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Searching for up to 100 curated homologs for AO356_24885 AO356_24885 pyruvate dehydrogenase (338 a.a.)

Found high-coverage hits (≥70%) to 53 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q9HWN0 acetoin dehydrogenase system (subunit 1/2) (EC 2.3.1.190) from Pseudomonas aeruginosa (see paper)
    89% identity, 99% coverage of query (606 bits)

Q52015 acetoin dehydrogenase system (EC 2.3.1.190) from Pseudomonas putida (see paper)
    80% identity, 99% coverage of query (545 bits)

P27746 acetoin dehydrogenase system (EC 2.3.1.190) from Alcaligenes eutrophus H16 (see paper)
acoB / AAA21949.1 acetoin:DCPIP oxidoreductase-beta from Cupriavidus necator (see paper)
    74% identity, 95% coverage of query (474 bits)

acoB / Q3A7P0 acetoin:DCPIP oxidoreductase β subunit from Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1) (see paper)
    61% identity, 99% coverage of query (410 bits)

acoB / AAA18916.1 acetoin:DCPIP oxidoreductase beta subunit from Pelobacter carbinolicus (see paper)
    60% identity, 99% coverage of query (409 bits)

Q46143 acetoin dehydrogenase system (EC 2.3.1.190) from Clostridium magnum (see paper)
acoB TPP-dependent acetoin dehydrogenase complex, E1 component, beta subunit; EC 1.1.1.- from Clostridium magnum (see paper)
AAA21745.1 TPP-dependent acetoin dehydrogenase beta-subunit from Clostridium magnum (see paper)
    44% identity, 99% coverage of query (303 bits)

Q9HIA4 branched-chain-2-oxoacid decarboxylase (subunit 2/2) (EC 4.1.1.72) from Thermoplasma acidophilum (see paper)
    48% identity, 97% coverage of query (290 bits)

Q97YF5 acetoin dehydrogenase system (EC 2.3.1.190) from Saccharolobus solfataricus (see paper)
    43% identity, 96% coverage of query (270 bits)

P21874 pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Geobacillus stearothermophilus (see paper)
    45% identity, 98% coverage of query (270 bits)

3dufD / P21874 Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
    45% identity, 98% coverage of query (270 bits)

3dv0D Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex
    45% identity, 98% coverage of query (270 bits)

3dv0B Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex
    45% identity, 98% coverage of query (270 bits)

1w85B The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2
    45% identity, 98% coverage of query (270 bits)

bfmBAB / P37941 2-keto-isovalerate dehydrogenase component β subunit (EC 1.2.4.4) from Bacillus subtilis (strain 168) (see 2 papers)
    41% identity, 98% coverage of query (269 bits)

ODPB_STAAU / P0A0A3 Pyruvate dehydrogenase E1 component subunit beta; EC 1.2.4.1 from Staphylococcus aureus (see paper)
    44% identity, 98% coverage of query (261 bits)

A2Z2Z0 pyruvate dehydrogenase (acetyl-transferring) (subunit 1/2) (EC 1.2.4.1) from Oryza sativa Indica Group (see paper)
    42% identity, 96% coverage of query (261 bits)

pdhB / AAC24933.1 pyruvate decarboxylase E-1 beta subunit from Bacillus subtilis (see 3 papers)
    44% identity, 97% coverage of query (259 bits)

ODBB_THET8 / Q5SLR3 2-oxoisovalerate dehydrogenase subunit beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    44% identity, 97% coverage of query (254 bits)

1umbD / Q5SLR3 Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
    44% identity, 97% coverage of query (253 bits)

1umdD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate
    44% identity, 97% coverage of query (253 bits)

1umcD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate
    44% identity, 97% coverage of query (253 bits)

ODPB1_ARATH / Q38799 Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial; PDHE1-B; Protein MACCI-BOU; EC 1.2.4.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q38799 pyruvate dehydrogenase system (subunit 1/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 1/2) (EC 1.2.4.1) from Arabidopsis thaliana (see paper)
    39% identity, 100% coverage of query (252 bits)

PDHB / P11177 pyruvate dehydrogenase E1 component β subunit from Homo sapiens (see 7 papers)
ODPB_HUMAN / P11177 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1 from Homo sapiens (Human) (see 6 papers)
P11177 pyruvate dehydrogenase system (subunit 1/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 1/2) (EC 1.2.4.1) from Homo sapiens (see 2 papers)
    40% identity, 96% coverage of query (247 bits)

Q9D051 pyruvate dehydrogenase system (subunit 1/2) (EC 1.2.1.104) from Mus musculus (see paper)
    40% identity, 97% coverage of query (247 bits)

PDHB / P26269 pyruvate dehydrogenase β subunit from Ascaris suum (see paper)
    40% identity, 97% coverage of query (246 bits)

6cerD / P11177 Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
    40% identity, 95% coverage of query (246 bits)

P52904 pyruvate dehydrogenase system (subunit 3/3) (EC 1.2.1.104) from Pisum sativum (see paper)
    41% identity, 96% coverage of query (246 bits)

6cfoB Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate
    40% identity, 95% coverage of query (246 bits)

ODPB_YEAST / P32473 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; Pyruvate dehydrogenase complex component E1 beta; PDHE1-B; EC 1.2.4.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    39% identity, 98% coverage of query (243 bits)

ODPB_DROME / Q7K5K3 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; EC 1.2.4.1 from Drosophila melanogaster (Fruit fly) (see paper)
    38% identity, 98% coverage of query (242 bits)

ODPB_SCHPO / Q09171 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
pdb1 / RF|NP_596272.1 pyruvate dehydrogenase e1 component beta subunit Pdb1; EC 1.2.4.1 from Schizosaccharomyces pombe (see paper)
    40% identity, 95% coverage of query (242 bits)

P73405 pyruvate dehydrogenase system (subunit 1/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 1/2) (EC 1.2.4.1) from Synechocystis sp. PCC 6803 (see 2 papers)
    40% identity, 96% coverage of query (241 bits)

Pf6N2E2_480 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2E2
    39% identity, 96% coverage of query (234 bits)

SMc03202 branched-chain alpha-ketoacid dehydrogenase, E1 component beta subunit (EC 1.2.4.4) from Sinorhizobium meliloti 1021
    39% identity, 99% coverage of query (233 bits)

AO356_22985 branched-chain alpha-ketoacid dehydrogenase, E1 component beta subunit (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2C3
    39% identity, 96% coverage of query (233 bits)

PfGW456L13_3541 branched-chain alpha-ketoacid dehydrogenase, E1 component beta subunit (EC 1.2.4.4) from Pseudomonas fluorescens GW456-L13
    39% identity, 96% coverage of query (233 bits)

PS417_17550 branched-chain alpha-ketoacid dehydrogenase, E1 component beta subunit (EC 1.2.4.4) from Pseudomonas simiae WCS417
    39% identity, 96% coverage of query (230 bits)

1qs0B / P09061 Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
    39% identity, 96% coverage of query (225 bits)

bkdA2 / GI|790516 2-oxoisovalerate dehydrogenase subunit beta; EC 1.2.4.4 from Pseudomonas putida (see 2 papers)
    39% identity, 96% coverage of query (225 bits)

ODPB_CHATD / G0RYE0 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; Pyruvate dehydrogenase complex component E1 beta; PDHE1-B; EC 1.2.4.1 from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila) (see 2 papers)
G0RYE0 pyruvate dehydrogenase system (subunit 1/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 1/2) (EC 1.2.4.1) from Chaetomium thermophilum (see paper)
    40% identity, 96% coverage of query (224 bits)

pdhC pyruvate dehydrogenase (lipoamide) from Emericella nidulans (see paper)
    38% identity, 94% coverage of query (223 bits)

Q1KSF0 pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Toxoplasma gondii (see paper)
    38% identity, 99% coverage of query (222 bits)

ODBB_BOVIN / P21839 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; EC 1.2.4.4 from Bos taurus (Bovine) (see paper)
    40% identity, 99% coverage of query (221 bits)

2j9fD / P21953 Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase e1b (see paper)
    39% identity, 99% coverage of query (220 bits)

BCKDHB / P21953 branched-chain α-keto acid dehydrogenase E1 component β subunit (EC 1.2.4.4) from Homo sapiens (see 15 papers)
ODBB_HUMAN / P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; EC 1.2.4.4 from Homo sapiens (Human) (see 5 papers)
P21953 branched-chain alpha-keto acid dehydrogenase system (subunit 1/2) (EC 1.2.1.25) from Homo sapiens (see 5 papers)
    40% identity, 99% coverage of query (220 bits)

ODBB2_ARATH / Q9LDY2 2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; Protein DARK INDUCIBLE 4; EC 1.2.4.4 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    38% identity, 99% coverage of query (220 bits)

1dtwB Human branched-chain alpha-keto acid dehydrogenase
    39% identity, 99% coverage of query (220 bits)

P35738 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (subunit 1/2) (EC 1.2.4.4) from Rattus norvegicus (see paper)
    39% identity, 99% coverage of query (218 bits)

Q6P3A8 branched-chain alpha-keto acid dehydrogenase system (subunit 1/2) (EC 1.2.1.25) from Mus musculus (see paper)
    39% identity, 99% coverage of query (218 bits)

Build an alignment

Build an alignment for AO356_24885 and 49 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

6yakDDD 6yakDDD (see paper)
    24% identity, 70% coverage of query (66.6 bits)

YajP / b0420 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
dxs / P77488 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) from Escherichia coli (strain K12) (see 26 papers)
DXS_ECOLI / P77488 1-deoxy-D-xylulose-5-phosphate synthase; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS; EC 2.2.1.7 from Escherichia coli (strain K12) (see 3 papers)
    23% identity, 80% coverage of query (54.3 bits)

2o1sA / P77488 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from escherichia coli (see paper)
    23% identity, 80% coverage of query (54.3 bits)

2o1sB / P77488 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from escherichia coli (see paper)
    23% identity, 80% coverage of query (53.5 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory