Searching for up to 100 curated homologs for AZOBR_RS00495 FitnessBrowser__azobra:AZOBR_RS00495 (242 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YdgB / b1606 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
folM / P0AFS3 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli (strain K12) (see 6 papers)
FOLM_ECOLI / P0AFS3 Dihydromonapterin reductase; H(2)-MPt reductase; Dihydrofolate reductase; DHFR; EC 1.5.1.50; EC 1.5.1.3 from Escherichia coli (strain K12) (see 2 papers)
P0AFS3 dihydromonapterin reductase (EC 1.5.1.50) from Escherichia coli (see 3 papers)
folM / RF|NP_416123 dihydrofolate reductase folM; EC 1.5.1.3 from Escherichia coli K12 (see 4 papers)
38% identity, 96% coverage of query (146 bits)
5bt9C / A9MA73 Crystal structure of folm alternative dihydrofolate reductase 1 from brucella canis complexed with NADP (see paper)
32% identity, 96% coverage of query (94.7 bits)
Build an alignment for AZOBR_RS00495 and 2 homologs with ≥ 30% identity
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pruA / Q7CZX3 dihydropterin reductase monomer (EC 1.5.1.33; EC 1.5.1.50) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see 2 papers)
29% identity, 96% coverage of query (84.0 bits)
6rx5A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 1 (nmt- c0003)
30% identity, 96% coverage of query (80.5 bits)
6gd0A Trypanosoma brucei ptr1 in complex with inhibitor 4g (f133)
30% identity, 96% coverage of query (80.5 bits)
3bmoA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax4)
30% identity, 96% coverage of query (79.7 bits)
2c7vC / O76290 Structure of trypanosoma brucei pteridine reductase (ptr1) in ternary complex with cofactor and the antifolate methotrexate (see paper)
30% identity, 96% coverage of query (77.0 bits)
6rx6A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 4 (nmt- c0026)
31% identity, 96% coverage of query (77.0 bits)
6rx0A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 3 (nmt- c0013)
31% identity, 96% coverage of query (77.0 bits)
6howA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 2a (f219).
31% identity, 96% coverage of query (77.0 bits)
6gexA Trypanosoma brucei ptr1 in complex with inhibitor 2h (f246)
31% identity, 96% coverage of query (77.0 bits)
6gdoA Trypanosoma brucei ptr1 in complex with inhibitor 2g (f240)
31% identity, 96% coverage of query (77.0 bits)
5k6aA Trypanosoma brucei pteridine reductase 1 (ptr1) in complex with compound 1
31% identity, 96% coverage of query (77.0 bits)
2x9nA High resolution structure of tbptr1 in complex with cyromazine
31% identity, 96% coverage of query (77.0 bits)
3gn1C Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (ddd00067116)
30% identity, 96% coverage of query (77.0 bits)
8of2A Trypanosoma brucei pteridine reductase 1 (tbptr1) in complex with 2,4, 6 triamminopyrimidine (tap)
31% identity, 96% coverage of query (76.6 bits)
6tbxA Trypanosoma brucei ptr1 (tbptr1) in complex with a tricyclic-based inhibitor
31% identity, 96% coverage of query (76.6 bits)
6hnrA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 1 (f217)
31% identity, 96% coverage of query (76.6 bits)
6hncA Trypanosoma brucei ptr1 in complex with cycloguanil
31% identity, 96% coverage of query (76.6 bits)
5jdiA Trypanosoma brucei ptr1 in complex with cofactor and inhibitor nmt- h024 (compound 2)
31% identity, 96% coverage of query (76.6 bits)
4cmiA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (76.6 bits)
4cmgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (76.6 bits)
4cmaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (76.6 bits)
4cm6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (76.6 bits)
4cm5A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (76.6 bits)
5jdcA Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
31% identity, 96% coverage of query (76.3 bits)
5jcxA Trypanosoma brucei ptr1 in complex with inhibitor np-29
31% identity, 96% coverage of query (76.3 bits)
5jcjA Trypanosoma brucei ptr1 in complex with inhibitor nmt-h037 (compound 7)
31% identity, 96% coverage of query (76.3 bits)
5izcA Trypanosoma brucei ptr1 in complex with inhibitor f032
31% identity, 96% coverage of query (76.3 bits)
4wcfA Trypanosoma brucei ptr1 in complex with inhibitor 9
31% identity, 96% coverage of query (76.3 bits)
4cmeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
31% identity, 96% coverage of query (76.3 bits)
4cm9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
31% identity, 96% coverage of query (76.3 bits)
3jqgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6-[(4- methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine (ax6)
31% identity, 96% coverage of query (76.3 bits)
3jqfA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 1,3,5- triazine-2,4,6-triamine (ax2)
31% identity, 96% coverage of query (76.3 bits)
3jqeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (dx8)
31% identity, 96% coverage of query (76.3 bits)
3jqdA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-4-oxo-6-phenyl-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (dx7)
31% identity, 96% coverage of query (76.3 bits)
3jqcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-bromo-4-oxo-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (ju2)
31% identity, 96% coverage of query (76.3 bits)
3jqbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-5-(2-phenylethyl)-3,7-dihydro-4h-pyrrolo[2,3-d]pyrimidin-4-one (dx6)
31% identity, 96% coverage of query (76.3 bits)
3jqaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-1,9-dihydro-6h-purine-6-thione (dx4)
31% identity, 96% coverage of query (76.3 bits)
3jq9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (ax1)
31% identity, 96% coverage of query (76.3 bits)
3jq7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6- phenylpteridine-2,4,7-triamine (dx2)
31% identity, 96% coverage of query (76.3 bits)
3jq6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7- bis(1-methylethyl)pteridine-2,4-diamine (dx1)
31% identity, 96% coverage of query (76.3 bits)
3gn2A Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (ddd00066730)
31% identity, 96% coverage of query (76.3 bits)
2yhiA Trypanosoma brucei ptr1 in complex with inhibitor wh16
31% identity, 96% coverage of query (76.3 bits)
2wd8A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00071204
31% identity, 96% coverage of query (76.3 bits)
2wd7A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00066750
31% identity, 96% coverage of query (76.3 bits)
2vz0A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00066641
31% identity, 96% coverage of query (76.3 bits)
3bmqA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax5)
30% identity, 96% coverage of query (75.9 bits)
4cmjA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (75.1 bits)
4cmcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (75.1 bits)
4cmbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (75.1 bits)
4cm4A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (75.1 bits)
4cm3A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (75.1 bits)
4clxA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (75.1 bits)
4cloA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (75.1 bits)
4cldA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (75.1 bits)
4cl8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (75.1 bits)
3mcvA Structure of ptr1 from trypanosoma brucei in ternary complex with 2,4- diamino-5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]-pyrimidine and NADP+
30% identity, 96% coverage of query (75.1 bits)
2yhuA Trypanosoma brucei ptr1 in complex with inhibitor whf30
30% identity, 96% coverage of query (75.1 bits)
2x9gA High resolution structure of tbptr1 in complex with pemetrexed
30% identity, 96% coverage of query (75.1 bits)
4cm7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (74.7 bits)
4clhA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (74.7 bits)
4cleA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (74.7 bits)
7opjA Trypanosoma brucei ptr1 (tbptr1) in complex with pyrimethamine
30% identity, 96% coverage of query (74.7 bits)
6gd4A Trypanosoma brucei ptr1 in complex with inhibitor 4c (f188)
30% identity, 96% coverage of query (74.7 bits)
6gclA Trypanosoma brucei ptr1 in complex with inhibitor 3a (f020)
30% identity, 96% coverage of query (74.7 bits)
4wcdA Trypanosoma brucei ptr1 in complex with inhibitor 10
30% identity, 96% coverage of query (74.7 bits)
4cmkA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (74.7 bits)
4cm8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (74.7 bits)
4clrA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (74.7 bits)
2x9vA High resolution structure of tbptr1 with trimetrexate
30% identity, 96% coverage of query (74.7 bits)
6geyA Trypanosoma brucei ptr1 in complex with inhibitor 4g (f125)
30% identity, 96% coverage of query (74.3 bits)
6gdpA Trypanosoma brucei ptr1 in complex with inhibitor 4l (f162)
30% identity, 96% coverage of query (74.3 bits)
6gcqA Trypanosoma brucei ptr1 in complex with inhibitor 2b (f192)
30% identity, 96% coverage of query (74.3 bits)
6gcpA Trypanosoma brucei ptr1 in complex with inhibitor 2d (f186)
30% identity, 96% coverage of query (74.3 bits)
6gckA Trypanosoma brucei ptr1 in complex with inhibitor 1e (f206)
30% identity, 96% coverage of query (74.3 bits)
4cm1A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
30% identity, 96% coverage of query (74.3 bits)
3jq8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7,7- trimethyl-7,8-dihydropteridine-2,4-diamine (dx3)
31% identity, 96% coverage of query (73.2 bits)
5jdcC Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
30% identity, 96% coverage of query (72.8 bits)
swb2 / D2KTX1 3-hydroxykynurenate reductase/dehydratase from Streptomyces sp. SNA15896 (see paper)
31% identity, 74% coverage of query (71.6 bits)
5izcC / O76290 Trypanosoma brucei ptr1 in complex with inhibitor f032 (see paper)
30% identity, 96% coverage of query (71.2 bits)
3jq7C Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6- phenylpteridine-2,4,7-triamine (dx2)
29% identity, 96% coverage of query (71.2 bits)
5k6aC Trypanosoma brucei pteridine reductase 1 (ptr1) in complex with compound 1
30% identity, 96% coverage of query (70.1 bits)
6tbxC Trypanosoma brucei ptr1 (tbptr1) in complex with a tricyclic-based inhibitor
29% identity, 96% coverage of query (69.7 bits)
1mxfA Crystal structure of inhibitor complex of putative pteridine reductase 2 (ptr2) from trypanosoma cruzi
30% identity, 97% coverage of query (68.2 bits)
1mxhA / Q8I814 Crystal structure of substrate complex of putative pteridine reductase 2 (ptr2) from trypanosoma cruzi (see paper)
29% identity, 97% coverage of query (67.0 bits)
3rkrA / B2BKB1 Crystal structure of a metagenomic short-chain oxidoreductase (sdr) in complex with NADP (see paper)
32% identity, 76% coverage of query (67.0 bits)
Elen_0198 / C8WJW0 NAD-dependent bile acid 3β-dehydrogenase (EC 1.1.1.391) from Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B) (see 4 papers)
3BHD1_EGGLE / C8WJW0 3beta-hydroxysteroid dehydrogenase 1; 3beta-HSDH 1; 3beta-hydroxycholanate 3-dehydrogenase (NAD(+)) 1; NAD-dependent bile acid 3beta-dehydrogenase; EC 1.1.1.-; EC 1.1.1.391 from Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B) (Eubacterium lentum) (see paper)
C8WJW0 3beta-hydroxycholanate 3-dehydrogenase (NAD+) (EC 1.1.1.391) from Eggerthella lenta (see paper)
28% identity, 100% coverage of query (66.6 bits)
6rxcD Leishmania major pteridine reductase 1 (lmptr1) in complex with inhibitor 4 (nmt-c0026)
29% identity, 95% coverage of query (66.6 bits)
A4HCP1 pteridine reductase (EC 1.5.1.33) from Leishmania braziliensis (see paper)
29% identity, 100% coverage of query (64.7 bits)
gdh / P12310 glcDH (EC 1.1.1.47) from Bacillus subtilis (strain 168) (see 6 papers)
27% identity, 98% coverage of query (63.5 bits)
A6N8S2 glucose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.47) from Bacillus subtilis (see paper)
27% identity, 98% coverage of query (63.2 bits)
DHG_PRIMG / P40288 Glucose 1-dehydrogenase; EC 1.1.1.47 from Priestia megaterium (Bacillus megaterium) (see paper)
P40288 glucose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.47) from Priestia megaterium (see 9 papers)
26% identity, 98% coverage of query (62.8 bits)
A0A068FPP9 glucose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.47) from Bacillus sp. (in: Bacteria) (see paper)
24% identity, 100% coverage of query (62.0 bits)
YbbO / b0493 NADP+-dependent aldehyde reductase YbbO (EC 1.1.1.2) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ybbO / P0AFP4 NADP+-dependent aldehyde reductase YbbO (EC 1.1.1.2) from Escherichia coli (strain K12) (see 3 papers)
29% identity, 77% coverage of query (62.0 bits)
1g6kA / P40288 Crystal structure of glucose dehydrogenase mutant e96a complexed with NAD+
26% identity, 98% coverage of query (62.0 bits)
mtmTIII / Q194Q5 dTDP-D-mycarose 4-ketoreductase from Streptomyces argillaceus (see paper)
30% identity, 95% coverage of query (62.0 bits)
2qhxC Structure of pteridine reductase from leishmania major complexed with a ligand
29% identity, 95% coverage of query (62.0 bits)
stfT / CAJ42322.1 ketoreductase from Streptomyces steffisburgensis (see paper)
32% identity, 76% coverage of query (60.5 bits)
7pxxA The crystal structure of leishmania major pteridine reductase 1 in complex with substrate folic acid
28% identity, 95% coverage of query (60.5 bits)
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Lawrence Berkeley National Laboratory