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Searching for up to 100 curated homologs for AZOBR_RS26295 FitnessBrowser__azobra:AZOBR_RS26295 (354 a.a.)

Found high-coverage hits (≥70%) to 45 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.11.6 / Q1M7Q1 Putative ABC transporter component, component of The γ-aminobutyrate (GABA) uptake system, GtsABCD from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
    44% identity, 90% coverage of query (278 bits)

TC 3.A.1.11.7 / Q97Q42 Spermidine/putrescine import ATP-binding protein PotA, component of The spermidine/putrescine uptake porter, PotABCD from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    47% identity, 83% coverage of query (265 bits)

A0A142UTH4 ABC-type polyamine transporter (subunit 4/4) (EC 7.6.2.11) from Streptococcus suis (see paper)
    44% identity, 97% coverage of query (265 bits)

PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
    44% identity, 90% coverage of query (261 bits)

TC 3.A.1.11.3 / Q44383 MotB, component of Mannopine porter from Agrobacterium tumefaciens (see paper)
    44% identity, 98% coverage of query (261 bits)

TC 3.A.1.20.1 / O54370 BitD, component of The iron transporter, BitABCDEF from Treponema hyodysenteriae (Serpulina hyodysenteriae) (see paper)
    39% identity, 99% coverage of query (260 bits)

Q8YM92 ABC-type polyamine transporter (subunit 3/3) (EC 7.6.2.11) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
    42% identity, 89% coverage of query (258 bits)

1g291 / Q9YGA6 Malk (see paper)
    46% identity, 75% coverage of query (249 bits)

MALK_THELN / Q9YGA6 Trehalose/maltose import ATP-binding protein MalK; EC 7.5.2.1 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 5 papers)
    46% identity, 75% coverage of query (249 bits)

TC 3.A.1.1.24 / TC 3.A.1.1.25 / Q72L52 Sugar-binding transport ATP-binding protein aka MalK1 aka TT_C0211, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    47% identity, 78% coverage of query (249 bits)

2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
    42% identity, 86% coverage of query (247 bits)

TC 3.A.1.1.38 / Q9WYQ2 Glycerol-3-phosphate-transporting ATPase, component of Inositol phosphate porter (Rodionova et al. 2013). Binds inositol phosphate with low Kd and inositol with a lower affinity from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    41% identity, 99% coverage of query (245 bits)

TC 3.A.1.1.16 / Q8TZQ3 MalK aka PF1933, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
    48% identity, 70% coverage of query (245 bits)

YdcT / b1441 putative ABC transporter ATP-binding protein YdcT from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ydcT / P77795 putative ABC transporter ATP-binding protein YdcT from Escherichia coli (strain K12) (see 3 papers)
YDCT_ECOLI / P77795 Uncharacterized ABC transporter ATP-binding protein YdcT from Escherichia coli (strain K12) (see paper)
    41% identity, 93% coverage of query (244 bits)

PotG / b0855 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
PotG / P31134 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 2 papers)
POTG_ECOLI / P31134 Putrescine transport ATP-binding protein PotG; EC 7.6.2.16 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.11.2 / P31134 PotG aka B0855, component of Putrescine porter from Escherichia coli (see 4 papers)
    38% identity, 98% coverage of query (243 bits)

Pf1N1B4_5115 sucrose ABC transporter, ATPase component from Pseudomonas fluorescens FW300-N1B4
    42% identity, 85% coverage of query (243 bits)

TC 3.A.1.1.10 / Q9KWT9 AlgS, component of Alginate (MW 27,000 Da) (and Alginate oligosaccharides) uptake porter. Sphingomonas species A1 is a 'pit-forming' bacterium that directly incorporates alginate into its cytoplasm through a pit-dependent transport system, termed a 'superchannel' (Murata et al., 2008). The pit is a novel organ acquired through the fluidity and reconstitution of cell surface molecules, and through cooperation with the transport machinery in the cells. It confers upon bacterial cells a more efficient way to secure and assimilate macromolecules from Sphingomonas sp (see paper)
algS / BAB03314.1 AlgS from Sphingomonas sp (see paper)
    43% identity, 89% coverage of query (239 bits)

MSMX_BACSU / P94360 Oligosaccharides import ATP-binding protein MsmX; Maltodextrin import ATP-binding protein MsmX; Melibiose/raffinose/stachyose import ATP-binding protein MsmX; EC 7.5.2.- from Bacillus subtilis (strain 168) (see 5 papers)
TC 3.A.1.1.26 / TC 3.A.1.1.34 / P94360 MsmX, component of The maltose porter, MdxEFG and MsmX from Bacillus subtilis (see 3 papers)
    45% identity, 75% coverage of query (233 bits)

B9J850 pterin deaminase (EC 3.5.4.11) from Agrobacterium tumefaciens (see paper)
    43% identity, 85% coverage of query (232 bits)

8hprD Lpqy-sugabc in state 4
    44% identity, 79% coverage of query (232 bits)

TC 3.A.1.10.2 / P74127 FutC aka SLL1878, component of Ferric iron (Fe3+) porter (see paper)
    42% identity, 87% coverage of query (231 bits)

8hprC Lpqy-sugabc in state 4
    44% identity, 79% coverage of query (231 bits)

TC 3.A.1.1.23 / P96483 MsiK protein, component of The cellobiose/cellotriose (and possibly higher cellooligosaccharides), CebEFGMsiK [MsiK functions to energize several ABC transporters including those for maltose/maltotriose and trehalose] from Streptomyces reticuli (see paper)
    39% identity, 97% coverage of query (230 bits)

8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
    44% identity, 79% coverage of query (229 bits)

sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    45% identity, 79% coverage of query (226 bits)

MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
    38% identity, 98% coverage of query (224 bits)

3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
    38% identity, 98% coverage of query (224 bits)

3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
    38% identity, 98% coverage of query (224 bits)

3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
    38% identity, 98% coverage of query (224 bits)

3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
    38% identity, 98% coverage of query (224 bits)

2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
    39% identity, 98% coverage of query (224 bits)

1q12A Crystal structure of the atp-bound e. Coli malk
    38% identity, 98% coverage of query (224 bits)

MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    38% identity, 98% coverage of query (220 bits)

Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
    41% identity, 78% coverage of query (193 bits)

2awnC / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
    36% identity, 95% coverage of query (184 bits)

3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
    35% identity, 83% coverage of query (165 bits)

2awnA / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
    33% identity, 98% coverage of query (160 bits)

Build an alignment

Build an alignment for AZOBR_RS26295 and 37 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
    26% identity, 71% coverage of query (94.0 bits)

8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
    29% identity, 81% coverage of query (88.2 bits)

8sx7A Bovine multidrug resistance protein 4 (mrp4) bound to dhea-s in msp lipid nanodisc
    28% identity, 73% coverage of query (85.9 bits)

8sx8A Bovine multidrug resistance protein 4 (mrp4) bound to prostaglandin e1 in msp lipid nanodisc
    28% identity, 73% coverage of query (85.9 bits)

8bmpB / Q1GBI9 Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp (see paper)
    26% identity, 73% coverage of query (84.7 bits)

5d3mB Folate ecf transporter: amppnp bound state
    26% identity, 73% coverage of query (84.7 bits)

8swnA / F1MUC1 Bovine multidrug resistance protein 4 (mrp4) e1202q mutant bound to atp in msp lipid nanodisc (see paper)
    29% identity, 73% coverage of query (84.3 bits)

8bmsB Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
    26% identity, 73% coverage of query (83.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory