Searching for up to 100 curated homologs for AO356_28540 FitnessBrowser__pseudo5_N2C3_1:AO356_28540 (430 a.a.)
Found high-coverage hits (≥70%) to 58 curated proteins.
Removed hits that are identical to the query, leaving 57
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
SAUU_CUPNH / Q0K843 Probable sulfoacetate transporter SauU from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
32% identity, 97% coverage of query (220 bits)
LgoT / b4356 galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lgoT / P39398 galactonate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
LGOT_ECOLI / P39398 Probable L-galactonate transporter; Galactonate:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
yjjL / RF|NP_418776 inner membrane transport protein yjjL from Escherichia coli K12 (see 2 papers)
31% identity, 91% coverage of query (197 bits)
Build an alignment for AO356_28540 and 2 homologs with ≥ 30% identity
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PS417_04205 D-galacturonate transporter (MFS superfamily) from Pseudomonas simiae WCS417
29% identity, 97% coverage of query (194 bits)
GUDP_BACSU / P42237 Probable galactarate/D-glucarate transporter GudP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.14.1 / P42237 Glucarate porter from Bacillus subtilis (see 3 papers)
31% identity, 90% coverage of query (183 bits)
YidT / b3691 D-galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 9 papers)
dgoT / P0AA76 D-galactonate:H+ symporter from Escherichia coli (strain K12) (see 11 papers)
DGOT_ECOLI / P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.14.7 / P0AA76 Galactonate transporter from Escherichia coli (see 4 papers)
31% identity, 92% coverage of query (181 bits)
6e9nA / J7QAK3 E. Coli d-galactonate:proton symporter in the inward open form (see paper)
31% identity, 92% coverage of query (181 bits)
GudP / b2789 galactarate/D-glucarate transporter GudP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gudP / Q46916 galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 5 papers)
GUDP_ECOLI / Q46916 Probable galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.14.40 / C4ZZU4 Glucarate transporter, GudP. Encoded in an operon with GudD, a glucarate dehydratase from Escherichia coli (strain K12 / MC4100 / BW2952)
30% identity, 91% coverage of query (178 bits)
GarP / b3127 galactarate/D-glucarate transporter GarP from Escherichia coli K-12 substr. MG1655 (see 6 papers)
garP / P0AA80 galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 5 papers)
GARP_ECOLI / P0AA80 Probable galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 2 papers)
30% identity, 92% coverage of query (174 bits)
TC 2.A.1.14.14 / Q8FDB7 Probable D-galactarate (glucarate?):H+ symporter, GarP or YhaU from Escherichia coli O6 (see paper)
30% identity, 92% coverage of query (174 bits)
6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form
30% identity, 92% coverage of query (156 bits)
ANTR2_ARATH / Q8GX78 Ascorbate transporter, chloroplastic; Phosphate transporter PHT4;4; AtPHT4;4; Probable anion transporter 2 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
26% identity, 92% coverage of query (132 bits)
HSERO_RS23010 D-galacturonate transporter ExuT from Herbaspirillum seropedicae SmR1
28% identity, 85% coverage of query (130 bits)
ANTR3_ARATH / Q7XJR2 Probable anion transporter 3, chloroplastic; Phosphate transporter PHT4;2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q7XJR2 ABC-type phosphate transporter (EC 7.3.2.1) from Arabidopsis thaliana (see paper)
27% identity, 85% coverage of query (126 bits)
ANTR5_ARATH / Q9FKV1 Probable anion transporter 5; Phosphate transporter PHT4;6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
25% identity, 92% coverage of query (124 bits)
ANTR1_ARATH / O82390 Sodium-dependent phosphate transport protein 1, chloroplastic; Anion transporter 1; Na(+)/PI cotransporter 1; Phosphate transporter PHT4;1; Sodium/phosphate cotransporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
O82390 ABC-type phosphate transporter (EC 7.3.2.1) from Arabidopsis thaliana (see 2 papers)
TC 2.A.1.14.22 / O82390 The chloroplast thylakoid Na+:phosphate symporter, ANTR1 (512aas) (Pavón et al., 2008). Residues essential for function have been identified from Arabidopsis thaliana (see 7 papers)
25% identity, 92% coverage of query (120 bits)
ANTR6_ARATH / Q3E9A0 Probable anion transporter 6, chloroplastic; Phosphate transporter PHT4;5 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
25% identity, 88% coverage of query (113 bits)
S17A5_SHEEP / Q9MZD1 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein SP55; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Ovis aries (Sheep) (see paper)
25% identity, 86% coverage of query (112 bits)
S17A9_MOUSE / Q8VCL5 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Mus musculus (Mouse) (see 5 papers)
25% identity, 90% coverage of query (111 bits)
S17A9_RAT / P0DX21 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Rattus norvegicus (Rat) (see 2 papers)
25% identity, 90% coverage of query (109 bits)
S17A5_HUMAN / Q9NRA2 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Homo sapiens (Human) (see 10 papers)
TC 2.A.1.14.10 / Q9NRA2 Lysosomal sialate transporter (Salla disease and infantile sialate storage disease protein (Morin et al., 2004)). Also transports glucuronic acid and aspartate. Structure-function studies have identify crucial residues and substrate-induced conformational changes (Courville et al., 2010). Also called SLC17A5. The substrate binding pocket has been identified based on modeling studies (see 8 papers)
25% identity, 86% coverage of query (108 bits)
S17A9_HUMAN / Q9BYT1 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Homo sapiens (Human) (see 4 papers)
TC 2.A.1.14.21 / Q9BYT1 The vesicular purine nucleotide (ADP, ATP, GTP) transporter, VNUT or SLC17A9. It is found in synaptic vesicles and chromafin granules (Sawada et al., 2008)) and is associated with disseminated superficial actinic porokeratosis (DSAP), a rare autosomal dominant genodermatosis (Cui et al. 2014). It plays a key role in purinergic signaling through its ability to transport nucleotides using the pmf. It catalyzes Cl--dependent transport activity involving essential arginines in the transmembrane region. Ketoacids inhibit these transporters through modulation of Cl- activation, but Cl- and the arginine residues are not important for ATP binding (Iwai et al. 2019). High expression of SLC17A9 correlates with a poor prognosis for colorectal cancer from Homo sapiens (Human) (see 5 papers)
24% identity, 88% coverage of query (107 bits)
S17A5_RAT / Q5Q0U0 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 (Anion/sugar transporter), member 5; Vesicular excitatory amino acid transporter; VEAT from Rattus norvegicus (Rat) (see 2 papers)
26% identity, 85% coverage of query (107 bits)
ANTR4_ARATH / Q66GI9 Probable anion transporter 4, chloroplastic; Phosphate transporter PHT4;3 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
27% identity, 88% coverage of query (107 bits)
S17A5_MOUSE / Q8BN82 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Mus musculus (Mouse) (see 3 papers)
26% identity, 85% coverage of query (107 bits)
TC 2.A.1.14.2 / P0AA78 Hexuronate (glucuronate; galacturonate) porter, ExuT (Nemoz et al. 1976). It also transports D-glucose (HJ Kim et al., Front. Microbiol., 23 January 2020) from Escherichia coli (see 3 papers)
24% identity, 97% coverage of query (104 bits)
ExuT / b3093 hexuronate transporter from Escherichia coli K-12 substr. MG1655 (see 5 papers)
exuT / P0AA78 hexuronate transporter from Escherichia coli (strain K12) (see 3 papers)
EXUT_ECOLI / P0AA78 Hexuronate transporter; Aldohexuronate transport system from Escherichia coli (strain K12) (see 5 papers)
24% identity, 97% coverage of query (104 bits)
TC 2.A.1.14.8 / Q9RPP3 Phthalate porter from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
25% identity, 91% coverage of query (94.7 bits)
PS417_07265 2-deoxy-D-ribonate transporter 1 from Pseudomonas simiae WCS417
24% identity, 86% coverage of query (92.8 bits)
Pf1N1B4_5129 D-galacturonate transporter ExuT from Pseudomonas fluorescens FW300-N1B4
25% identity, 71% coverage of query (92.8 bits)
BWI76_RS23725 2-deoxy-D-ribonate transporter 2 from Klebsiella michiganensis M5al
23% identity, 87% coverage of query (92.4 bits)
ABAQ_ACIBT / P0DPR4 Quinolone resistance transporter from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (see 2 papers)
23% identity, 94% coverage of query (87.0 bits)
CA265_RS19855 D-galacturonate transporter ExuT from Pedobacter sp. GW460-11-11-14-LB5
25% identity, 74% coverage of query (82.0 bits)
H281DRAFT_00642 2-deoxy-D-ribonate transporter from Paraburkholderia bryophila 376MFSha3.1
26% identity, 94% coverage of query (82.0 bits)
NPT3_MOUSE / Q5SZA1 Sodium-dependent phosphate transport protein 3; Na(+)/PI cotransporter 3; Sodium/phosphate cotransporter 3; Solute carrier family 17 member 2 from Mus musculus (Mouse) (see paper)
25% identity, 88% coverage of query (81.6 bits)
TC 2.A.1.15.4 / P94131 cis,cis-muconate porter, MucK from Acinetobacter calcoaceticus (see 2 papers)
mucK / AAC27117.1 cis,cis-muconate transport protein MucK from Acinetobacter baylyi (see paper)
25% identity, 89% coverage of query (80.9 bits)
S17A4_HUMAN / Q9Y2C5 Probable small intestine urate exporter; Solute carrier family 17 member 4 from Homo sapiens (Human) (see 4 papers)
TC 2.A.1.14.24 / Q9Y2C5 Intestinal mucosal sodium/phosphate symporter, SLC17A4. Maintains phosphate homeostasis; mediates intestinal absorption, bone deposition and resorption and renal excretion from Homo sapiens (see 3 papers)
23% identity, 84% coverage of query (80.1 bits)
TC 2.A.1.4.2 / P12681 P-glycerate:Pi antiporter, Pgt from Salmonella typhimurium (see 2 papers)
23% identity, 93% coverage of query (77.8 bits)
BWI76_RS23715 2-deoxy-D-ribonate transporter 1 from Klebsiella michiganensis M5al
22% identity, 90% coverage of query (76.6 bits)
BPHYT_RS04765 2-deoxy-D-ribonate transporter from Burkholderia phytofirmans PsJN
25% identity, 86% coverage of query (76.3 bits)
S17A4_MOUSE / Q5NCM1 Probable small intestine urate exporter; Solute carrier family 17 member 4 from Mus musculus (Mouse) (see paper)
22% identity, 84% coverage of query (74.7 bits)
TC 2.A.1.14.26 / F2YPN7 The plasma membrane Lethal (2)01810 glutamate uptake porter (Km=0.07μM) (Inhibited by aspartate) from Drosophila melanogaster
23% identity, 74% coverage of query (74.7 bits)
TC 2.A.1.14.15 / Q7YQJ7 Apical membrane renal proximal tubule. Voltage-driven but Na+-independent organic anion transporter, OATv1 (transports p-aminohippurate; probably transports organic anions but not cations and not inorganic phosphate. It may catalyze excretion of various drugs, xenobiotics, and their metabolites) from Sus scrofa (Pig) (see paper)
23% identity, 92% coverage of query (74.3 bits)
PS417_07260 2-deoxy-D-ribonate transporter 2 from Pseudomonas simiae WCS417
23% identity, 87% coverage of query (73.9 bits)
SPNS2_DANRE / A2SWM2 Sphingosine-1-phosphate transporter SPNS2; Protein spinster homolog 2; Protein two of hearts from Danio rerio (Zebrafish) (Brachydanio rerio) (see 2 papers)
TC 2.A.1.49.4 / A2SWM2 Protein Spinster homologue 2 (Spns2 or protein two of hearts) from Danio rerio (see 2 papers)
24% identity, 85% coverage of query (73.6 bits)
NPT1_RABIT / Q28722 Sodium-dependent phosphate transport protein 1; NAPI-1; Na(+)/PI cotransporter 1; Renal Na(+)-dependent phosphate cotransporter 1; Renal sodium-dependent phosphate transport protein 1; Renal sodium-phosphate transport protein 1; Sodium/phosphate cotransporter 1; Solute carrier family 17 member 1 from Oryctolagus cuniculus (Rabbit) (see paper)
23% identity, 84% coverage of query (70.5 bits)
TC 2.A.1.4.10 / O69759 2-phosphonoacetate/2-phosponopropionate uptake porter of 428 aas, PhnB from Pseudomonas fluorescens
27% identity, 87% coverage of query (68.6 bits)
VGLU3_HUMAN / Q8NDX2 Vesicular glutamate transporter 3; VGluT3; Solute carrier family 17 member 8 from Homo sapiens (Human) (see 2 papers)
TC 2.A.1.14.32 / Q8NDX2 Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8). Loss in mice produces circadian-dependent hyperdopaminergia and amiliorates motor disfunction and dopa-mediated dyskinesias in a model of Parkinson's Disease (Divito et al. 2015). VGLUT3 is expressed selectively in the inner hair cells (IHCs) and transports the neurotransmitter glutamate into synaptic vesicles. Mutation of the SLC17A8 gene is associated with DFNA25 (deafness, autosomal dominant 25), a non-syndromic hearing loss (ADNSHL) in humans (Ryu et al. 2016). Glut3 contributes to stress response and related psychopathologies from Homo sapiens (see 4 papers)
23% identity, 70% coverage of query (68.2 bits)
SPNS2_MOUSE / Q91VM4 Sphingosine-1-phosphate transporter SPNS2; Protein spinster homolog 2; Spinster homolog 2; Spns2 from Mus musculus (Mouse) (see 8 papers)
24% identity, 87% coverage of query (67.4 bits)
SPNS2_HUMAN / Q8IVW8 Sphingosine-1-phosphate transporter SPNS2; Protein spinster homolog 2 from Homo sapiens (Human) (see 4 papers)
TC 2.A.1.49.6 / Q8IVW8 Sphingosine-1-phosphate/dehydroshpingosine-1-P transport protein, Spinster 2. Involved in immune development and lymphocyte trafficing from Homo sapiens (see 2 papers)
24% identity, 87% coverage of query (67.4 bits)
YfaV / b2246 putative transporter YfaV from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TC 2.A.1.14.35 / P76470 Inner membrane transport protein RhmT from Escherichia coli (strain K12) (see 4 papers)
22% identity, 96% coverage of query (67.0 bits)
7yubR / Q8IVW8 S1p-bound human spns2 (see paper)
24% identity, 87% coverage of query (65.5 bits)
MHBT_KLEOX / Q5EXK5 3-hydroxybenzoate transporter MhbT from Klebsiella oxytoca (see paper)
23% identity, 75% coverage of query (64.7 bits)
7yudR Fty720p-bound human spns2
24% identity, 87% coverage of query (63.2 bits)
SPIN_DROME / Q9GQQ0 Protein spinster; Protein benchwarmer; Protein diphthong from Drosophila melanogaster (Fruit fly) (see 3 papers)
TC 2.A.1.49.1 / Q9GQQ0 The spinster protein, spin1 or spns1 gene product (involved in synaptic growth regulation; interacts with Bcl-2/Bcl-xL, affecting programmed cell death) (see 6 papers)
spin / GI|12003970 protein spinster from Drosophila melanogaster (see paper)
21% identity, 81% coverage of query (62.4 bits)
8jhqA / Q8IVW8,Q9V2J8 Cryo-em structure of human s1p transporter spns2 bound with s1p (see paper)
23% identity, 87% coverage of query (61.2 bits)
8g92A Structure of inhibitor 16d-bound spns2
24% identity, 87% coverage of query (59.3 bits)
MOT12_HUMAN / Q6ZSM3 Monocarboxylate transporter 12; MCT 12; Creatine transporter 2; CRT2; Solute carrier family 16 member 12 from Homo sapiens (Human) (see 7 papers)
25% identity, 70% coverage of query (52.0 bits)
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Lawrence Berkeley National Laboratory