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Searching for up to 100 curated homologs for Ac3H11_458 FitnessBrowser__acidovorax_3H11:Ac3H11_458 (284 a.a.)

Found high-coverage hits (≥70%) to 8 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PstA / b3726 phosphate ABC transporter membrane subunit PstA (EC 7.3.2.1) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PstA / P07654 phosphate ABC transporter membrane subunit PstA (EC 7.3.2.1) from Escherichia coli (strain K12) (see 2 papers)
PstA / P07654 phosphate ABC transporter membrane subunit PstA (EC 7.3.2.1) from Escherichia coli (strain K12) (see 2 papers)
PSTA_ECOLI / P07654 Phosphate transport system permease protein PstA from Escherichia coli (strain K12) (see paper)
TC 3.A.1.7.1 / P07654 PstA aka PhoT aka B3726, component of Phosphate porter, PhoSPstABC.  Serves as both a transporter and a sensor for transcriptional activation of the pho regulon in the presence of low external phosphate.  The unphosphorylated EIIANtr protein of the PTS (TC# 4.A) activates PhoR, the senor kinase that phosphorylates the response regulator, PhoB, that activates the pho regulon from Escherichia coli (see 8 papers)
    56% identity, 99% coverage of query (330 bits)

TC 3.A.1.7.2 / Q7WTY6 PstA, component of Phosphate transporter, PstSCAB from Mycobacterium smegmatis (see paper)
    41% identity, 80% coverage of query (167 bits)

TC 3.A.1.7.3 / C3KCB6 Phosphate transport system permease protein, component of High-affinity phosphate-specific permease, PstAB/PhoS. The 3-d structure of PhoS = (PBP) = PfluDING) has been solved at high resolution by x-ray crystallography (Ahn et al. 2007) with phosphate bound (4F1U and 4F1V; 0.95Å resolution) and with arsenate bound (4F18 and 4F19; 0.88Å resolution) (Elias et al. 2012). Phosphate binds with 500-fold higher affinity than arsenate due to a dense and rigid network of ion-dipole interactions (Elias et al. 2012). The PBP from Halomonas sp from Pseudomonas fluorescens (strain SBW25)
    36% identity, 98% coverage of query (164 bits)

PSTA1_MYCTU / P9WG11 Phosphate transport system permease protein PstA 1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    35% identity, 95% coverage of query (137 bits)

TC 3.A.1.7.5 / O51235 Phosphate ABC transporter, permease protein PstA, component of The phosphate transporter, PstABCS from Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    32% identity, 82% coverage of query (114 bits)

PSTA2_MYCTU / P9WG09 Phosphate transport system permease protein PstA 2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    34% identity, 85% coverage of query (110 bits)

Build an alignment

Build an alignment for Ac3H11_458 and 6 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

TC 3.A.1.7.5 / O51234 Phosphate ABC transporter, permease protein PstC, component of The phosphate transporter, PstABCS from Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    26% identity, 75% coverage of query (69.3 bits)

PSTC1_MYCTU / P9WG07 Phosphate transport system permease protein PstC 1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    26% identity, 84% coverage of query (54.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory