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Searching for up to 100 curated homologs for AO353_25115 FitnessBrowser__pseudo3_N2E3:AO353_25115 (424 a.a.)

Found high-coverage hits (≥70%) to 49 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Pf1N1B4_5112 sucrose ABC transporter, substrate-binding component from Pseudomonas fluorescens FW300-N1B4
    95% identity, 92% coverage of query (777 bits)

TC 3.A.1.1.25 / Q72H68 Trehalose/maltose-binding protein aka TT_C1627, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    45% identity, 95% coverage of query (361 bits)

6jahA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with glucose
    45% identity, 95% coverage of query (360 bits)

6jagA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with sucrose
    45% identity, 95% coverage of query (360 bits)

6jadA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with palatinose
    45% identity, 95% coverage of query (360 bits)

6j9yA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with maltose
    45% identity, 95% coverage of query (360 bits)

6jamA / Q5SLD7 Crystal structure of abc transporter alpha-glycoside-binding mutant protein r356a in complex with trehalose (see paper)
    45% identity, 95% coverage of query (358 bits)

6jaiA Crystal structure of abc transporter alpha-glycoside-binding mutant protein d118a in complex with maltose
    45% identity, 95% coverage of query (358 bits)

6jb0A Crystal structure of abc transporter alpha-glycoside-binding mutant protein w287a in complex with trehalose
    45% identity, 95% coverage of query (356 bits)

SM_b20325 ABC transporter for D-trehalose/D-maltose/sucrose, substrate-binding component (ThuE) from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q7 ThuE aka RB0311 aka SMB20325, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 3 papers)
    45% identity, 87% coverage of query (345 bits)

TC 3.A.1.1.19 / Q8L126 PalE, component of Platinose (isomaltulose) (6-O-α-D-glucopyranosyl-D-fructofuranose) porter from Agrobacterium tumefaciens (see 3 papers)
palE / BAB96538.1 PalE from Agrobacterium tumefaciens (see 3 papers)
    46% identity, 94% coverage of query (343 bits)

TC 3.A.1.1.12 / Q9AI68 PalE, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    40% identity, 100% coverage of query (326 bits)

TC 3.A.1.1.41 / G4FGN8 Extracellular solute-binding protein family 1, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    38% identity, 92% coverage of query (277 bits)

6dtqA / G4XU73 Maltose bound t. Maritima male3 (see paper)
    38% identity, 92% coverage of query (277 bits)

7qhvAAA / A9CEY9 7qhvAAA (see paper)
    33% identity, 88% coverage of query (201 bits)

smoF / A9CEY9 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol binding protein from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
SMOF_AGRFC / A9CEY9 Sulfoquinovosyl glycerol-binding protein SmoF; SQGro-binding protein SmoF; SQ monooxygenase cluster protein F from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see 2 papers)
    33% identity, 88% coverage of query (200 bits)

7ofyA Crystal structure of sq binding protein from agrobacterium tumefaciens in complex with sulfoquinovosyl glycerol (sqgro)
    33% identity, 88% coverage of query (200 bits)

7yzsAAA Sulfoquinovosyl binding protein
    33% identity, 87% coverage of query (198 bits)

1eu8A / Q7LYW7 Structure of trehalose maltose binding protein from thermococcus litoralis (see paper)
    32% identity, 93% coverage of query (197 bits)

TC 3.A.1.1.7 / O51923 MalE aka PF1739, component of Maltose/trehalose porter (see paper)
    32% identity, 93% coverage of query (197 bits)

7yzuA Crystal structure of the sulfoquinovosyl binding protein smof complexed with sqme
    33% identity, 87% coverage of query (195 bits)

MALE_THELN / Q7LYW7 Trehalose/maltose-binding protein MalE; TMBP from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 4 papers)
    31% identity, 93% coverage of query (194 bits)

Build an alignment

Build an alignment for AO353_25115 and 22 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

SM_b21221 ABC transporter for D-Glucosamine, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    26% identity, 77% coverage of query (102 bits)

LPQY_MYCT3 / G7CES0 Trehalose-binding lipoprotein LpqY; Extracellular solute-binding protein; SugABC transporter substrate-binding protein LpqY; SugABC transporter SBP LpqY from Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile) (see paper)
    26% identity, 76% coverage of query (80.9 bits)

7apeA / G7CES0 Crystal structure of lpqy from mycobacterium thermoresistible in complex with trehalose (see paper)
    26% identity, 76% coverage of query (80.1 bits)

5iaiA / B9JM84 Crystal structure of abc transporter solute binding protein arad_9887 from agrobacterium radiobacter k84, target efi-510945 in complex with ribitol
    24% identity, 79% coverage of query (72.8 bits)

8ja7E / P9WGU9 Cryo-em structure of mycobacterium tuberculosis lpqy-sugabc in complex with trehalose
    26% identity, 75% coverage of query (72.0 bits)

lpqY / P9WGU9 trehalose-binding lipoprotein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
LPQY_MYCTU / P9WGU9 Trehalose-binding lipoprotein LpqY; SugABC transporter substrate-binding protein LpqY; SugABC transporter SBP LpqY from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / Q7D8J9 PROBABLE SUGAR-BINDING LIPOPROTEIN LPQY, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    26% identity, 75% coverage of query (71.6 bits)

8jabA Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-06
    26% identity, 75% coverage of query (71.6 bits)

8jadA Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-17
    26% identity, 75% coverage of query (71.6 bits)

8jacA Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-16
    26% identity, 75% coverage of query (71.6 bits)

8ja9A Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-03
    26% identity, 75% coverage of query (71.6 bits)

7cafE / A0R2C3 Mycobacterium smegmatis lpqy-sugabc complex in the pre-translocation state (see paper)
    24% identity, 73% coverage of query (69.7 bits)

SM_b21103 ABC transporter for L-Fucose, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    26% identity, 74% coverage of query (67.4 bits)

2gh9A / Q72I44 Thermus thermophilus maltotriose binding protein bound with maltotriose (see paper)
    25% identity, 75% coverage of query (67.0 bits)

HSERO_RS17000 ABC transporter for D-sorbitol/xylitol, substrate-binding component from Herbaspirillum seropedicae SmR1
    25% identity, 84% coverage of query (65.1 bits)

Q92AS8 ABC-type beta-glucan transporter (EC 7.5.2.3) from Listeria innocua (see paper)
    23% identity, 80% coverage of query (64.7 bits)

5ysdB / Q92AS8 Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose (see paper)
    23% identity, 79% coverage of query (64.3 bits)

5ysdA Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose
    23% identity, 79% coverage of query (64.3 bits)

5ysbA Crystal structure of beta-1,2-glucooligosaccharide binding protein in ligand-free form
    23% identity, 79% coverage of query (64.3 bits)

4qrzA / A9CGI0 Crystal structure of sugar transporter atu4361 from agrobacterium fabrum c58, target efi-510558, with bound maltotriose
    23% identity, 79% coverage of query (63.9 bits)

4qsdA Crystal structure of atu4361 sugar transporter from agrobacterium fabrum c58, target efi-510558, with bound sucrose
    23% identity, 79% coverage of query (63.9 bits)

PGA1_c13210 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Phaeobacter inhibens BS107
    25% identity, 77% coverage of query (62.4 bits)

2zyoA / Q9AJF5 Crystal structure of cyclo/maltodextrin-binding protein complexed with maltotetraose (see paper)
    25% identity, 75% coverage of query (58.5 bits)

4ryaA / B9JRF8 Crystal structure of abc transporter solute binding protein avi_3567 from agrobacterium vitis s4, target efi-510645, with bound d-mannitol
    22% identity, 70% coverage of query (58.2 bits)

Pf6N2E2_1963 ABC transporter for D-sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    23% identity, 82% coverage of query (58.2 bits)

AO356_00025 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    23% identity, 82% coverage of query (57.0 bits)

MANBP_PSEAE / Q9I1E0 Mannitol-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    22% identity, 82% coverage of query (52.0 bits)

6lceA / A0A0A1GL90 Crystal structure of beta-l-arabinobiose binding protein - selenomethionine derivative (see paper)
    23% identity, 78% coverage of query (48.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory