Sites on a Tree

 

Searching for up to 100 curated homologs for AO353_19865 FitnessBrowser__pseudo3_N2E3:AO353_19865 (327 a.a.)

Found high-coverage hits (≥70%) to 95 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

furX / Q46UZ9 furfuryl alcohol dehydrogenase (EC 1.1.1.1) from Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (see paper)
    36% identity, 99% coverage of query (187 bits)

3s2eA / Q46UZ9 Crystal structure of furx nadh complex 1
    36% identity, 99% coverage of query (186 bits)

ADH_MORSE / Q8GIX7 Alcohol dehydrogenase; ADH; EC 1.1.1.1 from Moraxella sp. (strain TAE123) (see 3 papers)
Q8GIX7 alcohol dehydrogenase (EC 1.1.1.1) from Moraxella sp. (see paper)
    35% identity, 99% coverage of query (186 bits)

4z6kA / Q8GIX7 Alcohol dehydrogenase from the antarctic psychrophile moraxella sp. Tae 123
    35% identity, 99% coverage of query (186 bits)

3s2fE Crystal structure of furx nadh:furfural
    36% identity, 99% coverage of query (186 bits)

3s2fA Crystal structure of furx nadh:furfural
    36% identity, 99% coverage of query (186 bits)

3s2eE Crystal structure of furx nadh complex 1
    36% identity, 99% coverage of query (186 bits)

RR42_RS34260 Alcohol dehydrogenase (EC 1.1.1.1) from Cupriavidus basilensis FW507-4G11
    35% identity, 99% coverage of query (184 bits)

P12311 Alcohol dehydrogenase; ADH-T; EC 1.1.1.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus)
    35% identity, 99% coverage of query (182 bits)

3piiA Crystal structure of mutant of ht- alcohol dehydrogenase with substrate analogue butyramide
    34% identity, 100% coverage of query (180 bits)

P42328 alcohol dehydrogenase (EC 1.1.1.1) from Geobacillus stearothermophilus (see 8 papers)
1rjwA / P42328 Crystal structure of NAD(+)-dependent alcohol dehydrogenase from bacillus stearothermophilus strain lld-r (see paper)
    34% identity, 100% coverage of query (179 bits)

1lluA / Q9HTD9 The ternary complex of pseudomonas aeruginosa alcohol dehydrogenase with its coenzyme and weak substrate (see paper)
    35% identity, 99% coverage of query (179 bits)

Q6RS93 alcohol dehydrogenase (EC 1.1.1.1) from Parageobacillus thermoglucosidasius (see paper)
    33% identity, 100% coverage of query (178 bits)

Q8L3C9 alcohol dehydrogenase (EC 1.1.1.1) from Flavobacterium frigidimaris (see paper)
    33% identity, 99% coverage of query (178 bits)

6iqdA / P42327 Crystal structure of alcohol dehydrogenase from geobacillus stearothermophilus (see paper)
    32% identity, 100% coverage of query (175 bits)

6n7lC / A0A077EGR8 Crystal structure of an alcohol dehydrogenase from elizabethkingia anophelis nuhp1
    33% identity, 99% coverage of query (173 bits)

6z42A / E1V3M3 The low resolution structure of a zinc-dependent alcohol dehydrogenase from halomonas elongata.
    36% identity, 99% coverage of query (165 bits)

3meqA / A0A0H3G9R2 Crystal structure of alcohol dehydrogenase from brucella melitensis
    33% identity, 99% coverage of query (164 bits)

adhA / Q8NLX9 Zn2+-dependent alcohol dehydrogenase (EC 1.1.1.1; EC 1.1.1.244) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 5 papers)
    30% identity, 99% coverage of query (161 bits)

NOTN_ASPSM / E1ACQ9 Alcohol dehydrogenase notN; Notoamide biosynthesis cluster protein N; EC 1.1.1.1 from Aspergillus sp. (strain MF297-2) (see 3 papers)
    32% identity, 98% coverage of query (140 bits)

A3MVR8 alcohol dehydrogenase (EC 1.1.1.1) from Pyrobaculum calidifontis (see paper)
    31% identity, 99% coverage of query (137 bits)

Build an alignment

Build an alignment for AO353_19865 and 21 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

T1WVG5 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
    29% identity, 96% coverage of query (137 bits)

T1WUT6 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
    31% identity, 91% coverage of query (130 bits)

Q7XWU3 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Oryza sativa Japonica Group (see paper)
    31% identity, 96% coverage of query (130 bits)

patD / A0A075TMP0 neopatulin dehydrogenase from Penicillium expansum (see paper)
PATD_PENEN / A0A075TMP0 Alcohol dehydrogenase patD; Patulin biosynthesis cluster protein D; EC 1.1.1.- from Penicillium expansum (Blue mold rot fungus) (see 8 papers)
    32% identity, 99% coverage of query (125 bits)

CADH9_ARATH / P42734 Probable cinnamyl alcohol dehydrogenase 9; AtCAD9; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    29% identity, 92% coverage of query (123 bits)

CADH3_ARATH / Q9SJ10 Cinnamyl alcohol dehydrogenase 3; AtCAD3; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    30% identity, 92% coverage of query (123 bits)

CADH6_ARATH / O65621 Probable cinnamyl alcohol dehydrogenase 6; AtCAD6; Cinnamyl alcohol dehydrogenase-like protein A; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    29% identity, 92% coverage of query (122 bits)

CAD7 / Q02971 cinnamyl alcohol dehydrogenase 7 (EC 1.1.1.195) from Arabidopsis thaliana (see 2 papers)
CADH7_ARATH / Q02971 Cinnamyl alcohol dehydrogenase 7; AtCAD7; Cinnamyl alcohol dehydrogenase-like protein B; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    31% identity, 96% coverage of query (120 bits)

ADHA_SYNY3 / P74721 Aldehyde reductase AdhA; Alcohol dehydrogenase AdhA; EC 1.1.1.2 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 3 papers)
P74721 alcohol dehydrogenase (EC 1.1.1.1) from Synechocystis sp. PCC 6803 (see paper)
    31% identity, 97% coverage of query (120 bits)

F9VMI9 alcohol dehydrogenase (EC 1.1.1.1) from Sulfurisphaera tokodaii (see paper)
    28% identity, 100% coverage of query (119 bits)

4eezB / D2BLA0 Crystal structure of lactococcus lactis alcohol dehydrogenase variant re1 (see paper)
    28% identity, 96% coverage of query (118 bits)

SAD / Q94G59 sinapyl alcohol dehydrogenase (EC 1.1.1.195) from Populus tremuloides (see paper)
    29% identity, 96% coverage of query (117 bits)

T1WUU2 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
    30% identity, 96% coverage of query (117 bits)

MTD / Q38707 mannitol dehydrogenase (EC 1.1.1.255) from Apium graveolens (see paper)
Q38707 mannitol dehydrogenase (EC 1.1.1.255) from Apium graveolens (see paper)
    28% identity, 96% coverage of query (117 bits)

T1WWB9 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
    30% identity, 96% coverage of query (116 bits)

E3UTQ9 allyl-alcohol dehydrogenase (EC 1.1.1.54) from Fusarium oxysporum (see paper)
    27% identity, 99% coverage of query (116 bits)

T1WWR8 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
    28% identity, 96% coverage of query (116 bits)

CADH2_ARATH / Q9SJ25 Cinnamyl alcohol dehydrogenase 2; AtCAD2; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    30% identity, 92% coverage of query (116 bits)

Q1HGA8 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Linum usitatissimum (see 3 papers)
    25% identity, 92% coverage of query (116 bits)

1yqdA / Q94G59 Sinapyl alcohol dehydrogenase complexed with NADP+ (see paper)
    29% identity, 96% coverage of query (115 bits)

ADH5 / P38113 alcohol dehydrogenase V (EC 1.1.1.1; EC 1.1.1.190) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 10 papers)
ADH5_YEAST / P38113 Alcohol dehydrogenase 5; Alcohol dehydrogenase V; EC 1.1.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    27% identity, 99% coverage of query (115 bits)

F6L7F5 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Camellia sinensis (see paper)
    28% identity, 96% coverage of query (114 bits)

5vktA / C5XC49 Cinnamyl alcohol dehydrogenases (sbcad4) from sorghum bicolor (l.) Moench (see paper)
    31% identity, 91% coverage of query (114 bits)

C5XC49 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Sorghum bicolor (see 2 papers)
    31% identity, 91% coverage of query (114 bits)

A0A1D6BJ11 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Triticum aestivum (see paper)
    28% identity, 92% coverage of query (114 bits)

Q9CEN0 alcohol dehydrogenase (EC 1.1.1.1) from Lactococcus lactis subsp. lactis (see paper)
    28% identity, 96% coverage of query (113 bits)

chnD / Q9F7D8 6-hydroxyhexanoate dehydrogenase (EC 1.1.1.258) from Acinetobacter sp. (strain SE19) (see paper)
    30% identity, 97% coverage of query (112 bits)

CAD1_MEDTR / A0A072VPZ8 Cinnamyl alcohol dehydrogenase 1; Mt-CAD1; Coniferol dehydrogenase; Coumaroyl alcohol dehydrogenase; Sinapyl alcohol dehydrogenase; EC 1.1.1.195 from Medicago truncatula (Barrel medic) (Medicago tribuloides) (see paper)
    26% identity, 93% coverage of query (112 bits)

GEDH1 / Q2KNL6 geraniol dehydrogenase (EC 1.1.1.183) from Ocimum basilicum (see paper)
GEDH1_OCIBA / Q2KNL6 Geraniol dehydrogenase 1; ObaGEDH1; EC 1.1.1.183 from Ocimum basilicum (Sweet basil) (see paper)
Q2KNL6 geraniol dehydrogenase (NADP+) (EC 1.1.1.183) from Ocimum basilicum (see paper)
    30% identity, 96% coverage of query (112 bits)

B5AR58 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Leucaena leucocephala (see paper)
    26% identity, 93% coverage of query (110 bits)

Q8H0L8 alcohol dehydrogenase [NAD(P)+] (EC 1.1.1.71) from Solanum tuberosum (see paper)
    30% identity, 92% coverage of query (109 bits)

5fi3A / A0A0F6SD02 Heteroyohimbine synthase thas1 from catharanthus roseus - complex with NADP+ (see paper)
    28% identity, 96% coverage of query (109 bits)

B5TR18 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Leucaena leucocephala (see paper)
    26% identity, 91% coverage of query (109 bits)

T3R_CATRO / A0A161CAI1 16-methoxy-2,3-dihydro-3-hydroxytabersonine synthase; 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase; Alcohol dehydrogenase-like protein 1; ADHL1; Tabersonine 3-reductase; EC 1.1.99.41 from Catharanthus roseus (Madagascar periwinkle) (Vinca rosea) (see 2 papers)
A0A161CAI1 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase (EC 1.1.99.41) from Catharanthus roseus (see 2 papers)
    28% identity, 96% coverage of query (109 bits)

K9S0X0 geraniol dehydrogenase (NADP+) (EC 1.1.1.183) from Perilla frutescens var. hirtella (see paper)
    29% identity, 96% coverage of query (109 bits)

K9S1J6 geraniol dehydrogenase (NADP+) (EC 1.1.1.183) from Perilla frutescens (see paper)
    29% identity, 96% coverage of query (108 bits)

YddN / b1478 ethanol dehydrogenase / alcohol dehydrogenase (EC 1.1.1.1) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
adhP / P39451 ethanol dehydrogenase / alcohol dehydrogenase (EC 1.1.1.1) from Escherichia coli (strain K12) (see 5 papers)
4gkvB / P39451 Structure of escherichia coli adhp (ethanol-inducible dehydrogenase) with bound NAD (see paper)
    30% identity, 99% coverage of query (108 bits)

7bu3A Structure of alcohol dehydrogenase yjgb in complex with NADP from escherichia coli
    29% identity, 92% coverage of query (107 bits)

7bu2B / P27250 Structure of alcohol dehydrogenase yjgb from escherichia coli (see paper)
    29% identity, 92% coverage of query (106 bits)

8a3nB / W8JWW7 Geissoschizine synthase from catharanthus roseus - binary complex with NADP+ (see paper)
    24% identity, 95% coverage of query (104 bits)

6k3gB / Q6V4H0 Crystal structure of 10-hydroxygeraniol dehydrogenase from cantharanthus roseus in complex with NADP+ (see paper)
    29% identity, 96% coverage of query (103 bits)

7cguA / A0A8A5L0G9 Crystal structure of abhar
    28% identity, 96% coverage of query (103 bits)

5h81B / A0A1C7D193 Heteroyohimbine synthase thas2 from catharanthus roseus - complex with NADP+ (see paper)
    27% identity, 96% coverage of query (99.0 bits)

4ej6A / Q92PZ3 Crystal structure of a putative zinc-binding dehydrogenase (target psi-012003) from sinorhizobium meliloti 1021
    34% identity, 77% coverage of query (99.0 bits)

4ejmA Crystal structure of a putative zinc-binding dehydrogenase (target psi-012003) from sinorhizobium meliloti 1021 bound to NADP
    34% identity, 77% coverage of query (98.6 bits)

1uufA / P75691 Crystal structure of a zinc-type alcohol dehydrogenase-like protein yahk
    34% identity, 71% coverage of query (98.2 bits)

6c49A / A0A1E3MC83 Crystal structure of alcohol dehydrogenase from acinetobacter baumannii
    27% identity, 92% coverage of query (95.5 bits)

4c4oB / O42703 Structure of carbonyl reductase cpcr2 from candida parapsilosis in complex with nadh
    29% identity, 96% coverage of query (93.2 bits)

araDH / Q97YM2 D-arabinose 1-dehydrogenase subunit (EC 1.1.1.427) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see 2 papers)
ARADH_SACS2 / Q97YM2 D-arabinose 1-dehydrogenase (NADP(+)); AraDH; D-Ara dehydrogenase; EC 1.1.1.427 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 2 papers)
Q97YM2 D-threo-aldose 1-dehydrogenase (EC 1.1.1.122) from Saccharolobus solfataricus (see 2 papers)
    28% identity, 100% coverage of query (93.2 bits)

3wlfA Crystal structure of (r)-carbonyl reductase from candida parapsilosis in complex with (r)-1-phenyl-1,2-ethanediol
    29% identity, 96% coverage of query (93.2 bits)

6isvB / M5A8V4 Structure of acetophenone reductase from geotrichum candidum nbrc 4597 in complex with NAD (see paper)
    30% identity, 94% coverage of query (92.8 bits)

5h83A / A0A1C7D195 Heteroyohimbine synthase hys from catharanthus roseus - apo form (see paper)
    29% identity, 96% coverage of query (91.7 bits)

3wnqA Crystal structure of (r)-carbonyl reductase h49a mutant from candida parapsilosis in complex with 2-hydroxyacetophenone
    29% identity, 96% coverage of query (89.4 bits)

6ffxA Crystal structure of r. Ruber adh-a, mutant f43h (see paper)
    30% identity, 94% coverage of query (85.5 bits)

5o9dA Crystal structure of r. Ruber adh-a, mutant y294f, w295a, y54f, f43h, h39y
    30% identity, 94% coverage of query (85.5 bits)

ADHL_GADMO / P81601 Alcohol dehydrogenase class-3 chain L; Alcohol dehydrogenase class-III chain L; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase; EC 1.1.1.1; EC 1.1.1.-; EC 1.1.1.284 from Gadus morhua (Atlantic cod) (see paper)
    28% identity, 86% coverage of query (81.3 bits)

5kiaA / Q2T9E1 Crystal structure of l-threonine 3-dehydrogenase from burkholderia thailandensis
    26% identity, 99% coverage of query (81.3 bits)

CADH2_ORYSJ / Q6ZHS4 Cinnamyl alcohol dehydrogenase 2; OsCAD2; Protein GOLD HULL AND INTERNODE 2; EC 1.1.1.195 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
Q6ZHS4 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Oryza sativa Japonica Group (see paper)
    26% identity, 92% coverage of query (77.8 bits)

P80467 Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase; EC 1.1.1.1; EC 1.1.1.-; EC 1.1.1.284 from Saara hardwickii (Indian spiny-tailed lizard) (Uromastyx hardwickii)
    27% identity, 86% coverage of query (72.8 bits)

4cpdA / B2ZRE3 Alcohol dehydrogenase tadh from thermus sp. Atn1
    30% identity, 82% coverage of query (72.0 bits)

ADHX_MYXGL / P80360 Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase; EC 1.1.1.1; EC 1.1.1.-; EC 1.1.1.284 from Myxine glutinosa (Atlantic hagfish) (see paper)
    29% identity, 97% coverage of query (71.2 bits)

2cf6A Crystal structures of the arabidopsis cinnamyl alcohol dehydrogenases atcad5
    26% identity, 92% coverage of query (70.5 bits)

2cf5A / O49482 Crystal structures of the arabidopsis cinnamyl alcohol dehydrogenases, atcad5 (see paper)
    26% identity, 92% coverage of query (70.5 bits)

CAD5 / O49482 cinnamyl alcohol dehydrogenase 5 (EC 1.1.1.195) from Arabidopsis thaliana (see 3 papers)
CADH5_ARATH / O49482 Cinnamyl alcohol dehydrogenase 5; AtCAD5; Cinnamyl alcohol dehydrogenase D; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
O49482 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Arabidopsis thaliana (see 2 papers)
    26% identity, 92% coverage of query (70.5 bits)

7vb6A Crystal structure of hydroxynitrile lyase from linum usitatissium complexed with (r)-2-hydroxy-2-methylbutanenitrile
    24% identity, 79% coverage of query (70.5 bits)

7vb5A Crystal structure of hydroxynitrile lyase from linum usitatissimum complexed with acetone cyanohydrin
    24% identity, 79% coverage of query (70.5 bits)

7vb3B / P93243 Crystal structure of hydroxynitrile lyase from linum usitatissimum (see paper)
    24% identity, 79% coverage of query (70.5 bits)

4jbiA 2.35a resolution structure of NADPH bound thermostable alcohol dehydrogenase from pyrobaculum aerophilum
    26% identity, 100% coverage of query (70.5 bits)

4jbhA 2.2a resolution structure of cobalt and zinc bound thermostable alcohol dehydrogenase from pyrobaculum aerophilum
    26% identity, 100% coverage of query (70.5 bits)

4jbgA / Q8ZUP0 1.75a resolution structure of a thermostable alcohol dehydrogenase from pyrobaculum aerophilum (see paper)
    26% identity, 100% coverage of query (70.5 bits)

HNL / P93243 aliphatic (R)-hydroxynitrile lyase monomer (EC 4.1.2.46) from Linum usitatissimum (see 2 papers)
AHNL_LINUS / P93243 Aliphatic (R)-hydroxynitrile lyase; LuHNL; EC 4.1.2.46 from Linum usitatissimum (Flax) (Linum humile) (see 3 papers)
P93243 aliphatic (R)-hydroxynitrile lyase (EC 4.1.2.46) from Linum usitatissimum (see 2 papers)
    24% identity, 79% coverage of query (70.1 bits)

3gazA / Q2G4L9 Crystal structure of an alcohol dehydrogenase superfamily protein from novosphingobium aromaticivorans
    28% identity, 89% coverage of query (58.9 bits)

6dkhC / P39346 The crystal structure of l-idonate 5-dehydrogenase from escherichia coli str. K-12 substr. Mg1655
    25% identity, 79% coverage of query (55.8 bits)

6ie0B / O34788 X-ray crystal structure of 2r,3r-butanediol dehydrogenase from bacillus subtilis
    26% identity, 78% coverage of query (44.7 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory