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Searching for up to 100 curated homologs for AZOBR_RS17545 FitnessBrowser__azobra:AZOBR_RS17545 (390 a.a.)

Found high-coverage hits (≥70%) to 69 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4kemA / D3P639 Crystal structure of a tartrate dehydratase from azospirillum, target efi-502395, with bound mg and a putative acrylate ion, ordered active site
    88% identity, 100% coverage of query (692 bits)

tarD / Q89FH0 D-tartrate dehydratase (EC 4.2.1.81) from Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) (see paper)
TARD_BRADU / Q89FH0 D(-)-tartrate dehydratase; EC 4.2.1.81 from Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) (see paper)
    69% identity, 99% coverage of query (553 bits)

2dw6A / Q89FH0 Crystal structure of the mutant k184a of d-tartrate dehydratase from bradyrhizobium japonicum complexed with mg++ and d-tartrate (see paper)
    69% identity, 99% coverage of query (551 bits)

TAGAD_SALTY / Q8ZL58 L-talarate/galactarate dehydratase; TalrD/GalrD; StTGD; EC 4.2.1.156; EC 4.2.1.42 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
Q8ZL58 L-talarate dehydratase (EC 4.2.1.156); galactarate dehydratase (EC 4.2.1.42) from Salmonella enterica subsp. enterica serovar Typhimurium (see 2 papers)
    30% identity, 89% coverage of query (135 bits)

2pp1A / Q8ZL58 Crystal structure of l-talarate/galactarate dehydratase from salmonella typhimurium lt2 liganded with mg and l-lyxarohydroxamate (see paper)
    30% identity, 89% coverage of query (135 bits)

2pp3A Crystal structure of l-talarate/galactarate dehydratase mutant k197a liganded with mg and l-glucarate
    30% identity, 89% coverage of query (133 bits)

Build an alignment

Build an alignment for AZOBR_RS17545 and 6 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

2og9A Crystal structure of mandelate racemase/muconate lactonizing enzyme from polaromonas sp. Js666
    28% identity, 95% coverage of query (121 bits)

araD / Q97U96 D-arabinonate dehydratase subunit (EC 4.2.1.5) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
ARAD_SACS2 / Q97U96 Arabinonate dehydratase; EC 4.2.1.5 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
Q97U96 Arabinonate dehydratase (EC 4.2.1.5) from Saccharolobus solfataricus (see paper)
    30% identity, 72% coverage of query (119 bits)

3cb3A / Q12GE3 Crystal structure of l-talarate dehydratase from polaromonas sp. Js666 complexed with mg and l-glucarate
    28% identity, 98% coverage of query (117 bits)

4h19A / Q7CU39 Crystal structure of an enolase (mandelate racemase subgroup, target efi-502087) from agrobacterium tumefaciens, with bound mg and d- ribonohydroxamate, ordered loop
    27% identity, 88% coverage of query (100 bits)

ACI_STRCO / Q9RKF7 3,6-anhydro-alpha-L-galactonate cycloisomerase; AHGA cycloisomerase; EC 5.5.1.25 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    31% identity, 73% coverage of query (96.7 bits)

3ck5A / Q9RKF7 Crystal structure of a racemase from streptomyces coelicolor a3(2) with bound magnesium
    30% identity, 73% coverage of query (96.3 bits)

2qq6B / Q1AYK7 Crystal structure of mandelate racemase/muconate lactonizing enzyme- like protein from rubrobacter xylanophilus dsm 9941
    26% identity, 70% coverage of query (90.5 bits)

2ox4C / Q5NN22 Crystal structure of putative dehydratase from zymomonas mobilis zm4
    25% identity, 76% coverage of query (82.4 bits)

3bjsB / Q120Q7 Crystal structure of a member of enolase superfamily from polaromonas sp. Js666
    29% identity, 70% coverage of query (82.0 bits)

SSO26655 / Q97VG1 D-xylonate dehydratase subunit (EC 4.2.1.25; EC 4.2.1.82) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
    26% identity, 72% coverage of query (80.5 bits)

5olcC / G0L7B8 Crystal structure of the 3,6-anhydro-d-galactonate cycloisomerase from zobellia galactanivorans (see paper)
    27% identity, 71% coverage of query (79.3 bits)

SM_b21107 dehydratase involved in L-fucose catabolism from Sinorhizobium meliloti 1021
    25% identity, 96% coverage of query (79.0 bits)

3ozmA / A0A0H3LT39 Crystal structure of enolase superfamily member from bordetella bronchiseptica complexed with mg, m-xylarate and l-lyxarate
    26% identity, 76% coverage of query (78.6 bits)

3ozmD Crystal structure of enolase superfamily member from bordetella bronchiseptica complexed with mg, m-xylarate and l-lyxarate
    26% identity, 76% coverage of query (78.6 bits)

gci / A9CEQ8 D-galactarolactone cycloisomerase monomer (EC 5.5.1.27) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
GCI_AGRFC / A9CEQ8 D-galactarolactone cycloisomerase; EC 5.5.1.27 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see 2 papers)
A9CEQ8 D-galactarolactone cycloisomerase (EC 5.5.1.27) from Agrobacterium tumefaciens (see paper)
4hpnA / A9CEQ8 Crystal structure of a proposed galactarolactone cycloisomerase from agrobacterium tumefaciens, target efi-500704, with bound ca, ordered loops (see paper)
    28% identity, 73% coverage of query (76.6 bits)

DMGD_HALED / E1V4Y0 D-galactonate dehydratase family member RspA; D-gluconate dehydratase; D-mannonate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.39; EC 4.2.1.8 from Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9) (see paper)
    27% identity, 71% coverage of query (75.1 bits)

mdlA / P11444 mandelate racemase (EC 5.1.2.2) from Pseudomonas putida (see paper)
MANR_PSEPU / P11444 Mandelate racemase; MR; EC 5.1.2.2 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 4 papers)
R9RJF1 mandelate racemase (EC 5.1.2.2) from Pseudomonas aeruginosa (see paper)
    26% identity, 75% coverage of query (74.3 bits)

7mqxE / P11444 P. Putida mandelate racemase forms an oxobenzoxaborole adduct with 2- formylphenylboronic acid (see paper)
    26% identity, 75% coverage of query (74.3 bits)

1dtnA Mandelate racemase mutant d270n co-crystallized with (s)-atrolactate
    26% identity, 75% coverage of query (74.3 bits)

6vimA P. Putida mandelate racemase co-crystallized with phenylboronic acid
    26% identity, 75% coverage of query (74.3 bits)

4x2pA P. Putida mandelate racemase in complex with 3-hydroxypyruvate
    26% identity, 75% coverage of query (74.3 bits)

4m6uA P. Putida mandelate racemase co-crystallized with tartronic acid
    26% identity, 75% coverage of query (74.3 bits)

4fp1A P. Putida mandelate racemase co-crystallized with 3,3,3-trifluoro-2- hydroxy-2-(trifluoromethyl) propionic acid
    26% identity, 75% coverage of query (74.3 bits)

3uxlA P. Putida mandelate racemase co-crystallized with the intermediate analogue cupferron
    26% identity, 75% coverage of query (74.3 bits)

3uxkA P. Putida mandelate racemase co-crystallized with the intermediate analogue benzohydroxamate
    26% identity, 75% coverage of query (74.3 bits)

2mnrA Mechanism of the reaction catalyzed by mandelate racemase. 2. Crystal structure of mandelate racemase at 2.5 angstroms resolution: identification of the active site and possible catalytic residues
    26% identity, 75% coverage of query (74.3 bits)

BPHYT_RS16405 galactonate dehydratase [EC: 4.2.1.6] from Burkholderia phytofirmans PsJN
    27% identity, 70% coverage of query (73.9 bits)

1mdlA Mandelate racemase mutant k166r co-crystallized with (r)-mandelate
    26% identity, 75% coverage of query (73.2 bits)

4hncA P. Putida c92s/k166c/c264s mandelate racemase co-crystallized with benzilic acid
    26% identity, 75% coverage of query (72.4 bits)

3sqsA / A8LS88 Crystal structure of a putative mandelate racemase/muconate lactonizing protein from dinoroseobacter shibae dfl 12
    25% identity, 74% coverage of query (71.6 bits)

2o56A / Q8ZKY6 Crystal structure of a member of the enolase superfamily from salmonella typhimurium
    24% identity, 76% coverage of query (71.6 bits)

GAD_SACS2 / Q97U27 D-gluconate/D-galactonate dehydratase; GAD; GNAD; EC 4.2.1.140; EC 4.2.1.39; EC 4.2.1.6 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 2 papers)
Q97U27 gluconate/galactonate dehydratase (EC 4.2.1.140) from Saccharolobus solfataricus (see paper)
    27% identity, 72% coverage of query (69.3 bits)

GAD_PICTO / Q6L1T2 D-gluconate/D-galactonate dehydratase; GAD; GNAD; EC 4.2.1.140; EC 4.2.1.39; EC 4.2.1.6 from Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828 / KAW 2/3) (see paper)
Q6L1T2 gluconate/galactonate dehydratase (EC 4.2.1.140); gluconate dehydratase (EC 4.2.1.39) from Picrophilus torridus (see paper)
    23% identity, 71% coverage of query (68.2 bits)

IMND2_ENTGE / C9A1P5 D-galactonate dehydratase family member EGBG_02030 from Enterococcus gallinarum (strain EG2) (see paper)
    24% identity, 70% coverage of query (66.6 bits)

HSERO_RS05235 L-fuconate dehydratase (EC 4.2.1.68) from Herbaspirillum seropedicae SmR1
    25% identity, 72% coverage of query (64.3 bits)

3ugvF / A8TYI5 Crystal structure of an enolase from alpha pretobacterium bal199 (efi target efi-501650) with bound mg
    26% identity, 70% coverage of query (63.5 bits)

3sjnA / A8H9D1 Crystal structure of enolase spea_3858 (target efi-500646) from shewanella pealeana with magnesium bound
    22% identity, 71% coverage of query (62.4 bits)

3rraB / B2UCA8 Crystal structure of enolase prk14017 (target efi-500653) from ralstonia pickettii 12j with magnesium bound
    25% identity, 71% coverage of query (60.8 bits)

G3YE52 galactonate dehydratase (EC 4.2.1.6) from Aspergillus niger (see paper)
    25% identity, 70% coverage of query (59.7 bits)

RHMD_POLSJ / Q12DF1 L-rhamnonate dehydratase; RhamD; EC 4.2.1.90 from Polaromonas sp. (strain JS666 / ATCC BAA-500) (see paper)
    24% identity, 84% coverage of query (58.5 bits)

G3Y8T6 galactonate dehydratase (EC 4.2.1.6) from Aspergillus niger (see paper)
    26% identity, 72% coverage of query (57.8 bits)

clcB / Q706U0 chloromuconate cycloisomerase subunit (EC 5.5.1.7; EC 5.5.1.11) from Pseudomonas putida (see 5 papers)
clcB / CAE92860.1 chloromuconate cycloisomerase from Pseudomonas putida (see 3 papers)
    25% identity, 71% coverage of query (57.0 bits)

NSAR_DEIRA / Q9RYA6 N-succinylamino acid racemase; NSAAR; NSAR; N-acylamino acid racemase; NAAAR; o-succinylbenzoate synthase; OSB synthase; OSBS; EC 5.1.1.-; EC 4.2.1.113 from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see 4 papers)
    27% identity, 72% coverage of query (55.5 bits)

3fvdB / A3SNF7 Crystal structure of a member of enolase superfamily from roseovarius nubinhibens ism complexed with magnesium
    24% identity, 73% coverage of query (55.5 bits)

lra3 / Q1NEI8 L-rhamnonate dehydratase (EC 4.2.1.90) from Sphingomonas sp. (strain SKA58) (see paper)
    25% identity, 75% coverage of query (55.1 bits)

3gy1B / A6M2W4 Crystal structure of putative mandelate racemase/muconate lactonizing protein from clostridium beijerinckii ncimb 8052
    19% identity, 75% coverage of query (55.1 bits)

2gghC / Q9RYA6 The mutant a68c-d72c-nlq of deinococcus radiodurans nacylamino acid racemase (see paper)
    26% identity, 72% coverage of query (53.9 bits)

7s8wA Amycolatopsis sp. T-1-60 n-succinylamino acid racemase/o- succinylbenzoate synthase r266q mutant in complex with n- succinylphenylglycine
    25% identity, 86% coverage of query (53.5 bits)

NSAR_AMYSP / Q44244 N-succinylamino acid racemase; NSAR; N-acylamino acid racemase; AAR; NAAAR; o-succinylbenzoate synthase; OSB synthase; OSBS; EC 5.1.1.-; EC 4.2.1.113 from Amycolatopsis sp. (see 6 papers)
Q44244 o-succinylbenzoate synthase (EC 4.2.1.113) from Amycolatopsis sp. (see paper)
    25% identity, 86% coverage of query (53.1 bits)

1sjdA X-ray structure of o-succinylbenzoate synthase complexed with n- succinyl phenylglycine
    25% identity, 86% coverage of query (53.1 bits)

1sjcA X-ray structure of o-succinylbenzoate synthase complexed with n- succinyl methionine
    25% identity, 86% coverage of query (53.1 bits)

1sjbA X-ray structure of o-succinylbenzoate synthase complexed with o- succinylbenzoic acid
    25% identity, 86% coverage of query (53.1 bits)

4a6gA / Q44244 N-acyl amino acid racemase from amycalotopsis sp. Ts-1-60: g291d- f323y mutant in complex with n-acetyl methionine (see paper)
    25% identity, 86% coverage of query (52.4 bits)

5fjtA N-acyl amino acid racemase from amycolatopsis sp. Ts-1-60: g291d f323 mutant in complex with n-acetyl phenylalanine
    25% identity, 86% coverage of query (52.4 bits)

5fjoA N-acyl amino acid racemase from amycolatopsis sp. Ts-1-60: g291d- f323y mutant in complex with n-acetyl naphthylalanine
    25% identity, 86% coverage of query (52.4 bits)

aar / CAC00653.1 N-acylamino acid racemase from Amycolatopsis lurida (see paper)
    24% identity, 85% coverage of query (49.7 bits)

CH_124262 putative galactonate dehydratase from Magnaporthe grisea 70-15 (see 2 papers)
    22% identity, 70% coverage of query (49.3 bits)

IMAND_CLOB8 / A6M2W4 D-galactonate dehydratase family member Cbei_4837 from Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) (see paper)
    18% identity, 75% coverage of query (48.9 bits)

tfdDII / P42428 dienelactone hydrolase II subunit (EC 5.5.1.7) from Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (see paper)
    24% identity, 74% coverage of query (48.1 bits)

3fcpA / A6T9N5 Crystal structure of muconate lactonizing enzyme from klebsiella pneumoniae
    23% identity, 72% coverage of query (46.2 bits)

4hcdA / Q7CSI0 Crystal structure of d-glucarate dehydratase from agrobacterium tumefaciens complexed with magnesium
    23% identity, 73% coverage of query (45.8 bits)

4hclA Crystal structure of d-glucarate dehydratase from agrobacterium tumefaciens complexed with magnesium and l-lyxarohydroxamate
    23% identity, 73% coverage of query (45.8 bits)

4mmwA Crystal structure of d-glucarate dehydratase from agrobacterium tumefaciens complexed with magnesium, l-xylarohydroxamate and l- lyxarohydroxamate
    23% identity, 73% coverage of query (45.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory