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Searching for up to 100 curated homologs for AO353_25120 FitnessBrowser__pseudo3_N2E3:AO353_25120 (320 a.a.)

Found high-coverage hits (≥70%) to 53 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Pf1N1B4_5113 sucrose ABC transporter, permease component 1 from Pseudomonas fluorescens FW300-N1B4
    96% identity, 92% coverage of query (478 bits)

SM_b20326 ABC transporter for D-trehalose/D-maltose/sucrose, permease component 1 (ThuF) from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q6 ThuF aka RB0312 aka SMB20326, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 3 papers)
    61% identity, 93% coverage of query (379 bits)

TC 3.A.1.1.19 / Q8L125 PalF, component of Platinose (isomaltulose) (6-O-α-D-glucopyranosyl-D-fructofuranose) porter from Agrobacterium tumefaciens (see 3 papers)
    61% identity, 92% coverage of query (376 bits)

TC 3.A.1.1.25 / Q72H67 Maltose transport system permease protein malF aka TT_C1628, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    49% identity, 92% coverage of query (268 bits)

TC 3.A.1.1.12 / Q9AI67 PalF, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    51% identity, 92% coverage of query (244 bits)

TC 3.A.1.1.41 / G4FGN7 ABC-type transporter, integral membrane subunit, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    44% identity, 91% coverage of query (243 bits)

MALF_THELN / O51924 Trehalose/maltose transport system permease protein MalF from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 3 papers)
    40% identity, 92% coverage of query (200 bits)

TC 3.A.1.1.7 / O51924 MalF, component of Maltose/trehalose porter from Thermococcus litoralis (see paper)
    40% identity, 92% coverage of query (179 bits)

7cagA / A0R2C2 Mycobacterium smegmatis lpqy-sugabc complex in the catalytic intermediate state (see paper)
    39% identity, 90% coverage of query (176 bits)

sugA / P9WG03 ABC-type trehalose transporter integral membrane protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGA_MYCTU / P9WG03 Trehalose transport system permease protein SugA from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
TC 3.A.1.1.31 / O50452 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGA, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    40% identity, 89% coverage of query (174 bits)

SM_b21220 ABC transporter for D-Glucosamine, permease component 2 from Sinorhizobium meliloti 1021
    40% identity, 86% coverage of query (158 bits)

TC 3.A.1.1.37 / Q9WYB4 Predicted arabinoside porter. Regulated by arabinose-responsive regulator AraR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    32% identity, 93% coverage of query (149 bits)

smoG / Q7CS30 ABC-type 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol transporter permease subunit from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
    31% identity, 85% coverage of query (135 bits)

Build an alignment

Build an alignment for AO353_25120 and 13 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

MELD_BACSU / O34706 Melibiose/raffinose/stachyose import permease protein MelD from Bacillus subtilis (strain 168) (see paper)
    27% identity, 93% coverage of query (133 bits)

GGTC_SYNY3 / Q55472 Osmoprotective compounds uptake permease protein GgtC from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
TC 3.A.1.1.32 / Q55472 Membrane bound sugar transport protein, component of The glucosylglycerol uptake transporter (functions in osmoprotection and also transports sucrose and trehalose (Mikkat and Hagemann, 2000) (most similar to 3.A.1.1.8) from Synechocystis sp. (strain PCC 6803) (see paper)
    27% identity, 90% coverage of query (132 bits)

Q6MNM0 ABC-type maltose transporter (EC 7.5.2.1) from Bdellovibrio bacteriovorus (see paper)
TC 3.A.1.1.51 / Q6MNM0 Maltose - maltoheptose transporter, MalEFGK from Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
    28% identity, 88% coverage of query (125 bits)

Dshi_0548 ABC transporter for Xylitol, permease component 1 from Dinoroseobacter shibae DFL-12
    33% identity, 88% coverage of query (125 bits)

Dshi_1651 glucose/maltose/trehalose/sucrose ABC transporter, permease component 1 from Dinoroseobacter shibae DFL-12
    28% identity, 96% coverage of query (123 bits)

SM_b21104 ABC transporter for L-Fucose, permease component 1 from Sinorhizobium meliloti 1021
    30% identity, 77% coverage of query (122 bits)

YcjO / b1311 putative ABC transporter membrane subunit YcjO from Escherichia coli K-12 substr. MG1655 (see 2 papers)
TC 3.A.1.1.46 / P0AFR7 Inner membrane ABC transporter permease protein YcjO, component of Probable glucoside uptake porter, YcjNOPV from Escherichia coli (strain K12)
    31% identity, 82% coverage of query (120 bits)

TC 3.A.1.1.4 / P29823 LacF, component of Lactose porter from Agrobacterium radiobacter (see paper)
    28% identity, 94% coverage of query (119 bits)

BPHYT_RS16110 ABC transporter for D-Sorbitol, permease component 2 from Burkholderia phytofirmans PsJN
    29% identity, 99% coverage of query (117 bits)

PGA1_c13200 ABC transporter for D-Sorbitol, permease component 2 from Phaeobacter inhibens BS107
    30% identity, 85% coverage of query (115 bits)

TC 3.A.1.1.11 / Q93KC0 TogM, component of Saturated and unsaturated oligogalacturonide transporter, TogMNAB (transports di- to tetrasaccharide pectin degradation products which consist of D-galacuronate, sometimes with 4-deoxy-L-threo-5-hexosulose uronate at the reducing end of the oligosaccharide) (Hugouvieux-Cotte-Pattat et al. 2001). Regulated by pectin utilization regulator KdgR from Erwinia chrysanthemi (see paper)
    29% identity, 86% coverage of query (114 bits)

TC 3.A.1.1.44 / Q9KZ07 Putative maltose permease, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    28% identity, 99% coverage of query (112 bits)

SMc02872 ABC transporter for N-Acetyl-D-glucosamine, permease protein 1 from Sinorhizobium meliloti 1021
    27% identity, 94% coverage of query (110 bits)

TC 3.A.1.1.50 / Q5SLB6 Sugar ABC transporter, permease protein, component of Probable glycerophosphocholine (GPC) uptake porter (Chandravanshi et al. 2016). The system may include a receptor and three membrane proteins (of 378 aas and 6 TMSs, 299 aas and 7 TMSs, and 113 aas and 3 TMSs (?). The ATPase has not been identified from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    28% identity, 88% coverage of query (110 bits)

ARAP_BACSU / P94529 Arabinooligosaccharides transport system permease protein AraP from Bacillus subtilis (strain 168) (see 3 papers)
TC 3.A.1.1.34 / P94529 L-arabinose transport system permease protein AraP, component of The arabinosaccharide transporter AraNPQMsmX. Transports α-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units; the key transporter for α-1,5-arabinotriose and α-1,5-arabinotetraose, but not for α-1,5-arabinobiose which is transported by AraE. MsmX is also used by the MdxEFG-MsmX system (3.A.1.1.36) (Ferreira and Sá-Nogueira, 2010). Involved in the uptake of pectin oligosaccharides with either MsmX or YurJ as the ATPase from Bacillus subtilis (see 4 papers)
araP / GB|CAB14834.1 L-arabinose transport system permease protein AraP from Bacillus subtilis (see 4 papers)
    29% identity, 84% coverage of query (110 bits)

Ac3H11_2943 ABC transporter for D-Sorbitol, permease component 2 from Acidovorax sp. GW101-3H11
    31% identity, 86% coverage of query (109 bits)

TC 3.A.1.1.18 / Q8RJU9 NgcF, component of N-Acetylglucosamine/N,N'-diacetyl chitobiose porter (NgcK (C) not identified) from Streptomyces olivaceoviridis (Streptomyces corchorusii) (see paper)
    27% identity, 92% coverage of query (109 bits)

Ac3H11_2064 glucose ABC transporter, permease component 1 from Acidovorax sp. GW101-3H11
    26% identity, 75% coverage of query (108 bits)

TC 3.A.1.1.16 / Q8TZP9 MalF, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
    27% identity, 91% coverage of query (108 bits)

PGA1_c27940 N-Acetyl-D-glucosamine ABC transport system, permease component 1 from Phaeobacter inhibens BS107
    28% identity, 92% coverage of query (107 bits)

SMc04258 ABC transporter for D-Cellobiose and D-Salicin, permease component 2 from Sinorhizobium meliloti 1021
    27% identity, 94% coverage of query (106 bits)

mtlF / Q4KC56 polyol ABC-type transporter permease component MtlF from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
    31% identity, 92% coverage of query (105 bits)

AO356_00020 ABC transporter for D-Sorbitol, permease component 2 from Pseudomonas fluorescens FW300-N2C3
    31% identity, 90% coverage of query (104 bits)

TC 3.A.1.1.49 / O30492 MtlF, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK from Pseudomonas fluorescens
    31% identity, 91% coverage of query (103 bits)

PS417_12710 ABC transporter for D-Mannitol and D-Sorbitol, permease component 2 from Pseudomonas simiae WCS417
    31% identity, 92% coverage of query (103 bits)

Psest_0864 maltose ABC transporter, permease component 1 (MalF) from Pseudomonas stutzeri RCH2
    29% identity, 94% coverage of query (102 bits)

DASB_STRCO / Q9K490 Diacetylchitobiose uptake system permease protein DasB from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    27% identity, 85% coverage of query (100 bits)

TC 3.A.1.1.26 / O06990 MalF aka yvdH, component of The maltose porter, MdxEFG and MsmX from Bacillus subtilis (see 2 papers)
    27% identity, 74% coverage of query (100 bits)

TC 3.A.1.1.48 / D6ZW63 MalF-type ABC sugar transport systems permease component, component of The lacto-N-biose I (LNB; Gal β-1,3-GlcNAc)/galacto-N-biose (GNB; Gal β-1,3-GalNAc) transporter from Bifidobacterium longum subsp. longum (strain JDM301)
    24% identity, 99% coverage of query (99.0 bits)

TC 3.A.1.1.20 / Q7WWQ9 Transmembrane permease MsmF, component of The fructooligosaccharide porter, MsmEFGK from Lactobacillus acidophilus (see 2 papers)
msmF / GI|33149339 transmembrane permease MsmF from Lactobacillus acidophilus (see paper)
    25% identity, 85% coverage of query (99.0 bits)

TC 3.A.1.1.5 / O30832 SmoF, component of Hexitol (glucitol; mannitol) porter from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
    32% identity, 92% coverage of query (98.2 bits)

PS417_22140 glucose/xylose ABC transporter, permease component 2 from Pseudomonas simiae WCS417
    27% identity, 82% coverage of query (98.2 bits)

GANP_BACSU / O32261 Galactooligosaccharides transport system permease protein GanP from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.1.2 / O32261 Putative arabinogalactan oligomer transport system permease protein ganP, component of The galactooligosaccharide (transports the di, tri and tetrasaccharides) uptake porter GanOPQ (GanSPQ; MalEFG) functioning with the energizing ATPase MsmX (see 3.A.1.1.26) from Bacillus subtilis (see 2 papers)
    27% identity, 85% coverage of query (97.4 bits)

Pf6N2E2_1962 ABC transporter for D-sorbitol, permease component 1 from Pseudomonas fluorescens FW300-N2E2
    31% identity, 82% coverage of query (96.3 bits)

Ac3H11_793 ABC transporter for Glycerol, permease component 1 from Acidovorax sp. GW101-3H11
    26% identity, 93% coverage of query (95.9 bits)

TC 3.A.1.1.30 / Q88P37 GtsB (GLcF), component of Glucose porter, GtsABCD from Pseudomonas putida (strain KT2440) (see paper)
    26% identity, 75% coverage of query (95.5 bits)

TC 3.A.1.1.28 / Q00750 MsmF aka SMU.879, component of The raffinose/stachyose transporter, MsmEFGK (MalK (3.A.1.1.27) can probably substitute for MsmK; Webb et al., 2008). This system may also transport melibiose, isomaltotriose and sucrose as well as isomaltosaccharides from Streptococcus mutans (see 2 papers)
    26% identity, 89% coverage of query (95.5 bits)

TC 3.A.1.1.23 / Q9X9R6 CBP protein aka CebF, component of The cellobiose/cellotriose (and possibly higher cellooligosaccharides), CebEFGMsiK [MsiK functions to energize several ABC transporters including those for maltose/maltotriose and trehalose] from Streptomyces reticuli (see paper)
    26% identity, 88% coverage of query (95.1 bits)

SM_b21653 ABC transporter for Lactose, permease component 1 from Sinorhizobium meliloti 1021
    27% identity, 90% coverage of query (95.1 bits)

TC 3.A.1.1.33 / Q8KN18 Putative sugar transporter integral membrane protein, component of The N,N'-diacetylchitobiose uptake transporter, DasABC/MsiK (MsiK energizes several ABC transporters (see 3.A.1.1.23)) from Streptomyces sp. 139 (see 2 papers)
    27% identity, 87% coverage of query (95.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory