Sites on a Tree

 

Searching for up to 100 curated homologs for Ac3H11_4087 FitnessBrowser__acidovorax_3H11:Ac3H11_4087 (473 a.a.)

Found high-coverage hits (≥70%) to 23 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AKECT_STUS1 / A4VFY3 Aspartate kinase Ask_Ect; Aspartokinase; EC 2.7.2.4 from Stutzerimonas stutzeri (strain A1501) (Pseudomonas stutzeri) (see paper)
ask / CBM40643.1 aspartokinase from Pseudomonas stutzeri (see paper)
    46% identity, 96% coverage of query (392 bits)

Build an alignment

Build an alignment for Ac3H11_4087 and 1 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

Q5JK18 aspartate kinase (EC 2.7.2.4) from Oryza sativa Japonica Group (see paper)
    29% identity, 71% coverage of query (107 bits)

2cdqA / Q9LYU8 Crystal structure of arabidopsis thaliana aspartate kinase complexed with lysine and s-adenosylmethionine (see paper)
    27% identity, 73% coverage of query (102 bits)

AK1_ARATH / Q9LYU8 Aspartokinase 1, chloroplastic; Aspartate kinase 1; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9LYU8 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see 2 papers)
    27% identity, 73% coverage of query (102 bits)

AK2_ARATH / O23653 Aspartokinase 2, chloroplastic; Aspartate kinase 2; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O23653 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see 2 papers)
    27% identity, 72% coverage of query (94.4 bits)

Q97MC0 aspartate kinase (EC 2.7.2.4) from Clostridium acetobutylicum (see paper)
    25% identity, 80% coverage of query (90.5 bits)

3tviE / Q97MC0 Crystal structure of clostridium acetobutylicum aspartate kinase (caak): an important allosteric enzyme for industrial amino acids production (see paper)
    25% identity, 80% coverage of query (90.5 bits)

AK3 / Q9S702 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see paper)
AK3_ARATH / Q9S702 Aspartokinase 3, chloroplastic; Aspartate kinase 3; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9S702 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see 2 papers)
    26% identity, 73% coverage of query (89.7 bits)

3c1nA Crystal structure of allosteric inhibition threonine-sensitive aspartokinase from methanococcus jannaschii with l-threonine
    25% identity, 95% coverage of query (87.4 bits)

CA265_RS23475 aspartate kinase; homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Pedobacter sp. GW460-11-11-14-LB5
    24% identity, 96% coverage of query (85.5 bits)

BT2403 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Bacteroides thetaiotaomicron VPI-5482
    24% identity, 96% coverage of query (84.7 bits)

AAA16972.1 aspartokinase-homoserine dehydrogenase, partial from Daucus carota (see paper)
    25% identity, 95% coverage of query (84.3 bits)

3tviA Crystal structure of clostridium acetobutylicum aspartate kinase (caak): an important allosteric enzyme for industrial amino acids production
    24% identity, 80% coverage of query (80.5 bits)

ThrD / b0002 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
thrA / P00561 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 33 papers)
P00561 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Escherichia coli (see paper)
    24% identity, 96% coverage of query (80.1 bits)

O60163 Probable aspartokinase; Aspartate kinase; EC 2.7.2.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    24% identity, 77% coverage of query (79.3 bits)

AKH1_ARATH / Q9SA18 Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic; AK-HD 1; AK-HSDH 1; Beta-aspartyl phosphate homoserine 1; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    24% identity, 95% coverage of query (77.8 bits)

AKH2_ARATH / O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    24% identity, 95% coverage of query (77.4 bits)

Q9RUL9 aspartate kinase (EC 2.7.2.4) from Deinococcus radiodurans (see paper)
    23% identity, 97% coverage of query (73.2 bits)

AK_YEAST / P10869 Aspartokinase; Aspartate kinase; EC 2.7.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P10869 aspartate kinase (EC 2.7.2.4) from Saccharomyces cerevisiae (see paper)
    25% identity, 77% coverage of query (64.3 bits)

FUB3_GIBM7 / W7MS01 Aspartate kinase FUB3; Fusaric acid biosynthesis protein 3; EC 2.7.2.4 from Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides) (see 10 papers)
    23% identity, 97% coverage of query (52.0 bits)

Apk / b4024 aspartate kinase III (EC 2.7.2.4) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lysC / P08660 aspartate kinase III (EC 2.7.2.4) from Escherichia coli (strain K12) (see 27 papers)
AK3_ECOLI / P08660 Lysine-sensitive aspartokinase 3; Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III; EC 2.7.2.4 from Escherichia coli (strain K12) (see 2 papers)
P08660 aspartate kinase (EC 2.7.2.4) from Escherichia coli (see paper)
    22% identity, 96% coverage of query (49.7 bits)

2j0wA / P08660 Crystal structure of e. Coli aspartokinase iii in complex with aspartate and adp (r-state) (see paper)
    22% identity, 96% coverage of query (47.8 bits)

2j0xA Crystal structure of e. Coli aspartokinase iii in complex with lysine and aspartate (t-state)
    22% identity, 96% coverage of query (47.8 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory