Searching for up to 100 curated homologs for Ac3H11_1156 FitnessBrowser__acidovorax_3H11:Ac3H11_1156 (298 a.a.)
Found high-coverage hits (≥70%) to 39 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
T23O_CUPMC / Q1LK00 Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans) (see 2 papers)
kynA tryptophan 2,3-dioxygenase; EC 1.13.11.11 from Ralstonia metallidurans CH34 (see 2 papers)
67% identity, 100% coverage of query (400 bits)
RR42_RS15390 Tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Cupriavidus basilensis FW507-4G11
67% identity, 99% coverage of query (400 bits)
2noxB / Q1LK00 Crystal structure of tryptophan 2,3-dioxygenase from ralstonia metallidurans (see paper)
69% identity, 91% coverage of query (384 bits)
AO353_05970 Tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Pseudomonas fluorescens FW300-N2E3
61% identity, 100% coverage of query (365 bits)
PS417_23705 Tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Pseudomonas simiae WCS417
60% identity, 100% coverage of query (363 bits)
PfGW456L13_4292 Tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Pseudomonas fluorescens GW456-L13
61% identity, 100% coverage of query (361 bits)
T23O_PSEFL / Q84HF6 Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Pseudomonas fluorescens (see paper)
56% identity, 100% coverage of query (335 bits)
T23O_XANCP / Q8PDA8 Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see 2 papers)
Q8PDA8 tryptophan 2,3-dioxygenase (EC 1.13.11.11); indoleamine 2,3-dioxygenase (EC 1.13.11.52) from Xanthomonas campestris pv. campestris (see 6 papers)
kynA tryptophan 2,3-dioxygenase; EC 1.13.11.11 from Xanthomonas campestris pv. campestris (see 3 papers)
49% identity, 90% coverage of query (257 bits)
2nw9A Crystal structure of tryptophan 2,3-dioxygenase (tdo) from xanthomonas campestris in complex with ferrous heme and 6-fluoro-tryptophan. Northeast structural genomics target xcr13
49% identity, 88% coverage of query (255 bits)
7p46A / Q8PDA8 Crystal structure of xanthomonas campestris tryptophan 2,3-dioxygenase (tdo) (see paper)
48% identity, 90% coverage of query (254 bits)
1yw0A Crystal structure of the tryptophan 2,3-dioxygenase from xanthomonas campestris. Northeast structural genomics target xcr13.
45% identity, 88% coverage of query (214 bits)
acmG / D6R243 tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Streptomyces anulatus (see 3 papers)
40% identity, 87% coverage of query (188 bits)
sibP / C0LTN0 tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Streptosporangium sibiricum (see paper)
39% identity, 87% coverage of query (176 bits)
A9V766 tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Monosiga brevicollis (see paper)
31% identity, 98% coverage of query (128 bits)
T23O_DROME / P20351 Tryptophan 2,3-dioxygenase; TDO; Protein vermilion; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Drosophila melanogaster (Fruit fly) (see 2 papers)
P20351 tryptophan 2,3-dioxygenase (EC 1.13.11.11); indoleamine 2,3-dioxygenase (EC 1.13.11.52) from Drosophila melanogaster (see 3 papers)
31% identity, 95% coverage of query (120 bits)
4hkaA / P20351 Crystal structure of drosophila melanogaster tryptophan 2,3- dioxygenase in complex with heme (see paper)
32% identity, 82% coverage of query (119 bits)
Build an alignment for Ac3H11_1156 and 16 homologs with ≥ 30% identity
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P48776 tryptophan 2,3-dioxygenase (EC 1.13.11.11); indoleamine 2,3-dioxygenase (EC 1.13.11.52) from Mus musculus (see 2 papers)
29% identity, 100% coverage of query (116 bits)
5ti9C Crystal structure of human tdo in complex with trp and dioxygen, northeast structural genomics consortium target hr6161
29% identity, 88% coverage of query (115 bits)
T23O_AEDAE / Q17P71 Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Aedes aegypti (Yellowfever mosquito) (Culex aegypti) (see paper)
29% identity, 88% coverage of query (114 bits)
T23O_RAT / P21643 Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Rattus norvegicus (Rat) (see paper)
P21643 tryptophan 2,3-dioxygenase (EC 1.13.11.11); indoleamine 2,3-dioxygenase (EC 1.13.11.52) from Rattus norvegicus (see 2 papers)
29% identity, 94% coverage of query (112 bits)
6pyzC / P48775 Crystal structure of human tryptophan 2,3-dioxygenase in complex with pf-06840003 in active site (see paper)
30% identity, 88% coverage of query (110 bits)
TDO2 / P48775 tryptophan 2,3-dioxygenase monomer (EC 1.13.11.11) from Homo sapiens (see 4 papers)
T23O_HUMAN / P48775 Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Homo sapiens (Human) (see 3 papers)
P48775 tryptophan 2,3-dioxygenase (EC 1.13.11.11); indoleamine 2,3-dioxygenase (EC 1.13.11.52) from Homo sapiens (see 10 papers)
28% identity, 100% coverage of query (109 bits)
6pyzA / P48775 Crystal structure of human tryptophan 2,3-dioxygenase in complex with pf-06840003 in active site (see paper)
28% identity, 88% coverage of query (107 bits)
5ti9A Crystal structure of human tdo in complex with trp and dioxygen, northeast structural genomics consortium target hr6161
28% identity, 88% coverage of query (107 bits)
6vbnA Crystal structure of htdo2 bound to inhibitor gne1
29% identity, 87% coverage of query (107 bits)
T23O_CAEEL / Q09474 Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Caenorhabditis elegans (see 2 papers)
Q09474 tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Caenorhabditis elegans (see paper)
28% identity, 87% coverage of query (102 bits)
6a4iD / P48775 Crystal structure of human tdo inhibitor complex
32% identity, 78% coverage of query (101 bits)
8qv7B / P48775 Crystal structure of human tdo with alpha-methyl-l-tryptophan
30% identity, 77% coverage of query (101 bits)
6a4iA Crystal structure of human tdo inhibitor complex
28% identity, 87% coverage of query (99.0 bits)
6a4iB Crystal structure of human tdo inhibitor complex
29% identity, 88% coverage of query (97.8 bits)
8r5qC Structure of apo tdo with a bound inhibitor
29% identity, 77% coverage of query (96.3 bits)
8r5qA Structure of apo tdo with a bound inhibitor
29% identity, 77% coverage of query (95.5 bits)
8r5qB Structure of apo tdo with a bound inhibitor
29% identity, 77% coverage of query (95.5 bits)
7lu7CCC Tryptophan 2,3-dioxygenase
28% identity, 77% coverage of query (91.7 bits)
7lu7AAA Tryptophan 2,3-dioxygenase
28% identity, 77% coverage of query (90.5 bits)
5ti9D Crystal structure of human tdo in complex with trp and dioxygen, northeast structural genomics consortium target hr6161
27% identity, 88% coverage of query (88.6 bits)
swb10 / D2KTX9 β-hydroxy-L-tryptophan 2,3-dioxygenase from Streptomyces sp. SNA15896 (see 2 papers)
27% identity, 88% coverage of query (83.2 bits)
tioF / Q333W0 β-hydroxy-L-tryptophan 2,3-dioxygenase from Micromonospora sp. ML1 (see 2 papers)
24% identity, 88% coverage of query (78.6 bits)
ecm11 / Q0X0B4 β-hydroxy-L-tryptophan 2,3-dioxygenase from Streptomyces lasalocidi (see 2 papers)
25% identity, 84% coverage of query (60.1 bits)
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Lawrence Berkeley National Laboratory