pseudonarcissus (Daffodil) (see paper)
    31% identity, 84% coverage of query (191 bits)

F8RL28 phenylalanine ammonia-lyase (EC 4.3.1.24) from Fragaria x ananassa (see paper)
    30% identity, 87% coverage of query (191 bits)

Q68G84 phenylalanine aminomutase (EC 5.4.3.10) from Taxus wallichiana var. chinensis (see 2 papers)
PAM_TAXWC / Q68G84 Phenylalanine aminomutase (L-beta-phenylalanine forming); Phenylalanine ammonia-lyase; EC 5.4.3.10; EC 4.3.1.24 from Taxus wallichiana var. chinensis (Chinese yew) (Taxus chinensis) (see 3 papers)
Q68G84 phenylalanine aminomutase (L-beta-phenylalanine forming) (EC 5.4.3.10); phenylalanine aminomutase (D-beta-phenylalanine forming) (EC 5.4.3.11) from Taxus chinensis (see 2 papers)
pam / AAU01182.1 phenylalanine aminomutase from Taxus chinensis (see paper)
    32% identity, 83% coverage of query (190 bits)

C5XXT9 phenylalanine ammonia-lyase (EC 4.3.1.24) from Sorghum bicolor (see paper)
    31% identity, 84% coverage of query (190 bits)

Q0GA81 phenylalanine ammonia-lyase (EC 4.3.1.24) from Jatropha curcas (see paper)
    31% identity, 87% coverage of query (189 bits)

Q68G83 phenylalanine ammonia-lyase (EC 4.3.1.24); phenylalanine aminomutase (L-beta-phenylalanine forming) (EC 5.4.3.10) from Taxus chinensis (see 2 papers)
    31% identity, 83% coverage of query (189 bits)

D5KS97 phenylalanine ammonia-lyase (EC 4.3.1.24); phenylalanine/tyrosine ammonia-lyase (EC 4.3.1.25) from Bambusa oldhamii (see paper)
    30% identity, 88% coverage of query (189 bits)

PAL1_PETCR / P24481 Phenylalanine ammonia-lyase 1; EC 4.3.1.24 from Petroselinum crispum (Parsley) (Petroselinum hortense) (see 2 papers)
    30% identity, 88% coverage of query (189 bits)

A9XIW5 phenylalanine ammonia-lyase (EC 4.3.1.24) from Salvia miltiorrhiza (see paper)
    30% identity, 87% coverage of query (188 bits)

Q6ST23 phenylalanine ammonia-lyase (EC 4.3.1.24) from Bambusa oldhamii (see 2 papers)
    31% identity, 84% coverage of query (188 bits)

U5TV35 tyrosine ammonia-lyase (EC 4.3.1.23) from Rhodotorula glutinis (see paper)
    33% identity, 85% coverage of query (187 bits)

Q852S1 phenylalanine ammonia-lyase (EC 4.3.1.24) from Daucus carota (see paper)
    30% identity, 88% coverage of query (187 bits)

PALY_RHOTO / P11544 Phenylalanine/tyrosine ammonia-lyase; Bifunctional phenylalanine ammonia-lyase; Bifunctional PAL; EC 4.3.1.25 from Rhodotorula toruloides (Yeast) (Rhodosporidium toruloides) (see 2 papers)
P11544 phenylalanine ammonia-lyase (EC 4.3.1.24); phenylalanine/tyrosine ammonia-lyase (EC 4.3.1.25) from Rhodotorula toruloides (see 4 papers)
    33% identity, 85% coverage of query (187 bits)

Q6GZ04 phenylalanine aminomutase (EC 5.4.3.10) from Taxus canadensis (see paper)
PAM_TAXCA / Q6GZ04 Phenylalanine aminomutase (L-beta-phenylalanine forming); Phenylalanine ammonia-lyase; EC 5.4.3.10; EC 4.3.1.24 from Taxus canadensis (Canadian yew) (see paper)
Q6GZ04 phenylalanine aminomutase (L-beta-phenylalanine forming) (EC 5.4.3.10) from Taxus canadensis (see paper)
    31% identity, 83% coverage of query (187 bits)

B1GS31 phenylalanine ammonia-lyase (EC 4.3.1.24) from Cynara cardunculus var. scolymus (see paper)
    31% identity, 88% coverage of query (187 bits)

L0BXX7 phenylalanine ammonia-lyase (EC 4.3.1.24) from Plectranthus scutellarioides (see paper)
    30% identity, 87% coverage of query (186 bits)

PAL1_NARPS / A0A2H5AIW0 Phenylalanine ammonia-lyase 1; EC 4.3.1.24 from Narcissus pseudonarcissus (Daffodil) (see paper)
    30% identity, 94% coverage of query (186 bits)

Q5EIB6 phenylalanine ammonia-lyase (EC 4.3.1.24) from Rhodiola sachalinensis (see paper)
    30% identity, 87% coverage of query (185 bits)

4c5sC / Q68G84 Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis (see paper)
    32% identity, 85% coverage of query (184 bits)

6hqfA Structure of phenylalanine ammonia-lyase from petroselinum crispum in complex with (r)-apep
    30% identity, 92% coverage of query (184 bits)

6f6tB / P24481 Phenylalanine ammonia-lyase (pal) from petroselinum crispum complexed with s-appa
    30% identity, 88% coverage of query (183 bits)

5ltmB / Q3M5Z3 Crystal structure of phenylalanine ammonia-lyase from anabaena variabilis (y78f-c503s-c565s) bound to cinnamate (see paper)
    31% identity, 85% coverage of query (181 bits)

PAL_NOSP7 / B2J528 Phenylalanine ammonia-lyase; EC 4.3.1.24 from Nostoc punctiforme (strain ATCC 29133 / PCC 73102) (see paper)
    30% identity, 87% coverage of query (181 bits)

6rgsB / P24481 Crystal structure of phenylalanine ammonia lyase (pal) from petroselinum crispum bound to cinnamate
    31% identity, 79% coverage of query (166 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory