Searching for up to 100 curated homologs for AO356_20660 FitnessBrowser__pseudo5_N2C3_1:AO356_20660 (443 a.a.)
Found high-coverage hits (≥70%) to 61 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YidT / b3691 D-galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 9 papers)
dgoT / P0AA76 D-galactonate:H+ symporter from Escherichia coli (strain K12) (see 11 papers)
DGOT_ECOLI / P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.14.7 / P0AA76 Galactonate transporter from Escherichia coli (see 4 papers)
43% identity, 96% coverage of query (366 bits)
6e9nA / J7QAK3 E. Coli d-galactonate:proton symporter in the inward open form (see paper)
44% identity, 93% coverage of query (365 bits)
GudP / b2789 galactarate/D-glucarate transporter GudP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gudP / Q46916 galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 5 papers)
GUDP_ECOLI / Q46916 Probable galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.14.40 / C4ZZU4 Glucarate transporter, GudP. Encoded in an operon with GudD, a glucarate dehydratase from Escherichia coli (strain K12 / MC4100 / BW2952)
43% identity, 99% coverage of query (360 bits)
PS417_04205 D-galacturonate transporter (MFS superfamily) from Pseudomonas simiae WCS417
40% identity, 95% coverage of query (351 bits)
GUDP_BACSU / P42237 Probable galactarate/D-glucarate transporter GudP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.14.1 / P42237 Glucarate porter from Bacillus subtilis (see 3 papers)
41% identity, 97% coverage of query (350 bits)
6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form
42% identity, 94% coverage of query (335 bits)
TC 2.A.1.14.14 / Q8FDB7 Probable D-galactarate (glucarate?):H+ symporter, GarP or YhaU from Escherichia coli O6 (see paper)
38% identity, 97% coverage of query (330 bits)
GarP / b3127 galactarate/D-glucarate transporter GarP from Escherichia coli K-12 substr. MG1655 (see 6 papers)
garP / P0AA80 galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 5 papers)
GARP_ECOLI / P0AA80 Probable galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 2 papers)
38% identity, 97% coverage of query (330 bits)
SAUU_CUPNH / Q0K843 Probable sulfoacetate transporter SauU from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
32% identity, 94% coverage of query (198 bits)
HSERO_RS23010 D-galacturonate transporter ExuT from Herbaspirillum seropedicae SmR1
32% identity, 86% coverage of query (198 bits)
Build an alignment for AO356_20660 and 10 homologs with ≥ 30% identity
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LgoT / b4356 galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lgoT / P39398 galactonate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
LGOT_ECOLI / P39398 Probable L-galactonate transporter; Galactonate:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
yjjL / RF|NP_418776 inner membrane transport protein yjjL from Escherichia coli K12 (see 2 papers)
28% identity, 97% coverage of query (175 bits)
AO356_28540 D-mannose transporter from Pseudomonas fluorescens FW300-N2C3
31% identity, 91% coverage of query (165 bits)
ANTR2_ARATH / Q8GX78 Ascorbate transporter, chloroplastic; Phosphate transporter PHT4;4; AtPHT4;4; Probable anion transporter 2 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
29% identity, 92% coverage of query (156 bits)
TC 2.A.1.14.2 / P0AA78 Hexuronate (glucuronate; galacturonate) porter, ExuT (Nemoz et al. 1976). It also transports D-glucose (HJ Kim et al., Front. Microbiol., 23 January 2020) from Escherichia coli (see 3 papers)
25% identity, 86% coverage of query (153 bits)
ExuT / b3093 hexuronate transporter from Escherichia coli K-12 substr. MG1655 (see 5 papers)
exuT / P0AA78 hexuronate transporter from Escherichia coli (strain K12) (see 3 papers)
EXUT_ECOLI / P0AA78 Hexuronate transporter; Aldohexuronate transport system from Escherichia coli (strain K12) (see 5 papers)
25% identity, 86% coverage of query (153 bits)
EXUT_DICCH / P94774 Galacturonate transporter from Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi) (see 3 papers)
TC 2.A.1.14.41 / P94774 The Aldohexuronate (glucuronate, galacturonate) uptake porter from Dickeya chrysanthemi
exuT / AAB70881.1 exuT from Dickeya chrysanthemi (see paper)
29% identity, 74% coverage of query (151 bits)
ANTR1_ARATH / O82390 Sodium-dependent phosphate transport protein 1, chloroplastic; Anion transporter 1; Na(+)/PI cotransporter 1; Phosphate transporter PHT4;1; Sodium/phosphate cotransporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
O82390 ABC-type phosphate transporter (EC 7.3.2.1) from Arabidopsis thaliana (see 2 papers)
TC 2.A.1.14.22 / O82390 The chloroplast thylakoid Na+:phosphate symporter, ANTR1 (512aas) (Pavón et al., 2008). Residues essential for function have been identified from Arabidopsis thaliana (see 7 papers)
28% identity, 95% coverage of query (145 bits)
VGLU1_MOUSE / Q3TXX4 Vesicular glutamate transporter 1; VGluT1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7 from Mus musculus (Mouse) (see 11 papers)
29% identity, 78% coverage of query (124 bits)
VGLU1_RAT / Q62634 Vesicular glutamate transporter 1; VGluT1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7 from Rattus norvegicus (Rat) (see 13 papers)
TC 2.A.1.14.13 / Q62634 Broad specificity brain synaptic vesicle anion:Na+ symporter (transports glutamate, phosphate, chloride, etc.)(BNPI, EAT-4, VGLUT1) Chloride and ketone bodies regulate VGLUT activities from Rattus norvegicus (Rat) (see 10 papers)
29% identity, 78% coverage of query (124 bits)
VGLU1_HUMAN / Q9P2U7 Vesicular glutamate transporter 1; VGluT1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7 from Homo sapiens (Human) (see paper)
TC 2.A.1.14.30 / Q9P2U7 Vesicular glutamate transporter 1, VGluT1 or PNP1 of 560 aas and 12 TMSs. Brain-specific Na+-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7). Several proteins must be retrieved to the synaptic vesicle before it can export neurotransmitters, and cargo retrieval is a collective cargo-driven process, dependent on VGluT1 from Homo sapiens (see 2 papers)
29% identity, 78% coverage of query (122 bits)
S17A9_MOUSE / Q8VCL5 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Mus musculus (Mouse) (see 5 papers)
26% identity, 95% coverage of query (118 bits)
ANTR3_ARATH / Q7XJR2 Probable anion transporter 3, chloroplastic; Phosphate transporter PHT4;2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q7XJR2 ABC-type phosphate transporter (EC 7.3.2.1) from Arabidopsis thaliana (see paper)
27% identity, 89% coverage of query (118 bits)
S17A9_HUMAN / Q9BYT1 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Homo sapiens (Human) (see 4 papers)
TC 2.A.1.14.21 / Q9BYT1 The vesicular purine nucleotide (ADP, ATP, GTP) transporter, VNUT or SLC17A9. It is found in synaptic vesicles and chromafin granules (Sawada et al., 2008)) and is associated with disseminated superficial actinic porokeratosis (DSAP), a rare autosomal dominant genodermatosis (Cui et al. 2014). It plays a key role in purinergic signaling through its ability to transport nucleotides using the pmf. It catalyzes Cl--dependent transport activity involving essential arginines in the transmembrane region. Ketoacids inhibit these transporters through modulation of Cl- activation, but Cl- and the arginine residues are not important for ATP binding (Iwai et al. 2019). High expression of SLC17A9 correlates with a poor prognosis for colorectal cancer from Homo sapiens (Human) (see 5 papers)
27% identity, 91% coverage of query (114 bits)
S17A9_RAT / P0DX21 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Rattus norvegicus (Rat) (see 2 papers)
25% identity, 95% coverage of query (114 bits)
VGLU3_MOUSE / Q8BFU8 Vesicular glutamate transporter 3; VGluT3; Solute carrier family 17 member 8 from Mus musculus (Mouse) (see 5 papers)
TC 2.A.1.14.23 / Q8BFU8 Vesicular glutamate transporter #3 (VGLUT3) [Its absence in mice causes sensorineural deafness and seizures]. 70% identical to VGLUT2 (TC# 2.A.1.14.16) (Gras et al., 2002). VGLUT1-3 concentrate glutamate into synaptic vesicles before its exocytotic release and contribute to the regulation of serotonergic transmission and anxiety (Amilhon et al., 2010). It may catalyze uptake of the neurotransmitter coupled with H+ export and K+ uptake from Mus musculus (see 6 papers)
26% identity, 78% coverage of query (113 bits)
VGLU3_RAT / Q7TSF2 Vesicular glutamate transporter 3; VGluT3; Solute carrier family 17 member 8 from Rattus norvegicus (Rat) (see 8 papers)
26% identity, 78% coverage of query (112 bits)
ANTR5_ARATH / Q9FKV1 Probable anion transporter 5; Phosphate transporter PHT4;6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
27% identity, 84% coverage of query (112 bits)
VGLU2_HUMAN / Q9P2U8 Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 from Homo sapiens (Human) (see 2 papers)
TC 2.A.1.14.31 / Q9P2U8 Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6) from Homo sapiens (see 5 papers)
25% identity, 78% coverage of query (111 bits)
VGLU2_RAT / Q9JI12 Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 from Rattus norvegicus (Rat) (see 10 papers)
TC 2.A.1.14.16 / Q9JI12 The broad specificity brain synaptic vesicle anion transporter (transports glutamate in a Δψ-dependent fashion requiring Cl- but phosphate by a Na+-dependent mechanism via a different pathway/mechanism from Rattus norvegicus (see 8 papers)
25% identity, 78% coverage of query (111 bits)
VGLU2_MOUSE / Q8BLE7 Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 from Mus musculus (Mouse) (see 9 papers)
25% identity, 78% coverage of query (111 bits)
TC 2.A.1.14.26 / F2YPN7 The plasma membrane Lethal (2)01810 glutamate uptake porter (Km=0.07μM) (Inhibited by aspartate) from Drosophila melanogaster
26% identity, 80% coverage of query (110 bits)
VGL2B_DANRE / Q5W8I7 Vesicular glutamate transporter 2.2; Solute carrier family 17 member 6-A; Vesicular glutamate transporter 2-B from Danio rerio (Zebrafish) (Brachydanio rerio) (see 2 papers)
25% identity, 78% coverage of query (110 bits)
S17A5_HUMAN / Q9NRA2 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Homo sapiens (Human) (see 10 papers)
TC 2.A.1.14.10 / Q9NRA2 Lysosomal sialate transporter (Salla disease and infantile sialate storage disease protein (Morin et al., 2004)). Also transports glucuronic acid and aspartate. Structure-function studies have identify crucial residues and substrate-induced conformational changes (Courville et al., 2010). Also called SLC17A5. The substrate binding pocket has been identified based on modeling studies (see 8 papers)
27% identity, 85% coverage of query (109 bits)
VGLU3_HUMAN / Q8NDX2 Vesicular glutamate transporter 3; VGluT3; Solute carrier family 17 member 8 from Homo sapiens (Human) (see 2 papers)
TC 2.A.1.14.32 / Q8NDX2 Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8). Loss in mice produces circadian-dependent hyperdopaminergia and amiliorates motor disfunction and dopa-mediated dyskinesias in a model of Parkinson's Disease (Divito et al. 2015). VGLUT3 is expressed selectively in the inner hair cells (IHCs) and transports the neurotransmitter glutamate into synaptic vesicles. Mutation of the SLC17A8 gene is associated with DFNA25 (deafness, autosomal dominant 25), a non-syndromic hearing loss (ADNSHL) in humans (Ryu et al. 2016). Glut3 contributes to stress response and related psychopathologies from Homo sapiens (see 4 papers)
26% identity, 78% coverage of query (109 bits)
7t3nA / Q9JI12 R184q/e191q mutant of rat vesicular glutamate transporter 2 (vglut2)
25% identity, 78% coverage of query (109 bits)
ANTR4_ARATH / Q66GI9 Probable anion transporter 4, chloroplastic; Phosphate transporter PHT4;3 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
28% identity, 83% coverage of query (108 bits)
VGL2A_DANRE / Q5W8I8 Vesicular glutamate transporter 2.1; Protein blumenkohl; Solute carrier family 17 member 6-B; Vesicular glutamate transporter 2-A from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
24% identity, 86% coverage of query (108 bits)
S17A5_SHEEP / Q9MZD1 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein SP55; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Ovis aries (Sheep) (see paper)
26% identity, 84% coverage of query (106 bits)
BWI76_RS23715 2-deoxy-D-ribonate transporter 1 from Klebsiella michiganensis M5al
24% identity, 93% coverage of query (105 bits)
ANTR6_ARATH / Q3E9A0 Probable anion transporter 6, chloroplastic; Phosphate transporter PHT4;5 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
26% identity, 88% coverage of query (103 bits)
S17A4_MOUSE / Q5NCM1 Probable small intestine urate exporter; Solute carrier family 17 member 4 from Mus musculus (Mouse) (see paper)
26% identity, 82% coverage of query (102 bits)
S17A5_MOUSE / Q8BN82 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Mus musculus (Mouse) (see 3 papers)
29% identity, 80% coverage of query (100 bits)
S17A4_HUMAN / Q9Y2C5 Probable small intestine urate exporter; Solute carrier family 17 member 4 from Homo sapiens (Human) (see 4 papers)
TC 2.A.1.14.24 / Q9Y2C5 Intestinal mucosal sodium/phosphate symporter, SLC17A4. Maintains phosphate homeostasis; mediates intestinal absorption, bone deposition and resorption and renal excretion from Homo sapiens (see 3 papers)
27% identity, 83% coverage of query (100 bits)
PS417_07265 2-deoxy-D-ribonate transporter 1 from Pseudomonas simiae WCS417
26% identity, 91% coverage of query (98.2 bits)
TC 2.A.1.14.8 / Q9RPP3 Phthalate porter from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
22% identity, 95% coverage of query (97.8 bits)
S17A5_RAT / Q5Q0U0 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 (Anion/sugar transporter), member 5; Vesicular excitatory amino acid transporter; VEAT from Rattus norvegicus (Rat) (see 2 papers)
28% identity, 78% coverage of query (96.7 bits)
EAT4_CAEEL / P34644 Probable vesicular glutamate transporter eat-4; Abnormal pharyngeal pumping eat-4 from Caenorhabditis elegans (see 9 papers)
TC 2.A.1.14.42 / P34644 Vesicular glutamate transporter, EAT-4/VGLUT of 576 aas from Caenorhabditis elegans
24% identity, 90% coverage of query (95.5 bits)
ABAQ_ACIBT / P0DPR4 Quinolone resistance transporter from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (see 2 papers)
24% identity, 92% coverage of query (94.0 bits)
Q03567 Uncharacterized transporter slc-17.2 from Caenorhabditis elegans
23% identity, 93% coverage of query (91.7 bits)
TC 2.A.1.4.11 / Q9ZE92 Glycerol-3-phosphate:inorganic phosphate antiporter, GlpT from Rickettsia prowazekii (strain Madrid E)
25% identity, 92% coverage of query (90.9 bits)
YHDC_SCHPO / Q9P6J0 Uncharacterized transporter C1683.12 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
22% identity, 92% coverage of query (86.3 bits)
Q9HTV5 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Pseudomonas aeruginosa (see paper)
27% identity, 84% coverage of query (86.3 bits)
BPHYT_RS04765 2-deoxy-D-ribonate transporter from Burkholderia phytofirmans PsJN
26% identity, 87% coverage of query (84.3 bits)
GlpT / b2240 sn-glycerol 3-phosphate:phosphate antiporter from Escherichia coli K-12 substr. MG1655 (see 24 papers)
glpT / P08194 sn-glycerol 3-phosphate:phosphate antiporter from Escherichia coli (strain K12) (see 48 papers)
TC 2.A.1.4.3 / P08194 Glycerol-P:Pi antiporter (may function by a 'rocker switch' mechanism; Law et al., 2007). The 3-d structure is known (3.3Å resolution) (Huang et al., 2003; Lemieux et al., 2005; Lemieux, 2007) from Escherichia coli (see 7 papers)
25% identity, 84% coverage of query (84.0 bits)
NICT_PSEPK / Q88FY6 Putative metabolite transport protein NicT; Nicotinate degradation protein T from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
22% identity, 91% coverage of query (83.2 bits)
TC 2.A.1.4.6 / Q9Z7N9 Glucose-6-P:Pi antiporter, Hpt (may also transport other organophosphates including C3 organophosphates) from Chlamydia pneumoniae (Chlamydophila pneumoniae) (see 3 papers)
24% identity, 91% coverage of query (80.5 bits)
G6PT1_HUMAN / O43826 Glucose-6-phosphate exchanger SLC37A4; Glucose-5-phosphate transporter; Glucose-6-phosphate translocase; Solute carrier family 37 member 4; Transformation-related gene 19 protein; TRG-19 from Homo sapiens (Human) (see 24 papers)
TC 2.A.1.4.5 / O43826 Microsomal (ER/Golgi) glucose-6-P:Pi antiporter (glycogen storage disease (GSD1b and 1c); Gierke''s disease protein) (SLC37A2 in mice, associated with white adipose tissue obesity and expressed at high levels in macrophage) (4 isoforms present in humans (Chen et al., 2008)) from Homo sapiens (Human) (see 23 papers)
SLC37A4 / RF|NP_001458.1 glucose-6-phosphate translocase from Homo sapiens
24% identity, 91% coverage of query (78.6 bits)
A0A0H3JLD7 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Staphylococcus aureus (see paper)
24% identity, 88% coverage of query (76.3 bits)
P53322 High-affinity nicotinic acid transporter; Nicotinic acid permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
19% identity, 76% coverage of query (47.4 bits)
YaiK / b0353 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
mhpT / P77589 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
MHPT_ECOLI / P77589 3-(3-hydroxy-phenyl)propionate transporter; 3HPP transporter; 3-(3-hydroxy-phenyl)propionate:H(+) symporter; 3HPP:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.15.2 / P77589 MhpT. A specific 3-(3-hydroxyphenyl)propionate (3HPP) transporter; vital for E. coli K-12 W3110 to grow on this substrate from Escherichia coli (see 3 papers)
24% identity, 86% coverage of query (45.4 bits)
SPNS2_HUMAN / Q8IVW8 Sphingosine-1-phosphate transporter SPNS2; Protein spinster homolog 2 from Homo sapiens (Human) (see 4 papers)
TC 2.A.1.49.6 / Q8IVW8 Sphingosine-1-phosphate/dehydroshpingosine-1-P transport protein, Spinster 2. Involved in immune development and lymphocyte trafficing from Homo sapiens (see 2 papers)
23% identity, 79% coverage of query (43.9 bits)
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