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Searching for up to 100 curated homologs for Ac3H11_3400 FitnessBrowser__acidovorax_3H11:Ac3H11_3400 (375 a.a.)

Found high-coverage hits (≥70%) to 19 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

RR42_RS17310 D-lactate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6) from Cupriavidus basilensis FW507-4G11
    53% identity, 98% coverage of query (313 bits)

Psest_3840 D-lactate/glycolate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6; EC 1.1.99.14) from Pseudomonas stutzeri RCH2
    50% identity, 98% coverage of query (298 bits)

Gox / b4468 glycolate dehydrogenase, putative FAD-binding subunit (EC 1.1.99.14) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
glcE / P52073 glycolate dehydrogenase, putative FAD-binding subunit (EC 1.1.99.14) from Escherichia coli (strain K12) (see 3 papers)
GLCE_ECOLI / P52073 Glycolate oxidase subunit GlcE; Glycolate dehydrogenase subunit GlcE; EC 1.1.99.14 from Escherichia coli (strain K12) (see 4 papers)
glcE / RF|YP_026191.1 glycolate oxidase, subunit glcE from Escherichia coli K12 (see paper)
glcE / AAB02531.1 glycolate oxidase subunit from Escherichia coli (see paper)
    44% identity, 99% coverage of query (280 bits)

SMc00833 D-lactate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6) from Sinorhizobium meliloti 1021
    38% identity, 97% coverage of query (213 bits)

PGA1_c29710 D-lactate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6) from Phaeobacter inhibens BS107
    38% identity, 96% coverage of query (179 bits)

Build an alignment

Build an alignment for Ac3H11_3400 and 5 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

DLD_ARCFU / O29853 D-lactate dehydrogenase; EC 1.1.99.6 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see 2 papers)
O29853 D-lactate dehydrogenase (acceptor) (EC 1.1.99.6) from Archaeoglobus fulgidus (see 2 papers)
    24% identity, 77% coverage of query (69.7 bits)

Q9I6H4 D-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) from Pseudomonas aeruginosa (see paper)
    25% identity, 90% coverage of query (63.9 bits)

3pm9A / Q6NAV4 Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
    25% identity, 93% coverage of query (61.2 bits)

8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid
    23% identity, 89% coverage of query (56.2 bits)

LDHD_DANRE / F1QXM5 Probable D-lactate dehydrogenase, mitochondrial; DLD; Lactate dehydrogenase D; EC 1.1.2.4 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
    23% identity, 89% coverage of query (55.8 bits)

8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid
    23% identity, 89% coverage of query (55.1 bits)

8jdbA / Q7TNG8 Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
    22% identity, 89% coverage of query (54.7 bits)

8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid
    22% identity, 89% coverage of query (54.7 bits)

8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid
    22% identity, 89% coverage of query (54.7 bits)

8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid
    22% identity, 89% coverage of query (54.7 bits)

8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid
    22% identity, 89% coverage of query (54.7 bits)

8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid
    22% identity, 89% coverage of query (54.7 bits)

8jdsA Crystal structure of mldhd in complex with pyruvate
    22% identity, 89% coverage of query (54.7 bits)

YghM / b2979 glycolate dehydrogenase, putative FAD-linked subunit (EC 1.1.99.14) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
glcD / P0AEP9 glycolate dehydrogenase, putative FAD-linked subunit (EC 1.1.99.14) from Escherichia coli (strain K12) (see 7 papers)
GLCD_ECOLI / P0AEP9 Glycolate oxidase subunit GlcD; Glycolate dehydrogenase subunit GlcD; EC 1.1.99.14 from Escherichia coli (strain K12) (see 4 papers)
glcD / RF|NP_417453 glycolate oxidase subunit glcD from Escherichia coli K12 (see paper)
glcD / AAB02530.1 glycolate oxidase subunit from Escherichia coli (see paper)
    26% identity, 75% coverage of query (50.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory