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Searching for up to 100 curated homologs for AO353_23490 FitnessBrowser__pseudo3_N2E3:AO353_23490 (255 a.a.)

Found high-coverage hits (≥70%) to 34 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

8ewoA / Q9I2T1 Crystal structure of putative glyoxylase ii from pseudomonas aeruginosa
    72% identity, 100% coverage of query (374 bits)

Q8YZ99 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
    47% identity, 100% coverage of query (225 bits)

YafR / b0212 hydroxyacylglutathione hydrolase GloB (EC 3.1.2.6) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
gloB / P0AC84 hydroxyacylglutathione hydrolase GloB (EC 3.1.2.6) from Escherichia coli (strain K12) (see 9 papers)
GLO2_ECOLI / P0AC84 Hydroxyacylglutathione hydrolase GloB; Glyoxalase II; Glx II; EC 3.1.2.6 from Escherichia coli (strain K12) (see 2 papers)
6rz0A / P0AC84 Crystal structure of escherichia coli glyoxalase ii
gloB / MB|P0AC84 hydroxyacylglutathione hydrolase; EC 3.1.2.6 from Escherichia coli K12 (see 3 papers)
    48% identity, 100% coverage of query (225 bits)

2qedA / Q8ZRM2 Crystal structure of salmonella thyphimurium lt2 glyoxalase ii (see paper)
    47% identity, 100% coverage of query (224 bits)

GLO2_SALTY / Q8ZRM2 Hydroxyacylglutathione hydrolase; Glyoxalase II; Glx II; EC 3.1.2.6 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
Q8ZRM2 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    47% identity, 100% coverage of query (224 bits)

GLO2N_ARATH / Q9SID3 Hydroxyacylglutathione hydrolase 2, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    42% identity, 100% coverage of query (207 bits)

2q42A / Q9SID3 Ensemble refinement of the protein crystal structure of glyoxalase ii from arabidopsis thaliana gene at2g31350 (see paper)
    42% identity, 100% coverage of query (206 bits)

Q940L0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Oryza sativa (see 3 papers)
    42% identity, 100% coverage of query (201 bits)

GLO2M_ARATH / O24495 Hydroxyacylglutathione hydrolase 1, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    40% identity, 100% coverage of query (194 bits)

GLO2C_ARATH / O24496 Hydroxyacylglutathione hydrolase cytoplasmic; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    40% identity, 100% coverage of query (179 bits)

GLO2_RAT / O35952 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; Round spermatid protein RSP29; EC 3.1.2.6 from Rattus norvegicus (Rat) (see 2 papers)
O35952 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Rattus norvegicus (see paper)
    38% identity, 100% coverage of query (163 bits)

1qh3A / Q16775 Human glyoxalase ii with cacodylate and acetate ions present in the active site (see paper)
    38% identity, 100% coverage of query (162 bits)

GLO2_HUMAN / Q16775 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Homo sapiens (Human) (see 3 papers)
Q16775 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Homo sapiens (see 8 papers)
    38% identity, 100% coverage of query (162 bits)

1qh5B Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
    38% identity, 100% coverage of query (162 bits)

1qh5A Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
    38% identity, 100% coverage of query (162 bits)

PNKD_HUMAN / Q8N490 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; Trans-activated by hepatitis C virus core protein 2; EC 3.-.-.- from Homo sapiens (Human) (see 8 papers)
    37% identity, 99% coverage of query (147 bits)

PNKD_MOUSE / Q69ZP3 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; EC 3.-.-.- from Mus musculus (Mouse) (see 3 papers)
    36% identity, 99% coverage of query (141 bits)

GLO22_SCHPO / O94250 Probable hydroxyacylglutathione hydrolase C13B11.03c; Glyoxalase II; Glx II; EC 3.1.2.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    32% identity, 99% coverage of query (119 bits)

2p18A / Q2PYN0 Crystal structure of the leishmania infantum glyoxalase ii (see paper)
    31% identity, 92% coverage of query (118 bits)

GLO21_SCHPO / Q9UT36 Probable hydroxyacylglutathione hydrolase C824.07; Glyoxalase II; Glx II; EC 3.1.2.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    33% identity, 95% coverage of query (116 bits)

Q2PYN0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Leishmania infantum (see 3 papers)
    31% identity, 92% coverage of query (110 bits)

Q6KF36 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Trypanosoma brucei (see paper)
GLXII / GI|47604513 glyoxalase II from Trypanosoma brucei brucei (see paper)
glxII / CAD37800.1 glyoxalase II from Trypanosoma brucei brucei (see paper)
    33% identity, 88% coverage of query (108 bits)

Build an alignment

Build an alignment for AO353_23490 and 22 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

GLO2 / Q05584 glyoxalase II (cytoplasmic) (EC 3.1.2.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
GLO2_YEAST / Q05584 Hydroxyacylglutathione hydrolase, cytoplasmic isozyme; Glyoxalase II; Glx II; EC 3.1.2.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
GLO2 / CAA71335.1 glyoxalase-II from Saccharomyces cerevisiae (see paper)
    29% identity, 95% coverage of query (95.5 bits)

GLO4 / Q12320 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
Q12320 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Saccharomyces cerevisiae (see paper)
GLO4 / CAA58065.1 glyoxalase-II from Saccharomyces cerevisiae (see 3 papers)
    30% identity, 95% coverage of query (83.2 bits)

4ysbA / Q1D4C9 Crystal structure of ethe1 from myxococcus xanthus (see paper)
    29% identity, 74% coverage of query (75.9 bits)

Q581U6 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Trypanosoma brucei (see paper)
    25% identity, 71% coverage of query (75.5 bits)

ETHE1_ARATH / Q9C8L4 Persulfide dioxygenase ETHE1 homolog, mitochondrial; Glyoxalase II; Glx II; Sulfur dioxygenase ETHE1; EC 1.13.11.18 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9C8L4 persulfide dioxygenase (EC 1.13.11.18) from Arabidopsis thaliana (see paper)
    29% identity, 78% coverage of query (71.6 bits)

2gcuA / Q9C8L4 X-ray structure of gene product from arabidopsis thaliana at1g53580 (see paper)
    29% identity, 78% coverage of query (71.2 bits)

ETHE1 / O95571 mitochondrial persulfide dioxygenase monomer (EC 1.13.11.18) from Homo sapiens (see 6 papers)
ETHE1_HUMAN / O95571 Persulfide dioxygenase ETHE1, mitochondrial; Ethylmalonic encephalopathy protein 1; Hepatoma subtracted clone one protein; Sulfur dioxygenase ETHE1; EC 1.13.11.18 from Homo sapiens (Human) (see 6 papers)
    26% identity, 82% coverage of query (68.6 bits)

4chlB / O95571 Human ethylmalonic encephalopathy protein 1 (hethe1) (see paper)
    25% identity, 82% coverage of query (68.6 bits)

ETHE1_MOUSE / Q9DCM0 Persulfide dioxygenase ETHE1, mitochondrial; Ethylmalonic encephalopathy protein 1 homolog; Hepatoma subtracted clone one protein; Sulfur dioxygenase ETHE1; EC 1.13.11.18 from Mus musculus (Mouse) (see paper)
    27% identity, 71% coverage of query (64.7 bits)

GLO2_ENCCU / Q8SSH0 Probable hydroxyacylglutathione hydrolase ECU02_0580; Glyoxalase II; Glx II; EC 3.1.2.6 from Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) (see paper)
    24% identity, 99% coverage of query (64.3 bits)

BLH_AGRFC / Q8UAA9 Beta-lactamase hydrolase-like protein; BLH; EC 3.-.-.- from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
    27% identity, 80% coverage of query (58.9 bits)

BLH_XYLFA / Q9PFB0 Beta-lactamase hydrolase-like protein; BLH; EC 3.-.-.- from Xylella fastidiosa (strain 9a5c) (see paper)
    27% identity, 77% coverage of query (55.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory