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Searching for up to 100 curated homologs for AZOBR_RS25645 FitnessBrowser__azobra:AZOBR_RS25645 (370 a.a.)

Found high-coverage hits (≥70%) to 62 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Ac3H11_2396 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, substrate-binding component from Acidovorax sp. GW101-3H11
    30% identity, 92% coverage of query (138 bits)

HSERO_RS00870 L-proline ABC transporter, substrate-binding component from Herbaspirillum seropedicae SmR1
    30% identity, 94% coverage of query (137 bits)

TC 3.A.1.4.3 / Q9L3M3 BraC, component of General L- (and D-)amino acid uptake porter (transports acidic, basic, polar, semipolar and hydrophobic amino acids). The amino and carboxyl groups do not need to be α since γ-aminobutyric acid (GABA) is a substrate. The system may function with additional binding proteins since L-alanine uptake is not dependent on BraC from Rhizobium leguminosarum (biovar viciae) (see 2 papers)
braC / CAB75553.1 periplasmic binding protein from Rhizobium leguminosarum bv. viciae (see 2 papers)
    32% identity, 92% coverage of query (125 bits)

BRAC_PSEAE / P21175 Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein; LIVAT-BP; Leu/Ile/Val/Thr/Ala-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
TC 3.A.1.4.8 / P21175 Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    31% identity, 91% coverage of query (125 bits)

3ip5A / Q7CX36 Structure of atu2422-gaba receptor in complex with alanine (see paper)
    33% identity, 71% coverage of query (122 bits)

3ip9A Structure of atu2422-gaba receptor in complex with gaba
    33% identity, 71% coverage of query (122 bits)

3ip7A Structure of atu2422-gaba receptor in complex with valine
    33% identity, 71% coverage of query (122 bits)

3ip6A Structure of atu2422-gaba receptor in complex with proline
    33% identity, 71% coverage of query (122 bits)

LivJ / b3460 branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
LivJ / P0AD96 branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein (EC 7.4.2.2) from Escherichia coli (strain K12) (see 12 papers)
TC 3.A.1.4.1 / P0AD96 Leu/Ile/Val-binding protein LivJ aka B3460 aka LIV-BP, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 9 papers)
    31% identity, 71% coverage of query (119 bits)

Build an alignment

Build an alignment for AZOBR_RS25645 and 9 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

TC 3.A.1.4.10 / Q8DQI1 ABC transporter substrate-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
    27% identity, 91% coverage of query (119 bits)

3td9A / Q9X0L9 Crystal structure of a leucine binding protein livk (tm1135) from thermotoga maritima msb8 at 1.90 a resolution
    28% identity, 92% coverage of query (119 bits)

3ipcA Structure of atu2422-gaba f77a mutant receptor in complex with leucine
    33% identity, 71% coverage of query (119 bits)

HrbC / b3458 L-leucine/L-phenylalanine ABC transporter periplasmic binding protein (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 17 papers)
livK / P04816 L-leucine/L-phenylalanine ABC transporter periplasmic binding protein (EC 7.4.2.2) from Escherichia coli (strain K12) (see 16 papers)
TC 3.A.1.4.1 / P04816 Livk aka B3458, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 9 papers)
livK leucine-specific-binding protein LivK from Escherichia coli K12 (see 9 papers)
    29% identity, 86% coverage of query (118 bits)

4gnrA / J9PBT7 1.0 angstrom resolution crystal structure of the branched-chain amino acid transporter substrate binding protein livj from streptococcus pneumoniae str. Canada mdr_19a in complex with isoleucine
    28% identity, 89% coverage of query (117 bits)

LIVB3_RHIL3 / Q1MDE9 Leu/Ile/Val-binding protein BraC3 from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
    28% identity, 91% coverage of query (117 bits)

Pf6N2E2_2921 ABC transporter for L-leucine/L-phenylalanine/D-alanine, substrate-binding component LivK from Pseudomonas fluorescens FW300-N2E2
    29% identity, 91% coverage of query (114 bits)

1usiA / P04816 L-leucine-binding protein with phenylalanine bound (see paper)
    29% identity, 82% coverage of query (112 bits)

1uskA L-leucine-binding protein with leucine bound
    29% identity, 82% coverage of query (112 bits)

AZOBR_RS08260 L-proline and D-alanine ABC transporter, substrate-binding component from Azospirillum brasilense Sp245
    28% identity, 85% coverage of query (110 bits)

4n0qB / Q8YEE8 Crystal structure of an abc transporter, substrate-binding protein from brucella melitensis 16m in complex with l-leucine using a crystal grown in a crystal former (microlytic)
    27% identity, 86% coverage of query (104 bits)

4mlcA / B8FZ96 Abc transporter substrate-binding protein fromdesulfitobacterium hafniense
    27% identity, 86% coverage of query (100 bits)

4q6wA / Q7VS30 Crystal structure of periplasmic binding protein type 1 from bordetella pertussis tohama i complexed with 3-hydroxy benzoic acid
    28% identity, 91% coverage of query (98.2 bits)

4q6bA Crystal structure of abc transporter substrate-binding protein fromdesulfitobacterium hafniense complex with leu
    27% identity, 86% coverage of query (97.1 bits)

AABP_PSEAE / Q9HUQ0 Amino acid binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    25% identity, 72% coverage of query (90.5 bits)

TC 3.A.1.4.6 / Q8YVY4 NatB, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
    26% identity, 75% coverage of query (84.3 bits)

TC 3.A.1.4.2 / Q55387 NatB aka SLR0559, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
    25% identity, 82% coverage of query (76.6 bits)

4eygB / Q13AR6 Crystal structure of solute binding protein of abc transporter from rhodopseudomonas palustris bisb5 in complex with vanillic acid (see paper)
    22% identity, 79% coverage of query (72.4 bits)

4rv5A The crystal structure of a solute-binding protein from anabaena variabilis atcc 29413 in complex with pyruvic acid
    23% identity, 79% coverage of query (70.5 bits)

4obbA The crystal structure of a solute-binding protein from anabaena variabilis atcc 29413 in complex with (3s)-3-methyl-2-oxopentanoic acid.
    23% identity, 79% coverage of query (70.5 bits)

4nqrA / Q3MFZ5 The crystal structure of a solute-binding protein (n280d mutant) from anabaena variabilis atcc 29413 in complex with alanine
    23% identity, 79% coverage of query (69.7 bits)

4rdcA The crystal structure of a solute-binding protein (n280d mutant) from anabaena variabilis atcc 29413 in complex with proline
    23% identity, 79% coverage of query (69.7 bits)

4qymA The crystal structure of a solute-binding protein (n280d mutant) from anabaena variabilis atcc 29413 in complex with methionine
    23% identity, 79% coverage of query (69.7 bits)

4otzA The crystal structure of a solute-binding protein (n280d mutant) from anabaena variabilis atcc 29413 in complex with cystein
    23% identity, 79% coverage of query (69.7 bits)

4og2A The crystal structure of a solute-binding protein (n280d mutant) from anabaena variabilis atcc 29413 in complex with leucine
    23% identity, 79% coverage of query (69.7 bits)

4oatA The crystal structure of a solute-binding protein (n280d mutant) from anabaena variabilis atcc 29413 in complex with isoleucine.
    23% identity, 79% coverage of query (69.7 bits)

4nv3A The crystal structure of a solute-binding protein (n280d mutant) from anabaena variabilis atcc 29413 in complex with valine.
    23% identity, 79% coverage of query (69.7 bits)

TC 3.A.1.4.11 / Q6N8W4 Putative branched-chain amino acid transport system substrate-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    27% identity, 99% coverage of query (65.1 bits)

4jb0A / Q6N8W4 Rhodopseudomonas palustris (strain cga009) rp1789 transport protein (see paper)
    26% identity, 89% coverage of query (64.3 bits)

8hicA / Q7V3V9 Crystal structure of urta from prochlorococcus marinus str. Mit 9313 in complex with urea and calcium
    27% identity, 83% coverage of query (63.5 bits)

4zpjA / D1C6A8 Abc transporter substrate-binding protein from sphaerobacter thermophilus
    22% identity, 88% coverage of query (62.0 bits)

3lopA / Q8XUX2 Crystal structure of substrate-binding periplasmic protein (pbp) from ralstonia solanacearum
    24% identity, 84% coverage of query (62.0 bits)

4dqdA / Q2IR47 The crystal structure of a transporter in complex with 3-phenylpyruvic acid (see paper)
    21% identity, 92% coverage of query (60.1 bits)

3sg0A The crystal structure of an extracellular ligand-binding receptor from rhodopseudomonas palustris haa2
    21% identity, 92% coverage of query (60.1 bits)

7s6eB / Q0I663 Crystal structure of urta from synechococcus cc9311 in complex with urea and calcium
    27% identity, 84% coverage of query (59.7 bits)

fmdD / CAA75186.1 amide-urea binding protein from Methylophilus methylotrophus (see paper)
    24% identity, 85% coverage of query (59.3 bits)

4eyqA Crystal structure of solute binding protein of abc transporter from rhodopseudomonas palustris haa2 in complex with caffeic acid/3-(4- hydroxy-phenyl)pyruvic acid
    26% identity, 89% coverage of query (59.3 bits)

GLR23_ARATH / Q9SHV2 Glutamate receptor 2.3; Ligand-gated ion channel 2.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    22% identity, 76% coverage of query (55.5 bits)

4ms3A Crystal structure of the extracellular domain of human gaba(b) receptor bound to the endogenous agonist gaba
    24% identity, 92% coverage of query (54.3 bits)

4mqfA Crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist 2-hydroxysaclofen
    22% identity, 92% coverage of query (49.3 bits)

4ms4A Crystal structure of the extracellular domain of human gaba(b) receptor bound to the agonist baclofen
    22% identity, 92% coverage of query (49.3 bits)

4ms1A Crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist cgp46381
    22% identity, 92% coverage of query (49.3 bits)

4mrmA Crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist phaclofen
    22% identity, 92% coverage of query (49.3 bits)

4mr9A Crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist sch50911
    22% identity, 92% coverage of query (49.3 bits)

4mr8A Crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist cgp35348
    22% identity, 92% coverage of query (49.3 bits)

4mr7A Crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist cgp54626
    22% identity, 92% coverage of query (49.3 bits)

6uo8A / Q9UBS5 Human metabotropic gaba(b) receptor bound to agonist skf97541 and positive allosteric modulator gs39783 (see paper)
    22% identity, 92% coverage of query (48.9 bits)

6w2yA Cryoem structure of gabab1b homodimer
    22% identity, 92% coverage of query (48.9 bits)

6wivA Structure of human gaba(b) receptor in an inactive state
    22% identity, 92% coverage of query (48.9 bits)

7c7qA Cryo-em structure of the baclofen/bhff-bound human gaba(b) receptor in active state
    22% identity, 92% coverage of query (48.9 bits)

6w2xA Cryoem structure of inactive gabab heterodimer
    22% identity, 92% coverage of query (48.5 bits)

3i09A / A0A0H2WF95 Crystal structure of a periplasmic binding protein (bma2936) from burkholderia mallei at 1.80 a resolution
    24% identity, 79% coverage of query (44.7 bits)

3i45A / Q2RWX8 Crystal structure of putative twin-arginine translocation pathway signal protein from rhodospirillum rubrum atcc 11170
    24% identity, 76% coverage of query (43.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory