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Searching for up to 100 curated homologs for AO353_21000 FitnessBrowser__pseudo3_N2E3:AO353_21000 (326 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

3jynA / Q88B47 Crystal structures of pseudomonas syringae pv. Tomato dc3000 quinone oxidoreductase complexed with NADPH (see paper)
    49% identity, 100% coverage of query (314 bits)

Hzc / b4051 putative quinone oxidoreductase 1 (EC 1.6.5.5) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
QOR1_ECOLI / P28304 Quinone oxidoreductase 1; NADPH:quinone reductase 1; Zeta-crystallin homolog protein; EC 1.6.5.5 from Escherichia coli (strain K12) (see paper)
qor / AAA23691.1 quinone oxidoreductase from Escherichia coli (see paper)
    46% identity, 100% coverage of query (291 bits)

1qorA / P28304 Crystal structure of escherichia coli quinone oxidoreductase complexed with NADPH (see paper)
    46% identity, 99% coverage of query (288 bits)

caa43 / Q59I44 2-haloacrylate reductase (EC 1.3.1.103) from Burkholderia sp. (see paper)
CAA43_BURSP / Q59I44 2-haloacrylate reductase; EC 1.3.1.103 from Burkholderia sp. (see paper)
Q59I44 2-haloacrylate reductase (EC 1.3.1.103) from Burkholderia sp. (see 5 papers)
caa43 / BAD91551.1 2-haloacrylate reductase from Burkholderia sp. WS (see paper)
    46% identity, 100% coverage of query (276 bits)

4rvuA / O53146 The native structure of mycobacterial rv1454c complexed with NADPH (see paper)
    44% identity, 99% coverage of query (262 bits)

P38230 NADPH:quinone reductase (EC 1.6.5.5) from Saccharomyces cerevisiae (see paper)
    42% identity, 99% coverage of query (231 bits)

3qwbA / P38230 Crystal structure of saccharomyces cerevisiae zeta-crystallin-like quinone oxidoreductase zta1 complexed with NADPH (see paper)
    42% identity, 99% coverage of query (230 bits)

QOR_SCHPO / O74489 Probable quinone oxidoreductase; NADPH:quinone reductase; EC 1.6.5.5 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    37% identity, 98% coverage of query (192 bits)

2eihA / Q5SL27 Crystal structure of NAD-dependent alcohol dehydrogenase
    30% identity, 99% coverage of query (145 bits)

QOR_BOVIN / O97764 Zeta-crystallin from Bos taurus (Bovine) (see paper)
    30% identity, 100% coverage of query (129 bits)

QOR_CAVPO / P11415 Quinone oxidoreductase; NADPH:quinone reductase; Zeta-crystallin; EC 1.6.5.5 from Cavia porcellus (Guinea pig) (see 3 papers)
    30% identity, 100% coverage of query (124 bits)

Build an alignment

Build an alignment for AO353_21000 and 11 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

1yb5A / Q08257 Crystal structure of human zeta-crystallin with bound NADP
    28% identity, 96% coverage of query (119 bits)

QOR_HUMAN / Q08257 Quinone oxidoreductase; NADPH:quinone reductase; Zeta-crystallin; EC 1.6.5.5 from Homo sapiens (Human) (see 2 papers)
Q08257 2-hexadecenal reductase (EC 1.3.1.27); NADPH:quinone reductase (EC 1.6.5.5) from Homo sapiens (see 2 papers)
    28% identity, 96% coverage of query (119 bits)

6lhrC / Q99536 Crystal structure of the complex between vesicle amine transport-1 and NADP (see paper)
    29% identity, 91% coverage of query (117 bits)

VAT1_HUMAN / Q99536 Synaptic vesicle membrane protein VAT-1 homolog; EC 1.-.-.- from Homo sapiens (Human) (see 3 papers)
    29% identity, 91% coverage of query (117 bits)

QORX_HUMAN / Q53FA7 Quinone oxidoreductase PIG3; NADPH:quinone reductase PIG3; Tumor protein p53-inducible protein 3; Protein PIG3; p53-induced gene 3 protein; EC 1.6.5.5 from Homo sapiens (Human) (see 2 papers)
    29% identity, 98% coverage of query (115 bits)

2obyA / Q53FA7 Crystal structure of human p53 inducible oxidoreductase (tp53i3,pig3)
    29% identity, 98% coverage of query (115 bits)

3tqhA / Q83CT0 Structure of the quinone oxidoreductase from coxiella burnetii (see paper)
    31% identity, 99% coverage of query (114 bits)

VAT1_DANRE / Q8JFV8 Synaptic vesicle membrane protein VAT-1 homolog; EC 1.-.-.- from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
    29% identity, 96% coverage of query (114 bits)

P12311 Alcohol dehydrogenase; ADH-T; EC 1.1.1.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus)
    30% identity, 80% coverage of query (110 bits)

5k1sA / Q1D4I2 Crystal structure of aibc (see paper)
    29% identity, 99% coverage of query (109 bits)

Q6RS93 alcohol dehydrogenase (EC 1.1.1.1) from Parageobacillus thermoglucosidasius (see paper)
    31% identity, 80% coverage of query (108 bits)

mas / Q02251 mycocerosic acid synthase monomer (EC 2.3.1.111) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see 7 papers)
MCAS_MYCBO / Q02251 Mycocerosic acid synthase; EC 2.3.1.111 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see paper)
    29% identity, 98% coverage of query (108 bits)

AAA25369.1 mycocerosic acid synthase from Mycobacterium tuberculosis (see paper)
    29% identity, 98% coverage of query (108 bits)

ref / CAA89858.1 ARP protein from Arabidopsis thaliana (see paper)
    29% identity, 92% coverage of query (107 bits)

PPSC_MYCTU / P96202 Phenolphthiocerol/phthiocerol polyketide synthase subunit C; (Phenol)carboxyphthiodiolenone synthase subunit C; Beta-ketoacyl-acyl-carrier-protein synthase I; Phthiocerol synthesis polyketide synthase type I PpsC; EC 2.3.1.292 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
PPSC_MYCBO / Q7TXL8 Phenolphthiocerol/phthiocerol polyketide synthase subunit C; (Phenol)carboxyphthiodiolenone synthase subunit C; Beta-ketoacyl-acyl-carrier-protein synthase I; Phthiocerol synthesis polyketide synthase type I PpsC; EC 2.3.1.292 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see paper)
    29% identity, 99% coverage of query (107 bits)

PHIA_FUNX7 / A0A348HAX6 Highly reducing polyketide synthase phiA; HR-PKS phiA; Phomoidride biosynthesis cluster protein A; EC 2.3.1.- from Fungal sp. (strain ATCC 74256) (see 2 papers)
    30% identity, 73% coverage of query (106 bits)

P42328 alcohol dehydrogenase (EC 1.1.1.1) from Geobacillus stearothermophilus (see 8 papers)
1rjwA / P42328 Crystal structure of NAD(+)-dependent alcohol dehydrogenase from bacillus stearothermophilus strain lld-r (see paper)
    30% identity, 80% coverage of query (105 bits)

5bp4R / A0R1E8 5bp4R (see paper)
    30% identity, 93% coverage of query (104 bits)

5bp4L / A0R1E8 5bp4L (see paper)
    30% identity, 93% coverage of query (104 bits)

5bp4A / A0R1E8 5bp4A (see paper)
    30% identity, 93% coverage of query (104 bits)

3piiA Crystal structure of mutant of ht- alcohol dehydrogenase with substrate analogue butyramide
    30% identity, 80% coverage of query (104 bits)

PKS5_MYCS2 / A0R1E8 Mycocerosic acid synthase-like polyketide synthase; MAS-like PKS; Polyketide synthase Pks5; EC 2.3.1.- from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see 2 papers)
A0R1E8 mycocerosate synthase (EC 2.3.1.111) from Mycolicibacterium smegmatis (see paper)
    30% identity, 93% coverage of query (103 bits)

msl2 / P9WQE9 phthioceranic/hydroxyphthioceranic acid synthase monomer (EC 2.3.1.287) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
PHAS_MYCTU / P9WQE9 Phthioceranic/hydroxyphthioceranic acid synthase; Polyketide synthase pks2; EC 2.3.1.287 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 6 papers)
P9WQE9 mycolipanoate synthase (EC 2.3.1.252) from Mycobacterium tuberculosis (see paper)
    30% identity, 92% coverage of query (101 bits)

VAT1_RAT / Q3MIE4 Synaptic vesicle membrane protein VAT-1 homolog; Mitofusin-binding protein; Protein MIB; EC 1.-.-.- from Rattus norvegicus (Rat) (see paper)
    31% identity, 91% coverage of query (100 bits)

VAT1L_HUMAN / Q9HCJ6 Synaptic vesicle membrane protein VAT-1 homolog-like; EC 1.-.-.- from Homo sapiens (Human) (see paper)
    33% identity, 74% coverage of query (100 bits)

tubF / CAF05651.1 TubF protein from Archangium disciforme (see paper)
    31% identity, 71% coverage of query (97.4 bits)

VAT1_MOUSE / Q62465 Synaptic vesicle membrane protein VAT-1 homolog; EC 1.-.-.- from Mus musculus (Mouse) (see paper)
    31% identity, 91% coverage of query (97.1 bits)

A0A1W5T7B8 (4-hydroxyphenyl)alkanoate synthase (EC 2.3.1.261) from Beauveria bassiana (see paper)
    31% identity, 71% coverage of query (96.7 bits)

YGD6_SCHPO / O94564 Zinc-type alcohol dehydrogenase-like protein C1773.06c; EC 1.-.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    29% identity, 71% coverage of query (96.7 bits)

curH / F4Y428 curacin polyketide synthase CurH from Moorena producens 3L (see 4 papers)
    26% identity, 99% coverage of query (94.4 bits)

1lluA / Q9HTD9 The ternary complex of pseudomonas aeruginosa alcohol dehydrogenase with its coenzyme and weak substrate (see paper)
    28% identity, 91% coverage of query (90.1 bits)

6iqdA / P42327 Crystal structure of alcohol dehydrogenase from geobacillus stearothermophilus (see paper)
    28% identity, 76% coverage of query (88.6 bits)

pks12 / I6XD69 mycoketide-CoA synthase monomer (EC 2.3.1.295) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
PKS12_MYCTU / I6XD69 Mycoketide-CoA synthase; Polyketide synthase Pks12; EC 2.3.1.295 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
    30% identity, 95% coverage of query (87.4 bits)

3meqA / A0A0H3G9R2 Crystal structure of alcohol dehydrogenase from brucella melitensis
    30% identity, 83% coverage of query (87.0 bits)

4z6kA / Q8GIX7 Alcohol dehydrogenase from the antarctic psychrophile moraxella sp. Tae 123
    27% identity, 94% coverage of query (86.3 bits)

ADH_MORSE / Q8GIX7 Alcohol dehydrogenase; ADH; EC 1.1.1.1 from Moraxella sp. (strain TAE123) (see 3 papers)
Q8GIX7 alcohol dehydrogenase (EC 1.1.1.1) from Moraxella sp. (see paper)
    27% identity, 90% coverage of query (85.9 bits)

6oweA Enoyl-coa carboxylases/reductases in complex with ethylmalonyl coa
    26% identity, 80% coverage of query (85.5 bits)

6na4B / E4N096 Co crystal structure of ecr with butryl-coa
    26% identity, 80% coverage of query (85.5 bits)

6na4C Co crystal structure of ecr with butryl-coa
    26% identity, 80% coverage of query (85.5 bits)

2eerB / Q96XE0 Structural study of project id st2577 from sulfolobus tokodaii strain7
    24% identity, 99% coverage of query (84.7 bits)

5dp2A / Q6DNE7 Curf er cyclopropanase from curacin a biosynthetic pathway (see paper)
    29% identity, 80% coverage of query (83.6 bits)

6z42A / E1V3M3 The low resolution structure of a zinc-dependent alcohol dehydrogenase from halomonas elongata.
    27% identity, 87% coverage of query (79.7 bits)

3s2fE Crystal structure of furx nadh:furfural
    27% identity, 90% coverage of query (79.0 bits)

3s2fA Crystal structure of furx nadh:furfural
    27% identity, 90% coverage of query (79.0 bits)

3s2eE Crystal structure of furx nadh complex 1
    27% identity, 90% coverage of query (79.0 bits)

3s2eA / Q46UZ9 Crystal structure of furx nadh complex 1
    27% identity, 90% coverage of query (79.0 bits)

5dozA / Q6E7K0 Crystal structure of jamj enoyl reductase (NADPH bound) (see paper)
    25% identity, 90% coverage of query (76.6 bits)

4eezB / D2BLA0 Crystal structure of lactococcus lactis alcohol dehydrogenase variant re1 (see paper)
    28% identity, 74% coverage of query (73.6 bits)

4a0sA / F0V3Z3 Structure of the 2-octenoyl-coa carboxylase reductase cinf in complex with NADP and 2-octenoyl-coa (see paper)
    25% identity, 94% coverage of query (72.4 bits)

ADH1 / P00330 alcohol dehydrogenase 1 (EC 1.1.1.1; EC 1.1.1.190) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 10 papers)
ADH1_YEAST / P00330 Alcohol dehydrogenase 1; Alcohol dehydrogenase I; ADHI; NADH-dependent methylglyoxal reductase; YADH-1; EC 1.1.1.1; EC 1.1.1.54; EC 1.1.1.78 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 12 papers)
    26% identity, 74% coverage of query (72.4 bits)

5envA / P00330 Yeast alcohol dehydrogenase with bound coenzyme (see paper)
    26% identity, 74% coverage of query (72.0 bits)

4w6zA Yeast alcohol dehydrogenase i, saccharomyces cerevisiae fermentative enzyme
    26% identity, 74% coverage of query (72.0 bits)

1r37A Alcohol dehydrogenase from sulfolobus solfataricus complexed with NAD(h) and 2-ethoxyethanol
    24% identity, 99% coverage of query (71.2 bits)

P39462 alcohol dehydrogenase (EC 1.1.1.1) from Saccharolobus solfataricus (see 7 papers)
1jvbA / P39462 Alcohol dehydrogenase from the archaeon sulfolobus solfataricus (see paper)
    24% identity, 99% coverage of query (71.2 bits)

P39462 NAD-dependent alcohol dehydrogenase; EC 1.1.1.1 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
    24% identity, 99% coverage of query (71.2 bits)

5yatA / C4R0S8 Crystal structure of mitochondrial alcohol dehydrogenase isozyme iii from komagataella phaffii gs115 (see paper)
    26% identity, 83% coverage of query (70.5 bits)

MECR / Q9BV79 mitochondrial trans-2-enoyl-[acyl-carrier protein] reductase monomer (EC 1.3.1.104) from Homo sapiens (see 3 papers)
MECR_HUMAN / Q9BV79 Enoyl-[acyl-carrier-protein] reductase, mitochondrial; 2-enoyl thioester reductase; Nuclear receptor-binding factor 1; HsNrbf-1; NRBF-1; EC 1.3.1.104 from Homo sapiens (Human) (see 4 papers)
    27% identity, 84% coverage of query (69.3 bits)

1iyzA / Q8L3C8 Crystal structures of the quinone oxidoreductase from thermus thermophilus hb8 and its complex with NADPH (see paper)
    32% identity, 76% coverage of query (69.3 bits)

4jbiA 2.35a resolution structure of NADPH bound thermostable alcohol dehydrogenase from pyrobaculum aerophilum
    26% identity, 97% coverage of query (68.9 bits)

4jbhA 2.2a resolution structure of cobalt and zinc bound thermostable alcohol dehydrogenase from pyrobaculum aerophilum
    26% identity, 97% coverage of query (68.9 bits)

4jbgA / Q8ZUP0 1.75a resolution structure of a thermostable alcohol dehydrogenase from pyrobaculum aerophilum (see paper)
    26% identity, 97% coverage of query (68.9 bits)

ADH2 / P00331 alcohol dehydrogenase II (EC 1.1.1.1; EC 1.1.1.190) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 10 papers)
ADH2_YEAST / P00331 Alcohol dehydrogenase 2; Alcohol dehydrogenase II; ADHII; YADH-2; EC 1.1.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
    25% identity, 74% coverage of query (68.6 bits)

4idfA Structure of the fragaria x ananassa enone oxidoreductase in complex with NADPH and hmf
    28% identity, 95% coverage of query (62.8 bits)

4ideA Structure of the fragaria x ananassa enone oxidoreductase in complex with NADP+ and edhmf
    28% identity, 95% coverage of query (62.8 bits)

4iddA Structure of the fragaria x ananassa enone oxidoreductase in complex with NADPH and ehmf
    28% identity, 95% coverage of query (62.8 bits)

4idcA Structure of the fragaria x ananassa enone oxidoreductase in complex with NADPH and hdmf
    28% identity, 95% coverage of query (62.8 bits)

4idbA / O23939 Structure of the fragaria x ananassa enone oxidoreductase in complex with NADP+ (see paper)
    28% identity, 95% coverage of query (62.8 bits)

P80338 Alcohol dehydrogenase 1; Alcohol dehydrogenase I; EC 1.1.1.1 from Struthio camelus (Common ostrich)
    27% identity, 85% coverage of query (62.8 bits)

4b7xB / Q9I377 Crystal structure of hypothetical protein pa1648 from pseudomonas aeruginosa. (see paper)
    28% identity, 71% coverage of query (62.0 bits)

P23991 Alcohol dehydrogenase 1; ADH-1; Alcohol dehydrogenase I; EC 1.1.1.1 from Gallus gallus (Chicken)
    27% identity, 85% coverage of query (61.6 bits)

1pl6A / Q00796 Human sdh/nadh/inhibitor complex (see paper)
    26% identity, 71% coverage of query (59.7 bits)

1h2bB / Q9Y9P9 Crystal structure of the alcohol dehydrogenase from the hyperthermophilic archaeon aeropyrum pernix at 1.65a resolution (see paper)
    25% identity, 99% coverage of query (59.3 bits)

DHSO_SHEEP / P07846 Sorbitol dehydrogenase; SDH; L-iditol 2-dehydrogenase; Polyol dehydrogenase; Xylitol dehydrogenase; XDH; EC 1.1.1.-; EC 1.1.1.14; EC 1.1.1.9 from Ovis aries (Sheep) (see 3 papers)
    27% identity, 71% coverage of query (58.9 bits)

3qe3A / P07846 Sheep liver sorbitol dehydrogenase (see paper)
    27% identity, 71% coverage of query (58.5 bits)

5vm2A / P77280 Crystal structure of eck1772, an oxidoreductase/dehydrogenase of unknown specificity involved in membrane biogenesis from escherichia coli
    27% identity, 71% coverage of query (58.5 bits)

ENOXC_FRAAN / Q941I0 2-methylene-furan-3-one reductase; Enone oxidoreductase; FaEO; Quinone oxidoreductase; FaQR; EC 1.3.1.105 from Fragaria ananassa (Strawberry) (Fragaria chiloensis x Fragaria virginiana) (see 2 papers)
Q941I0 2-methylene-furan-3-one reductase (EC 1.3.1.105) from Fragaria x ananassa (see 2 papers)
    28% identity, 95% coverage of query (58.2 bits)

P25406 Alcohol dehydrogenase 1B; Alcohol dehydrogenase I-B; ADH IB; EC 1.1.1.1 from Saara hardwickii (Indian spiny-tailed lizard) (Uromastyx hardwickii)
    24% identity, 80% coverage of query (58.2 bits)

P19631 Alcohol dehydrogenase 1; ADH3; Alcohol dehydrogenase subunit alpha; EC 1.1.1.1 from Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
    26% identity, 85% coverage of query (57.8 bits)

3gazA / Q2G4L9 Crystal structure of an alcohol dehydrogenase superfamily protein from novosphingobium aromaticivorans
    29% identity, 71% coverage of query (57.4 bits)

6isvB / M5A8V4 Structure of acetophenone reductase from geotrichum candidum nbrc 4597 in complex with NAD (see paper)
    27% identity, 88% coverage of query (56.6 bits)

6n7lC / A0A077EGR8 Crystal structure of an alcohol dehydrogenase from elizabethkingia anophelis nuhp1
    26% identity, 78% coverage of query (56.2 bits)

4gi2A / C5AP81 Crotonyl-coa carboxylase/reductase
    24% identity, 92% coverage of query (55.8 bits)

3i4cC / P39462 Crystal structure of sulfolobus solfataricus adh(ssadh) double mutant (w95l,n249y) (see paper)
    24% identity, 94% coverage of query (55.8 bits)

P12711 Alcohol dehydrogenase class-3; Alcohol dehydrogenase 2; Alcohol dehydrogenase 5; Alcohol dehydrogenase B2; ADH-B2; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase; EC 1.1.1.1; EC 1.1.1.-; EC 1.1.1.284 from Rattus norvegicus (Rat)
    24% identity, 71% coverage of query (55.5 bits)

P81431 Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase; EC 1.1.1.1; EC 1.1.1.-; EC 1.1.1.284 from Octopus vulgaris (Common octopus)
    26% identity, 72% coverage of query (54.7 bits)

P22797 Alcohol dehydrogenase 1; Alcohol dehydrogenase, major; EC 1.1.1.1 from Pelophylax perezi (Perez's frog) (Rana perezi)
    24% identity, 73% coverage of query (53.9 bits)

4ej6A / Q92PZ3 Crystal structure of a putative zinc-binding dehydrogenase (target psi-012003) from sinorhizobium meliloti 1021
    25% identity, 94% coverage of query (53.5 bits)

4ejmA Crystal structure of a putative zinc-binding dehydrogenase (target psi-012003) from sinorhizobium meliloti 1021 bound to NADP
    25% identity, 94% coverage of query (53.5 bits)

YddN / b1478 ethanol dehydrogenase / alcohol dehydrogenase (EC 1.1.1.1) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
adhP / P39451 ethanol dehydrogenase / alcohol dehydrogenase (EC 1.1.1.1) from Escherichia coli (strain K12) (see 5 papers)
4gkvB / P39451 Structure of escherichia coli adhp (ethanol-inducible dehydrogenase) with bound NAD (see paper)
    25% identity, 76% coverage of query (53.5 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory