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Searching for up to 100 curated homologs for AO353_21305 FitnessBrowser__pseudo3_N2E3:AO353_21305 (352 a.a.)

Found high-coverage hits (≥70%) to 24 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Psest_3840 D-lactate/glycolate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6; EC 1.1.99.14) from Pseudomonas stutzeri RCH2
    72% identity, 98% coverage of query (513 bits)

Gox / b4468 glycolate dehydrogenase, putative FAD-binding subunit (EC 1.1.99.14) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
glcE / P52073 glycolate dehydrogenase, putative FAD-binding subunit (EC 1.1.99.14) from Escherichia coli (strain K12) (see 3 papers)
GLCE_ECOLI / P52073 Glycolate oxidase subunit GlcE; Glycolate dehydrogenase subunit GlcE; EC 1.1.99.14 from Escherichia coli (strain K12) (see 4 papers)
glcE / RF|YP_026191.1 glycolate oxidase, subunit glcE from Escherichia coli K12 (see paper)
glcE / AAB02531.1 glycolate oxidase subunit from Escherichia coli (see paper)
    65% identity, 98% coverage of query (447 bits)

RR42_RS17310 D-lactate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6) from Cupriavidus basilensis FW507-4G11
    51% identity, 95% coverage of query (294 bits)

SMc00833 D-lactate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6) from Sinorhizobium meliloti 1021
    37% identity, 95% coverage of query (192 bits)

PGA1_c29710 D-lactate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6) from Phaeobacter inhibens BS107
    33% identity, 97% coverage of query (156 bits)

Build an alignment

Build an alignment for AO353_21305 and 5 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

DLD_ARCFU / O29853 D-lactate dehydrogenase; EC 1.1.99.6 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see 2 papers)
O29853 D-lactate dehydrogenase (acceptor) (EC 1.1.99.6) from Archaeoglobus fulgidus (see 2 papers)
    25% identity, 80% coverage of query (81.3 bits)

8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid
    25% identity, 84% coverage of query (72.0 bits)

8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid
    24% identity, 84% coverage of query (71.6 bits)

8jdbA / Q7TNG8 Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
    25% identity, 84% coverage of query (70.5 bits)

8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid
    25% identity, 84% coverage of query (70.5 bits)

8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid
    25% identity, 84% coverage of query (70.5 bits)

8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid
    25% identity, 84% coverage of query (70.5 bits)

8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid
    25% identity, 84% coverage of query (70.5 bits)

8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid
    25% identity, 84% coverage of query (70.5 bits)

8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid
    25% identity, 84% coverage of query (70.5 bits)

8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid
    25% identity, 84% coverage of query (70.5 bits)

8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid
    25% identity, 84% coverage of query (70.1 bits)

8jdsA Crystal structure of mldhd in complex with pyruvate
    25% identity, 84% coverage of query (70.1 bits)

8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid
    24% identity, 84% coverage of query (69.7 bits)

8jdeA Crystal structure of mldhd in complex with d-lactate
    24% identity, 84% coverage of query (69.7 bits)

8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid
    24% identity, 84% coverage of query (67.8 bits)

LDHD_MOUSE / Q7TNG8 Probable D-lactate dehydrogenase, mitochondrial; DLD; Lactate dehydrogenase D; EC 1.1.2.4 from Mus musculus (Mouse) (see paper)
    24% identity, 84% coverage of query (67.4 bits)

D2HDH_STUS1 / A4VGK4 D-2-hydroxyglutarate dehydrogenase; D-2-HG dehydrogenase; D2HGDH; D-malate dehydrogenase; EC 1.1.99.39; EC 1.1.99.- from Stutzerimonas stutzeri (strain A1501) (Pseudomonas stutzeri) (see 2 papers)
    24% identity, 84% coverage of query (66.2 bits)

D2HDH_RAT / P84850 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Rattus norvegicus (Rat) (see paper)
    23% identity, 86% coverage of query (63.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory