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Searching for up to 100 curated homologs for AZOBR_RS27130 AZOBR_RS27130 polyamine ABC transporter substrate-binding protein (259 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

SMc00140 L-lysine ABC transporter, substrate-binding component from Sinorhizobium meliloti 1021
    41% identity, 99% coverage of query (191 bits)

BPHYT_RS24000 L-histidine ABC transporter, substrate-binding component from Burkholderia phytofirmans PsJN
    39% identity, 90% coverage of query (184 bits)

TC 3.A.1.3.6 / P35120 NocT aka ATU6027 aka AGR_PTI_67, component of Nopaline porter from Agrobacterium tumefaciens (see 3 papers)
    37% identity, 95% coverage of query (180 bits)

TC 3.A.1.3.5 / P0A4F8 Octopine-binding periplasmic protein OccT aka OccJ, component of Octopine porter from Agrobacterium tumefaciens (see 2 papers)
    39% identity, 96% coverage of query (179 bits)

ARGBP_PSEAE / G3XD47 L-arginine-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
TC 3.A.1.3.11 / O50181 AotJ aka PA0888, component of Arginine/ornithine (but not lysine) porter from Pseudomonas aeruginosa (see 2 papers)
    39% identity, 88% coverage of query (176 bits)

5ovzA / P35120 High resolution structure of the pbp noct in complex with nopaline (see paper)
    37% identity, 90% coverage of query (176 bits)

TC 3.A.1.3.23 / Q9HU31 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter periplasmic binding protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    38% identity, 88% coverage of query (176 bits)

5otcA Structure of the periplasmic binding protein (pbp) noct from agrobacterium tumefaciens c58 in complex with noroctopinic acid.
    37% identity, 89% coverage of query (176 bits)

5otaA Structure of the periplasmic binding protein (pbp) noct from agrobacterium tumefaciens c58 in complex with octopinic acid
    37% identity, 89% coverage of query (176 bits)

5ot9A Structure of the periplasmic binding protein (pbp) noct from a.Tumefaciens c58 in complex with histopine.
    37% identity, 89% coverage of query (176 bits)

4powA Structure of the pbp noct in complex with pyronopaline
    37% identity, 89% coverage of query (176 bits)

5itoA Structure of the periplasmic binding protein m117n-noct from a. Tumefaciens in complex with octopine
    37% identity, 90% coverage of query (176 bits)

5orgA / P0A4F8 Structure of the periplasmic binding protein (pbp) occj from a. Tumefaciens b6 in complex with octopine. (see paper)
    40% identity, 89% coverage of query (175 bits)

Pf1N1B4_3431 ABC transporter for L-Arginine and L-Citrulline, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N1B4
    36% identity, 99% coverage of query (172 bits)

PP_3593 L-lysine and D-lysine ABC transporter, substrate-binding component from Pseudomonas putida KT2440
    39% identity, 88% coverage of query (172 bits)

Pf6N2E2_5660 L-Arginine ABC transporter, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    36% identity, 99% coverage of query (171 bits)

AO356_09900 ABC transporter for L-Lysine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    33% identity, 95% coverage of query (170 bits)

AO356_18700 L-Arginine ABC transporter, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    36% identity, 99% coverage of query (169 bits)

AO353_03055 ABC transporter for L-Arginine and L-Citrulline, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E3
    35% identity, 99% coverage of query (168 bits)

ARGT_SALTY / P02911 Lysine/arginine/ornithine-binding periplasmic protein; LAO-binding protein from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 6 papers)
argT / RF|NP_461297.1 lysine/arginine/ornithine ABC transporter, periplasmic lysine/arginine/ornithine-binding protein ArgT from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
    38% identity, 99% coverage of query (168 bits)

HP15_3031 L-arginine ABC transporter, periplasmic substrate-binding component ArtJ/HisJ/ArtI/AotJ/ArgT from Marinobacter adhaerens HP15
    37% identity, 95% coverage of query (165 bits)

ArgT / b2310 lysine/arginine/ornithine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
TC 3.A.1.3.1 / TC 3.A.1.3.29 / P09551 ArgT aka B2310, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (see 5 papers)
    37% identity, 99% coverage of query (164 bits)

5owfA Structure of a lao-binding protein mutant with glutamine
    38% identity, 88% coverage of query (164 bits)

1lafE / P02911 Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
    38% identity, 88% coverage of query (162 bits)

1lstA Three-dimensional structures of the periplasmic lysine-, arginine-, ornithine-binding protein with and without a ligand
    38% identity, 88% coverage of query (162 bits)

1lahE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein
    38% identity, 88% coverage of query (162 bits)

1lagE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein
    38% identity, 88% coverage of query (162 bits)

8hqrA / Q4FLC2 Crystal structure of the arginine-/lysine-binding protein sar11_1210 from 'candidatus pelagibacter ubique' htcc1062 bound to arginine
    38% identity, 92% coverage of query (160 bits)

HISJ_SALTY / P02910 Histidine-binding periplasmic protein; HBP from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
hisJ / GB|AAV76512.1 histidine ABC transporter, periplasmic histidine-binding protein HisJ from Salmonella enterica subsp. enterica serovar Typhimurium (see 5 papers)
    37% identity, 88% coverage of query (159 bits)

1hslA / P0AEU0 Refined 1.89 angstroms structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport(slash)chemosensory receptors (see paper)
    37% identity, 88% coverage of query (159 bits)

HisJ / b2309 histidine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
HISJ_ECOLI / P0AEU0 Histidine-binding periplasmic protein; HBP from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.29 / P0AEU0 Histidine-binding periplasmic protein, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
hisJ / GB|AAC75369.1 histidine ABC transporter, periplasmic histidine-binding protein HisJ from Escherichia coli (see 7 papers)
    37% identity, 88% coverage of query (158 bits)

BPHYT_RS07735 ABC transporter for L-Arginine, periplasmic substrate-binding component from Burkholderia phytofirmans PsJN
    36% identity, 88% coverage of query (155 bits)

ArtI / b0863 putative ABC transporter periplasmic binding protein ArtI from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ARTI_ECOLI / P30859 Putative ABC transporter arginine-binding protein 2 from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.3 / P30859 ArtI aka B0863, component of Arginine porter from Escherichia coli (see 7 papers)
    37% identity, 86% coverage of query (154 bits)

PS417_21745 ABC transporter for L-Arginine, substrate-binding component from Pseudomonas simiae WCS417
    33% identity, 99% coverage of query (154 bits)

ArtJ / b0860 L-arginine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see paper)
ArtJ / P30860 L-arginine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli (strain K12) (see paper)
ARTJ_ECOLI / P30860 ABC transporter arginine-binding protein 1 from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.3 / P30860 ArtJ aka B0860, component of Arginine porter from Escherichia coli (see 7 papers)
artJ / GB|BAA35574.1 arginine ABC transporter, periplasmic arginine-binding protein ArtJ from Escherichia coli K12 (see 8 papers)
    32% identity, 97% coverage of query (144 bits)

Pf6N2E2_2958 ABC transporter for L-Lysine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    34% identity, 97% coverage of query (142 bits)

AO356_05495 ABC transporter for L-Lysine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    33% identity, 97% coverage of query (140 bits)

3tqlA / Q83E49 Structure of the amino acid abc transporter, periplasmic amino acid- binding protein from coxiella burnetii. (see paper)
    32% identity, 86% coverage of query (137 bits)

4zv1A An ancestral arginine-binding protein bound to arginine (see paper)
    34% identity, 86% coverage of query (132 bits)

4zv2A An ancestral arginine-binding protein bound to glutamine
    33% identity, 86% coverage of query (132 bits)

3i6vA / Q5LTV6 Crystal structure of a periplasmic his/glu/gln/arg/opine family- binding protein from silicibacter pomeroyi in complex with lysine
    37% identity, 86% coverage of query (129 bits)

3vvdA / Q72JG5 Crystal structure of ttc0807 complexed with ornithine (see paper)
    35% identity, 86% coverage of query (121 bits)

3vv5A Crystal structure of ttc0807 complexed with (s)-2-aminoethyl-l- cysteine (aec)
    35% identity, 86% coverage of query (121 bits)

3vvfA Crystal structure of ttc0807 complexed with arginine
    35% identity, 86% coverage of query (121 bits)

3vveA Crystal structure of ttc0807 complexed with lysine
    35% identity, 86% coverage of query (121 bits)

Build an alignment

Build an alignment for AZOBR_RS27130 and 45 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

2y7iA / Q8ZKA9 Structural basis for high arginine specificity in salmonella typhimurium periplasmic binding protein stm4351. (see paper)
    29% identity, 86% coverage of query (120 bits)

TcyJ / b1920 cystine ABC transporter periplasmic binding protein (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
tcyJ / P0AEM9 cystine ABC transporter periplasmic binding protein (EC 7.4.2.12) from Escherichia coli (strain K12) (see 13 papers)
TCYJ_ECOLI / P0AEM9 L-cystine-binding protein TcyJ; CBP; Protein FliY; Sulfate starvation-induced protein 7; SSI7 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.3.10 / P0AEM9 Cystine-binding periplasmic protein FLIY aka CysX aka B1920, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 7 papers)
    33% identity, 89% coverage of query (115 bits)

AAC45332.1 high affinity cystine binding protein from Lactobacillus reuteri (see 4 papers)
    28% identity, 98% coverage of query (100 bits)

6svfA / Q9WZ62 Crystal structure of the p235gk mutant of argbp from t. Maritima (see paper)
    29% identity, 86% coverage of query (98.2 bits)

2q2aA / D0VWX8 Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus (see paper)
    28% identity, 85% coverage of query (94.7 bits)

2pvuA Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus
    28% identity, 85% coverage of query (94.7 bits)

2q2cA Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus
    28% identity, 85% coverage of query (94.4 bits)

5t0wA Crystal structure of the ancestral amino acid-binding protein anccdt- 1, a precursor of cyclohexadienyl dehydratase
    27% identity, 86% coverage of query (94.0 bits)

Ac3H11_2555 ABC transporter for L-Histidine, periplasmic substrate-binding component 1 from Acidovorax sp. GW101-3H11
    30% identity, 90% coverage of query (93.6 bits)

TC 3.A.1.3.17 / Q8YSA2 Basic amino acid uptake transporter, BgtAB (see paper)
    28% identity, 97% coverage of query (92.0 bits)

ARTP_BACSU / P54535 Arginine-binding extracellular protein ArtP from Bacillus subtilis (strain 168) (see paper)
    28% identity, 87% coverage of query (87.4 bits)

3k4uE / Q7MAG0 Crystal structure of putative binding component of abc transporter from wolinella succinogenes dsm 1740 complexed with lysine
    26% identity, 86% coverage of query (85.1 bits)

YXEM_BACSU / P54952 Probable amino-acid-binding protein YxeM from Bacillus subtilis (strain 168) (see 2 papers)
    26% identity, 92% coverage of query (80.9 bits)

4ohnA / A0A0H2UKY8 Crystal structure of an abc uptake transporter substrate binding protein from streptococcus pneumoniae with bound histidine
    27% identity, 88% coverage of query (78.6 bits)

2ylnA / Q5F9M1 Crystal structure of the l-cystine solute receptor of neisseria gonorrhoeae in the closed conformation (see paper)
    27% identity, 85% coverage of query (75.9 bits)

8gtuA / C6XGT2 Crystal structure of putative amino acid binding periplasmic abc transporter protein from candidatus liberibacter asiaticus in complex with clidinium (see paper)
    25% identity, 88% coverage of query (73.2 bits)

8gu1A Crystal structure of putative amino acid binding periplasmic abc transporter protein from candidatus liberibacter asiaticus in complex with pimozide
    25% identity, 87% coverage of query (72.0 bits)

6aalA Crystal structure of putative amino acid binding periplasmic abc transporter protein from candidatus liberibacter asiaticus in complex with arginine
    25% identity, 87% coverage of query (72.0 bits)

6a80A Crystal structure of putative amino acid binding periplasmic abc transporter protein from candidatus liberibacter asiaticus in complex with cystine
    25% identity, 87% coverage of query (72.0 bits)

5lomB / Q7D447 Crystal structure of the pbp soca from agrobacterium tumefaciens c58 in complex with dfg at 1.5 a resolution (see paper)
    26% identity, 89% coverage of query (72.0 bits)

5l9oA Crystal structure of agrobacterium tumefaciens c58 strain pbp soca in complex with glucopine
    26% identity, 89% coverage of query (72.0 bits)

5l9oB Crystal structure of agrobacterium tumefaciens c58 strain pbp soca in complex with glucopine
    26% identity, 89% coverage of query (72.0 bits)

8eyzA / P0AEQ3 Engineered glutamine binding protein bound to gln and a cobaloxime ligand (see paper)
    26% identity, 86% coverage of query (67.8 bits)

3qaxB / Q9Z869 Crystal structure analysis of the cpb0502
    23% identity, 85% coverage of query (66.2 bits)

ARTJ_CHLPN / Q9Z869 Probable ABC transporter arginine-binding protein ArtJ from Chlamydia pneumoniae (Chlamydophila pneumoniae) (see 2 papers)
    23% identity, 85% coverage of query (66.2 bits)

4eq9A / Q8DRG2 1.4 angstrom crystal structure of abc transporter glutathione-binding protein gsht from streptococcus pneumoniae strain canada mdr_19a in complex with glutathione
    23% identity, 88% coverage of query (62.0 bits)

4kqpA / Q9CES5 Crystal structure of lactococcus lactis glnp substrate binding domain 2 (sbd2) in complex with glutamine at 0.95 a resolution (see paper)
    24% identity, 86% coverage of query (61.6 bits)

1xt8B / Q0P9S0 Crystal structure of cysteine-binding protein from campylobacter jejuni at 2.0 a resolution (see paper)
    25% identity, 84% coverage of query (60.5 bits)

4i62A / A0A0H2ZN67 1.05 angstrom crystal structure of an amino acid abc transporter substrate-binding protein abpa from streptococcus pneumoniae canada mdr_19a bound to l-arginine
    25% identity, 85% coverage of query (60.1 bits)

2q89A Crystal structure of ehub in complex with hydroxyectoine
    25% identity, 85% coverage of query (59.7 bits)

2q88A / Q92WC8 Crystal structure of ehub in complex with ectoine (see paper)
    25% identity, 85% coverage of query (59.7 bits)

2yjpA / Q5F5B5 Crystal structure of the solute receptors for l-cysteine of neisseria gonorrhoeae (see paper)
    27% identity, 83% coverage of query (59.3 bits)

4h5fA Crystal structure of an amino acid abc transporter substrate-binding protein from streptococcus pneumoniae canada mdr_19a bound to l- arginine, form 1
    26% identity, 83% coverage of query (58.2 bits)

4nf4A Crystal structure of glun1/glun2a ligand-binding domain in complex with dcka and glutamate
    25% identity, 71% coverage of query (57.8 bits)

5tpaB Structure of the human glun1/glun2a lbd in complex with compound 9 (gne3500)
    26% identity, 70% coverage of query (57.4 bits)

5i2kB Structure of the human glun1/glun2a lbd in complex with 7-{[ethyl(4- fluorophenyl)amino]methyl}-n,2-dimethyl-5-oxo-5h-[1,3]thiazolo[3,2- a]pyrimidine-3-carboxamide (compound 19)
    25% identity, 75% coverage of query (56.6 bits)

1pbqA Crystal structure of the nr1 ligand binding core in complex with 5,7- dichlorokynurenic acid (dcka) at 1.90 angstroms resolution
    25% identity, 70% coverage of query (56.6 bits)

1y1zA Crystal structure of the nr1 ligand binding core in complex with acbc
    25% identity, 70% coverage of query (56.6 bits)

4kfqA Crystal structure of the nmda receptor glun1 ligand binding domain in complex with 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]quinoxalin- 4(5h)-one
    25% identity, 70% coverage of query (56.6 bits)

1pb9A Crystal structure of the nr1 ligand binding core in complex with d- cycloserine at 1.60 angstroms resolution
    25% identity, 70% coverage of query (56.6 bits)

5tp9B Structure of the human glun1/glun2a lbd in complex with compound 2 (gne9178)
    25% identity, 75% coverage of query (56.6 bits)

5kdtB Structure of the human glun1/glun2a lbd in complex with gne0723
    25% identity, 75% coverage of query (56.6 bits)

1pb8A Crystal structure of the nr1 ligand binding core in complex with d- serine at 1.45 angstroms resolution
    25% identity, 70% coverage of query (56.2 bits)

5h8nB Structure of the human glun1/glun2a lbd in complex with nam
    25% identity, 75% coverage of query (56.2 bits)

1pbqB / P35439 Crystal structure of the nr1 ligand binding core in complex with 5,7- dichlorokynurenic acid (dcka) at 1.90 angstroms resolution (see paper)
    25% identity, 70% coverage of query (56.2 bits)

1y20A Crystal structure of the nr1 ligand-binding core in complex with acpc
    25% identity, 70% coverage of query (56.2 bits)

5i56A Agonist-bound glun1/glun2a agonist binding domains with tcn201
    25% identity, 70% coverage of query (56.2 bits)

5h8qB Structure of the human glun1/glun2a lbd in complex with gne8324
    25% identity, 75% coverage of query (56.2 bits)

5i2nB Structure of the human glun1/glun2a lbd in complex with n-ethyl-7-{[2- fluoro-3-(trifluoromethyl)phenyl]methyl}-2-methyl-5-oxo-5h-[1, 3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 29)
    25% identity, 74% coverage of query (55.8 bits)

5h8hB Structure of the human glun1/glun2a lbd in complex with gne3419
    25% identity, 74% coverage of query (55.8 bits)

5i59A Glutamate- and glycine-bound glun1/glun2a agonist binding domains with mpx 007
    25% identity, 73% coverage of query (55.8 bits)

5kcjB Structure of the human glun1/glun2a lbd in complex with gne6901
    25% identity, 74% coverage of query (55.8 bits)

5eyfB / Q3XZW5 Crystal structure of solute-binding protein from enterococcus faecium with bound glutamate
    27% identity, 79% coverage of query (54.7 bits)

7yfgC / P35439 Structure of the rat glun1-glun2c nmda receptor in complex with glycine and glutamate (major class in asymmetry) (see paper)
    25% identity, 70% coverage of query (52.0 bits)

4c0rA / Q93DA5 Molecular and structural basis of glutathione import in gram-positive bacteria via gsht and the cystine abc importer tcybc of streptococcus mutans. (see paper)
    23% identity, 86% coverage of query (50.1 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory