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Searching for up to 100 curated homologs for AO356_25650 FitnessBrowser__pseudo5_N2C3_1:AO356_25650 (263 a.a.)

Found high-coverage hits (≥70%) to 53 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PHEC_PSEAE / Q01269 Cyclohexadienyl dehydratase; EC 4.2.1.51; EC 4.2.1.91 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q01269 arogenate dehydratase (EC 4.2.1.91) from Pseudomonas aeruginosa (see 3 papers)
    51% identity, 88% coverage of query (246 bits)

5t0wA Crystal structure of the ancestral amino acid-binding protein anccdt- 1, a precursor of cyclohexadienyl dehydratase
    36% identity, 88% coverage of query (161 bits)

5kkwA / Q4FLR5 Crystal structure of sar11_1068 bound to a sulfobetaine (3-(1- methylpiperidinium-1-yl)propane-1-sulfonate)
    33% identity, 87% coverage of query (121 bits)

Build an alignment

Build an alignment for AO356_25650 and 3 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

3k4uE / Q7MAG0 Crystal structure of putative binding component of abc transporter from wolinella succinogenes dsm 1740 complexed with lysine
    27% identity, 85% coverage of query (95.5 bits)

4zv2A An ancestral arginine-binding protein bound to glutamine
    29% identity, 85% coverage of query (90.5 bits)

4zv1A An ancestral arginine-binding protein bound to arginine (see paper)
    28% identity, 85% coverage of query (87.4 bits)

4h5fA Crystal structure of an amino acid abc transporter substrate-binding protein from streptococcus pneumoniae canada mdr_19a bound to l- arginine, form 1
    29% identity, 85% coverage of query (84.7 bits)

6svfA / Q9WZ62 Crystal structure of the p235gk mutant of argbp from t. Maritima (see paper)
    25% identity, 87% coverage of query (84.7 bits)

AO353_21710 ABC transporter for D-glucosamine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E3
    27% identity, 98% coverage of query (74.3 bits)

AO356_00480 ABC transporter for D-Glucosamine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    27% identity, 94% coverage of query (73.2 bits)

TC 3.A.1.3.6 / P35120 NocT aka ATU6027 aka AGR_PTI_67, component of Nopaline porter from Agrobacterium tumefaciens (see 3 papers)
    25% identity, 97% coverage of query (73.2 bits)

Ac3H11_2555 ABC transporter for L-Histidine, periplasmic substrate-binding component 1 from Acidovorax sp. GW101-3H11
    23% identity, 87% coverage of query (72.4 bits)

TcyJ / b1920 cystine ABC transporter periplasmic binding protein (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
tcyJ / P0AEM9 cystine ABC transporter periplasmic binding protein (EC 7.4.2.12) from Escherichia coli (strain K12) (see 13 papers)
TCYJ_ECOLI / P0AEM9 L-cystine-binding protein TcyJ; CBP; Protein FliY; Sulfate starvation-induced protein 7; SSI7 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.3.10 / P0AEM9 Cystine-binding periplasmic protein FLIY aka CysX aka B1920, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 7 papers)
    24% identity, 97% coverage of query (71.2 bits)

5itoA Structure of the periplasmic binding protein m117n-noct from a. Tumefaciens in complex with octopine
    24% identity, 86% coverage of query (71.2 bits)

5otcA Structure of the periplasmic binding protein (pbp) noct from agrobacterium tumefaciens c58 in complex with noroctopinic acid.
    24% identity, 86% coverage of query (70.9 bits)

5otaA Structure of the periplasmic binding protein (pbp) noct from agrobacterium tumefaciens c58 in complex with octopinic acid
    24% identity, 86% coverage of query (70.9 bits)

5ot9A Structure of the periplasmic binding protein (pbp) noct from a.Tumefaciens c58 in complex with histopine.
    24% identity, 86% coverage of query (70.9 bits)

4powA Structure of the pbp noct in complex with pyronopaline
    24% identity, 86% coverage of query (70.9 bits)

5ovzA / P35120 High resolution structure of the pbp noct in complex with nopaline (see paper)
    24% identity, 86% coverage of query (70.5 bits)

Pf6N2E2_2053 ABC transporter for D-Glucosamine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    27% identity, 89% coverage of query (69.7 bits)

AAC45332.1 high affinity cystine binding protein from Lactobacillus reuteri (see 4 papers)
    22% identity, 95% coverage of query (65.5 bits)

4ymxA / Q8RCC4 Crystal structure of the substrate binding protein of an amino acid abc transporter (see paper)
    24% identity, 84% coverage of query (63.9 bits)

TC 3.A.1.3.17 / Q8YSA2 Basic amino acid uptake transporter, BgtAB (see paper)
    23% identity, 95% coverage of query (63.2 bits)

4i62A / A0A0H2ZN67 1.05 angstrom crystal structure of an amino acid abc transporter substrate-binding protein abpa from streptococcus pneumoniae canada mdr_19a bound to l-arginine
    23% identity, 86% coverage of query (62.8 bits)

HisJ / b2309 histidine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
HISJ_ECOLI / P0AEU0 Histidine-binding periplasmic protein; HBP from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.29 / P0AEU0 Histidine-binding periplasmic protein, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
hisJ / GB|AAC75369.1 histidine ABC transporter, periplasmic histidine-binding protein HisJ from Escherichia coli (see 7 papers)
    24% identity, 84% coverage of query (61.6 bits)

ARGT_SALTY / P02911 Lysine/arginine/ornithine-binding periplasmic protein; LAO-binding protein from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 6 papers)
argT / RF|NP_461297.1 lysine/arginine/ornithine ABC transporter, periplasmic lysine/arginine/ornithine-binding protein ArgT from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
    24% identity, 84% coverage of query (61.6 bits)

1lafE / P02911 Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
    24% identity, 84% coverage of query (61.2 bits)

1lstA Three-dimensional structures of the periplasmic lysine-, arginine-, ornithine-binding protein with and without a ligand
    24% identity, 84% coverage of query (61.2 bits)

1lahE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein
    24% identity, 84% coverage of query (61.2 bits)

1lagE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein
    24% identity, 84% coverage of query (61.2 bits)

1hslA / P0AEU0 Refined 1.89 angstroms structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport(slash)chemosensory receptors (see paper)
    24% identity, 84% coverage of query (60.5 bits)

HISJ_SALTY / P02910 Histidine-binding periplasmic protein; HBP from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
hisJ / GB|AAV76512.1 histidine ABC transporter, periplasmic histidine-binding protein HisJ from Salmonella enterica subsp. enterica serovar Typhimurium (see 5 papers)
    24% identity, 84% coverage of query (60.5 bits)

5owfA Structure of a lao-binding protein mutant with glutamine
    24% identity, 84% coverage of query (59.7 bits)

HISJ_CAMJE / Q46125 Probable histidine-binding protein; HBP; p29 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
    23% identity, 95% coverage of query (59.3 bits)

8gu1A Crystal structure of putative amino acid binding periplasmic abc transporter protein from candidatus liberibacter asiaticus in complex with pimozide
    23% identity, 84% coverage of query (58.9 bits)

6aalA Crystal structure of putative amino acid binding periplasmic abc transporter protein from candidatus liberibacter asiaticus in complex with arginine
    23% identity, 84% coverage of query (58.9 bits)

6a80A Crystal structure of putative amino acid binding periplasmic abc transporter protein from candidatus liberibacter asiaticus in complex with cystine
    23% identity, 84% coverage of query (58.9 bits)

8gtuA / C6XGT2 Crystal structure of putative amino acid binding periplasmic abc transporter protein from candidatus liberibacter asiaticus in complex with clidinium (see paper)
    23% identity, 84% coverage of query (58.5 bits)

C6XGT2 ABC-type cystine transporter (EC 7.4.2.12) from Candidatus Liberibacter asiaticus (see paper)
    23% identity, 84% coverage of query (57.8 bits)

5lomB / Q7D447 Crystal structure of the pbp soca from agrobacterium tumefaciens c58 in complex with dfg at 1.5 a resolution (see paper)
    24% identity, 84% coverage of query (57.8 bits)

5l9oA Crystal structure of agrobacterium tumefaciens c58 strain pbp soca in complex with glucopine
    24% identity, 84% coverage of query (57.8 bits)

5l9oB Crystal structure of agrobacterium tumefaciens c58 strain pbp soca in complex with glucopine
    24% identity, 84% coverage of query (57.8 bits)

ArgT / b2310 lysine/arginine/ornithine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
TC 3.A.1.3.1 / TC 3.A.1.3.29 / P09551 ArgT aka B2310, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (see 5 papers)
    22% identity, 84% coverage of query (54.3 bits)

cjaA / CAJ20048.1 glutamine-binding protein from Campylobacter jejuni (see paper)
    25% identity, 74% coverage of query (54.3 bits)

ARGT_CORGL / Q8NQU2 Arginine-binding protein ArgT from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    22% identity, 85% coverage of query (53.9 bits)

5eyfB / Q3XZW5 Crystal structure of solute-binding protein from enterococcus faecium with bound glutamate
    24% identity, 78% coverage of query (53.1 bits)

4kqpA / Q9CES5 Crystal structure of lactococcus lactis glnp substrate binding domain 2 (sbd2) in complex with glutamine at 0.95 a resolution (see paper)
    19% identity, 84% coverage of query (50.8 bits)

8eyzA / P0AEQ3 Engineered glutamine binding protein bound to gln and a cobaloxime ligand (see paper)
    21% identity, 84% coverage of query (48.9 bits)

2v25A / Q0P9X8 Structure of the campylobacter jejuni antigen peb1a, an aspartate and glutamate receptor with bound aspartate (see paper)
    24% identity, 82% coverage of query (43.1 bits)

2q2aA / D0VWX8 Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus (see paper)
    21% identity, 83% coverage of query (42.7 bits)

2pvuA Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus
    21% identity, 83% coverage of query (42.4 bits)

2pyyB / D0VWX9 Crystal structure of the glur0 ligand-binding core from nostoc punctiforme in complex with (l)-glutamate (see paper)
    23% identity, 75% coverage of query (42.4 bits)

2q2cA Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus
    21% identity, 83% coverage of query (42.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory