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Searching for up to 100 curated homologs for AZOBR_RS29845 FitnessBrowser__azobra:AZOBR_RS29845 (342 a.a.)

Found high-coverage hits (≥70%) to 61 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

iolG / Q9WYP5 myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
IOLG_THEMA / Q9WYP5 Myo-inositol 2-dehydrogenase; EC 1.1.1.18 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
Q9WYP5 D-chiro-inositol 1-dehydrogenase (EC 1.1.1.369) from Thermotoga maritima (see paper)
    32% identity, 73% coverage of query (111 bits)

Build an alignment

Build an alignment for AZOBR_RS29845 and 1 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

3q2kK / Q79H45 Crystal structure of the wlba dehydrogenase from bordetella pertussis in complex with nadh and udp-glcnaca (see paper)
    28% identity, 99% coverage of query (110 bits)

3q2kC / Q79H45 Crystal structure of the wlba dehydrogenase from bordetella pertussis in complex with nadh and udp-glcnaca (see paper)
    27% identity, 99% coverage of query (105 bits)

3e18A / Q929L3 Crystal structure of NAD-binding protein from listeria innocua
    26% identity, 97% coverage of query (100 bits)

2glxA / Q2I8V6 Crystal structure analysis of bacterial 1,5-af reductase (see paper)
    32% identity, 85% coverage of query (95.1 bits)

5a03C / Q9A8X3 Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with xylose (see paper)
    27% identity, 97% coverage of query (95.1 bits)

5a06A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with sorbitol
    27% identity, 97% coverage of query (95.1 bits)

5a05A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with maltotriose
    27% identity, 97% coverage of query (95.1 bits)

5a04A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with glucose
    27% identity, 97% coverage of query (95.1 bits)

5a03E Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with xylose
    27% identity, 97% coverage of query (95.1 bits)

5a02A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with glycerol
    27% identity, 97% coverage of query (95.1 bits)

APSD_PARG4 / B1G894 D-apiose dehydrogenase; EC 1.1.1.420 from Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M) (see paper)
    28% identity, 97% coverage of query (94.7 bits)

3q2iA / Q7NQL0 Crystal structure of the wlba dehydrognase from chromobactrium violaceum in complex with nadh and udp-glcnaca at 1.50 a resolution (see paper)
    27% identity, 99% coverage of query (94.4 bits)

HSERO_RS12095 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Herbaspirillum seropedicae SmR1
    29% identity, 94% coverage of query (94.0 bits)

afr / Q2I8V6 1,5-anhydro-D-fructose reductase (EC 1.1.1.292) from Ensifer adhaerens (see 3 papers)
AFR_ENSAD / Q2I8V6 1,5-anhydro-D-fructose reductase; Anhydrofructose reductase; 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming); EC 1.1.1.292 from Ensifer adhaerens (Sinorhizobium morelense) (see 2 papers)
Q2I8V6 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Ensifer adhaerens (see 2 papers)
    31% identity, 85% coverage of query (94.0 bits)

Q92KZ3 1,5-anhydro-D-fructose reductase (EC 1.1.1.263); 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Sinorhizobium meliloti (see paper)
4koaA / Q92KZ3 Crystal structure analysis of 1,5-anhydro-d-fructose reductase from sinorhizobium meliloti (see paper)
    33% identity, 85% coverage of query (94.0 bits)

Q7NQL0 UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase (EC 1.1.1.335) from Chromobacterium violaceum (see paper)
    26% identity, 99% coverage of query (90.5 bits)

iolX / P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (strain 168) (see paper)
IOLX_BACSU / P40332 scyllo-inositol 2-dehydrogenase (NAD(+)); EC 1.1.1.370 from Bacillus subtilis (strain 168) (see paper)
P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (see 2 papers)
    25% identity, 74% coverage of query (84.7 bits)

XDH2_HALVD / D4GP30 D-xylose 1-dehydrogenase (NADP(+)) 2; XDH 2; EC 1.1.1.179 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
D4GP30 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) (EC 1.1.1.179) from Haloferax volcanii (see paper)
    29% identity, 97% coverage of query (79.7 bits)

iolW / O32223 scyllo-inositol dehydrogenase (NADP+) (EC 1.1.1.371) from Bacillus subtilis (strain 168) (see paper)
IOLW_BACSU / O32223 scyllo-inositol 2-dehydrogenase (NADP(+)) IolW; NADP(+)-dependent scyllo-inositol dehydrogenase 1; NADP(+)-dependent SI dehydrogenase 1; EC 1.1.1.371 from Bacillus subtilis (strain 168) (see 3 papers)
O32223 scyllo-inositol 2-dehydrogenase (NADP+) (EC 1.1.1.371) from Bacillus subtilis (see 2 papers)
    24% identity, 96% coverage of query (78.2 bits)

1zh8A / Q9WYE8 Crystal structure of oxidoreductase (tm0312) from thermotoga maritima at 2.50 a resolution
    27% identity, 76% coverage of query (77.0 bits)

YhhX / b3440 putative oxidoreductase YhhX from Escherichia coli K-12 substr. MG1655 (see 6 papers)
yhhX / RF|NP_417897 uncharacterized oxidoreductase yhhX from Escherichia coli K12 (see 2 papers)
    27% identity, 78% coverage of query (76.6 bits)

NanY / b4280 KpLE2 phage-like element; 2,7-anhydro-N-acetylneuraminate hydratase from Escherichia coli K-12 substr. MG1655 (see 4 papers)
nanY / P39353 KpLE2 phage-like element; 2,7-anhydro-N-acetylneuraminate hydratase from Escherichia coli (strain K12) (see 6 papers)
YJHC_ECOLI / P39353 Uncharacterized oxidoreductase YjhC; EC 1.-.-.- from Escherichia coli (strain K12) (see paper)
    25% identity, 78% coverage of query (76.6 bits)

6o15A / P39353 Crystal structure of a putative oxidoreductase yjhc from escherichia coli in complex with NAD(h) (see paper)
    25% identity, 78% coverage of query (75.9 bits)

dfgE / I5AX46 C-glycoside oxidase (EC 1.1.3.50) from [Eubacterium] cellulosolvens 6 (see 2 papers)
    21% identity, 97% coverage of query (75.1 bits)

1h6dA / Q07982 Oxidized precursor form of glucose-fructose oxidoreductase from zymomonas mobilis complexed with glycerol (see paper)
    24% identity, 97% coverage of query (71.2 bits)

gfo / Q07982 glucose-fructose oxidoreductase (EC 1.1.99.28) from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see paper)
Q07982 glucose-fructose oxidoreductase (EC 1.1.99.28) from Zymomonas mobilis (see 4 papers)
    24% identity, 97% coverage of query (70.9 bits)

1rydA Crystal structure of glucose-fructose oxidoreductase from zymomonas mobilis
    24% identity, 97% coverage of query (70.9 bits)

6jw7A / Q6L737 The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin a (see paper)
    31% identity, 77% coverage of query (70.1 bits)

6jw8A The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin b
    31% identity, 77% coverage of query (70.1 bits)

6jw6A The crystal structure of kand2 in complex with NAD
    31% identity, 80% coverage of query (70.1 bits)

1evjA Crystal structure of glucose-fructose oxidoreductase (gfor) delta1-22 s64d
    24% identity, 97% coverage of query (68.6 bits)

Q9DBB8 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) from Mus musculus (see paper)
    26% identity, 75% coverage of query (68.2 bits)

A0A064C3N0 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Streptococcus pneumoniae (see paper)
    23% identity, 74% coverage of query (67.0 bits)

7xr9A Crystal structure of dgpa with glucose
    23% identity, 95% coverage of query (66.2 bits)

YdgJ / b1624 putative oxidoreductase YdgJ from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ydgJ / RF|NP_416141 uncharacterized oxidoreductase ydgJ from Escherichia coli K12 (see 2 papers)
    26% identity, 97% coverage of query (65.9 bits)

UGNO_METMP / Q6M0B9 UDP-N-acetylglucosamine 3-dehydrogenase; UDP-GlcNAc oxidoreductase; UDP-N-acetyl-alpha-D-glucosamine:NAD(+) 3-oxidoreductase; EC 1.1.1.374 from Methanococcus maripaludis (strain S2 / LL) (see paper)
Q6M0B9 UDP-N-acetylglucosamine 3-dehydrogenase (EC 1.1.1.374) from Methanococcus maripaludis (see paper)
    23% identity, 96% coverage of query (65.9 bits)

3m2tA / Q7NY68 The crystal structure of dehydrogenase from chromobacterium violaceum
    24% identity, 95% coverage of query (63.9 bits)

Q9EZV8 inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium fredii (see paper)
    30% identity, 78% coverage of query (63.9 bits)

7xreC / A0A3Q9WWX8 Crystal structure of dgpa
    23% identity, 81% coverage of query (63.2 bits)

Echvi_3375 predicted 3-ketohexose reductase from Echinicola vietnamensis KMM 6221, DSM 17526
    24% identity, 75% coverage of query (62.8 bits)

dgpA / A0A3Q9WWX8 puerarin 3-dehydrogenase from human intestinal bacterium PUE (see 5 papers)
    24% identity, 81% coverage of query (60.8 bits)

SM_b20330 glucoside 3-dehydrogenase; active on raffinose or trehalose (thuB) (EC 1.1.99.13) from Sinorhizobium meliloti 1021
    28% identity, 73% coverage of query (59.7 bits)

K7ZP76 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Paracoccus laeviglucosivorans (see paper)
lgdA / BAM68195.1 scyllo-inositol dehydrogenase with L-glucose dehydrogenase activity from Paracoccus laeviglucosivorans (see 2 papers)
    27% identity, 96% coverage of query (59.7 bits)

5yaqB Crystal structure of scyllo-inositol dehydrogenase with l-glucose dehydrogenase activity complexed with scyllo-inosose
    27% identity, 96% coverage of query (58.9 bits)

5ya8A Crystal structure of scyllo-inositol dehydrogenase with l-glucose dehydrogenase activity complexed with myo-inositol
    27% identity, 96% coverage of query (58.9 bits)

E1U887 inositol 2-dehydrogenase (EC 1.1.1.18) from Lacticaseibacillus casei (see paper)
    27% identity, 79% coverage of query (58.5 bits)

4minA / A0A0J9X1Y2 Crystal structure of myo-inositol dehydrogenase from lactobacillus casei with bound cofactor NAD
    27% identity, 79% coverage of query (58.2 bits)

4mjlD Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD and d-chiro-inositol
    27% identity, 79% coverage of query (58.2 bits)

4mioD Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD(h) and myo-inositol
    27% identity, 79% coverage of query (58.2 bits)

4mioA Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD(h) and myo-inositol
    27% identity, 79% coverage of query (58.2 bits)

Q148L6 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) from Bos taurus (see paper)
    26% identity, 75% coverage of query (57.8 bits)

IOLU_BACSU / O05265 scyllo-inositol 2-dehydrogenase (NADP(+)) IolU; NADP(+)-dependent scyllo-inositol dehydrogenase 2; NADP(+)-dependent SI dehydrogenase 2; EC 1.1.1.371 from Bacillus subtilis (strain 168) (see 2 papers)
O05265 scyllo-inositol 2-dehydrogenase (NADP+) (EC 1.1.1.371) from Bacillus subtilis (see paper)
    26% identity, 77% coverage of query (57.4 bits)

PS417_11875 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas simiae WCS417
    27% identity, 78% coverage of query (57.0 bits)

DHDH_PIG / Q9TV69 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Dimeric dihydrodiol dehydrogenase; Sus2DD; EC 1.3.1.20; EC 1.1.1.179 from Sus scrofa (Pig) (see 3 papers)
    27% identity, 74% coverage of query (57.0 bits)

6ktkC / K7ZP76 Crystal structure of scyllo-inositol dehydrogenase r178a mutant, complexed with nadh and l-glucono-1,5-lactone, from paracoccus laeviglucosivorans (see paper)
    27% identity, 96% coverage of query (56.6 bits)

AO356_23190 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas fluorescens FW300-N2C3
    28% identity, 78% coverage of query (56.6 bits)

AO353_21365 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas fluorescens FW300-N2E3
    27% identity, 78% coverage of query (54.7 bits)

3ceaA / F9ULF9 Crystal structure of myo-inositol 2-dehydrogenase (np_786804.1) from lactobacillus plantarum at 2.40 a resolution
    22% identity, 98% coverage of query (51.2 bits)

8qc8D Crystal structure of NAD-dependent glycoside hydrolase from flavobacterium sp. (Strain k172) in complex with co-factor NAD+ (see paper)
    24% identity, 72% coverage of query (44.7 bits)

4n54A / A0A0J9X1Y7 Crystal structure of scyllo-inositol dehydrogenase from lactobacillus casei with bound cofactor NAD(h) and scyllo-inositol
    21% identity, 73% coverage of query (44.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory