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Searching for up to 100 curated homologs for Ac3H11_1601 FitnessBrowser__acidovorax_3H11:Ac3H11_1601 (561 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q8U2A4 acetolactate synthase (EC 2.2.1.6) from Pyrococcus furiosus (see paper)
    31% identity, 95% coverage of query (266 bits)

ILVG_ECOLI / P0DP90 Acetolactate synthase isozyme 2 large subunit; AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit; EC 2.2.1.6 from Escherichia coli (strain K12) (see 2 papers)
ilvG / GB|CAA28573.1 acetolactate synthase isozyme 2 large subunit; EC 2.2.1.6 from Escherichia coli K12 (see 8 papers)
    31% identity, 95% coverage of query (241 bits)

P42463 acetolactate synthase (EC 2.2.1.6) from Corynebacterium glutamicum (see paper)
    30% identity, 95% coverage of query (236 bits)

ILVB1_MYCTU / P9WG41 Acetolactate synthase large subunit IlvB1; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WG41 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Mycobacterium tuberculosis (see paper)
    31% identity, 96% coverage of query (233 bits)

IlvI / b0077 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
ilvI / P00893 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli (strain K12) (see 7 papers)
P00893 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli (see paper)
    30% identity, 92% coverage of query (229 bits)

SYNPCC7002_A2770 / B1XMM5 2-oxoglutarate decarboxylase monomer (EC 4.1.1.71) from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (see 2 papers)
B1XMM5 oxoglutarate dehydrogenase (succinyl-transferring) (EC 1.2.4.2) from Synechococcus sp. PCC 7002 (see paper)
    30% identity, 94% coverage of query (229 bits)

Q5SJ01 acetolactate synthase (EC 2.2.1.6); pyruvate decarboxylase (EC 4.1.1.1) from Thermus thermophilus (see paper)
    32% identity, 91% coverage of query (228 bits)

Q5S3P7 acetolactate synthase (EC 2.2.1.6) from Streptomyces cinnamonensis (see 2 papers)
ilvB / AAV52901.1 acetohydroxy acid synthase large subunit from Streptomyces cinnamonensis (see paper)
    30% identity, 95% coverage of query (228 bits)

Build an alignment

Build an alignment for Ac3H11_1601 and 8 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

ilv1 / RF|NP_595382.1 acetolactate synthase catalytic subunit; EC 2.2.1.6 from Schizosaccharomyces pombe (see 2 papers)
    29% identity, 96% coverage of query (227 bits)

Q8RL88 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Geobacillus stearothermophilus (see paper)
ilvB / AAL99356.1 acetohydroxy acid synthase large subunit from Geobacillus stearothermophilus (see paper)
    30% identity, 94% coverage of query (224 bits)

P37251 acetolactate synthase (EC 2.2.1.6) from Bacillus subtilis (see paper)
    29% identity, 90% coverage of query (223 bits)

G0ZSE6 acetolactate synthase (EC 2.2.1.6) from Pseudomonas sp. (see paper)
    29% identity, 93% coverage of query (221 bits)

ilvB / AAB38426.1 acetolactate synthase from Mycobacterium avium (see paper)
    31% identity, 95% coverage of query (218 bits)

P45261 acetolactate synthase (EC 2.2.1.6) from Haemophilus influenzae (see paper)
    27% identity, 92% coverage of query (213 bits)

5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam
    28% identity, 96% coverage of query (211 bits)

ilvB / Q0KCU4 acetohydroxyacid synthase subunit B (EC 2.2.1.6) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
    29% identity, 94% coverage of query (210 bits)

1t9bA / P07342 Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
    28% identity, 96% coverage of query (210 bits)

als / CAA66718.1 acetolactate synthase from Synechocystis sp (see paper)
    28% identity, 94% coverage of query (209 bits)

Q42768 acetolactate synthase (EC 2.2.1.6) from Gossypium hirsutum (see paper)
    28% identity, 95% coverage of query (209 bits)

7egvA / A0A2N1LPC4 Acetolactate synthase from trichoderma harzianum with inhibitor harzianic acid (see paper)
    29% identity, 96% coverage of query (209 bits)

1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
    28% identity, 96% coverage of query (209 bits)

1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl
    28% identity, 96% coverage of query (209 bits)

1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron
    28% identity, 96% coverage of query (209 bits)

6u9dB / P07342 Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
    28% identity, 96% coverage of query (208 bits)

ilvB / AAA93098.1 acetolactate synthase from Streptomyces avermitilis (see paper)
    29% identity, 96% coverage of query (208 bits)

G4MMK2 acetolactate synthase (subunit 1/2) (EC 2.2.1.6) from Pyricularia oryzae (see paper)
    28% identity, 96% coverage of query (208 bits)

ILVB_YEAST / P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P07342 acetolactate synthase (EC 2.2.1.6) from Saccharomyces cerevisiae (see 5 papers)
    28% identity, 96% coverage of query (208 bits)

1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl
    28% identity, 96% coverage of query (207 bits)

1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
    28% identity, 96% coverage of query (207 bits)

1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl
    28% identity, 96% coverage of query (207 bits)

6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone
    28% identity, 95% coverage of query (203 bits)

6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam
    28% identity, 95% coverage of query (203 bits)

6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl
    28% identity, 95% coverage of query (203 bits)

AN4956 acetolactate synthase; EC 2.2.1.6 from Emericella nidulans (see paper)
    29% identity, 95% coverage of query (201 bits)

ilvB / O08353 acetohydroxy-acid synthase large subunit (EC 2.2.1.6) from Methanococcus aeolicus (see 2 papers)
    28% identity, 95% coverage of query (201 bits)

CFOL_ASPCN / A0A2I2F2I5 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; Chlorflavonin biosynthesis cluster protein L; EC 2.2.1.6 from Aspergillus candidus (see paper)
    29% identity, 96% coverage of query (201 bits)

6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl
    27% identity, 95% coverage of query (201 bits)

6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl
    28% identity, 95% coverage of query (200 bits)

6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl
    28% identity, 95% coverage of query (200 bits)

6deqA / A0A1D8PJF9 Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
    27% identity, 95% coverage of query (199 bits)

6wo1A / Q96VZ6 Hybrid acetohydroxyacid synthase complex structure with cryptococcus neoformans ahas catalytic subunit and saccharomyces cerevisiae ahas regulatory subunit (see paper)
    28% identity, 96% coverage of query (199 bits)

6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl
    28% identity, 95% coverage of query (199 bits)

Q04789 acetolactate synthase (EC 2.2.1.6); branched-chain-2-oxoacid decarboxylase (EC 4.1.1.72) from Bacillus subtilis (see 2 papers)
    26% identity, 96% coverage of query (198 bits)

P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco)
    29% identity, 95% coverage of query (198 bits)

ILV2 acetolactate synthase; EC 2.2.1.6 from Candida albicans (see paper)
    27% identity, 95% coverage of query (197 bits)

IlvB / b3671 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
ilvB / P08142 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli (strain K12) (see 4 papers)
P08142 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli (see paper)
    29% identity, 96% coverage of query (197 bits)

xsc / Q93PS3 sulfoacetaldehyde acetyltransferase subunit (EC 2.3.3.15) from Desulfonispora thiosulfatigenes (see 2 papers)
    28% identity, 100% coverage of query (196 bits)

P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco)
    28% identity, 95% coverage of query (196 bits)

V5Q0Z4 acetolactate synthase (EC 2.2.1.6) from Myosoton aquaticum (see paper)
    28% identity, 95% coverage of query (195 bits)

4rjiC Acetolactate synthase from bacillus subtilis bound to thdp - crystal form i (see paper)
    26% identity, 94% coverage of query (195 bits)

6bd9A Saccharomyces cerevisiae acetohydroxyacid synthase
    27% identity, 96% coverage of query (195 bits)

4rjkF Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii
    26% identity, 94% coverage of query (195 bits)

4rjkG Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii
    26% identity, 94% coverage of query (194 bits)

6bd3A Saccharomyces cerevisiae acetohydroxyacid synthase
    27% identity, 96% coverage of query (194 bits)

1jscA Crystal structure of the catalytic subunit of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors
    27% identity, 96% coverage of query (193 bits)

Q5VB49 acetolactate synthase (EC 2.2.1.6) from Helianthus annuus (see paper)
    27% identity, 95% coverage of query (192 bits)

Q0K022 sulfoacetaldehyde acetyltransferase (EC 2.3.3.15) from Cupriavidus necator (see paper)
    27% identity, 98% coverage of query (192 bits)

5imsA Saccharomyces cerevisiae acetohydroxyacid synthase
    27% identity, 96% coverage of query (192 bits)

Q5VB44 acetolactate synthase (EC 2.2.1.6) from Helianthus annuus (see paper)
    27% identity, 95% coverage of query (191 bits)

6lpiB / P08142 Crystal structure of ahas holo-enzyme (see paper)
    29% identity, 95% coverage of query (190 bits)

ILVB_ARATH / P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 16 papers)
P17597 acetolactate synthase (EC 2.2.1.6) from Arabidopsis thaliana (see 8 papers)
    28% identity, 92% coverage of query (190 bits)

5k2oA / P17597 Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
    28% identity, 92% coverage of query (190 bits)

7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium
    28% identity, 92% coverage of query (190 bits)

8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron
    28% identity, 92% coverage of query (190 bits)

5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam
    28% identity, 92% coverage of query (190 bits)

5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium
    28% identity, 92% coverage of query (190 bits)

5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl
    28% identity, 92% coverage of query (190 bits)

1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin
    28% identity, 92% coverage of query (190 bits)

1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl
    28% identity, 92% coverage of query (190 bits)

1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl
    28% identity, 92% coverage of query (190 bits)

1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron
    28% identity, 92% coverage of query (190 bits)

1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
    28% identity, 92% coverage of query (190 bits)

1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl
    28% identity, 92% coverage of query (190 bits)

3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester
    28% identity, 92% coverage of query (190 bits)

3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron
    28% identity, 92% coverage of query (190 bits)

xsc / Q84H44 sulfoacetaldehyde acetyltransferase monomer (EC 2.3.3.15) from Castellaniella defragrans (see paper)
XSC_CASDE / Q84H44 Sulfoacetaldehyde acetyltransferase; EC 2.3.3.15 from Castellaniella defragrans (Alcaligenes defragrans) (see paper)
Q84H44 sulfoacetaldehyde acetyltransferase (EC 2.3.3.15) from Castellaniella defragrans (see paper)
    28% identity, 92% coverage of query (189 bits)

A5X300 acetolactate synthase (EC 2.2.1.6) from Oryza sativa Indica Group (see paper)
    29% identity, 95% coverage of query (189 bits)

Q6K2E8 acetolactate synthase (EC 2.2.1.6) from Oryza sativa (see paper)
    29% identity, 95% coverage of query (189 bits)

5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium
    28% identity, 92% coverage of query (189 bits)

Q836A5 acetolactate synthase (EC 2.2.1.6) from Enterococcus faecalis (see 2 papers)
    27% identity, 95% coverage of query (188 bits)

Q5VB42 acetolactate synthase (EC 2.2.1.6) from Helianthus annuus (see paper)
    27% identity, 95% coverage of query (188 bits)

A0A1X9M8K4 sulfoacetaldehyde acetyltransferase (EC 2.3.3.15) from Alkalihalobacillus krulwichiae (see paper)
    27% identity, 96% coverage of query (187 bits)

6dekA Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit
    27% identity, 95% coverage of query (187 bits)

5dx6B / P27696 Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
    27% identity, 94% coverage of query (182 bits)

1ozfA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactors
    28% identity, 94% coverage of query (182 bits)

6vz8D / P17597 Arabidopsis thaliana acetohydroxyacid synthase complex with valine bound (see paper)
    28% identity, 92% coverage of query (181 bits)

5d6rB Acetolactate synthase from klebsiella pneumoniae in complex with mechanism-based inhibitor
    28% identity, 94% coverage of query (179 bits)

1ozgA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate
    27% identity, 94% coverage of query (179 bits)

5wdgA Acetolactate synthase from klebsiella pneumoniae in complex with a reaction intermediate
    27% identity, 94% coverage of query (173 bits)

5dx6A Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
    27% identity, 94% coverage of query (172 bits)

8beoB Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
    27% identity, 91% coverage of query (162 bits)

8beoA Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
    27% identity, 91% coverage of query (162 bits)

8i07D Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
    26% identity, 91% coverage of query (160 bits)

8i07A Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
    26% identity, 91% coverage of query (160 bits)

1powA The refined structures of a stabilized mutant and of wild-type pyruvate oxidase from lactobacillus plantarum
    26% identity, 92% coverage of query (160 bits)

4feeA High-resolution structure of pyruvate oxidase in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate carbanion-enamine, crystal b (see paper)
    26% identity, 92% coverage of query (160 bits)

2ezuA Pyruvate oxidase variant f479w in complex with reaction intermediate 2-acetyl-thiamin diphosphate
    26% identity, 92% coverage of query (160 bits)

2ez9A Pyruvate oxidase variant f479w in complex with reaction intermediate analogue 2-phosphonolactyl-thiamin diphosphate
    26% identity, 92% coverage of query (160 bits)

2ez8A Pyruvate oxidase variant f479w in complex with reaction intermediate 2-lactyl-thiamin diphosphate
    26% identity, 92% coverage of query (160 bits)

2ez4B Pyruvate oxidase variant f479w
    26% identity, 92% coverage of query (160 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory