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Searching for up to 100 curated homologs for AO356_14055 FitnessBrowser__pseudo5_N2C3_1:AO356_14055 (432 a.a.)

Found high-coverage hits (≥70%) to 41 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HSERO_RS23010 D-galacturonate transporter ExuT from Herbaspirillum seropedicae SmR1
    74% identity, 91% coverage of query (603 bits)

ExuT / b3093 hexuronate transporter from Escherichia coli K-12 substr. MG1655 (see 5 papers)
exuT / P0AA78 hexuronate transporter from Escherichia coli (strain K12) (see 3 papers)
EXUT_ECOLI / P0AA78 Hexuronate transporter; Aldohexuronate transport system from Escherichia coli (strain K12) (see 5 papers)
    57% identity, 98% coverage of query (500 bits)

TC 2.A.1.14.2 / P0AA78 Hexuronate (glucuronate; galacturonate) porter, ExuT (Nemoz et al. 1976). It also transports D-glucose (HJ Kim et al., Front. Microbiol., 23 January 2020) from Escherichia coli (see 3 papers)
    57% identity, 98% coverage of query (500 bits)

EXUT_DICCH / P94774 Galacturonate transporter from Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi) (see 3 papers)
TC 2.A.1.14.41 / P94774 The Aldohexuronate (glucuronate, galacturonate) uptake porter from Dickeya chrysanthemi
exuT / AAB70881.1 exuT from Dickeya chrysanthemi (see paper)
    58% identity, 76% coverage of query (405 bits)

Pf1N1B4_5129 D-galacturonate transporter ExuT from Pseudomonas fluorescens FW300-N1B4
    30% identity, 82% coverage of query (158 bits)

Build an alignment

Build an alignment for AO356_14055 and 5 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

6e9nA / J7QAK3 E. Coli d-galactonate:proton symporter in the inward open form (see paper)
    24% identity, 92% coverage of query (139 bits)

CA265_RS19855 D-galacturonate transporter ExuT from Pedobacter sp. GW460-11-11-14-LB5
    25% identity, 96% coverage of query (137 bits)

SAUU_CUPNH / Q0K843 Probable sulfoacetate transporter SauU from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
    26% identity, 88% coverage of query (137 bits)

YidT / b3691 D-galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 9 papers)
dgoT / P0AA76 D-galactonate:H+ symporter from Escherichia coli (strain K12) (see 11 papers)
DGOT_ECOLI / P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.14.7 / P0AA76 Galactonate transporter from Escherichia coli (see 4 papers)
    24% identity, 95% coverage of query (137 bits)

LgoT / b4356 galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lgoT / P39398 galactonate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
LGOT_ECOLI / P39398 Probable L-galactonate transporter; Galactonate:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
yjjL / RF|NP_418776 inner membrane transport protein yjjL from Escherichia coli K12 (see 2 papers)
    27% identity, 77% coverage of query (132 bits)

PS417_04205 D-galacturonate transporter (MFS superfamily) from Pseudomonas simiae WCS417
    25% identity, 98% coverage of query (131 bits)

BT4105 D-galacturonate transporter ExuT from Bacteroides thetaiotaomicron VPI-5482
    26% identity, 82% coverage of query (130 bits)

GarP / b3127 galactarate/D-glucarate transporter GarP from Escherichia coli K-12 substr. MG1655 (see 6 papers)
garP / P0AA80 galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 5 papers)
GARP_ECOLI / P0AA80 Probable galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 2 papers)
    26% identity, 89% coverage of query (128 bits)

TC 2.A.1.14.14 / Q8FDB7 Probable D-galactarate (glucarate?):H+ symporter, GarP or YhaU from Escherichia coli O6 (see paper)
    26% identity, 89% coverage of query (128 bits)

GUDP_BACSU / P42237 Probable galactarate/D-glucarate transporter GudP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.14.1 / P42237 Glucarate porter from Bacillus subtilis (see 3 papers)
    24% identity, 98% coverage of query (120 bits)

GudP / b2789 galactarate/D-glucarate transporter GudP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gudP / Q46916 galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 5 papers)
GUDP_ECOLI / Q46916 Probable galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.14.40 / C4ZZU4 Glucarate transporter, GudP.  Encoded in an operon with GudD, a glucarate dehydratase from Escherichia coli (strain K12 / MC4100 / BW2952)
    24% identity, 95% coverage of query (120 bits)

6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form
    23% identity, 92% coverage of query (115 bits)

AO356_28540 D-mannose transporter from Pseudomonas fluorescens FW300-N2C3
    27% identity, 95% coverage of query (114 bits)

S17A5_HUMAN / Q9NRA2 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Homo sapiens (Human) (see 10 papers)
TC 2.A.1.14.10 / Q9NRA2 Lysosomal sialate transporter (Salla disease and infantile sialate storage disease protein (Morin et al., 2004)). Also transports glucuronic acid and aspartate. Structure-function studies have identify crucial residues and substrate-induced conformational changes (Courville et al., 2010). Also called SLC17A5. The substrate binding pocket has been identified based on modeling studies (see 8 papers)
    27% identity, 72% coverage of query (87.4 bits)

ANTR2_ARATH / Q8GX78 Ascorbate transporter, chloroplastic; Phosphate transporter PHT4;4; AtPHT4;4; Probable anion transporter 2 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
    26% identity, 76% coverage of query (85.9 bits)

ANTR3_ARATH / Q7XJR2 Probable anion transporter 3, chloroplastic; Phosphate transporter PHT4;2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q7XJR2 ABC-type phosphate transporter (EC 7.3.2.1) from Arabidopsis thaliana (see paper)
    24% identity, 89% coverage of query (82.8 bits)

S17A5_SHEEP / Q9MZD1 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein SP55; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Ovis aries (Sheep) (see paper)
    27% identity, 72% coverage of query (80.9 bits)

TC 2.A.1.4.2 / P12681 P-glycerate:Pi antiporter, Pgt from Salmonella typhimurium (see 2 papers)
    23% identity, 96% coverage of query (75.1 bits)

TC 2.A.1.14.26 / F2YPN7 The plasma membrane Lethal (2)01810 glutamate uptake porter (Km=0.07μM) (Inhibited by aspartate) from Drosophila melanogaster
    25% identity, 71% coverage of query (72.0 bits)

ANTR4_ARATH / Q66GI9 Probable anion transporter 4, chloroplastic; Phosphate transporter PHT4;3 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    27% identity, 84% coverage of query (71.6 bits)

ANTR1_ARATH / O82390 Sodium-dependent phosphate transport protein 1, chloroplastic; Anion transporter 1; Na(+)/PI cotransporter 1; Phosphate transporter PHT4;1; Sodium/phosphate cotransporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
O82390 ABC-type phosphate transporter (EC 7.3.2.1) from Arabidopsis thaliana (see 2 papers)
TC 2.A.1.14.22 / O82390 The chloroplast thylakoid Na+:phosphate symporter, ANTR1 (512aas) (Pavón et al., 2008). Residues essential for function have been identified from Arabidopsis thaliana (see 7 papers)
    24% identity, 85% coverage of query (70.9 bits)

NPT1_HUMAN / Q14916 Sodium-dependent phosphate transport protein 1; Na(+)/PI cotransporter 1; Na/Pi-4; Renal Na(+)-dependent phosphate cotransporter 1; Renal sodium-dependent phosphate transport protein 1; Renal sodium-phosphate transport protein 1; Sodium/phosphate cotransporter 1; Solute carrier family 17 member 1 from Homo sapiens (Human) (see 3 papers)
TC 2.A.1.14.27 / Q14916 Voltage-driven Na+:phosphate cotransporter; solute carrier family 17, member 1 from Homo sapiens (see 7 papers)
    25% identity, 83% coverage of query (68.2 bits)

NPT1_RABIT / Q28722 Sodium-dependent phosphate transport protein 1; NAPI-1; Na(+)/PI cotransporter 1; Renal Na(+)-dependent phosphate cotransporter 1; Renal sodium-dependent phosphate transport protein 1; Renal sodium-phosphate transport protein 1; Sodium/phosphate cotransporter 1; Solute carrier family 17 member 1 from Oryctolagus cuniculus (Rabbit) (see paper)
    25% identity, 83% coverage of query (67.4 bits)

S17A4_MOUSE / Q5NCM1 Probable small intestine urate exporter; Solute carrier family 17 member 4 from Mus musculus (Mouse) (see paper)
    26% identity, 74% coverage of query (67.0 bits)

A0A0H3JLD7 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Staphylococcus aureus (see paper)
    23% identity, 88% coverage of query (65.9 bits)

BWI76_RS23725 2-deoxy-D-ribonate transporter 2 from Klebsiella michiganensis M5al
    21% identity, 85% coverage of query (65.5 bits)

H281DRAFT_00642 2-deoxy-D-ribonate transporter from Paraburkholderia bryophila 376MFSha3.1
    24% identity, 94% coverage of query (64.3 bits)

ANTR5_ARATH / Q9FKV1 Probable anion transporter 5; Phosphate transporter PHT4;6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    23% identity, 78% coverage of query (59.7 bits)

NIAP_ACIAD / Q6FFF7 Niacin transporter NiaP from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    24% identity, 96% coverage of query (59.3 bits)

Q9HTV5 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Pseudomonas aeruginosa (see paper)
    24% identity, 91% coverage of query (58.5 bits)

TC 2.A.1.4.6 / Q9Z7N9 Glucose-6-P:Pi antiporter, Hpt (may also transport other organophosphates including C3 organophosphates) from Chlamydia pneumoniae (Chlamydophila pneumoniae) (see 3 papers)
    22% identity, 91% coverage of query (57.0 bits)

UhpC / b3667 inner membrane protein sensing glucose-6-phosphate from Escherichia coli K-12 substr. MG1655 (see 4 papers)
UHPC_ECOLI / P09836 Membrane sensor protein UhpC from Escherichia coli (strain K12) (see 5 papers)
TC 2.A.1.4.4 / P09836 Hexose-P:Pi antiporter regulatory protein; senses external glucose-6-P and transports it with high affinity and low efficiency from Escherichia coli (see 7 papers)
uhpC regulatory protein UhpC from Escherichia coli K12 (see 7 papers)
uhpC / ECOCYC|GLU-UHPC membrane protein regulates uhpT expression from Escherichia coli K12 (see 2 papers)
    22% identity, 91% coverage of query (56.6 bits)

TC 2.A.1.53.1 / Q5ZY33 The threonine uptake permease, PhtA (Sauer et al., 2005) (required for maximal growth in macrophages and Acanthamoeba castellanii) (see paper)
    22% identity, 89% coverage of query (56.6 bits)

TC 2.A.1.53.6 / I7I0I1 MFS uptake permease specific for pyrimidines, PhtC of 422 aas and 12 TMSs from Legionella pneumophila subsp. pneumophila
    24% identity, 88% coverage of query (56.2 bits)

SPIN_DROME / Q9GQQ0 Protein spinster; Protein benchwarmer; Protein diphthong from Drosophila melanogaster (Fruit fly) (see 3 papers)
TC 2.A.1.49.1 / Q9GQQ0 The spinster protein, spin1 or spns1 gene product (involved in synaptic growth regulation; interacts with Bcl-2/Bcl-xL, affecting programmed cell death) (see 6 papers)
spin / GI|12003970 protein spinster from Drosophila melanogaster (see paper)
    22% identity, 73% coverage of query (46.6 bits)

MHBT_KLEOX / Q5EXK5 3-hydroxybenzoate transporter MhbT from Klebsiella oxytoca (see paper)
    23% identity, 78% coverage of query (45.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory