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Searching for up to 100 curated homologs for Ac3H11_2831 FitnessBrowser__acidovorax_3H11:Ac3H11_2831 (443 a.a.)

Found high-coverage hits (≥70%) to 35 curated proteins.

Removed hits that are identical to the query, leaving 34

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Shew_1276 Isocitrate lyase (EC 4.1.3.1) from Shewanella loihica PV-4
    73% identity, 98% coverage of query (674 bits)

SO1484 Isocitrate lyase (EC 4.1.3.1) from Shewanella oneidensis MR-1
    72% identity, 98% coverage of query (672 bits)

Sama_2380 Isocitrate lyase (EC 4.1.3.1) from Shewanella amazonensis SB2B
    71% identity, 99% coverage of query (672 bits)

Icl / b4015 isocitrate lyase (EC 4.1.3.1) from Escherichia coli K-12 substr. MG1655 (see paper)
aceA / P0A9G6 isocitrate lyase (EC 4.1.3.1) from Escherichia coli (strain K12) (see 25 papers)
ACEA_ECOLI / P0A9G6 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Escherichia coli (strain K12) (see 7 papers)
    72% identity, 98% coverage of query (663 bits)

BWI76_RS01665 Isocitrate lyase (EC 4.1.3.1) from Klebsiella michiganensis M5al
    71% identity, 98% coverage of query (656 bits)

Pf1N1B4_4042 Isocitrate lyase (EC 4.1.3.1) from Pseudomonas fluorescens FW300-N1B4
    71% identity, 98% coverage of query (652 bits)

1igwC / P0A9G6 Crystal structure of the isocitrate lyase from the a219c mutant of escherichia coli (see paper)
    71% identity, 94% coverage of query (634 bits)

1igwA / P0A9G6 Crystal structure of the isocitrate lyase from the a219c mutant of escherichia coli (see paper)
    67% identity, 94% coverage of query (579 bits)

7cmyC / Q81GQ9 Isocitrate lyase from bacillus cereus atcc 14579 in complex with magnessium ion, glyoxylate, and succinate
    60% identity, 98% coverage of query (533 bits)

6lrtA / A9WDE7 Crystal structure of isocitrate lyase (caur_3889) from chloroflexus aurantiacus in complex with isocitrate and manganese ion
    60% identity, 98% coverage of query (526 bits)

icl / P9WKK7 isocitrate lyase subunit (EC 4.1.3.1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
ACEA1_MYCTE / H8EVV4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) (see paper)
ACEA1_MYCBO / P0A5H4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see paper)
ACEA1_MYCTO / P9WKK6 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (see 3 papers)
ACEA_MYCTU / P9WKK7 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 7 papers)
P9WKK7 isocitrate lyase (EC 4.1.3.1) from Mycobacterium tuberculosis (see 4 papers)
    58% identity, 96% coverage of query (503 bits)

Q8RPZ0 isocitrate lyase (EC 4.1.3.1) from Streptomyces clavuligerus (see paper)
    58% identity, 96% coverage of query (502 bits)

6xppA Crystal structure of itaconate modified mycobaterium tuberculosis isocitrate lyase
    58% identity, 96% coverage of query (501 bits)

6c4aA / P9WKK7 Crystal structure of 3-nitropropionate modified isocitrate lyase from mycobacterium tuberculosis with pyruvate (see paper)
    58% identity, 96% coverage of query (500 bits)

7rb1A Isocitrate lyase-1 from mycobacterium tuberculosis covalently modified by 5-descarboxy-5-nitro-d-isocitric acid
    58% identity, 96% coverage of query (500 bits)

6wsiA Intact cis-2,3-epoxysuccinic acid bound to isocitrate lyase-1 from mycobacterium tuberculosis
    58% identity, 96% coverage of query (500 bits)

6vb9A Covalent adduct of cis-2,3-epoxysuccinic acid with isocitrate lyase-1 from mycobacterium tuberculosis
    58% identity, 96% coverage of query (500 bits)

5dqlA Crystal structure of 2-vinyl glyoxylate modified isocitrate lyase from mycobacterium tuberculosis
    58% identity, 96% coverage of query (500 bits)

Q97YI8 isocitrate lyase (EC 4.1.3.1) from Saccharolobus solfataricus (see paper)
    57% identity, 96% coverage of query (497 bits)

1f8iA Crystal structure of isocitrate lyase:nitropropionate:glyoxylate complex from mycobacterium tuberculosis
    58% identity, 96% coverage of query (497 bits)

A0A3S5YB92 isocitrate lyase (EC 4.1.3.1) from Rhodococcus hoagii (see paper)
    57% identity, 96% coverage of query (495 bits)

ACEA_CORGL / P42449 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
    57% identity, 96% coverage of query (492 bits)

icl / CAA82555.1 isocitrate lyase from Rhodococcus fascians (see paper)
    56% identity, 97% coverage of query (486 bits)

7rbxC / Q2YQA0 Crystal structure of isocitrate lyase and phosphorylmutase:isocitrate lyase from brucella melitensis biovar abortus 2308 bound to itaconic acid (see paper)
    57% identity, 94% coverage of query (476 bits)

GCP_CAEEL / Q10663 Bifunctional glyoxylate cycle protein; Gex-3-interacting protein 7; EC 4.1.3.1; EC 2.3.3.9 from Caenorhabditis elegans (see 2 papers)
    54% identity, 94% coverage of query (451 bits)

5e9gD / P0CT06 Structural insights of isocitrate lyases from magnaporthe oryzae (see paper)
    36% identity, 92% coverage of query (276 bits)

5e9fD / P0CT06 Structural insights of isocitrate lyases from magnaporthe oryzae (see paper)
    37% identity, 91% coverage of query (273 bits)

icl / CAB37065.1 isocitrate lyase from Eremothecium gossypii (see paper)
    36% identity, 70% coverage of query (186 bits)

Build an alignment

Build an alignment for Ac3H11_2831 and 28 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

ACEA_HYPME / O50078 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Hyphomicrobium methylovorum (see paper)
    27% identity, 89% coverage of query (145 bits)

Q93R40 isocitrate lyase (EC 4.1.3.1) from Colwellia maris (see paper)
    28% identity, 78% coverage of query (129 bits)

A8C781 isocitrate lyase (EC 4.1.3.1) from Azotobacter vinelandii (see paper)
    26% identity, 79% coverage of query (127 bits)

Q9I0K4 isocitrate lyase (EC 4.1.3.1) from Pseudomonas aeruginosa (see 2 papers)
    27% identity, 79% coverage of query (124 bits)

A8C5K8 isocitrate lyase (EC 4.1.3.1) from Colwellia psychrerythraea (see paper)
    27% identity, 78% coverage of query (123 bits)

Psest_2014 Isocitrate lyase (EC 4.1.3.1) from Pseudomonas stutzeri RCH2
    27% identity, 79% coverage of query (119 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory