Searching for up to 100 curated homologs for AZOBR_RS05770 AZOBR_RS05770 2-hydroxyacid dehydrogenase (462 a.a.)
Found high-coverage hits (≥70%) to 78 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
3pm9A / Q6NAV4 Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
54% identity, 99% coverage of query (485 bits)
DLD2_YEAST / P46681 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2; D-2HG--pyruvate transhydrogenase DLD2; Actin-interacting protein 2; D-lactate dehydrogenase [cytochrome] 2, mitochondrial; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
37% identity, 100% coverage of query (333 bits)
D2HDH_ARATH / O23240 D-2-hydroxyglutarate dehydrogenase, mitochondrial; AtD-2HGDH; EC 1.1.99.39 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
38% identity, 100% coverage of query (323 bits)
6lpnB / Q8N465 Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
39% identity, 99% coverage of query (321 bits)
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og)
39% identity, 99% coverage of query (321 bits)
6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg)
39% identity, 99% coverage of query (321 bits)
6lpqA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal)
39% identity, 99% coverage of query (321 bits)
6lppA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-2-hydroxyglutarate (d-2-hg)
39% identity, 99% coverage of query (321 bits)
D2HGDH / Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39) from Homo sapiens (see paper)
D2HDH_HUMAN / Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Homo sapiens (Human) (see 7 papers)
Q8N465 D-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) from Homo sapiens (see 3 papers)
39% identity, 99% coverage of query (319 bits)
D2HDH_RAT / P84850 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Rattus norvegicus (Rat) (see paper)
37% identity, 99% coverage of query (313 bits)
DLD3_YEAST / P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
P39976 (R)-2-hydroxyglutarate-pyruvate transhydrogenase (EC 1.1.99.40) from Saccharomyces cerevisiae (see paper)
36% identity, 100% coverage of query (308 bits)
D2HDH_XANCL / P0DV35 D-2-hydroxyglutarate dehydrogenase; D2HGDH; EC 1.1.99.39 from Xanthomonas citri pv. viticola (strain LMG 965 / NCPPB 2475 / ICMP 3867 / CFBP 7660) (Xanthomonas campestris pv. viticola) (see paper)
39% identity, 98% coverage of query (305 bits)
YN53_SCHPO / Q9C1X2 Putative D-lactate dehydrogenase C713.03, mitochondrial; EC 1.1.2.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
34% identity, 100% coverage of query (275 bits)
D2HDH_STUS1 / A4VGK4 D-2-hydroxyglutarate dehydrogenase; D-2-HG dehydrogenase; D2HGDH; D-malate dehydrogenase; EC 1.1.99.39; EC 1.1.99.- from Stutzerimonas stutzeri (strain A1501) (Pseudomonas stutzeri) (see 2 papers)
35% identity, 100% coverage of query (273 bits)
Q9I6H4 D-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) from Pseudomonas aeruginosa (see paper)
34% identity, 100% coverage of query (262 bits)
Rv0161 / O07406 trans-delta20-39-hydroxy-40-methyl-C60:1-[acp] oxidoreductase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
36% identity, 98% coverage of query (248 bits)
SMc04384 (R)-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) from Sinorhizobium meliloti 1021
37% identity, 99% coverage of query (244 bits)
7qh2C / H6LBS1 Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
34% identity, 94% coverage of query (199 bits)
lctD / H6LBS1 lactate dehydrogenase (EC 1.1.1.436) from Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1) (see 2 papers)
LCTD_ACEWD / H6LBS1 Lactate dehydrogenase (NAD(+),ferredoxin) subunit LctD; EC 1.1.1.436 from Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1) (see paper)
H6LBS1 lactate dehydrogenase (NAD+, ferredoxin) (subunit 1/3) (EC 1.3.1.110) from Acetobacterium woodii (see paper)
34% identity, 94% coverage of query (199 bits)
DLD_ARCFU / O29853 D-lactate dehydrogenase; EC 1.1.99.6 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see 2 papers)
O29853 D-lactate dehydrogenase (acceptor) (EC 1.1.99.6) from Archaeoglobus fulgidus (see 2 papers)
35% identity, 92% coverage of query (195 bits)
DLD_ANAHA / D4MUV9 D-lactate dehydrogenase; EC 1.1.99.6 from Anaerostipes hadrus (see paper)
32% identity, 94% coverage of query (193 bits)
W1QLN6 D-lactate dehydrogenase (cytochrome) (EC 1.1.2.4) from Ogataea angusta (see 2 papers)
31% identity, 93% coverage of query (188 bits)
LDHD_DANRE / F1QXM5 Probable D-lactate dehydrogenase, mitochondrial; DLD; Lactate dehydrogenase D; EC 1.1.2.4 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
31% identity, 92% coverage of query (187 bits)
Q9YEU4 D-lactate dehydrogenase (EC 1.1.1.28); D-lactate dehydrogenase (acceptor) (EC 1.1.99.6) from Aeropyrum pernix (see 2 papers)
30% identity, 100% coverage of query (186 bits)
LDHD / Q86WU2 mitochondrial D-lactate dehydrogenase (EC 1.1.2.4) from Homo sapiens (see 3 papers)
LDHD_HUMAN / Q86WU2 Probable D-lactate dehydrogenase, mitochondrial; DLD; Lactate dehydrogenase D; EC 1.1.2.4 from Homo sapiens (Human) (see 3 papers)
Q86WU2 D-lactate dehydrogenase (cytochrome) (EC 1.1.2.4) from Homo sapiens (see paper)
31% identity, 93% coverage of query (186 bits)
LDHD_MOUSE / Q7TNG8 Probable D-lactate dehydrogenase, mitochondrial; DLD; Lactate dehydrogenase D; EC 1.1.2.4 from Mus musculus (Mouse) (see paper)
31% identity, 93% coverage of query (184 bits)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid
32% identity, 93% coverage of query (184 bits)
A0A0G2K1W9 D-lactate dehydrogenase (EC 1.1.1.28) from Rattus norvegicus (see paper)
32% identity, 93% coverage of query (182 bits)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid
31% identity, 93% coverage of query (182 bits)
8jdeA Crystal structure of mldhd in complex with d-lactate
32% identity, 93% coverage of query (182 bits)
8jdsA Crystal structure of mldhd in complex with pyruvate
32% identity, 93% coverage of query (182 bits)
8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid
32% identity, 93% coverage of query (181 bits)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid
31% identity, 93% coverage of query (181 bits)
8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid
31% identity, 93% coverage of query (180 bits)
8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid
31% identity, 93% coverage of query (180 bits)
G4MWZ3 D-lactate dehydrogenase (EC 1.1.1.28) from Pyricularia oryzae (see paper)
32% identity, 99% coverage of query (179 bits)
8jdbA / Q7TNG8 Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
31% identity, 93% coverage of query (177 bits)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid
31% identity, 93% coverage of query (177 bits)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid
31% identity, 93% coverage of query (177 bits)
8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid
31% identity, 93% coverage of query (177 bits)
8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid
31% identity, 93% coverage of query (177 bits)
8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid
31% identity, 93% coverage of query (177 bits)
8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid
30% identity, 93% coverage of query (176 bits)
SMc00832 D-lactate dehydrogenase, FAD-linked subunit GlcD (EC 1.1.99.6) from Sinorhizobium meliloti 1021
32% identity, 98% coverage of query (174 bits)
Build an alignment for AZOBR_RS05770 and 44 homologs with ≥ 30% identity
Or download the sequences
DLD1 / P32891 D-lactate dehydrogenase (EC 1.1.2.4) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 11 papers)
DLD1_YEAST / P32891 D-lactate dehydrogenase [cytochrome] 1, mitochondrial; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
28% identity, 92% coverage of query (171 bits)
E6N788 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15); D-lactate dehydrogenase (acceptor) (EC 1.1.99.6) from Candidatus Caldarchaeum subterraneum (see paper)
29% identity, 100% coverage of query (171 bits)
Psest_3841 D-lactate/glycolate dehydrogenase, FAD-linked subunit GlcD (EC 1.1.99.6; EC 1.1.99.14) from Pseudomonas stutzeri RCH2
29% identity, 98% coverage of query (169 bits)
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
32% identity, 98% coverage of query (162 bits)
DLD / Q94AX4 D-lactate dehydrogenase (cytochrome c) monomer (EC 1.1.2.4) from Arabidopsis thaliana (see 2 papers)
DLD_ARATH / Q94AX4 D-lactate dehydrogenase [cytochrome], mitochondrial; AtD-LDH; D-lactate ferricytochrome C oxidoreductase; Glycolate dehydrogenase; EC 1.1.2.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
30% identity, 93% coverage of query (161 bits)
Q974L0 D-lactate dehydrogenase (acceptor) (EC 1.1.99.6) from Sulfurisphaera tokodaii (see paper)
30% identity, 94% coverage of query (156 bits)
YghM / b2979 glycolate dehydrogenase, putative FAD-linked subunit (EC 1.1.99.14) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
glcD / P0AEP9 glycolate dehydrogenase, putative FAD-linked subunit (EC 1.1.99.14) from Escherichia coli (strain K12) (see 7 papers)
GLCD_ECOLI / P0AEP9 Glycolate oxidase subunit GlcD; Glycolate dehydrogenase subunit GlcD; EC 1.1.99.14 from Escherichia coli (strain K12) (see 4 papers)
glcD / RF|NP_417453 glycolate oxidase subunit glcD from Escherichia coli K12 (see paper)
glcD / AAB02530.1 glycolate oxidase subunit from Escherichia coli (see paper)
29% identity, 98% coverage of query (155 bits)
RR42_RS17300 D-lactate dehydrogenase, FAD-linked subunit GlcD (EC 1.1.99.6) from Cupriavidus basilensis FW507-4G11
29% identity, 98% coverage of query (155 bits)
DVU_3027 / Q726S9 quinone-dependent D-lactate dehydrogenase catalytic subunit (EC 1.1.2.5) from Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) (see 3 papers)
30% identity, 100% coverage of query (152 bits)
glcD1 / Q55124 glycolate dehydrogenase 1 (EC 1.1.99.14) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 4 papers)
Q55124 glycolate dehydrogenase (EC 1.1.99.14) from Synechocystis sp. PCC 6803 (see paper)
27% identity, 100% coverage of query (152 bits)
PGA1_c29720 D-lactate dehydrogenase, FAD-linked subunit GlcD (EC 1.1.99.6) from Phaeobacter inhibens BS107
27% identity, 100% coverage of query (145 bits)
G4RPF4 D-lactate dehydrogenase (acceptor) (EC 1.1.99.6) from Thermoproteus tenax (see paper)
30% identity, 92% coverage of query (134 bits)
5ae2B Ether lipid-generating enzyme agps in complex with inhibitor 1e
25% identity, 94% coverage of query (119 bits)
4bc9A Mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct with cyanoethyl
25% identity, 94% coverage of query (119 bits)
5ae3A Ether lipid-generating enzyme agps in complex with antimycin a
26% identity, 94% coverage of query (118 bits)
5ae1B Ether lipid-generating enzyme agps in complex with inhibitor zinc69435460
25% identity, 94% coverage of query (117 bits)
5ae2A Ether lipid-generating enzyme agps in complex with inhibitor 1e
25% identity, 94% coverage of query (117 bits)
4bc9B Mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct with cyanoethyl
25% identity, 94% coverage of query (117 bits)
6gouA Development of alkyl glycerone phosphate synthase inhibitors: complex with inhibitor 2i
25% identity, 94% coverage of query (117 bits)
4bc7B Mammalian alkyldihydroxyacetonephosphate synthase: arg419his mutant
25% identity, 94% coverage of query (117 bits)
AGPS / O00116 alkylglycerone-phosphate synthase (EC 2.5.1.26) from Homo sapiens (see 24 papers)
ADAS_HUMAN / O00116 Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkyl-DHAP synthase; Aging-associated gene 5 protein; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Homo sapiens (Human) (see 4 papers)
O00116 alkylglycerone-phosphate synthase (EC 2.5.1.26) from Homo sapiens (see 7 papers)
25% identity, 94% coverage of query (116 bits)
5adzC / P97275 Ether lipid-generating enzyme agps in complex with inhibitor 1a (see paper)
25% identity, 94% coverage of query (116 bits)
5ae1A Ether lipid-generating enzyme agps in complex with inhibitor zinc69435460
25% identity, 94% coverage of query (115 bits)
ADAS_CAVPO / P97275 Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkyl-DHAP synthase; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Cavia porcellus (Guinea pig) (see 4 papers)
P97275 alkylglycerone-phosphate synthase (EC 2.5.1.26) from Cavia porcellus (see paper)
25% identity, 94% coverage of query (114 bits)
5adzA / P97275 Ether lipid-generating enzyme agps in complex with inhibitor 1a (see paper)
25% identity, 94% coverage of query (114 bits)
ADAS_DICDI / O96759 Alkyldihydroxyacetonephosphate synthase; Alkyl-DHAP synthase; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Dictyostelium discoideum (Social amoeba) (see paper)
O96759 alkylglycerone-phosphate synthase (EC 2.5.1.26) from Dictyostelium discoideum (see paper)
24% identity, 95% coverage of query (113 bits)
ADAS_MOUSE / Q8C0I1 Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkyl-DHAP synthase; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Mus musculus (Mouse) (see paper)
Q8C0I1 alkylglycerone-phosphate synthase (EC 2.5.1.26) from Mus musculus (see paper)
25% identity, 94% coverage of query (112 bits)
ADAS_RAT / Q9EQR2 Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkyl-DHAP synthase; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Rattus norvegicus (Rat) (see 2 papers)
24% identity, 94% coverage of query (109 bits)
Q88DT2 D-2-hydroxyacid dehydrogenase (quinone) (EC 1.1.5.10); D-lactate dehydrogenase (quinone) (EC 1.1.5.12) from Pseudomonas putida (see paper)
25% identity, 92% coverage of query (108 bits)
CAA05690.1 alkyl-dihydroxyacetonephosphate synthase from Caenorhabditis elegans (see paper)
24% identity, 92% coverage of query (95.1 bits)
GYD1 / A8J2E9 glycolate dehydrogenase (EC 1.1.99.14) from Chlamydomonas reinhardtii (see 4 papers)
26% identity, 94% coverage of query (94.7 bits)
D2HDH_PANAA / A0A0H3KZS3 D-2-hydroxyglutarate dehydrogenase; D2HGDH; EC 1.1.99.39 from Pantoea ananatis (strain AJ13355) (see paper)
24% identity, 92% coverage of query (92.4 bits)
YdiJ / b1687 putative FAD-linked oxidoreductase YdiJ from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ydiJ / P77748 D-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) from Escherichia coli (strain K12) (see 5 papers)
D2HDH_ECOLI / P77748 D-2-hydroxyglutarate dehydrogenase; D2HGDH; EC 1.1.99.39 from Escherichia coli (strain K12) (see 2 papers)
25% identity, 93% coverage of query (89.7 bits)
PP_4493 D-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) from Pseudomonas putida KT2440
ydiJ / Q88EH0 (R)-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
D2HDH_PSEPK / Q88EH0 D-2-hydroxyglutarate dehydrogenase; D2HGDH; EC 1.1.99.39 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
25% identity, 92% coverage of query (81.3 bits)
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Lawrence Berkeley National Laboratory