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Searching for up to 100 curated homologs for AZOBR_RS19240 FitnessBrowser__azobra:AZOBR_RS19240 (364 a.a.)

Found high-coverage hits (≥70%) to 29 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4yicA / A0A0J9X284 Crystal structure of a trap transporter solute binding protein (ipr025997) from bordetella bronchiseptica rb50 (bb0280, target efi- 500035) with bound picolinic acid
    56% identity, 91% coverage of query (409 bits)

TC 2.A.56.3.4 / D5ALT6 TRAP dicarboxylate transporter, DctP-2 subunit, component of The 2-ketomonocarboxylate transporter (presented in order of affinity - 2-oxovalerate [highest affinity, KD=0.1 μM], 2-oxoisovalerate, 2-oxobutyrate, 2-oxoisocaproate, 2-oxo-3-methylvalerate, pyruvate [lowest affinity, KD=3 μM]) from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see paper)
    55% identity, 99% coverage of query (400 bits)

TAKP_CERS4 / Q3J1R2 Alpha-keto acid-binding periplasmic protein TakP; Extracytoplasmic solute receptor protein TakP; TRAP transporter alpha-keto acid-binding subunit P; TRAP-T family sorbitol/mannitol transporter, periplasmic binding protein, SmoM from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see paper)
    55% identity, 99% coverage of query (397 bits)

2hzlB / Q3J1R2 Crystal structures of a sodium-alpha-keto acid binding subunit from a trap transporter in its closed forms (see paper)
    55% identity, 91% coverage of query (395 bits)

TMBP_NOSS1 / Q8YSQ6 Monocarboxylate 2-oxoacid-binding periplasmic protein all3028; Extracellular solute-binding protein; Extracytoplasmic solute receptor protein all3028; TRAP transporter monocarboxylate 2-oxoacid-binding subunit P from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) (see paper)
TC 2.A.56.3.3 / Q8YSQ6 Extracellular solute-binding protein, component of The 2-oxo monocarboxylate transporter (Pernil et al., 2010). Transports pyruvate which is inhibited by various 2-ketoacids from Nostoc sp. (strain PCC 7120 / UTEX 2576) (see paper)
    49% identity, 98% coverage of query (379 bits)

7ug8B / Q0I6F8 Crystal structure of a solute receptor from synechococcus cc9311 in complex with alpha-ketovaleric and calcium
    49% identity, 88% coverage of query (334 bits)

5cm6A Crystal structure of a trap periplasmic solute binding protein from pseudoalteromonas atlantica t6c(patl_2292, target efi-510180) with bound sodium and pyruvate
    39% identity, 88% coverage of query (239 bits)

4petA / Q48AL6 Crystal structure of a trap periplasmic solute binding protein from colwellia psychrerythraea (cps_0129, target efi-510097) with bound calcium and pyruvate (see paper)
    37% identity, 88% coverage of query (231 bits)

Build an alignment

Build an alignment for AZOBR_RS19240 and 8 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

TLBP_THET8 / Q5SK82 Lactate-binding periplasmic protein TTHA0766; ABC transporter, solute-binding protein; Extracytoplasmic solute receptor protein TTHA0766; TRAP transporter lactate-binding subunit P from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    29% identity, 87% coverage of query (134 bits)

2zzvA / Q5SK82 Crystal structure of a periplasmic substrate binding protein in complex with calcium and lactate (see paper)
    29% identity, 71% coverage of query (117 bits)

2zzwA Crystal structure of a periplasmic substrate binding protein in complex with zinc and lactate
    29% identity, 71% coverage of query (117 bits)

4xf5A / Q1QZR9 Crystal structure of a trap periplasmic solute binding protein from chromohalobacter salexigens dsm 3043 (csal_0678), target efi-501078, with bound (s)-(+)-2-amino-1-propanol.
    25% identity, 86% coverage of query (95.5 bits)

4uabA Crystal structure of a trap periplasmic solute binding protein from chromohalobacter salexigens dsm 3043 (csal_0678), target efi-501078, with bound ethanolamine
    25% identity, 85% coverage of query (92.8 bits)

PP_1169 D-glucuronate / D-galacturonate TRAP transporter, solute receptor component from Pseudomonas putida KT2440
    25% identity, 82% coverage of query (65.1 bits)

4x8rA / A3PLM5 Crystal structure of a trap periplasmic solute binding protein from rhodobacter sphaeroides (rsph17029_2138, target efi-510205) with bound glucuronate
    22% identity, 74% coverage of query (64.3 bits)

4xfeA / I3UZ52 Crystal structure of a trap periplasmic solute binding protein from pseudomonas putida f1 (pput_1203), target efi-500184, with bound d- glucuronate
    25% identity, 73% coverage of query (63.2 bits)

TC 2.A.56.3.2 / Q9RBR1 FcbT1, component of Tripartite 4-chlorobenzoate symporter (also binds and may transport 4-bromo-, 4-iodo-, and 4-fluorobenzoate and with a lower affinity, 3-chlorobenzoate, 2-chlorobenzoate, 4-hydroxybenzoate, 3-hydroxybenzoate, and benzoate) (see paper)
    22% identity, 74% coverage of query (63.2 bits)

4n8yA / A5E8D2 Crystal structure of a trap periplasmic solute binding protein from bradyrhizobium sp. Btai1 b (bbta_0128), target efi-510056 (bbta_0128), complex with alpha/beta-d-galacturonate (see paper)
    22% identity, 73% coverage of query (54.3 bits)

DCTP2_POLSJ / Q122C7 Solute-binding protein Bpro_4736 from Polaromonas sp. (strain JS666 / ATCC BAA-500) (see paper)
    22% identity, 79% coverage of query (53.1 bits)

4mncA / Q122C7 Crystal structure of a trap periplasmic solute binding protein from polaromonas sp. Js666 (bpro_4736), target efi-510156, with bound benzoyl formate, space group p21 (see paper)
    21% identity, 70% coverage of query (51.2 bits)

4mijA / Q128M1 Crystal structure of a trap periplasmic solute binding protein from polaromonas sp. Js666 (bpro_3107), target efi-510173, with bound alpha/beta d-galacturonate, space group p21 (see paper)
    24% identity, 84% coverage of query (51.2 bits)

DCTP1_POLSJ / Q128M1 Solute-binding protein Bpro_3107 from Polaromonas sp. (strain JS666 / ATCC BAA-500) (see paper)
    24% identity, 82% coverage of query (50.4 bits)

4mhfA Crystal structure of a trap periplasmic solute binding protein from polaromonas sp. Js666 (bpro_3107), target efi-510173, with bound alpha/beta d-glucuronate, space group p21
    24% identity, 82% coverage of query (50.4 bits)

6wgmA / G5ZWD6 Crystal structure of a marine metagenome trap solute binding protein specific for pyroglutamate (sorcerer ii global ocean sampling expedition, unidentified microbe, scf7180008839099) in complex with co-purified pyroglutamate
    22% identity, 74% coverage of query (50.1 bits)

4nq8B / A0A0H3LPK2 Crystal structure of a trap periplasmic solute binding protein from bordetella bronchispeptica (bb3421), target efi-510039, with density modeled as pantoate (see paper)
    23% identity, 73% coverage of query (47.8 bits)

DCTP_CHRSD / Q1QUN2 Solute-binding protein Csal_2479 from Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11) (see paper)
    22% identity, 89% coverage of query (47.4 bits)

DCTP_BURCM / Q0B2F6 Solute-binding protein Bamb_6123 from Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD)) (see paper)
    21% identity, 71% coverage of query (43.9 bits)

4n17A Crystal structure of a trap periplasmic solute binding protein from burkholderia ambifaria (bam_6123), target efi-510059, with bound beta-d-galacturonate
    20% identity, 71% coverage of query (43.9 bits)

4n15A / Q0B2F6 Crystal structure of a trap periplasmic solute binding protein from burkholderia ambifaria (bam_6123), target efi-510059, with bound beta-d-glucuronate (see paper)
    20% identity, 71% coverage of query (43.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory