Searching for up to 100 curated homologs for Ac3H11_4867 FitnessBrowser__acidovorax_3H11:Ac3H11_4867 (710 a.a.)
Found high-coverage hits (≥70%) to 89 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
aacS / D6EQU8 acetoacetate-CoA ligase (EC 6.2.1.16) from Streptomyces lividans TK24 (see 2 papers)
D6EQU8 acetoacetate-CoA ligase (EC 6.2.1.16) from Streptomyces lividans (see paper)
47% identity, 96% coverage of query (579 bits)
4wd1A / D6EQU8 Acetoacetyl-coa synthetase from streptomyces lividans (see paper)
47% identity, 96% coverage of query (573 bits)
acsA / Q5P8R9 4-hydroxybenzoyl-acetyl-CoA synthetase from Aromatoleum aromaticum (strain EbN1) (see paper)
44% identity, 95% coverage of query (567 bits)
SMc00774 Acetoacetate--CoA ligase (EC 6.2.1.16) from Sinorhizobium meliloti 1021
AACS_RHIME / Q9Z3R3 Acetoacetyl-coenzyme A synthetase; Acetoacetyl-CoA synthetase; EC 6.2.1.16 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
Q9Z3R3 acetoacetate-CoA ligase (EC 6.2.1.16) from Sinorhizobium meliloti (see paper)
38% identity, 93% coverage of query (421 bits)
acsA / AAC64548.1 acetoacetyl-CoA synthetase from Sinorhizobium meliloti (see paper)
38% identity, 93% coverage of query (417 bits)
AACS_RAT / Q9JMI1 Acetoacetyl-CoA synthetase; EC 6.2.1.16 from Rattus norvegicus (Rat) (see 4 papers)
Q9JMI1 acetoacetyl-CoA synthase (EC 2.3.1.194) from Rattus norvegicus (see paper)
36% identity, 92% coverage of query (398 bits)
AACS_HUMAN / Q86V21 Acetoacetyl-CoA synthetase; Acyl-CoA synthetase family member 1; Protein sur-5 homolog; EC 6.2.1.16 from Homo sapiens (Human) (see paper)
36% identity, 92% coverage of query (397 bits)
AACS_MOUSE / Q9D2R0 Acetoacetyl-CoA synthetase; EC 6.2.1.16 from Mus musculus (Mouse) (see paper)
Q9D2R0 acetoacetate-CoA ligase (EC 6.2.1.16) from Mus musculus (see 2 papers)
36% identity, 92% coverage of query (396 bits)
SUR5_CAEEL / Q21166 Acetoacetyl-CoA synthetase; Suppressor of activated let-60 Ras protein 5; EC 6.2.1.16 from Caenorhabditis elegans (see paper)
31% identity, 93% coverage of query (351 bits)
VrtB / D7PHZ3 malonamate-CoA ligase from Penicillium aethiopicum (see paper)
VRTB_PENAE / D7PHZ3 Malonamoyl-CoA synthetase vrtB; Viridicatumtoxin synthesis protein B; EC 6.2.1.- from Penicillium aethiopicum (see 4 papers)
32% identity, 95% coverage of query (295 bits)
Build an alignment for Ac3H11_4867 and 10 homologs with ≥ 30% identity
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ACSA_MYCTU / P9WQD1 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
29% identity, 86% coverage of query (190 bits)
Q2XNL6 acetate-CoA ligase (EC 6.2.1.1) from Methanothermobacter thermautotrophicus (see paper)
27% identity, 88% coverage of query (189 bits)
Q2I0L7 acetate-CoA ligase (EC 6.2.1.1) from Methanothermobacter thermautotrophicus (see paper)
28% identity, 82% coverage of query (187 bits)
ACSA_METTP / A0B8F1 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila) (see paper)
A0B8F1 acetate-CoA ligase (EC 6.2.1.1) from Methanothrix thermoacetophila (see paper)
27% identity, 94% coverage of query (186 bits)
facA acetyl-coenzyme A synthetase; EC 6.2.1.1 from Emericella nidulans (see 2 papers)
26% identity, 92% coverage of query (184 bits)
Msed_1456 / A4YGR1 3-hydroxypropionyl-CoA synthetase subunit (EC 6.2.1.36) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see 2 papers)
HPCAS_METS5 / A4YGR1 3-hydroxypropionyl-coenzyme A synthetase; 3-hydroxypropionyl-CoA synthetase; EC 6.2.1.36 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see paper)
A4YGR1 propionate-CoA ligase (EC 6.2.1.17); 3-hydroxypropionyl-CoA synthase (EC 6.2.1.36) from Metallosphaera sedula (see 2 papers)
28% identity, 83% coverage of query (182 bits)
A0A144QFN1 acetate-CoA ligase (EC 6.2.1.1) from Dunaliella tertiolecta (see paper)
26% identity, 95% coverage of query (179 bits)
A4YGF9 4-hydroxybutyrate-CoA ligase (AMP-forming) (EC 6.2.1.40) from Metallosphaera sedula (see paper)
26% identity, 92% coverage of query (176 bits)
HPCAS_SULTO / Q973W5 3-hydroxypropionyl-coenzyme A synthetase; 3-hydroxypropionyl-CoA synthetase; EC 6.2.1.36 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
Q973W5 3-hydroxypropionyl-CoA synthase (EC 6.2.1.36) from Sulfurisphaera tokodaii (see paper)
28% identity, 88% coverage of query (174 bits)
ACS2L_HUMAN / Q9NUB1 Acetyl-coenzyme A synthetase 2-like, mitochondrial; Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; AceCS2; Acyl-CoA synthetase short-chain family member 1; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Homo sapiens (Human) (see 2 papers)
Q9NUB1 acetate-CoA ligase (EC 6.2.1.1) from Homo sapiens (see paper)
26% identity, 89% coverage of query (173 bits)
ACS2L_MOUSE / Q99NB1 Acetyl-coenzyme A synthetase 2-like, mitochondrial; Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; AceCS2; Acyl-CoA synthetase short-chain family member 1; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Mus musculus (Mouse) (see 3 papers)
Q99NB1 acetate-CoA ligase (EC 6.2.1.1) from Mus musculus (see paper)
26% identity, 88% coverage of query (172 bits)
ACSA_MYCS2 / A0R5G1 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
26% identity, 87% coverage of query (171 bits)
ACS1 / Q01574 acetyl CoA synthetase 1 (EC 6.2.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 4 papers)
ACS1_YEAST / Q01574 Acetyl-coenzyme A synthetase 1; Acetate--CoA ligase 1; Acyl-activating enzyme 1; EC 6.2.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
26% identity, 94% coverage of query (167 bits)
AcsA / b4069 acetyl-CoA synthetase (AMP-forming) (EC 6.2.1.1; EC 6.2.1.17) from Escherichia coli K-12 substr. MG1655 (see 48 papers)
acs / P27550 acetyl-CoA synthetase (AMP-forming) (EC 6.2.1.17; EC 6.2.1.1) from Escherichia coli (strain K12) (see 46 papers)
ACSA_ECOLI / P27550 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Escherichia coli (strain K12) (see 3 papers)
26% identity, 91% coverage of query (166 bits)
ACSA_SALTY / Q8ZKF6 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 5 papers)
25% identity, 91% coverage of query (166 bits)
AO353_03060 Acetyl-coenzyme A synthetase (EC 6.2.1.1) from Pseudomonas fluorescens FW300-N2E3
26% identity, 92% coverage of query (165 bits)
8sf3A Crystal structure of acetyl-coenzyme a synthetase from leishmania infantum (amp, acetate and coa bound)
26% identity, 91% coverage of query (165 bits)
5jrhA Crystal structure of salmonella enterica acetyl-coa synthetase (acs) in complex with camp and coenzyme a
25% identity, 91% coverage of query (165 bits)
2p2fA Acetyl-coa synthetase, wild-type with acetate, amp, and coa bound
25% identity, 91% coverage of query (165 bits)
acs1 / Q2LWR8 acetate—CoA ligase (EC 6.2.1.1) from Syntrophus aciditrophicus (strain SB) (see paper)
25% identity, 85% coverage of query (164 bits)
8u2rA / A4I093 Crystal structure of acetyl-coenzyme a synthetase from leishmania infantum (ethyl amp bound)
26% identity, 91% coverage of query (164 bits)
ACS_ARATH / B9DGD6 Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal; Acetate--CoA ligase; Acetyl-CoA synthetase; EC 6.2.1.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
B9DGD6 acetate-CoA ligase (EC 6.2.1.1) from Arabidopsis thaliana (see paper)
25% identity, 85% coverage of query (164 bits)
ACS2 / P52910 acetyl CoA synthetase 2 (EC 6.2.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
ACS2_YEAST / P52910 Acetyl-coenzyme A synthetase 2; Acetate--CoA ligase 2; Acyl-activating enzyme 2; EC 6.2.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
P52910 acetate-CoA ligase (EC 6.2.1.1) from Saccharomyces cerevisiae (see paper)
26% identity, 90% coverage of query (163 bits)
B1YBY4 4-hydroxybutyrate-CoA ligase (AMP-forming) (EC 6.2.1.40) from Pyrobaculum neutrophilum (see 2 papers)
29% identity, 83% coverage of query (163 bits)
acsA / P31638 acetyl-CoA synthetase (EC 6.2.1.1; EC 6.2.1.17) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
ACSA_CUPNH / P31638 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
27% identity, 91% coverage of query (162 bits)
2p20A / Q8ZKF6 Acetyl-coa synthetase, r584a mutation (see paper)
25% identity, 91% coverage of query (162 bits)
Q89WV5 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
25% identity, 91% coverage of query (162 bits)
AO356_18695 Acetyl-coenzyme A synthetase (EC 6.2.1.1) from Pseudomonas fluorescens FW300-N2C3
25% identity, 91% coverage of query (161 bits)
7kvyA / J3KJC6 Crystal structure of acetyl-coa synthetase in complex with adenosine- 5'-ethylphosphate and co-enzyme a from coccidioides immitis rs
25% identity, 88% coverage of query (161 bits)
1ry2A / Q01574 Crystal structure of yeast acetyl-coenzyme a synthetase in complex with amp (see paper)
27% identity, 86% coverage of query (160 bits)
1pg3A Acetyl coa synthetase, acetylated on lys609
25% identity, 91% coverage of query (160 bits)
8w0bA / Q8NJN3 8w0bA
27% identity, 88% coverage of query (159 bits)
ACS2 acetyl-coenzyme A synthetase 2; EC 6.2.1.1 from Candida albicans (see 2 papers)
27% identity, 88% coverage of query (159 bits)
8w0cA Acetyl-coenzyme A synthetase 2
27% identity, 88% coverage of query (159 bits)
8w0dA Acetyl-coenzyme A synthetase 2
27% identity, 88% coverage of query (159 bits)
8v4rA Crystal structure of acetyl-coa synthetase 2 in complex with amp and coa from candida albicans
27% identity, 88% coverage of query (159 bits)
7l3qA Crystal structure of acetyl-coa synthetase in complex with adenosine- 5'-methylphosphate and co-enzyme a from coccidioides immitis rs
25% identity, 89% coverage of query (159 bits)
ACS2 / CAC41017.1 Acetyl-CoA synthetase from Zygosaccharomyces bailii (see paper)
26% identity, 86% coverage of query (157 bits)
prpE / P55912 propionate-CoA ligase (EC 6.2.1.17) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
PRPE_SALTY / P55912 Propionate--CoA ligase; Propionyl-CoA synthetase; EC 6.2.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
26% identity, 88% coverage of query (155 bits)
P78773 Probable acetyl-coenzyme A synthetase; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
24% identity, 91% coverage of query (155 bits)
8w0jA Acetyl-coenzyme A synthetase 2
27% identity, 88% coverage of query (155 bits)
8v4pA Crystal structure of acetyl-coa synthetase 2 in complex with adenosine-5'-allylphosphate from candida albicans
27% identity, 88% coverage of query (155 bits)
8v4oA Crystal structure of acetyl-coa synthetase 2 in complex with amp from candida albicans
27% identity, 88% coverage of query (155 bits)
7kdnA / Q4WQ02 Crystal structure of acetyl-coa synthetase in complex with adenosine- 5'-propylphosphate from aspergillus fumigatus
25% identity, 86% coverage of query (154 bits)
7kdsA Crystal structure of acetyl-coa synthetase 2 in complex with adenosine-5'-propylphosphate from candida albicans
27% identity, 88% coverage of query (153 bits)
5k8fA Crystal structure of acetyl-coa synthetase in complex with atp and acetyl-amp from cryptococcus neoformans h99
26% identity, 83% coverage of query (152 bits)
ACSS3_RAT / A0A0G2K047 Acyl-CoA synthetase short-chain family member 3, mitochondrial; Acetate--CoA ligase 3; Acyl-CoA synthetase short-chain family member 3; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Rattus norvegicus (Rat) (see paper)
A0A0G2K047 propionate-CoA ligase (EC 6.2.1.17) from Rattus norvegicus (see paper)
26% identity, 88% coverage of query (151 bits)
ACSS3_HUMAN / Q9H6R3 Acyl-CoA synthetase short-chain family member 3, mitochondrial; Acetate--CoA ligase 3; Acyl-CoA synthetase short-chain family member 3; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Homo sapiens (Human) (see paper)
26% identity, 88% coverage of query (149 bits)
7l4gB / J9VFT1 Crystal structure of acetyl-coa synthetase in complex with acetyl adenylate from cryptococcus neoformans h99
26% identity, 82% coverage of query (148 bits)
5u29A Crystal structure of cryptococcus neoformans h99 acetyl-coa synthetase in complex with ac-ams
26% identity, 82% coverage of query (148 bits)
ACAS2 / Q9NR19 acetyl-coA synthetase (EC 6.2.1.1) from Homo sapiens (see 2 papers)
ACSA_HUMAN / Q9NR19 Acetyl-coenzyme A synthetase, cytoplasmic; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Homo sapiens (Human) (see 3 papers)
Q9NR19 acetate-CoA ligase (EC 6.2.1.1) from Homo sapiens (see 5 papers)
25% identity, 88% coverage of query (147 bits)
7kcpA Crystal structure of acetyl-coa synthetase in complex with adenosine- 5'-propylphosphate from coccidioides posadasii c735
25% identity, 78% coverage of query (146 bits)
8v5gA Crystal structure of acetyl-coa synthetase from cryptococcus neoformans h99 in complex with an ethylsulfamide amp inhibitor
26% identity, 83% coverage of query (144 bits)
7knpA Crystal structure of acetyl-coa synthetase in complex with adenosine- 5'-butylphosphate from cryptococcus neoformans var. Grubii serotype a (h99)
26% identity, 83% coverage of query (142 bits)
5gxdA / A8LRC0 Structure of acryloyl-coa lyase prpe from dinoroseobacter shibae dfl 12
27% identity, 82% coverage of query (142 bits)
ACSA_MOUSE / Q9QXG4 Acetyl-coenzyme A synthetase, cytoplasmic; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Mus musculus (Mouse) (see 4 papers)
24% identity, 91% coverage of query (141 bits)
8g0vA Crystal structure of acetyl-coa synthetase in complex with a propyne ester amp inhibitor from cryptococcus neoformans h99
26% identity, 82% coverage of query (140 bits)
8g0uA Crystal structure of acetyl-coa synthetase in complex with an isopropyl ester amp inhibitor from cryptococcus neoformans h99
26% identity, 82% coverage of query (140 bits)
7knoA Crystal structure of acetyl-coa synthetase in complex with adenosine- 5'-ethylphosphate from cryptococcus neoformans var. Grubii serotype a (h99)
26% identity, 82% coverage of query (140 bits)
5k8fC Crystal structure of acetyl-coa synthetase in complex with atp and acetyl-amp from cryptococcus neoformans h99
26% identity, 83% coverage of query (140 bits)
8g0tA Crystal structure of acetyl-coa synthetase in complex with a cyclopropyl ester amp inhibitor from cryptococcus neoformans h99
26% identity, 82% coverage of query (140 bits)
7kdnB Crystal structure of acetyl-coa synthetase in complex with adenosine- 5'-propylphosphate from aspergillus fumigatus
25% identity, 76% coverage of query (139 bits)
8w0mA Acetyl-coenzyme A synthetase 2
28% identity, 80% coverage of query (139 bits)
5ifiA Crystal structure of acetyl-coa synthetase in complex with adenosine- 5'-propylphosphate from cryptococcus neoformans h99
26% identity, 83% coverage of query (139 bits)
8w0lC Acetyl-coenzyme A synthetase 2
28% identity, 74% coverage of query (138 bits)
8epsA Crystal structure of acetyl-coa synthetase in complex with an allyl ester amp inhibitor from cryptococcus neoformans h99
26% identity, 83% coverage of query (138 bits)
8g0rA Crystal structure of acetyl-coa synthetase in complex with a cyclopentyl ester amp inhibitor from cryptococcus neoformans h99
26% identity, 83% coverage of query (137 bits)
7mmzA / Q5ZZ84 Crystal structure of acetyl-coenzyme a synthetase from legionella pneumophila philadelphia 1 in complex with ethyl-amp (see paper)
26% identity, 78% coverage of query (132 bits)
5k85C Crystal structure of acetyl-coa synthetase in complex with adenosine- 5'-propylphosphate and coenzyme a from cryptococcus neoformans h99
26% identity, 79% coverage of query (129 bits)
8biqB Crystal structure of acyl-coa synthetase from metallosphaera sedula in complex with acetyl-amp
24% identity, 80% coverage of query (90.1 bits)
8biqA / A4YDT1 Crystal structure of acyl-coa synthetase from metallosphaera sedula in complex with acetyl-amp
24% identity, 80% coverage of query (90.1 bits)
8bitA Crystal structure of acyl-coa synthetase from metallosphaera sedula in complex with coenzyme a and acetyl-amp
24% identity, 80% coverage of query (89.7 bits)
6m2uA The crystal structure of benzoate coenzyme a ligase double mutant (h333a/i334a) in complex with 2-chloro-1,3-thiazole-5-carboxylate-amp
23% identity, 76% coverage of query (58.2 bits)
6m2tA The crystal structure of benzoate coenzyme a ligase double mutant (h333a/i334a) in complex with 2-methyl-thiazole-5 carboxylate-amp
23% identity, 76% coverage of query (58.2 bits)
4rlfB / Q93TK0 Crystal structure of a benzoate coenzyme a ligase with p-toluic acid and o-toluic acid (see paper)
23% identity, 76% coverage of query (57.8 bits)
4rmnA Crystal structure of a benzoate coenzyme a ligase with 2-thiophene carboxylic acid
23% identity, 76% coverage of query (55.8 bits)
4zjzA Crystal structure of a benzoate coenzyme a ligase with benzoyl-amp
23% identity, 76% coverage of query (55.5 bits)
4rm3A Crystal structure of a benzoate coenzyme a ligase with 2-furoic acid
23% identity, 76% coverage of query (55.5 bits)
4rm2A Crystal structure of a benzoate coenzyme a ligase with 2-fluoro benzoic acid
23% identity, 76% coverage of query (55.5 bits)
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