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Searching for up to 100 curated homologs for AO353_25185 FitnessBrowser__pseudo3_N2E3:AO353_25185 (350 a.a.)

Found high-coverage hits (≥70%) to 37 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

OCD_PSEPK / Q88H32 Ornithine cyclodeaminase; OCD; EC 4.3.1.12 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
Q88H32 ornithine cyclodeaminase (EC 4.3.1.12) from Pseudomonas putida (see 2 papers)
    62% identity, 95% coverage of query (419 bits)

1u7hA / Q88H32 Structure and a proposed mechanism for ornithine cyclodeaminase from pseudomonas putida (see paper)
    62% identity, 95% coverage of query (416 bits)

1x7dA Crystal structure analysis of ornithine cyclodeaminase complexed with NAD and ornithine to 1.6 angstroms
    62% identity, 95% coverage of query (416 bits)

OCD_AGRT4 / Q59701 Ornithine cyclodeaminase; OCD; EC 4.3.1.12 from Agrobacterium tumefaciens (strain Ach5) (see paper)
CAA82989.1 ornithine cyclodeaminase from Agrobacterium tumefaciens (see 2 papers)
    56% identity, 95% coverage of query (375 bits)

arcB / P09773 ornithine cyclodeaminase (EC 4.3.1.12) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see 5 papers)
OCD_AGRFC / P09773 Ornithine cyclodeaminase; OCD; EC 4.3.1.12 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
    54% identity, 97% coverage of query (365 bits)

ocd / CAA82966.1 ornithine cyclodeaminase from Agrobacterium tumefaciens (see 3 papers)
    53% identity, 97% coverage of query (365 bits)

arcB / J7SH14 ornithine cyclodeaminase subunit (EC 4.3.1.12) from Clostridium sporogenes (strain ATCC 15579) (see 2 papers)
    53% identity, 96% coverage of query (349 bits)

1omoA / O28608 Alanine dehydrogenase dimer w/bound NAD (archaeal) (see paper)
    32% identity, 80% coverage of query (151 bits)

ALADH_ARCFU / O28608 Alanine dehydrogenase; AlaDH; EC 1.4.1.1 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see 2 papers)
O28608 alanine dehydrogenase (EC 1.4.1.1) from Archaeoglobus fulgidus (see paper)
    32% identity, 80% coverage of query (151 bits)

tubZ / CAF05645.1 TubZ protein from Archangium disciforme (see paper)
    32% identity, 83% coverage of query (129 bits)

6t3eB / H3ZMH3 Structure of thermococcus litoralis delta(1)-pyrroline-2-carboxylate reductase in complex with nadh and l-proline (see paper)
    31% identity, 77% coverage of query (127 bits)

Build an alignment

Build an alignment for AO353_25185 and 11 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

B1GT63 Strombine dehydrogenase (EC 1.5.1.22) from Suberites domuncula (see paper)
    27% identity, 81% coverage of query (113 bits)

PY2CR_BACCZ / Q63FA5 Delta(1)-pyrroline-2-carboxylate reductase; Pyr2C reductase; Proline ketimine reductase; EC 1.5.1.49 from Bacillus cereus (strain ZK / E33L) (see paper)
    30% identity, 76% coverage of query (112 bits)

5gzlA / D9UBW0 Cyclodeaminase_pa
    31% identity, 81% coverage of query (111 bits)

5gziA Cyclodeaminase_pa
    31% identity, 81% coverage of query (111 bits)

5yu4A Structural basis for recognition of l-lysine, l-ornithine, and l-2,4- diamino butyric acid by lysine cyclodeaminase
    31% identity, 81% coverage of query (111 bits)

5yu3A Structural basis for recognition of l-lysine, l-ornithine, and l-2,4- diamino butyric acid by lysine cyclodeaminase
    31% identity, 81% coverage of query (111 bits)

rapL / Q54304 L-lysine cyclodeaminase (EC 4.3.1.28) from Streptomyces rapamycinicus (strain ATCC 29253 / DSM 41530 / NRRL 5491 / AYB-994) (see paper)
RAPL_STRRN / Q54304 L-lysine cyclodeaminase; Rapamycin biosynthesis protein L; EC 4.3.1.28 from Streptomyces rapamycinicus (strain ATCC 29253 / DSM 41530 / NRRL 5491 / AYB-994) (Streptomyces hygroscopicus (strain ATCC 29253)) (see 2 papers)
    28% identity, 93% coverage of query (110 bits)

fkbL / Q9KIE2 L-lysine cyclodeaminase (EC 4.3.1.28) from Streptomyces hygroscopicus subsp. ascomyceticus (see paper)
    31% identity, 81% coverage of query (108 bits)

PY2CR_BACCR / Q81HB0 Delta(1)-pyrroline-2-carboxylate reductase; Pyr2C reductase; Proline ketimine reductase; EC 1.5.1.49 from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) (see paper)
    30% identity, 76% coverage of query (107 bits)

PY2CR_BACHK / Q6HMS8 Delta(1)-pyrroline-2-carboxylate reductase; Pyr2C reductase; Proline ketimine reductase; EC 1.5.1.49 from Bacillus thuringiensis subsp. konkukian (strain 97-27) (see paper)
    29% identity, 76% coverage of query (107 bits)

PY2CR_BACC1 / Q73CR9 Delta(1)-pyrroline-2-carboxylate reductase; Pyr2C reductase; Proline ketimine reductase; EC 1.5.1.49 from Bacillus cereus (strain ATCC 10987 / NRS 248) (see paper)
    29% identity, 76% coverage of query (105 bits)

Q9QYU4 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) (EC 1.5.1.21) from Rattus norvegicus (see paper)
    32% identity, 73% coverage of query (105 bits)

O54983 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) (EC 1.5.1.21) from Mus musculus (see paper)
    32% identity, 73% coverage of query (105 bits)

tadh / Q60FC7 tauropine dehydrogenase (EC 1.5.1.23) from Halichondria japonica (see 2 papers)
    25% identity, 81% coverage of query (96.3 bits)

4m54A / A0A0H3K9Y6 The structure of the staphyloferrin b precursor biosynthetic enzyme sbnb bound to n-(1-amino-1-carboxyl-2-ethyl)-glutamic acid and nadh (see paper)
    25% identity, 80% coverage of query (90.1 bits)

4mp6A / A0A0H3K9Y6 Staphyloferrin b precursor biosynthetic enzyme sbnb bound to citrate and NAD+ (see paper)
    25% identity, 78% coverage of query (87.4 bits)

sbnB / Q2G1N2 N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase monomer (EC 1.5.1.51) from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 2 papers)
SBNB_STAA8 / Q2G1N2 N-((2S)-2-amino-2-carboxyethyl)-L-glutamate dehydrogenase; Staphyloferrin B biosynthesis protein SbnB; EC 1.5.1.51 from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 3 papers)
A0A0H3K9Y6 N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase (EC 1.5.1.51) from Staphylococcus aureus (see 2 papers)
    25% identity, 78% coverage of query (87.4 bits)

4mpdA Staphyloferrin b precursor biosynthetic enzyme sbnb bound a- ketoglutarate and NAD+
    25% identity, 71% coverage of query (84.0 bits)

6rqaA / A1B8Z0 Crystal structure of the iminosuccinate reductase of paracoccus denitrificans in complex with NAD+ (see paper)
    28% identity, 71% coverage of query (82.4 bits)

6rqaB Crystal structure of the iminosuccinate reductase of paracoccus denitrificans in complex with NAD+
    28% identity, 71% coverage of query (82.4 bits)

BHCD_PARDP / A1B8Z0 Iminosuccinate reductase; EC 1.4.1.- from Paracoccus denitrificans (strain Pd 1222) (see paper)
    28% identity, 71% coverage of query (82.0 bits)

NFED_RHIML / P33728 Nodulation efficiency protein NfeD; EC 1.-.-.- from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
    24% identity, 79% coverage of query (60.5 bits)

YK01_SCHPO / Q9HDZ0 Uncharacterized protein P11E10.01 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    26% identity, 73% coverage of query (59.3 bits)

PY2CR_COLP3 / Q485R8 Delta(1)-pyrroline-2-carboxylate reductase; Pyr2C reductase; Proline ketimine reductase; EC 1.5.1.49 from Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) (see 2 papers)
Q485R8 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] (EC 1.5.1.1) from Colwellia psychrerythraea (see paper)
    24% identity, 73% coverage of query (58.9 bits)

PYCR1_BURM1 / A9AKH1 Delta(1)-pyrroline-2-carboxylate reductase 1; Pyr2C reductase 1; Proline ketimine reductase 1; EC 1.5.1.49 from Burkholderia multivorans (strain ATCC 17616 / 249) (see paper)
    25% identity, 75% coverage of query (49.3 bits)

PY2CR_PARDP / A1B196 Delta(1)-pyrroline-2-carboxylate reductase; Pyr2C reductase; Proline ketimine reductase; EC 1.5.1.49 from Paracoccus denitrificans (strain Pd 1222) (see paper)
    25% identity, 70% coverage of query (48.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory