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Searching for up to 100 curated homologs for AO356_08965 FitnessBrowser__pseudo5_N2C3_1:AO356_08965 (546 a.a.)

Found high-coverage hits (≥70%) to 31 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ODP2_PSEAE / Q59638 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; EC 2.3.1.12 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    77% identity, 100% coverage of query (744 bits)

AceF / b0115 pyruvate dehydrogenase, E2 subunit (EC 2.3.1.12) from Escherichia coli K-12 substr. MG1655 (see 48 papers)
aceF / P06959 pyruvate dehydrogenase E2 subunit (EC 2.3.1.12) from Escherichia coli (strain K12) (see 48 papers)
P06959 pyruvate dehydrogenase system (EC 1.2.1.104); prephenate dehydrogenase (EC 1.3.1.12); dihydrolipoyllysine-residue acetyltransferase (EC 2.3.1.12) from Escherichia coli (see 6 papers)
AceF-lipoate / ECOCYC|ACEF-LIPOATE pyruvate dehydrogenase, dihydrolipoyltransacetylase component E2 from Escherichia coli K12 (see 2 papers)
aceF / PDB|1QJO dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; EC 2.3.1.12 from Escherichia coli K12 (see 23 papers)
    50% identity, 99% coverage of query (480 bits)

P06959 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; EC 2.3.1.12 from Escherichia coli (strain K12)
    50% identity, 99% coverage of query (480 bits)

SMc03203 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Sinorhizobium meliloti 1021
    37% identity, 76% coverage of query (235 bits)

pdhC / AAC24934.1 dihydrolipoamide acetyltransferase E2 from Bacillus subtilis (see 3 papers)
    38% identity, 78% coverage of query (235 bits)

P21883 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; S complex, 48 kDa subunit; EC 2.3.1.12 from Bacillus subtilis (strain 168)
    38% identity, 78% coverage of query (235 bits)

P11961 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; EC 2.3.1.12 from Geobacillus stearothermophilus (Bacillus stearothermophilus)
    38% identity, 78% coverage of query (223 bits)

P16263 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Bacillus subtilis (see paper)
    34% identity, 78% coverage of query (204 bits)

Pf6N2E2_479 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Pseudomonas fluorescens FW300-N2E2
    34% identity, 76% coverage of query (198 bits)

Q6FYD4 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Bartonella quintana (see paper)
    33% identity, 78% coverage of query (186 bits)

ODP2_CORGL / Q8NNJ2 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDH component E2; EC 2.3.1.12 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 2 papers)
Q8NNJ2 pyruvate dehydrogenase system (subunit 2/3) (EC 1.2.1.104); 2-oxoglutarate dehydrogenase system (subunit 2/3) (EC 1.2.1.105); dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Corynebacterium glutamicum (see 3 papers)
    31% identity, 98% coverage of query (186 bits)

acoC TPP-dependent acetoin dehydrogenase complex, E2 component, dihydrolipoyllysine-residue acetyltransferase; EC 2.3.1.12 from Clostridium magnum (see paper)
AAA21747.1 dihydrolipoamide acetyltransferase from Clostridium magnum (see paper)
    30% identity, 73% coverage of query (183 bits)

PfGW456L13_3542 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Pseudomonas fluorescens GW456-L13
    33% identity, 76% coverage of query (179 bits)

Q8GCY1 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Bartonella vinsonii (see paper)
    34% identity, 77% coverage of query (179 bits)

Q9L6H8 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Brucella melitensis (see paper)
    35% identity, 78% coverage of query (179 bits)

ODB2_CAEEL / Q23571 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; Branched-chain alpha-keto acid dehydrogenase complex component E2; Dihydrolipoamide branched-chain transacylase E2; EC 2.3.1.168 from Caenorhabditis elegans (see paper)
    31% identity, 77% coverage of query (174 bits)

HP15_1631 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Marinobacter adhaerens HP15
    35% identity, 71% coverage of query (173 bits)

ODO2_YEAST / P19262 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; DLST; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; OGDHC subunit E2; Alpha-ketoglutarate dehydrogenase subunit E2; alpha-KGDHC subunit E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
P19262 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Saccharomyces cerevisiae (see paper)
    30% identity, 78% coverage of query (171 bits)

ODP2_MYCTU / P9WIS7 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Component of peroxynitrite reductase/peroxidase complex; Component of PNR/P; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDH component E2; EC 2.3.1.12 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 5 papers)
    34% identity, 96% coverage of query (168 bits)

Build an alignment

Build an alignment for AO356_08965 and 19 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

Q98UJ6 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Gallus gallus (see paper)
    29% identity, 80% coverage of query (166 bits)

ODP23_ARATH / Q5M729 Dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide S-acetyltransferase component 3 of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2 3; PDC-E2 3; PDCE2 3; EC 2.3.1.12 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    31% identity, 78% coverage of query (166 bits)

DBT / P11182 branched-chain α-keto acid dehydrogenase complex E2 component subunit (EC 2.3.1.168) from Homo sapiens (see 9 papers)
ODB2_HUMAN / P11182 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; 52 kDa mitochondrial autoantigen of primary biliary cirrhosis; Branched chain 2-oxo-acid dehydrogenase complex component E2; BCOADC-E2; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCKAD-E2; BCKADE2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168 from Homo sapiens (Human) (see 5 papers)
P11182 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Homo sapiens (see 3 papers)
    30% identity, 78% coverage of query (166 bits)

ODB2_BOVIN / P11181 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCKAD-E2; BCKADE2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168 from Bos taurus (Bovine) (see paper)
    31% identity, 77% coverage of query (166 bits)

Q9RH46 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Coxiella burnetii (see paper)
    30% identity, 73% coverage of query (160 bits)

E2(o) subunit / b0727 dihydrolipoyltranssuccinylase (EC 2.3.1.61) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
sucB / P0AFG6 2-oxoglutarate dehydrogenase E2 subunit (EC 2.3.1.61) from Escherichia coli (strain K12) (see paper)
ODO2_ECOLI / P0AFG6 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Escherichia coli (strain K12) (see 3 papers)
P0AFG6 2-oxoglutarate dehydrogenase system (EC 1.2.1.105); dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Escherichia coli (see 6 papers)
SucB-lipoate / ECOCYC|SUCB-LIPOATE dihydrolipoyltranssuccinase from Escherichia coli K12 (see 3 papers)
sucB / PDB|1PMR dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Escherichia coli K12 (see 14 papers)
    29% identity, 78% coverage of query (156 bits)

Q8QHL7 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Oncorhynchus mykiss (see paper)
    30% identity, 76% coverage of query (155 bits)

AN3695 anthranilate synthetase (Eurofung) from Emericella nidulans (see paper)
    31% identity, 70% coverage of query (155 bits)

DLAT / P10515 pyruvate dehydrogenase E2 component from Homo sapiens (see 5 papers)
ODP2_HUMAN / P10515 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Homo sapiens (Human) (see 9 papers)
P10515 pyruvate dehydrogenase system (subunit 2/5) (EC 1.2.1.104) from Homo sapiens (see 4 papers)
    29% identity, 74% coverage of query (143 bits)

ODP2_CHATD / G0S4X6 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; MRP3; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila) (see 3 papers)
    28% identity, 84% coverage of query (114 bits)

PDHX / O00330 pyruvate dehydrogenase complex E3-binding protein component from Homo sapiens (see 9 papers)
ODPX_HUMAN / O00330 Pyruvate dehydrogenase protein X component, mitochondrial; Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; E3-binding protein; E3BP; Lipoyl-containing pyruvate dehydrogenase complex component X; proX from Homo sapiens (Human) (see 8 papers)
O00330 pyruvate dehydrogenase system (subunit 3/5) (EC 1.2.1.104) from Homo sapiens (see 4 papers)
    26% identity, 74% coverage of query (111 bits)

ODP2_FUSO4 / A0A0D2Y5A7 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; FoDLAT; DLAT; EC 2.3.1.12 from Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) (Fusarium vascular wilt of tomato) (see paper)
    25% identity, 74% coverage of query (103 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory