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Searching for up to 100 curated homologs for AZOBR_RS16025 FitnessBrowser__azobra:AZOBR_RS16025 (413 a.a.)

Found high-coverage hits (≥70%) to 24 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

THRC_METAC / Q8TQD4 Threonine synthase; TS; EC 4.2.3.1 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
GB|AAM05023.1 threonine synthase; EC 4.2.3.1 from Methanosarcina acetivorans C2A (see paper)
    35% identity, 92% coverage of query (212 bits)

6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
    36% identity, 79% coverage of query (148 bits)

THRC_MYCTU / P9WG59 Threonine synthase; TS; EC 4.2.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WG59 threonine synthase (EC 4.2.3.1) from Mycobacterium tuberculosis (see 2 papers)
    36% identity, 79% coverage of query (146 bits)

6nmxA / A8HUA2 Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
    36% identity, 79% coverage of query (146 bits)

2d1fA / P9WG59 Structure of mycobacterium tuberculosis threonine synthase (see paper)
    36% identity, 79% coverage of query (146 bits)

6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
    36% identity, 79% coverage of query (146 bits)

A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    34% identity, 79% coverage of query (137 bits)

P83823 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see paper)
Q5SL02 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see 2 papers)
3aexA / Q5SL02 Catalytic intermediate analogue of threonine synthase from thermus thermophilus hb8 (see paper)
    36% identity, 80% coverage of query (136 bits)

1v7cA Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue
    36% identity, 80% coverage of query (136 bits)

3aeyA Apo form of threonine synthase from thermus thermophilus hb8
    36% identity, 80% coverage of query (136 bits)

1uimA Crystal structure of threonine synthase from thermus thermophilus hb8, orthorhombic crystal form
    36% identity, 80% coverage of query (136 bits)

thrC / CAA82669.1 threonine synthase from Bacillus sp. (see paper)
    34% identity, 79% coverage of query (134 bits)

Build an alignment

Build an alignment for AZOBR_RS16025 and 12 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

THRC1_ARATH / Q9S7B5 Threonine synthase 1, chloroplastic; Protein METHIONINE OVER-ACCUMULATOR 2; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    27% identity, 90% coverage of query (132 bits)

2c2bA Crystallographic structure of arabidopsis thaliana threonine synthase complexed with pyridoxal phosphate and s-adenosylmethionine
    27% identity, 93% coverage of query (132 bits)

2zsjA / O66740 Crystal structure of threonine synthase from aquifex aeolicus vf5
    34% identity, 79% coverage of query (127 bits)

O66740 threonine synthase (EC 4.2.3.1) from Aquifex aeolicus (see paper)
    34% identity, 79% coverage of query (127 bits)

THRC2_ARATH / Q9SSP5 Threonine synthase 2, chloroplastic; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    27% identity, 94% coverage of query (125 bits)

2c2gA / Q9S7B5 Crystal structure of threonine synthase from arabidopsis thaliana in complex with its cofactor pyridoxal phosphate (see paper)
    26% identity, 93% coverage of query (124 bits)

DvMF_1945 threonine synthase (EC 4.2.3.1) from Desulfovibrio vulgaris Miyazaki F
    30% identity, 79% coverage of query (101 bits)

MA_3297 / Q8TKU7 cysteate synthase monomer (EC 2.5.1.76) from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
CYAS_METAC / Q8TKU7 Cysteate synthase; CS; Cya synthase; EC 2.5.1.76 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
Q8TKU7 cysteate synthase (EC 2.5.1.76) from Methanosarcina acetivorans (see paper)
    27% identity, 71% coverage of query (65.5 bits)

A0A0U5AKI6 serine racemase (EC 5.1.1.18) from Crassostrea gigas (see paper)
    28% identity, 71% coverage of query (63.9 bits)

5vm5D Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9, with ser bound
    25% identity, 70% coverage of query (55.5 bits)

6am8B Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9 with trp bound as e(aex2)
    24% identity, 70% coverage of query (55.5 bits)

7rnpA Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9_h275e with 4-cl-trp non-covalently bound
    24% identity, 70% coverage of query (55.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory