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Searching for up to 100 curated homologs for BPHYT_RS02320 FitnessBrowser__BFirm:BPHYT_RS02320 (262 a.a.)

Found high-coverage hits (≥70%) to 92 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

pcaL / AAC38246.1 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase from Rhodococcus opacus (see paper)
    41% identity, 91% coverage of query (176 bits)

2xuaH / Q13KT2 Crystal structure of the enol-lactonase from burkholderia xenovorans lb400 (see paper)
    36% identity, 97% coverage of query (174 bits)

Q13KT2 3-oxoadipate enol-lactonase (EC 3.1.1.24) from Paraburkholderia xenovorans (see 2 papers)
    36% identity, 97% coverage of query (174 bits)

AO353_17230 Beta-ketoadipate enol-lactone hydrolase (EC 3.1.1.24) from Pseudomonas fluorescens FW300-N2E3
    36% identity, 95% coverage of query (173 bits)

Q0SH24 3-oxoadipate enol-lactonase (EC 3.1.1.24); 4-carboxymuconolactone decarboxylase (EC 4.1.1.44) from Rhodococcus jostii (see paper)
    39% identity, 93% coverage of query (167 bits)

catD / AAC46435.1 beta-ketoadipate enol-lactone hydrolase from Acinetobacter baylyi (see 8 papers)
    35% identity, 97% coverage of query (163 bits)

catD / BAA75208.1 b-ketoadipate enol-lactone hydrolase from Frateuria sp. ANA-18 (see paper)
catD / BAC82535.1 b-ketoadipate enol-lactone hydrolase from Frateuria sp. ANA-18 (see 3 papers)
    35% identity, 91% coverage of query (156 bits)

pcaD / Q88N36 subunit of 3-oxoadipate enol-lactone hydrolase (EC 3.1.1.24) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 5 papers)
Q88N36 3-oxoadipate enol-lactonase (EC 3.1.1.24) from Pseudomonas putida (see paper)
    35% identity, 95% coverage of query (149 bits)

pcaD / AAC37150.1 beta-ketoadipate enol-lactone hydrolase from Acinetobacter baylyi (see 11 papers)
    32% identity, 99% coverage of query (140 bits)

pcaD / AAF34270.1 beta-ketoadipate enol-lactone hydrolase from Agrobacterium tumefaciens (see 2 papers)
    33% identity, 93% coverage of query (138 bits)

6eb3B Structural and enzymatic characterization of an esterase from a metagenomic library
    30% identity, 99% coverage of query (99.0 bits)

Build an alignment

Build an alignment for BPHYT_RS02320 and 11 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

6eb3C Structural and enzymatic characterization of an esterase from a metagenomic library
    29% identity, 99% coverage of query (98.6 bits)

6eb3A Structural and enzymatic characterization of an esterase from a metagenomic library
    29% identity, 99% coverage of query (96.7 bits)

4uheA Structural studies of a thermophilic esterase from thermogutta terrifontis (malate bound)
    28% identity, 96% coverage of query (90.1 bits)

4uhdA Structural studies of a thermophilic esterase from thermogutta terrifontis (acetate bound)
    28% identity, 96% coverage of query (90.1 bits)

4uhfA / A0A0M3KKY6 Structural studies of a thermophilic esterase from thermogutta terrifontis (l37a mutant with butyrate bound) (see paper)
    28% identity, 96% coverage of query (89.7 bits)

bioH / BAB39459.1 BioH from Kurthia sp. 538-KA26 (see paper)
    28% identity, 85% coverage of query (88.6 bits)

O73957 carboxylesterase (EC 3.1.1.1) from Sulfolobus acidocaldarius (see paper)
    25% identity, 97% coverage of query (80.1 bits)

flnE / BAC75995.1 meta cleavage compound hydrolase from Terrabacter sp. DBF63 (see paper)
    27% identity, 98% coverage of query (77.8 bits)

Q8KT44 carboxylesterase (EC 3.1.1.1) from Lacticaseibacillus casei (see paper)
    25% identity, 95% coverage of query (74.7 bits)

5h3hB / K0ACL0 Esterase (eaest) from exiguobacterium antarcticum (see paper)
    23% identity, 95% coverage of query (71.6 bits)

PHAZ_PSEOL / P26495 Poly(3-hydroxyalkanoate) depolymerase; PHA depolymerase; ORF2; PHB depolymerase; EC 3.1.1.- from Pseudomonas oleovorans (see paper)
phaB / AAA25933.1 PHA-depolymerase from Pseudomonas oleovorans (see paper)
    25% identity, 91% coverage of query (70.5 bits)

A0A0H2WW38 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC 4.2.99.20) from Staphylococcus aureus (see paper)
    23% identity, 95% coverage of query (69.3 bits)

phaZ / Q8KQ22 intracellular poly(3-hydroxyoctanoate) depolymerase (EC 3.1.1.76) from Pseudomonas putida (see 6 papers)
    25% identity, 90% coverage of query (67.4 bits)

Q5Y152 poly(3-hydroxyoctanoate) depolymerase (EC 3.1.1.76) from Pseudomonas putida (see paper)
    25% identity, 90% coverage of query (67.4 bits)

EstN1 / K0IAM1 pimeloyl-[acyl-carrier protein] methyl ester esterase (EC 3.1.1.85) from Nitrososphaera gargensis (strain Ga9.2) (see paper)
    26% identity, 98% coverage of query (65.5 bits)

TGND_ACIAD / Q6F9F4 (E)-2-((N-methylformamido)methylene)succinate hydrolase; MFMS hydrolase; EC 3.5.1.- from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    24% identity, 93% coverage of query (64.3 bits)

bphD / BAM76235.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Janibacter sp. TYM3221 (see paper)
    28% identity, 98% coverage of query (63.9 bits)

Q9KJG6 triacylglycerol lipase (EC 3.1.1.3) from Pseudomonas aeruginosa (see paper)
    24% identity, 98% coverage of query (63.9 bits)

6i8wB / Q9KJG6 Crystal structure of a membrane phospholipase a, a novel bacterial virulence factor (see paper)
    24% identity, 98% coverage of query (63.9 bits)

lnmJ / Q8GGP2 leinamycin polyketide synthase LnmJ from Streptomyces atroolivaceus (see 5 papers)
    29% identity, 92% coverage of query (63.2 bits)

estRB8 / CAE54381.1 carboxylesterase, partial from Oleispira antarctica (see paper)
estRB8 / CAE54384.1 carboxylesterase from Oleispira antarctica (see paper)
    23% identity, 93% coverage of query (62.4 bits)

PFMAB_PESFW / W3XA95 Proline iminopeptidase PfmaB; PIP; Conidial pigment biosynthesis cluster protein B; EC 3.4.11.5 from Pestalotiopsis fici (strain W106-1 / CGMCC3.15140) (see 2 papers)
    23% identity, 98% coverage of query (62.4 bits)

B5SU85 2,6-dioxo-6-phenylhexa-3-enoate hydrolase (EC 3.7.1.8) from Dyella ginsengisoli (see paper)
    24% identity, 98% coverage of query (61.2 bits)

rdmC / Q54528 aclacinomycin methylesterase (EC 3.1.1.95) from Streptomyces purpurascens (see 2 papers)
RDMC_STREF / Q54528 Aclacinomycin methylesterase RdmC; EC 3.1.1.95 from Streptomyces purpurascens (see 3 papers)
Q54528 aclacinomycin methylesterase (EC 3.1.1.95) from Streptomyces purpurascens (see paper)
    27% identity, 82% coverage of query (61.2 bits)

1q0rA / Q54528 Crystal structure of aclacinomycin methylesterase (rdmc) with bound product analogue, 10-decarboxymethylaclacinomycin t (dcmat) (see paper)
    27% identity, 82% coverage of query (61.2 bits)

1q0zA Crystal structure of aclacinomycin methylesterase (rdmc) with bound product analogue, 10-decarboxymethylaclacinomycin a (dcma)
    27% identity, 82% coverage of query (61.2 bits)

AGH13449.1 hybrid C-C meta-cleavage hydrolase-carboxylesterase from Cycloclasticus zancles (see paper)
    26% identity, 97% coverage of query (60.8 bits)

BPHD_PSEFK / Q52011 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; 2,6-dioxo-6-phenylhexa-3-enoate hydrolase; EC 3.7.1.8 from Pseudomonas furukawaii (see paper)
bphD / BAA12881.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase from Pseudomonas oleovorans (see paper)
    24% identity, 99% coverage of query (60.1 bits)

BPHL_HUMAN / Q86WA6 Valacyclovir hydrolase; VACVase; Valacyclovirase; Biphenyl hydrolase-like protein; Biphenyl hydrolase-related protein; Bph-rp; Breast epithelial mucin-associated antigen; MCNAA; EC 3.1.-.- from Homo sapiens (Human) (see 2 papers)
    24% identity, 98% coverage of query (59.3 bits)

2ocgA / Q86WA6 Crystal structure of human valacyclovir hydrolase (see paper)
    24% identity, 98% coverage of query (58.9 bits)

2ociA Crystal structure of valacyclovir hydrolase complexed with a product analogue
    24% identity, 98% coverage of query (58.9 bits)

5z7xA / A0A0M4AMQ0 Crystal structure of striga hermonthica htl4 (shhtl4) (see paper)
    24% identity, 78% coverage of query (58.2 bits)

BPHD_PSEPU / Q52036 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; 2,6-dioxo-6-phenylhexa-3-enoate hydrolase; EC 3.7.1.8 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
    24% identity, 99% coverage of query (57.4 bits)

BPHD_PARXL / P47229 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; 2,6-dioxo-6-phenylhexa-3-enoate hydrolase; EC 3.7.1.8 from Paraburkholderia xenovorans (strain LB400) (see 2 papers)
P47229 2,6-dioxo-6-phenylhexa-3-enoate hydrolase (EC 3.7.1.8) from Paraburkholderia xenovorans (see 2 papers)
BphD / CAA46911.1 2-hydroxy-6-oxo-6-phenylhexa-2, 4-dienoate hydrolase from Pseudomonas sp (see paper)
    24% identity, 98% coverage of query (57.4 bits)

2og1A / P47229 Crystal structure of bphd, a c-c hydrolase from burkholderia xenovorans lb400 (see paper)
    24% identity, 98% coverage of query (57.4 bits)

2rhwA Crystal structure of the s112a mutant of a c-c hydrolase, bphd from burkholderia xenovorans lb400, in complex with 3,10-di-fluoro hopda
    24% identity, 98% coverage of query (55.8 bits)

2rhtA Crystal structure of the s112a mutant of a c-c hydrolase, bphd from burkholderia xenovorans lb400, in complex with 3-cl hopda
    24% identity, 98% coverage of query (55.8 bits)

2puhA Crystal structure of the s112a mutant of a c-c hydrolase, bphd from burkholderia xenovorans lb400, in complex with its substrate hopda
    24% identity, 98% coverage of query (55.8 bits)

Q6PLI2 poly(3-hydroxyoctanoate) depolymerase (EC 3.1.1.76) from Pseudomonas putida (see paper)
    24% identity, 91% coverage of query (55.5 bits)

hppC / AAB81313.1 2-hydroxy-6-ketonona-2,4-dienoate hydrolase from Rhodococcus globerulus (see paper)
    25% identity, 79% coverage of query (54.7 bits)

4ihaA Crystal structure of rice dwarf14 (d14) in complex with a gr24 hydrolysis intermediate
    25% identity, 89% coverage of query (52.4 bits)

2pujA Crystal structure of the s112a/h265a double mutant of a c-c hydrolase, bphd from burkholderia xenovorans lb400, in complex with its substrate hopda
    24% identity, 98% coverage of query (52.4 bits)

6ap8A Crystal structure of rice d14 bound to 2-(2-methyl-3-nitroanilino) benzoic acid
    25% identity, 89% coverage of query (52.4 bits)

5dj5A Crystal structure of rice dwarf14 in complex with synthetic strigolactone gr24
    25% identity, 89% coverage of query (52.4 bits)

6brtA / A0A0D9Z3K8 F-box protein cth with hydrolase (see paper)
    25% identity, 89% coverage of query (52.4 bits)

5zhsA Crystal structure of osd14 in complex with covalently bound kk052
    25% identity, 79% coverage of query (52.0 bits)

5zhtA Crystal structure of osd14 in complex with covalently bound kk073
    25% identity, 79% coverage of query (52.0 bits)

5zhrA Crystal structure of osd14 in complex with covalently bound kk094
    25% identity, 79% coverage of query (52.0 bits)

5yz7A Crystal structure of osd14 in complex with d-ring-opened 7'-carba-4bd
    25% identity, 79% coverage of query (52.0 bits)

D14_ORYSJ / Q10QA5 Strigolactone esterase D14; Protein DWARF 14; Protein DWARF 88; Protein HIGH-TILLERING DWARF 2; EC 3.1.-.- from Oryza sativa subsp. japonica (Rice) (see 11 papers)
    25% identity, 79% coverage of query (52.0 bits)

ABHD6_HUMAN / Q9BV23 Monoacylglycerol lipase ABHD6; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 6; EC 3.1.1.23 from Homo sapiens (Human) (see 2 papers)
    22% identity, 96% coverage of query (51.6 bits)

5z7yA Crystal structure of striga hermonthica htl7 (shhtl7)
    25% identity, 78% coverage of query (51.6 bits)

7snuA / A0A0M3PNA2 Crystal structure of shhtl7 from striga hermonthica in complex with strigolactone antagonist rg6 (see paper)
    25% identity, 78% coverage of query (51.6 bits)

7c8lA Hybrid designing of potent inhibitors of striga strigolactone receptor shhtl7
    25% identity, 78% coverage of query (51.6 bits)

ABHD6_MOUSE / Q8R2Y0 Monoacylglycerol lipase ABHD6; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 6; EC 3.1.1.23 from Mus musculus (Mouse) (see 4 papers)
    21% identity, 92% coverage of query (51.6 bits)

5z89A Structural basis for specific inhibition of highly sensitive shhtl7 receptor
    24% identity, 78% coverage of query (50.1 bits)

D14_ARATH / Q9SQR3 Strigolactone esterase D14; Protein DWARF 14; AtD14; EC 3.1.-.- from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
    23% identity, 81% coverage of query (48.9 bits)

carC / Q9AQM4 2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase monomer (EC 3.7.1.13) from Pseudomonas resinovorans (see paper)
CARC_PSERE / Q9AQM4 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoic acid hydrolase; HOPDA; EC 3.7.1.13 from Pseudomonas resinovorans (see 3 papers)
Q9AQM4 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase (EC 3.7.1.13) from Pseudomonas resinovorans (see paper)
carC / BAC41548.1 meta cleavage compound hydrolase from Pseudomonas resinovorans (see 9 papers)
    25% identity, 98% coverage of query (48.1 bits)

5cbkA / A0A0M5I297 Crystal structure of the strigolactone receptor shhtl5 from striga hermonthica (see paper)
    22% identity, 76% coverage of query (47.8 bits)

DAD2_PETHY / J9U5U9 Probable strigolactone esterase DAD2; Protein DECREASED APICAL DOMINANCE 2; EC 3.1.-.- from Petunia hybrida (Petunia) (see paper)
    22% identity, 87% coverage of query (47.4 bits)

4o08A Crystal structure of bacillus megaterium epoxide hydrolase in complex with an inhibitor
    21% identity, 98% coverage of query (47.4 bits)

4io0A / G9BEX6 Crystal structure of f128a mutant of an epoxide hydrolase from bacillus megaterium complexed with its product (r)-3-[1]naphthyloxy- propane-1,2-diol (see paper)
    21% identity, 98% coverage of query (47.4 bits)

6o5jA Crystal structure of dad2 bound to quinazolinone derivative
    22% identity, 87% coverage of query (47.0 bits)

6ap7A Crystal structure of dad2 in complex with 2-(2-methyl-3-nitroanilino) benzoic acid
    22% identity, 87% coverage of query (47.0 bits)

6ap6A / J9U5U9 Crystal structure of dad2 in complex with tolfenamic acid (see paper)
    22% identity, 87% coverage of query (47.0 bits)

RMS3_PEA / A0A109QYD3 Strigolactone esterase RMS3; Protein DWARF 14 homolog; PsD14; Protein RAMOSUS 3; EC 3.1.-.- from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see paper)
    22% identity, 82% coverage of query (46.6 bits)

3heaA The l29p/l124i mutation of pseudomonas fluorescens esterase
    23% identity, 96% coverage of query (46.2 bits)

3hi4A Switching catalysis from hydrolysis to perhydrolysis in p. Fluorescens esterase
    23% identity, 96% coverage of query (46.2 bits)

BioB / b3412 pimeloyl-acyl carrier protein methyl ester esterase (EC 3.1.1.85; EC 3.1.1.1) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
bioH / P13001 pimeloyl-acyl carrier protein methyl ester esterase (EC 3.1.1.85; EC 3.1.1.1) from Escherichia coli (strain K12) (see 8 papers)
BIOH_ECOLI / P13001 Pimeloyl-[acyl-carrier protein] methyl ester esterase; Biotin synthesis protein BioH; Carboxylesterase BioH; EC 3.1.1.85 from Escherichia coli (strain K12) (see 4 papers)
P13001 carboxylesterase (EC 3.1.1.1); pimelyl-[acyl-carrier protein] methyl ester esterase (EC 3.1.1.85) from Escherichia coli (see paper)
    25% identity, 91% coverage of query (45.8 bits)

3ia2A Pseudomonas fluorescens esterase complexed to the r-enantiomer of a sulfonate transition state analog
    23% identity, 96% coverage of query (45.8 bits)

ESTE_PSEFL / P22862 Arylesterase; Aryl-ester hydrolase; Carboxylic acid perhydrolase; PFE; Putative bromoperoxidase; EC 3.1.1.2; EC 1.-.-.- from Pseudomonas fluorescens (see 8 papers)
GI|951089 arylesterase; EC 1.-.-.-; EC 3.1.1.2 from Pseudomonas fluorescens (see 3 papers)
AAB60168.1 esterase from Pseudomonas fluorescens (see 2 papers)
    23% identity, 96% coverage of query (45.4 bits)

5hzgA / Q9SQR3 The crystal structure of the strigolactone-induced atd14-d3-ask1 complex (see paper)
    25% identity, 73% coverage of query (45.1 bits)

4etwA Structure of the enzyme-acp substrate gatekeeper complex required for biotin synthesis
    24% identity, 91% coverage of query (44.7 bits)

6qe2A Crystal structure of paleococcus ferrophilus monoacylglycerol lipase. (see paper)
    20% identity, 79% coverage of query (43.5 bits)

8hgwA / Q2MHH5 Crystal structure of mehph in complex with mbp (see paper)
    23% identity, 98% coverage of query (43.5 bits)

5dnuA / A0A0M3PN85 Crystal structure of striga kai2-like protein in complex with karrikin (see paper)
    22% identity, 78% coverage of query (43.1 bits)

4lyeA Crystal structure of the s105a mutant of a c-c hydrolase, dxnb2 from sphingomonas wittichii rw1, in complex with substrate hopda
    25% identity, 82% coverage of query (43.1 bits)

4lxiA Crystal structure of the s105a mutant of a carbon-carbon bond hydrolase, dxnb2 from sphingomonas wittichii rw1, in complex with 5, 8-dif hopda
    25% identity, 82% coverage of query (43.1 bits)

4lxhA Crystal structure of the s105a mutant of a carbon-carbon bond hydrolase, dxnb2 from sphingomonas wittichii rw1, in complex with 3- cl hopda (see paper)
    25% identity, 82% coverage of query (43.1 bits)

1m33A / P13001 Crystal structure of bioh at 1.7 a (see paper)
    24% identity, 91% coverage of query (43.1 bits)

1hl7A / Q8GJP7 Gamma lactamase from an aureobacterium species in complex with 3a,4,7, 7a-tetrahydro-benzo [1,3] dioxol-2-one (see paper)
    25% identity, 98% coverage of query (43.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory