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Searching for up to 100 curated homologs for AZOBR_RS25890 FitnessBrowser__azobra:AZOBR_RS25890 (265 a.a.)

Found high-coverage hits (≥70%) to 58 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Ac3H11_794 ABC transporter for Glycerol, permease component 2 from Acidovorax sp. GW101-3H11
    73% identity, 99% coverage of query (410 bits)

TC 3.A.1.1.35 / G3LHZ1 GlpQ, component of Glycerol uptake porter, GlpSTPQV from Rhizobium leguminosarum bv. viciae
    79% identity, 98% coverage of query (393 bits)

Dshi_0549 ABC transporter for Xylitol, permease component 2 from Dinoroseobacter shibae DFL-12
    33% identity, 98% coverage of query (153 bits)

SM_b21105 ABC transporter for L-Fucose, permease component 2 from Sinorhizobium meliloti 1021
    31% identity, 97% coverage of query (139 bits)

Build an alignment

Build an alignment for AZOBR_RS25890 and 4 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

mtlG / Q4KC55 polyol ABC-type transporter permease component MtlG from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
    28% identity, 95% coverage of query (127 bits)

TC 3.A.1.1.49 / O30493 MtlG, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK from Pseudomonas fluorescens
    28% identity, 95% coverage of query (127 bits)

Pf6N2E2_1961 ABC transporter for D-sorbitol, permease component 2 from Pseudomonas fluorescens FW300-N2E2
    29% identity, 95% coverage of query (127 bits)

AO356_00015 ABC transporter for D-Sorbitol, permease component 1 from Pseudomonas fluorescens FW300-N2C3
    29% identity, 95% coverage of query (126 bits)

PS417_12705 ABC transporter for D-Mannitol and D-Sorbitol, permease component 1 from Pseudomonas simiae WCS417
    28% identity, 95% coverage of query (126 bits)

BPHYT_RS16105 ABC transporter for D-Sorbitol, permease component 1 from Burkholderia phytofirmans PsJN
    30% identity, 97% coverage of query (124 bits)

TC 3.A.1.1.41 / G4FGN6 ABC-type transporter, integral membrane subunit, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    28% identity, 98% coverage of query (124 bits)

sugB / P9WG01 ABC-type trehalose transporter integral membrane protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGB_MYCTU / P9WG01 Trehalose transport system permease protein SugB from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
TC 3.A.1.1.31 / O50453 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGB, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 3 papers)
    33% identity, 97% coverage of query (120 bits)

SM_b20327 ABC transporter for D-trehalose/D-maltose/sucrose, permease component 2 (ThuG) from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q5 ThuG aka RB0313 aka SMB20327, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 3 papers)
    34% identity, 85% coverage of query (120 bits)

TC 3.A.1.1.44 / Q9KZ08 Putative maltose permease, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    30% identity, 99% coverage of query (116 bits)

Pf1N1B4_5114 sucrose ABC transporter, permease component 2 from Pseudomonas fluorescens FW300-N1B4
    30% identity, 97% coverage of query (115 bits)

TC 3.A.1.1.5 / O30833 SmoG, component of Hexitol (glucitol; mannitol) porter from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (see paper)
    27% identity, 94% coverage of query (111 bits)

TC 3.A.1.1.25 / Q72H66 Maltose transport system permease protein malG aka TT_C1629, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    33% identity, 83% coverage of query (110 bits)

PGA1_c13190 ABC transporter for D-Sorbitol, permease component 1 from Phaeobacter inhibens BS107
    28% identity, 95% coverage of query (110 bits)

HSERO_RS17010 ABC transporter for D-sorbitol/xylitol, permease component 2 from Herbaspirillum seropedicae SmR1
    32% identity, 90% coverage of query (109 bits)

Ac3H11_2942 ABC transporter for D-Sorbitol, permease component 1 from Acidovorax sp. GW101-3H11
    30% identity, 95% coverage of query (108 bits)

TC 3.A.1.1.12 / Q9AI66 PalG, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    28% identity, 97% coverage of query (107 bits)

DASC_STRCO / Q9K489 Diacetylchitobiose uptake system permease protein DasC from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    25% identity, 97% coverage of query (103 bits)

TC 3.A.1.1.24 / Q72KX4 Sugar transport system permease protein aka TT_C0326, component of The glucose/mannose porter TTC0326-8 plus MalK1 (ABC protein, shared with 3.A.1.1.25) from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    27% identity, 95% coverage of query (103 bits)

TC 3.A.1.1.33 / Q8KN17 Putative sugar transporter integral membrane protein, component of The N,N'-diacetylchitobiose uptake transporter, DasABC/MsiK (MsiK energizes several ABC transporters (see 3.A.1.1.23)) from Streptomyces sp. 139 (see 2 papers)
    25% identity, 94% coverage of query (103 bits)

GGTD_SYNY3 / Q55473 Osmoprotective compounds uptake permease protein GgtD from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
TC 3.A.1.1.32 / Q55473 Membrane bound sugar transport protein, component of The glucosylglycerol uptake transporter (functions in osmoprotection and also transports sucrose and trehalose (Mikkat and Hagemann, 2000) (most similar to 3.A.1.1.8) from Synechocystis sp. (strain PCC 6803) (see paper)
    30% identity, 82% coverage of query (102 bits)

TC 3.A.1.1.18 / Q8RJU8 NgcG, component of N-Acetylglucosamine/N,N'-diacetyl chitobiose porter (NgcK (C) not identified) from Streptomyces olivaceoviridis (Streptomyces corchorusii) (see paper)
    25% identity, 97% coverage of query (98.2 bits)

smoH / Q7CS31 ABC-type 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol transporter permease subunit from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
    26% identity, 94% coverage of query (96.7 bits)

TC 3.A.1.1.6 / Q48397 CymG, component of Cyclodextrin porter from Klebsiella oxytoca (see paper)
    28% identity, 99% coverage of query (96.7 bits)

TC 3.A.1.1.26 / O06991 MalG aka yvdI, component of The maltose porter, MdxEFG and MsmX from Bacillus subtilis (see 2 papers)
    29% identity, 83% coverage of query (95.9 bits)

TC 3.A.1.1.38 / Q9WYQ1 Sugar ABC transporter, permease protein, component of Inositol phosphate porter (Rodionova et al. 2013). Binds inositol phosphate with low Kd and inositol with a lower affinity from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    29% identity, 90% coverage of query (94.4 bits)

TC 3.A.1.1.16 / Q8TZQ0 MalG, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
    29% identity, 80% coverage of query (94.0 bits)

YcjP / b1312 putative ABC transporter membrane subunit YcjP from Escherichia coli K-12 substr. MG1655 (see 2 papers)
TC 3.A.1.1.46 / P77716 Inner membrane ABC transporter permease protein YcjP, component of Probable glucoside uptake porter, YcjNOPV from Escherichia coli (strain K12)
    27% identity, 97% coverage of query (93.6 bits)

ARAQ_BACSU / P94530 Arabinooligosaccharides transport system permease protein AraQ from Bacillus subtilis (strain 168) (see 3 papers)
TC 3.A.1.1.34 / P94530 L-arabinose transport system permease protein AraQ, component of The arabinosaccharide transporter AraNPQMsmX. Transports α-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units; the key transporter for α-1,5-arabinotriose and α-1,5-arabinotetraose, but not for α-1,5-arabinobiose which is transported by AraE. MsmX is also used by the MdxEFG-MsmX system (3.A.1.1.36) (Ferreira and Sá-Nogueira, 2010). Involved in the uptake of pectin oligosaccharides with either MsmX or YurJ as the ATPase from Bacillus subtilis (see 5 papers)
    28% identity, 98% coverage of query (90.9 bits)

Dshi_1650 glucose/maltose/trehalose/sucrose ABC transporter, permease component 2 from Dinoroseobacter shibae DFL-12
    30% identity, 85% coverage of query (90.5 bits)

MALG_THELN / Q7LYX6 Trehalose/maltose transport system permease protein MalG from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 3 papers)
TC 3.A.1.1.7 / O51925 MalG aka PF1741, component of Maltose/trehalose porter (see paper)
    27% identity, 94% coverage of query (89.4 bits)

NGCG_STRCO / O50501 Diacetylchitobiose uptake system permease protein NgcG from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    27% identity, 87% coverage of query (88.2 bits)

SMc03063 ABC transporter for D-maltose/D-trehalose/sucrose, permease component 2 (AglG) from Sinorhizobium meliloti 1021
TC 3.A.1.1.8 / Q9Z3R7 AglG aka R00697 aka SMC03063, component of Sucrose/maltose/trehalose porter (sucrose-inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 2 papers)
    31% identity, 85% coverage of query (87.0 bits)

Q9X2F5 ABC-type maltose transporter (subunit 1/2) (EC 7.5.2.1) from Thermotoga maritima (see paper)
TC 3.A.1.1.22 / Q9X2F5 MalG2; aka Maltose ABC transporter, permease protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins from Thermotoga maritima (see paper)
    28% identity, 77% coverage of query (87.0 bits)

SM_b21219 ABC transporter for D-Glucosamine, permease component 1 from Sinorhizobium meliloti 1021
    26% identity, 97% coverage of query (85.5 bits)

TC 3.A.1.1.15 / Q97ZC1 TreU, component of Trehalose porter from Sulfolobus solfataricus (see paper)
    32% identity, 74% coverage of query (85.1 bits)

TC 3.A.1.1.48 / D6ZW62 Permease of ABC transporter for sugars, component of The lacto-N-biose I (LNB; Gal β-1,3-GlcNAc)/galacto-N-biose (GNB; Gal β-1,3-GalNAc) transporter from Bifidobacterium longum subsp. longum (strain JDM301)
    25% identity, 95% coverage of query (82.4 bits)

TC 3.A.1.1.11 / Q93KB9 TogN, component of Saturated and unsaturated oligogalacturonide transporter, TogMNAB (transports di- to tetrasaccharide pectin degradation products which consist of D-galacuronate, sometimes with 4-deoxy-L-threo-5-hexosulose uronate at the reducing end of the oligosaccharide) (Hugouvieux-Cotte-Pattat et al. 2001). Regulated by pectin utilization regulator KdgR from Erwinia chrysanthemi (see paper)
    25% identity, 97% coverage of query (81.6 bits)

TC 3.A.1.1.27 / Q8DT26 MalG, component of Maltose/Maltotriose/maltodextrin (up to 7 glucose units) transporters MalXFGK (MsmK (3.A.1.1.28) can probably substitute for MalK; Webb et al., 2008) from Streptococcus mutans (see paper)
    27% identity, 94% coverage of query (79.7 bits)

TC 3.A.1.1.20 / Q7WWQ8 Transmembrane permease MsmG, component of The fructooligosaccharide porter, MsmEFGK from Lactobacillus acidophilus (see 2 papers)
msmG / GI|33149340 transmembrane permease MsmG from Lactobacillus acidophilus (see paper)
    26% identity, 96% coverage of query (78.6 bits)

GANQ_BACSU / O07011 Galactooligosaccharides transport system permease protein GanQ from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.1.2 / O07011 Putative arabinogalactan oligomer transport system permease protein ganQ, component of The galactooligosaccharide (transports the di, tri and tetrasaccharides) uptake porter GanOPQ (GanSPQ; MalEFG) functioning with the energizing ATPase MsmX (see 3.A.1.1.26) from Bacillus subtilis (see 2 papers)
    23% identity, 99% coverage of query (78.2 bits)

Q9X0S9 ABC-type maltose transporter (subunit 2/2) (EC 7.5.2.1) from Thermotoga maritima (see paper)
TC 3.A.1.1.22 / Q9X0S9 MalG1; aka Maltose ABC transporter, permease protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins from Thermotoga maritima (see paper)
    25% identity, 77% coverage of query (77.4 bits)

Ac3H11_2065 glucose ABC transporter, permease component 2 from Acidovorax sp. GW101-3H11
    26% identity, 98% coverage of query (75.1 bits)

SMc04257 ABC transporter for D-Cellobiose and D-Salicin, permease component 1 from Sinorhizobium meliloti 1021
    25% identity, 95% coverage of query (74.7 bits)

YTCP_BACSU / P53561 Polygalacturonan/rhamnogalacturonan transport system permease protein YtcP from Bacillus subtilis (strain 168) (see paper)
    27% identity, 97% coverage of query (74.7 bits)

TC 3.A.1.1.10 / Q9KWT7 AlgM2, component of Alginate (MW 27,000 Da) (and Alginate oligosaccharides) uptake porter. Sphingomonas species A1 is a 'pit-forming' bacterium that directly incorporates alginate into its cytoplasm through a pit-dependent transport system, termed a 'superchannel' (Murata et al., 2008). The pit is a novel organ acquired through the fluidity and reconstitution of cell surface molecules, and through cooperation with the transport machinery in the cells. It confers upon bacterial cells a more efficient way to secure and assimilate macromolecules from Sphingomonas sp (see paper)
    23% identity, 98% coverage of query (72.4 bits)

PGA1_c27950 N-Acetyl-D-glucosamine ABC transport system, permease component 2 from Phaeobacter inhibens BS107
    28% identity, 97% coverage of query (72.0 bits)

BWI76_RS01820 maltose ABC transporter, permease component 2 (MalG) from Klebsiella michiganensis M5al
    23% identity, 98% coverage of query (71.6 bits)

TC 3.A.1.1.13 / Q97UY9 GlcU, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see paper)
    28% identity, 94% coverage of query (70.1 bits)

MalG / b4032 maltose ABC transporter membrane subunit MalG (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
MalG / P68183 maltose ABC transporter membrane subunit MalG (EC 7.5.2.1) from Escherichia coli (strain K12) (see 6 papers)
MALG_ECOLI / P68183 Maltose/maltodextrin transport system permease protein MalG from Escherichia coli (strain K12) (see 5 papers)
P68183 ABC-type maltose transporter (subunit 2/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68183 Maltose transport system permease protein MalG aka B4032, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 13 papers)
malG / RF|NP_418456 maltose transport system permease protein malG from Escherichia coli K12 (see 15 papers)
    26% identity, 76% coverage of query (69.3 bits)

TC 3.A.1.1.30 / Q88P36 GtsC (GLcG), component of Glucose porter, GtsABCD from Pseudomonas putida (strain KT2440) (see paper)
    26% identity, 91% coverage of query (68.9 bits)

SMc02871 ABC transporter for N-Acetyl-D-glucosamine, permease protein 2 from Sinorhizobium meliloti 1021
    27% identity, 74% coverage of query (68.6 bits)

PS417_22135 glucose/xylose ABC transporter, permease component 1 from Pseudomonas simiae WCS417
    25% identity, 91% coverage of query (66.6 bits)

TC 3.A.1.1.4 / P29824 LacG, component of Lactose porter from Agrobacterium radiobacter (see paper)
    24% identity, 98% coverage of query (66.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory