Sites on a Tree

 

Searching for up to 100 curated homologs for Ac3H11_3348 FitnessBrowser__acidovorax_3H11:Ac3H11_3348 (184 a.a.)

Found high-coverage hits (≥70%) to 66 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

2xf4A Crystal structure of salmonella enterica serovar typhimurium ycbl (see paper)
    54% identity, 98% coverage of query (207 bits)

GloC / b0927 hydroxyacylglutathione hydrolase GloC (EC 3.1.2.6) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gloC / P75849 hydroxyacylglutathione hydrolase GloC (EC 3.1.2.6) from Escherichia coli (strain K12) (see 5 papers)
GLO22_ECOLI / P75849 Hydroxyacylglutathione hydrolase GloC; Accessory type II glyoxalase; Glyoxalase II 2; GlxII-2; EC 3.1.2.6 from Escherichia coli (strain K12) (see paper)
    54% identity, 98% coverage of query (206 bits)

7ev5A / A0A060M4R1 Crystal structure of bleg-1 b3 metallo-beta-lactamase (see paper)
    36% identity, 99% coverage of query (116 bits)

2zwrB / Q5SHV7 Crystal structure of ttha1623 from thermus thermophilus hb8 (see paper)
    39% identity, 99% coverage of query (110 bits)

2zziA Crystal structure of ttha1623 in a di-iron-bound form
    39% identity, 98% coverage of query (108 bits)

7l0bA Crystal structure of hydroxyacyl glutathione hydrolase (glob) from staphylococcus aureus, apoenzyme (see paper)
    32% identity, 99% coverage of query (97.8 bits)

A0A0D1GCF8 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Staphylococcus aureus (see paper)
    31% identity, 99% coverage of query (95.5 bits)

sdo / B7J413 sulfur dioxygenase α subunit (EC 1.13.11.18) from Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455) (see 4 papers)
B7J413 persulfide dioxygenase (EC 1.13.11.18) from Acidithiobacillus ferrooxidans (see paper)
    32% identity, 99% coverage of query (83.6 bits)

4ysbA / Q1D4C9 Crystal structure of ethe1 from myxococcus xanthus (see paper)
    31% identity, 99% coverage of query (80.1 bits)

2gcuA / Q9C8L4 X-ray structure of gene product from arabidopsis thaliana at1g53580 (see paper)
    34% identity, 97% coverage of query (79.3 bits)

ETHE1_ARATH / Q9C8L4 Persulfide dioxygenase ETHE1 homolog, mitochondrial; Glyoxalase II; Glx II; Sulfur dioxygenase ETHE1; EC 1.13.11.18 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9C8L4 persulfide dioxygenase (EC 1.13.11.18) from Arabidopsis thaliana (see paper)
    34% identity, 97% coverage of query (79.3 bits)

Y554_STRP6 / Q5XD24 Probable metallo-hydrolase M6_Spy0554; EC 3.-.-.- from Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
    30% identity, 98% coverage of query (78.6 bits)

Build an alignment

Build an alignment for Ac3H11_3348 and 12 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

6sg9FL 6sg9FL (see paper)
    28% identity, 86% coverage of query (73.9 bits)

ETHE1_MOUSE / Q9DCM0 Persulfide dioxygenase ETHE1, mitochondrial; Ethylmalonic encephalopathy protein 1 homolog; Hepatoma subtracted clone one protein; Sulfur dioxygenase ETHE1; EC 1.13.11.18 from Mus musculus (Mouse) (see paper)
    33% identity, 90% coverage of query (73.9 bits)

ETHE1 / O95571 mitochondrial persulfide dioxygenase monomer (EC 1.13.11.18) from Homo sapiens (see 6 papers)
ETHE1_HUMAN / O95571 Persulfide dioxygenase ETHE1, mitochondrial; Ethylmalonic encephalopathy protein 1; Hepatoma subtracted clone one protein; Sulfur dioxygenase ETHE1; EC 1.13.11.18 from Homo sapiens (Human) (see 6 papers)
    32% identity, 91% coverage of query (73.2 bits)

4chlB / O95571 Human ethylmalonic encephalopathy protein 1 (hethe1) (see paper)
    33% identity, 90% coverage of query (73.2 bits)

5ve5A / B2TEQ2 Crystal structure of persulfide dioxygenase rhodanese fusion protein with rhodanese domain inactivating mutation (c314s) from burkholderia phytofirmans in complex with glutathione (see paper)
    31% identity, 93% coverage of query (71.2 bits)

3tp9A / C8WS08 Crystal structure of alicyclobacillus acidocaldarius protein with beta-lactamase and rhodanese domains
    29% identity, 97% coverage of query (70.5 bits)

BLH_XYLFA / Q9PFB0 Beta-lactamase hydrolase-like protein; BLH; EC 3.-.-.- from Xylella fastidiosa (strain 9a5c) (see paper)
    31% identity, 96% coverage of query (68.9 bits)

G5ELA4 persulfide dioxygenase (EC 1.13.11.18) from Staphylococcus aureus (see paper)
    28% identity, 97% coverage of query (68.2 bits)

3r2uB 2.1 angstrom resolution crystal structure of metallo-beta-lactamase from staphylococcus aureus subsp. Aureus col
    28% identity, 97% coverage of query (65.9 bits)

A0A1E7YQH3 persulfide dioxygenase (EC 1.13.11.18) from Acidithiobacillus caldus (see paper)
    29% identity, 96% coverage of query (65.5 bits)

blhA / CBY83975.1 metallo-beta-lactamase family from Serratia sp. ATCC 39006 (see paper)
    29% identity, 94% coverage of query (64.7 bits)

6aufB / G6EHN2 Crystal structure of metalo beta lactamases mim-1 from novosphingobium pentaromativorans
    28% identity, 98% coverage of query (63.9 bits)

Q940L0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Oryza sativa (see 3 papers)
    30% identity, 90% coverage of query (63.2 bits)

2q42A / Q9SID3 Ensemble refinement of the protein crystal structure of glyoxalase ii from arabidopsis thaliana gene at2g31350 (see paper)
    28% identity, 90% coverage of query (60.5 bits)

GLO2N_ARATH / Q9SID3 Hydroxyacylglutathione hydrolase 2, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    28% identity, 90% coverage of query (60.1 bits)

3r2uA / A0A0H2X0Y8 2.1 angstrom resolution crystal structure of metallo-beta-lactamase from staphylococcus aureus subsp. Aureus col
    27% identity, 97% coverage of query (57.8 bits)

PNKD_HUMAN / Q8N490 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; Trans-activated by hepatitis C virus core protein 2; EC 3.-.-.- from Homo sapiens (Human) (see 8 papers)
    32% identity, 90% coverage of query (57.8 bits)

4efzA / Q3JRV4 Crystal structure of a hypothetical metallo-beta-lactamase from burkholderia pseudomallei
    30% identity, 94% coverage of query (57.8 bits)

LACB2_HUMAN / Q53H82 Endoribonuclease LACTB2; Beta-lactamase-like protein 2; EC 3.1.27.- from Homo sapiens (Human) (see paper)
4ad9A / Q53H82 Crystal structure of human lactb2. (see paper)
    26% identity, 87% coverage of query (57.4 bits)

Q8YZ99 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
    29% identity, 87% coverage of query (56.2 bits)

MBLC2_HUMAN / Q68D91 Acyl-coenzyme A thioesterase MBLAC2; Acyl-CoA thioesterase MBLAC2; Beta-lactamase MBLAC2; Metallo-beta-lactamase domain-containing protein 2; Palmitoyl-coenzyme A thioesterase MBLAC2; EC 3.1.2.2; EC 3.5.2.6 from Homo sapiens (Human) (see 2 papers)
    30% identity, 80% coverage of query (55.8 bits)

2p18A / Q2PYN0 Crystal structure of the leishmania infantum glyoxalase ii (see paper)
    28% identity, 92% coverage of query (55.8 bits)

GLO2M_ARATH / O24495 Hydroxyacylglutathione hydrolase 1, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    30% identity, 93% coverage of query (55.1 bits)

BLH_AGRFC / Q8UAA9 Beta-lactamase hydrolase-like protein; BLH; EC 3.-.-.- from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
    28% identity, 96% coverage of query (52.4 bits)

3vqzA Crystal structure of metallo-beta-lactamase, smb-1, in a complex with mercaptoacetic acid
    28% identity, 76% coverage of query (52.0 bits)

PNKD_MOUSE / Q69ZP3 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; EC 3.-.-.- from Mus musculus (Mouse) (see 3 papers)
    30% identity, 90% coverage of query (51.6 bits)

6k4tA / G5ELM3 Crystal structure of smb-1 metallo-beta-lactamase in a complex with tsa (see paper)
    26% identity, 76% coverage of query (51.6 bits)

6k4xA Crystal structure of smb-1 metallo-beta-lactamase in a complex with asb
    26% identity, 76% coverage of query (51.6 bits)

4yskA / A5VWI3 Crystal structure of apo-form sdoa from pseudomonas putida (see paper)
    29% identity, 85% coverage of query (51.2 bits)

4yslA Crystal structure of sdoa from pseudomonas putida in complex with glutathione
    29% identity, 85% coverage of query (51.2 bits)

5b1uA Crystal structure of metallo-beta-lactamase smb-1 bound to hydrolyzed imipenem
    26% identity, 76% coverage of query (51.2 bits)

5b15A Crystal structure of metallo-beta-lactamase smb-1 bound to hydrolyzed doripenem
    26% identity, 76% coverage of query (51.2 bits)

5ayaA Crystal structure of metallo-beta-lactamase smb-1 bound to l-captopril
    26% identity, 76% coverage of query (51.2 bits)

5axrA Crystal structure of metallo-beta-lactamase smb-1 bound to 2- mercaptoethanesulfonate
    26% identity, 76% coverage of query (51.2 bits)

5axoA Crystal structure of metallo-beta-lactamase smb-1 bound to hydrolyzed meropenem
    26% identity, 76% coverage of query (51.2 bits)

3vpeA Crystal structure of metallo-beta-lactamase smb-1
    26% identity, 76% coverage of query (51.2 bits)

6dr8A Metallo-beta-lactamase from cronobacter sakazakii (enterobacter sakazakii) harldq motif mutant s60/r118h/q121h/k254h
    27% identity, 90% coverage of query (50.8 bits)

GLO22_SCHPO / O94250 Probable hydroxyacylglutathione hydrolase C13B11.03c; Glyoxalase II; Glx II; EC 3.1.2.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    26% identity, 90% coverage of query (50.4 bits)

Q2PYN0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Leishmania infantum (see 3 papers)
    26% identity, 92% coverage of query (50.1 bits)

6nc5A Cronobacter sakazakii (enterobacter sakazakii) metallo-beta-lactamse harldq motif (see paper)
    26% identity, 90% coverage of query (48.1 bits)

7tzaA Structure of pqs response protein pqse in complex with n-(4-(3- neopentylureido)phenyl)-1h-indazole-7-carboxamide
    28% identity, 87% coverage of query (46.2 bits)

7r3eA / P20581,P54292 Fusion construct of pqse and rhlr in complex with the synthetic antagonist mbtl (see paper)
    28% identity, 87% coverage of query (44.3 bits)

3dh8A Structure of pseudomonas quinolone signal response protein pqse
    28% identity, 87% coverage of query (44.3 bits)

6mfiA / K4KM71 Mim-2 metallo-beta-lactamase (see paper)
    29% identity, 71% coverage of query (43.9 bits)

7kgwA Structure of pqs response protein pqse in complex n-(3-(1h-pyrazol-5- yl)phenyl)-1h-indazole-7-carboxamide
    28% identity, 87% coverage of query (43.9 bits)

2vw8A Crystal structure of quinolone signal response protein pqse from pseudomonas aeruginosa
    28% identity, 87% coverage of query (43.9 bits)

5hisA Crystal structure of pqs response protein pqse in complex with 3- methylthiophene-2-carboxylic acid
    28% identity, 87% coverage of query (43.9 bits)

5hipA Crystal structure of pqs response protein pqse in complex with 2- (pyridin-3-yl)benzoic acid
    28% identity, 87% coverage of query (43.9 bits)

7kgxA Structure of pqs response protein pqse in complex with 4-(3-(2-methyl- 2-morpholinobutyl)ureido)-n-(thiazol-2-yl)benzamide
    28% identity, 87% coverage of query (43.9 bits)

5hiqA Crystal structure of pqs response protein pqse in complex with 2-(1h- pyrrol-1-yl)benzoic acid
    28% identity, 87% coverage of query (43.9 bits)

5hioA Crystal structure of pqs response protein pqse in complex with 2- aminobenzoylacetate
    28% identity, 87% coverage of query (43.9 bits)

pqsE / P20581 2-aminobenzoylacetyl-CoA thioesterase (EC 3.1.2.32) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
PQSE_PSEAE / P20581 2-aminobenzoylacetyl-CoA thioesterase; EC 3.1.2.32 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 6 papers)
A0A0H2Z6F6 2-aminobenzoylacetyl-CoA thioesterase (EC 3.1.2.32) from Pseudomonas aeruginosa (see 2 papers)
P20581 2-aminobenzoylacetyl-CoA thioesterase (EC 3.1.2.32) from Pseudomonas aeruginosa (see 2 papers)
    28% identity, 87% coverage of query (43.9 bits)

2qedA / Q8ZRM2 Crystal structure of salmonella thyphimurium lt2 glyoxalase ii (see paper)
    34% identity, 72% coverage of query (43.5 bits)

GLO2_SALTY / Q8ZRM2 Hydroxyacylglutathione hydrolase; Glyoxalase II; Glx II; EC 3.1.2.6 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
Q8ZRM2 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    34% identity, 72% coverage of query (43.5 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory