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Searching for up to 100 curated homologs for Ac3H11_2717 FitnessBrowser__acidovorax_3H11:Ac3H11_2717 (329 a.a.)

Found high-coverage hits (≥70%) to 46 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

pimC / Q6N3I0 pimeloyl-CoA dehydrogenase large subunit (EC 1.3.1.62) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) (see paper)
    35% identity, 99% coverage of query (175 bits)

CHSE3_MYCTU / P96855 Acyl-CoA dehydrogenase FadE34; ACAD; 3-oxochol-4-en-24-oyl-CoA dehydrogenase; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
    33% identity, 99% coverage of query (152 bits)

IPDE1_MYCS2 / A0R4Z9 Acyl-CoA dehydrogenase IpdE1; 5OH-HIP-CoA dehydrogenase alpha subunit; EC 1.3.99.- from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    33% identity, 99% coverage of query (146 bits)

fadE30 / I6Y3V5 5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA dehydrogenase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
IPDE1_MYCTU / I6Y3V5 Acyl-CoA dehydrogenase IpdE1; 5OH-HIP-CoA dehydrogenase alpha subunit; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    34% identity, 99% coverage of query (144 bits)

chsE2 / P71858 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA dehydrogenase β subunit from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
CHSE2_MYCTU / P71858 Acyl-CoA dehydrogenase FadE29; ACAD; 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA dehydrogenase beta subunit; 3-oxo-4-pregnene-20-carboxyl-CoA dehydrogenase beta subunit; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
    32% identity, 97% coverage of query (139 bits)

ACD17_MYCTU / P95280 Putative acyl-CoA dehydrogenase FadE17; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    33% identity, 86% coverage of query (134 bits)

8hk0B / A0A1W5T3Z2 Crystal structure of fic32-33 complex from streptomyces ficellus nrrl 8067 (see paper)
    32% identity, 97% coverage of query (130 bits)

6wy8B / D1AB78 Tcur3481-tcur3483 steroid acad (see paper)
    30% identity, 99% coverage of query (129 bits)

6wy9A Tcur3481-tcur3483 steroid acad g363a variant
    30% identity, 99% coverage of query (129 bits)

4x28A / I6YCA3 Crystal structure of the chse4-chse5 complex from mycobacterium tuberculosis (see paper)
    31% identity, 97% coverage of query (126 bits)

ChsE4 / I6YCA3 3-oxocholest-4-en-26-oyl-CoA dehydrogenase α subunit from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
CHSE4_MYCTU / I6YCA3 Acyl-CoA dehydrogenase FadE26; ACAD; 3-oxocholest-4-en-26-oyl-CoA dehydrogenase alpha subunit; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
    31% identity, 97% coverage of query (126 bits)

Build an alignment

Build an alignment for Ac3H11_2717 and 11 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

2pg0A / Q5L0D5 Crystal structure of acyl-coa dehydrogenase from geobacillus kaustophilus
    27% identity, 98% coverage of query (96.7 bits)

ivd1 / CAC08233.1 isovaleryl-CoA dehydrogenase from Solanum tuberosum (see paper)
    27% identity, 99% coverage of query (94.0 bits)

MBCD_SOLTU / Q9FS88 2-methylacyl-CoA dehydrogenase, mitochondrial; 2-methylbutanoyl-CoA dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; 2MBCD; Isovaleryl-CoA dehydrogenase 1; St-IVD1; EC 1.3.8.5 from Solanum tuberosum (Potato) (see 2 papers)
    27% identity, 99% coverage of query (94.0 bits)

IVD_RAT / P12007 Isovaleryl-CoA dehydrogenase, mitochondrial; IVD; Butyryl-CoA dehydrogenase; EC 1.3.8.4; EC 1.3.8.1 from Rattus norvegicus (Rat) (see paper)
P12007 isovaleryl-CoA dehydrogenase (EC 1.3.8.4) from Rattus norvegicus (see 2 papers)
    28% identity, 99% coverage of query (94.0 bits)

ptmO4 / D8L2U8 (4S)-homoplatensicyl-CoA dehydrogenase from Streptomyces platensis (see paper)
D8L2U8 long-chain acyl-CoA dehydrogenase (EC 1.3.8.8) from Streptomyces platensis (see paper)
    28% identity, 99% coverage of query (93.2 bits)

hlmB / E2PZ80 L-cysteinyl-[NRPS] dehydrogenase from Streptomyces clavuligerus (see paper)
    28% identity, 100% coverage of query (90.5 bits)

8sgrA / P26440 8sgrA (see paper)
    27% identity, 99% coverage of query (89.0 bits)

1ivhA Structure of human isovaleryl-coa dehydrogenase at 2.6 angstroms resolution: structural basis for substrate specificity
    27% identity, 99% coverage of query (89.0 bits)

IVD_HUMAN / P26440 Isovaleryl-CoA dehydrogenase, mitochondrial; IVD; Butyryl-CoA dehydrogenase; EC 1.3.8.4; EC 1.3.8.1 from Homo sapiens (Human) (see 8 papers)
    27% identity, 99% coverage of query (88.6 bits)

dcaA / AAL09094.1 DcaA from Acinetobacter baylyi (see 11 papers)
    29% identity, 99% coverage of query (88.2 bits)

ivdA isovaleryl-coenzyme A dehydrogenase; EC 1.3.99.10 from Emericella nidulans (see paper)
ivdA / AAR23112.1 isovaleryl-coenzyme A dehydrogenase from Aspergillus nidulans (see paper)
    26% identity, 99% coverage of query (86.7 bits)

3nf4A / G7CDN2 Crystal structure of acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to flavin adenine dinucleotide (see paper)
    28% identity, 98% coverage of query (82.0 bits)

8sgsA Short-chain specific acyl-CoA dehydrogenase, mitochondrial
    25% identity, 83% coverage of query (79.3 bits)

7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
    25% identity, 83% coverage of query (79.3 bits)

7y0aC / P16219 Crystal structure of human short-chain acyl-coa dehydrogenase
    25% identity, 83% coverage of query (79.0 bits)

ACADS / P16219 short-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.1) from Homo sapiens (see 11 papers)
ACADS_HUMAN / P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 4 papers)
    25% identity, 83% coverage of query (79.0 bits)

5iduC / B2JPK4 Crystal structure of an acyl-coa dehydrogenase domain protein from burkholderia phymatum bound to fad
    27% identity, 87% coverage of query (79.0 bits)

4iv6B / A0QTW7 X-ray crystal structure of an isovaleryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
    28% identity, 100% coverage of query (78.6 bits)

1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa
    27% identity, 83% coverage of query (73.9 bits)

ACADS_RAT / P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
P15651 short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) from Rattus norvegicus (see 2 papers)
    27% identity, 83% coverage of query (73.6 bits)

4l1fA / D2RL84 Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
    24% identity, 99% coverage of query (73.6 bits)

1egcA Structure of t255e, e376g mutant of human medium chain acyl-coa dehydrogenase complexed with octanoyl-coa
    25% identity, 86% coverage of query (73.2 bits)

ACADM_DROME / Q9VSA3 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; EC 1.3.8.7 from Drosophila melanogaster (Fruit fly) (see paper)
    26% identity, 86% coverage of query (70.9 bits)

2a1tC / P11310 Structure of the human mcad:etf e165betaa complex (see paper)
    24% identity, 86% coverage of query (70.9 bits)

2vigB Crystal structure of human short-chain acyl coa dehydrogenase
    24% identity, 83% coverage of query (70.9 bits)

5jscA / Q13JS1 Crystal structure of a putative acyl-coa dehydrogenase from burkholderia xenovorans
    26% identity, 74% coverage of query (70.9 bits)

3mdeA Crystal structures of medium chain acyl-coa dehydrogenase from pig liver mitochondria with and without substrate
    25% identity, 98% coverage of query (70.5 bits)

3mddA / P41367 Crystal structures of medium chain acyl-coa dehydrogenase from pig liver mitochondria with and without substrate (see paper)
    25% identity, 98% coverage of query (70.5 bits)

1udyA Medium-chain acyl-coa dehydrogenase with 3-thiaoctanoyl-coa
    25% identity, 98% coverage of query (70.5 bits)

ACADM_PIG / P41367 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; MCAD; EC 1.3.8.7 from Sus scrofa (Pig) (see 3 papers)
P41367 medium-chain acyl-CoA dehydrogenase (EC 1.3.8.7) from Sus scrofa (see paper)
    26% identity, 86% coverage of query (70.5 bits)

ACADM / P11310 mitochondrial medium-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.7) from Homo sapiens (see 16 papers)
ACADM_HUMAN / P11310 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; MCAD; Medium chain acyl-CoA dehydrogenase; MCADH; EC 1.3.8.7 from Homo sapiens (Human) (see 25 papers)
P11310 medium-chain acyl-CoA dehydrogenase (EC 1.3.8.7) from Homo sapiens (see 3 papers)
    24% identity, 86% coverage of query (70.5 bits)

4hr3A / B1MFF5 Structure of a putative acyl-coa dehydrogenase from mycobacterium abscessus (see paper)
    27% identity, 84% coverage of query (69.3 bits)

6af6A / Q5W271 Piga with fad and proline (see paper)
    25% identity, 99% coverage of query (65.1 bits)

IBR3_ARATH / Q8RWZ3 Probable acyl-CoA dehydrogenase IBR3; Protein INDOLE-3-BUTYRIC ACID RESPONSE 3; EC 1.3.99.- from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    25% identity, 94% coverage of query (57.8 bits)

4ktoA / Q92VK1 Crystal structure of a putative isovaleryl-coa dehydrogenase (psi- nysgrc-012251) from sinorhizobium meliloti 1021
    23% identity, 99% coverage of query (51.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory