Searching for up to 100 curated homologs for BPHYT_RS03795 FitnessBrowser__BFirm:BPHYT_RS03795 (454 a.a.)
Found high-coverage hits (≥70%) to 63 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
PCAK_PSEPU / Q51955 4-hydroxybenzoate transporter PcaK from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
TC 2.A.1.15.1 / Q51955 4-Hydroxybenzoate/protocatechuate porter from Pseudomonas putida (see paper)
pcaK / AAA85137.1 PcaK from Pseudomonas putida (see paper)
39% identity, 93% coverage of query (278 bits)
PCAK_ACIAD / Q43975 4-hydroxybenzoate transporter PcaK; 4-HB transporter from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
37% identity, 92% coverage of query (269 bits)
proT / BAB32694.1 putative transporter from Pseudomonas straminea (see 2 papers)
37% identity, 97% coverage of query (261 bits)
GALT_PSEPU / E8ZB61 Gallate transporter; Gallate permease from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
galT / CBJ94499.1 gallic acid permease from Pseudomonas putida (see paper)
39% identity, 87% coverage of query (245 bits)
MHBT_KLEOX / Q5EXK5 3-hydroxybenzoate transporter MhbT from Klebsiella oxytoca (see paper)
35% identity, 96% coverage of query (244 bits)
TC 2.A.1.15.3 / Q46M63 2,4-Dichlorophenoxyacetate porter (see 5 papers)
36% identity, 94% coverage of query (238 bits)
TC 2.A.1.15.7 / Q6FBB3 Aromatic compound (benzoate) uptake transporter of 450 aas from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
33% identity, 96% coverage of query (222 bits)
TC 2.A.1.15.5 / O30513 Benzoate porter, BenK from Acinetobacter calcoaceticus (see 2 papers)
30% identity, 97% coverage of query (222 bits)
TC 2.A.1.15.14 / Q8VUZ0 Probable uptake transporter for 2,4-dichlorophenoxyacetic acid (2,4-D), CadK from Bradyrhizobium sp. HW13
33% identity, 86% coverage of query (203 bits)
TC 2.A.1.15.6 / O24842 Vanillate porter, VanK (see 4 papers)
31% identity, 95% coverage of query (189 bits)
YaiK / b0353 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
mhpT / P77589 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
MHPT_ECOLI / P77589 3-(3-hydroxy-phenyl)propionate transporter; 3HPP transporter; 3-(3-hydroxy-phenyl)propionate:H(+) symporter; 3HPP:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.15.2 / P77589 MhpT. A specific 3-(3-hydroxyphenyl)propionate (3HPP) transporter; vital for E. coli K-12 W3110 to grow on this substrate from Escherichia coli (see 3 papers)
35% identity, 91% coverage of query (188 bits)
Build an alignment for BPHYT_RS03795 and 11 homologs with ≥ 30% identity
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TC 2.A.1.15.11 / Q6M372 The Vanillate porter, VanK from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
28% identity, 96% coverage of query (149 bits)
NIAP_ACIAD / Q6FFF7 Niacin transporter NiaP from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
26% identity, 92% coverage of query (142 bits)
genK / Q8NLB7 gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
GENK_CORGL / Q8NLB7 Gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
28% identity, 84% coverage of query (139 bits)
NIAP_BACSU / O34691 Putative niacin/nicotinamide transporter NiaP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.82.4 / O34691 Niacin uptake porter NiaP from Bacillus subtilis (see 2 papers)
27% identity, 93% coverage of query (124 bits)
TC 2.A.1.15.8 / O24723 Probable 1-hydroxy-2-naphthoate transporter, orf1 (see paper)
25% identity, 94% coverage of query (110 bits)
SVOP_BOVIN / Q1JP63 Synaptic vesicle 2-related protein; SV2-related protein from Bos taurus (Bovine) (see paper)
25% identity, 88% coverage of query (99.4 bits)
SVOP_XENLA / Q2XWK0 Synaptic vesicle 2-related protein; SV2-related protein from Xenopus laevis (African clawed frog) (see paper)
25% identity, 88% coverage of query (99.0 bits)
TC 2.A.1.82.1 / F2CRE4 The barley copper uptake porter, CT-1 of 749 aas; nearly identical to the wheat orthologue from Hordeum vulgare var. distichum
27% identity, 83% coverage of query (95.1 bits)
SVOP_RAT / Q9Z2I7 Synaptic vesicle 2-related protein; SV2-related protein from Rattus norvegicus (Rat) (see paper)
25% identity, 88% coverage of query (91.7 bits)
TC 2.A.1.15.4 / P94131 cis,cis-muconate porter, MucK from Acinetobacter calcoaceticus (see 2 papers)
mucK / AAC27117.1 cis,cis-muconate transport protein MucK from Acinetobacter baylyi (see paper)
25% identity, 80% coverage of query (90.1 bits)
TC 2.A.1.82.3 / Q8BFT9 Synaptic vesicle 2-related protein (SV2-related protein), SVOP from Mus musculus (see 4 papers)
25% identity, 88% coverage of query (88.2 bits)
NanT / b3224 N-acetylneuraminate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 10 papers)
nanT / P41036 N-acetylneuraminate:H+ symporter from Escherichia coli (strain K12) (see 16 papers)
NANT_ECOLI / P41036 Sialic acid transporter NanT; Sialic acid permease; Sialic acid/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.12.1 / P41036 The sialic acid porter, NanT. N-acetylneuraminic acid (Neu5Ac) serves as a sole source of carbon and nitrogen for E. coli. It is a mucus-derived carbon source in the mammalian gut. NanT can also take up and allow efficient growth on the related sialic acids, N-glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-d-glycero-d-galactonononic acid (KDN) from Escherichia coli (see 4 papers)
26% identity, 91% coverage of query (83.6 bits)
S22AD_HUMAN / Q9Y226 Solute carrier family 22 member 13; Organic anion transporter 10; OAT10; Organic cation transporter-like 3; ORCTL-3; ORCTL3 from Homo sapiens (Human) (see 5 papers)
TC 2.A.1.19.17 / Q9Y226 Kidney organic cation transporter-like 3 ORCTL-3 (OAT10; SLC22A13; Like-3) (Bahn et al., 2008) (transports nicotinate, p-aminohippurate and urate; KM=20-40 mμM) via exchange for lactate) from Homo sapiens (Human) (see 4 papers)
26% identity, 78% coverage of query (82.8 bits)
S22AD_MOUSE / Q6A4L0 Solute carrier family 22 member 13; Organic anion transporter 10; OAT10; Organic cation transporter-like 3; ORCTL-3 from Mus musculus (Mouse) (see paper)
28% identity, 74% coverage of query (81.6 bits)
S22AB_HUMAN / Q9NSA0 Solute carrier family 22 member 11; Organic anion transporter 4; OAT4; Organic anion:dicarboxylate exchanger OAT4 from Homo sapiens (Human) (see 11 papers)
TC 2.A.1.19.10 / Q9NSA0 The apical proximal tubular kidney/placenta organic anion transporter 4, Oat4 (Slc22a11) (transports estrone sulfate (Km = 1 µM), dehydroepiandrosterone sulfate (Km = 60µM), many anionic drugs, diuretics, bile salts, urate and ochratoxin A). Catalyzes Na+-independent efflux, possibly using glutamate as a counter anion in an exchange reaction, especially in the placenta from Homo sapiens (Human) (see 7 papers)
SLC22A11 / GB|BAA95316.1 solute carrier family 22 member 11 from Homo sapiens
28% identity, 78% coverage of query (76.3 bits)
TC 2.A.1.15.9 / O51798 Probable 4-methylmuconolactone transporter, MmlH from Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) (see paper)
23% identity, 79% coverage of query (74.3 bits)
YaaU / b0045 putative transporter YaaU from Escherichia coli K-12 substr. MG1655 (see 4 papers)
23% identity, 80% coverage of query (73.2 bits)
S22A6_RAT / O35956 Solute carrier family 22 member 6; Organic anion transporter 1; rOAT1; renal organic anion transporter 1; rROAT1 from Rattus norvegicus (Rat) (see 7 papers)
TC 2.A.1.19.4 / O35956 The polyspecific organic anion, cation and neutral molecule transporter, Oat1 (Slc22a6) (transports neutral compounds such as cardiac glycosides [i.e., ouabain] and steroids [i.e., aldosterone; cortisol; dexamethasone]; cationic compounds such as N-propylajmalinium, and anionic compounds such as p-aminohippurate, dicarboxylates, cyclic nucleotides, prostaglandins, urate, β-lactam antibiotics, nonsteroidal anti-inflammatory drugs, diuretics, bile salts and steroid conjugates [i.e., estrone-3-sulfate and estradiol-17-glucuronide]) transporter (H+ symporter or uniporter) Probably catalyzes organic anion (uptake):dicarboxylate (efflux) antiport in the basolateral membrane of kidney proximal tubules) (Eraly et al., 2003a,b). A 3-dimensional model of OAT1 has led to the identification of residues involved in differential transport of substrates such as p-aminohippurate and cidofovir (Perry et al., 2006). Oat1 transports many antiviral agents from Rattus norvegicus (Rat) (see 7 papers)
Slc22a6 / RF|NP_058920.1 solute carrier family 22 member 6 from Rattus norvegicus (see paper)
27% identity, 83% coverage of query (70.9 bits)
OCT7_ARATH / Q940M4 Organic cation/carnitine transporter 7; AtOCT7 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
24% identity, 87% coverage of query (70.9 bits)
S22A6_HUMAN / Q4U2R8 Solute carrier family 22 member 6; Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; hROAT1 from Homo sapiens (Human) (see 20 papers)
TC 2.A.1.19.31 / Q4U2R8 Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1), from Homo sapiens (see 17 papers)
28% identity, 84% coverage of query (70.9 bits)
S22AD_RAT / B2GV36 Solute carrier family 22 member 13; Organic anion transporter 10; OAT10; Organic cation transporter-like 3; ORCTL-3 from Rattus norvegicus (Rat) (see paper)
27% identity, 74% coverage of query (70.9 bits)
S22A6_MOUSE / Q8VC69 Solute carrier family 22 member 6; Kidney-specific transport protein; Novel kidney transcript; mNKT; Organic anion transporter 1; mOAT1; Renal organic anion transporter 1; mROAT1 from Mus musculus (Mouse) (see 6 papers)
28% identity, 83% coverage of query (70.1 bits)
S22A6_MACFA / Q4W8A3 Solute carrier family 22 member 6; Organic anion transporter 1; mkOAT1; Renal organic anion transporter 1 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
27% identity, 84% coverage of query (70.1 bits)
8bw7A Cryo-em structure of rat slc22a6 bound to alpha-ketoglutaric acid
27% identity, 83% coverage of query (70.1 bits)
NanX / b4279 sialic acid transporter NanX from Escherichia coli K-12 substr. MG1655 (see 5 papers)
nanX / P39352 sialic acid transporter NanX from Escherichia coli (strain K12) (see 4 papers)
YJHB_ECOLI / P39352 Putative metabolite transport protein YjhB from Escherichia coli (strain K12) (see paper)
24% identity, 81% coverage of query (69.7 bits)
8bvsA Cryo-em structure of rat slc22a6 bound to tenofovir
27% identity, 83% coverage of query (68.6 bits)
8bvtA / O35956 Cryo-em structure of rat slc22a6 bound to probenecid (see paper)
27% identity, 83% coverage of query (68.6 bits)
TC 2.A.1.1.42 / Q8G3X1 The D-glucose:H+ symporter, GlcP (glucose uptake is inhibited by 2-deoxyglucose, mannose and galactose) from Bifidobacterium longum (see paper)
28% identity, 82% coverage of query (67.8 bits)
AraE / b2841 arabinose:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 5 papers)
araE / P0AE24 arabinose:H+ symporter from Escherichia coli (strain K12) (see 5 papers)
ARAE_ECOLI / P0AE24 Arabinose-proton symporter; Arabinose transporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.1.2 / P0AE24 Arabinose (xylose; galactose):H+ symporter, AraE (low affinity high capacity) from Escherichia coli (see 6 papers)
25% identity, 78% coverage of query (67.4 bits)
S22A7_MOUSE / Q91WU2 Solute carrier family 22 member 7; Organic anion transporter 2; mOAT2 from Mus musculus (Mouse) (see 3 papers)
25% identity, 78% coverage of query (67.0 bits)
S22AO_MICMU / A0A8B7HA97 Steroid transmembrane transporter SLC22A24; Solute carrier family 22 member 24 from Microcebus murinus (Gray mouse lemur) (Lemur murinus) (see paper)
25% identity, 78% coverage of query (66.6 bits)
TC 2.A.1.1.32 / P15729 Glucose/fructose:H+ symporter, GlcP (see 4 papers)
25% identity, 83% coverage of query (66.6 bits)
S22A6_PIG / Q8MK48 Solute carrier family 22 member 6; Organic anion transporter 1; pOAT1; Renal organic anion transporter 1; ROAT1 from Sus scrofa (Pig) (see paper)
27% identity, 84% coverage of query (65.9 bits)
S22A8_PIG / Q70BM6 Organic anion transporter 3; pOAT3; Organic anion/dicarboxylate exchanger; Solute carrier family 22 member 8 from Sus scrofa (Pig) (see paper)
25% identity, 88% coverage of query (65.1 bits)
S22A6_PSEAM / O57379 Solute carrier family 22 member 6; Organic anion transporter 1; Renal organic anion transporter 1; ROAT1; fROAT1 from Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus) (see paper)
27% identity, 78% coverage of query (63.9 bits)
OCT1_CAEEL / Q9U539 Organic cation transporter 1; CeOCT1 from Caenorhabditis elegans (see paper)
TC 2.A.1.19.37 / Q9U539 Organic cation transporter 1 (CeOCT1) of 568 aas and 12 TMSs from Caenorhabditis elegans (see 3 papers)
25% identity, 91% coverage of query (63.5 bits)
Q9VCA2 Organic cation transporter protein from Drosophila melanogaster (Fruit fly)
26% identity, 78% coverage of query (62.4 bits)
8et8A Cryo-em structure of the organic cation transporter 1 in complex with verapamil
23% identity, 74% coverage of query (57.4 bits)
8et7A / O15245 Cryo-em structure of the organic cation transporter 1 in complex with diphenhydramine (see paper)
23% identity, 74% coverage of query (57.4 bits)
S22A1_HUMAN / O15245 Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1 from Homo sapiens (Human) (see 26 papers)
TC 2.A.1.19.29 / O15245 Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1) from Homo sapiens (see 18 papers)
24% identity, 73% coverage of query (56.2 bits)
S22A3_HUMAN / O75751 Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMT; Organic cation transporter 3; OCT3 from Homo sapiens (Human) (see 11 papers)
TC 2.A.1.19.24 / O75751 Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) from Homo sapiens (see 3 papers)
25% identity, 79% coverage of query (52.8 bits)
S22A5_HUMAN / O76082 Organic cation/carnitine transporter 2; High-affinity sodium-dependent carnitine cotransporter; Solute carrier family 22 member 5 from Homo sapiens (Human) (see 28 papers)
TC 2.A.1.19.3 / O76082 The polyspecific organic cation (L- and D-carnitine, butyryl-L-carnitine, acetyl carnitine, γ-butyro-betaine, glycinebetaine, β-lactam antibiotics with a quaternary nitrogen such as cephaloridine, and others):Na+ symporter, OCTN2 (SLC22A5). Carnitine is transporter with high affinity (2 - 20 μM0 (Ingoglia et al. 2015). Associated with Crohn''s disease (Barton et al., 2005) as well as primary carnitine deficiency from Homo sapiens (Human) (see 28 papers)
25% identity, 80% coverage of query (52.8 bits)
7zhaA / O75751 Structure of human oct3 in complex with inhibitor decynium-22 (see paper)
26% identity, 79% coverage of query (50.8 bits)
S22A7_HUMAN / Q9Y694 Solute carrier family 22 member 7; Novel liver transporter; NLT; Organic anion transporter 2; hOAT2 from Homo sapiens (Human) (see 9 papers)
TC 2.A.1.19.25 / Q9Y694 Solute carrier family 22 member 7 (liver transporter) (Organic anion transporter 2) (hOAT2), transports cyclic nucleotodes and the anti-viral drug, acyclovir (Dahlin et al. 2013). Expressed in liver, kidney, brain and red blood cells from Homo sapiens (see 9 papers)
26% identity, 77% coverage of query (50.4 bits)
O74969 High-affinity glucose transporter ght2; Hexose transporter 2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
24% identity, 73% coverage of query (49.7 bits)
S22A2_RABIT / Q8MJI6 Solute carrier family 22 member 2; Organic cation transporter 2 from Oryctolagus cuniculus (Rabbit) (see paper)
21% identity, 75% coverage of query (47.8 bits)
XylE / b4031 D-xylose:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 7 papers)
xylE / P0AGF4 D-xylose:H+ symporter from Escherichia coli (strain K12) (see 8 papers)
XYLE_ECOLI / P0AGF4 D-xylose-proton symporter; D-xylose transporter from Escherichia coli (strain K12) (see paper)
TC 2.A.1.1.3 / P0AGF4 Xylose (xylopyranose):H+ symporter of 491 aas and 12 TMSs from Escherichia coli (see 7 papers)
xylE D-xylose-proton symporter from Escherichia coli K12 (see 7 papers)
22% identity, 74% coverage of query (45.4 bits)
4gc0A The structure of the mfs (major facilitator superfamily) proton:xylose symporter xyle bound to 6-bromo-6-deoxy-d-glucose
22% identity, 74% coverage of query (45.1 bits)
4gbzA The structure of the mfs (major facilitator superfamily) proton:xylose symporter xyle bound to d-glucose
22% identity, 74% coverage of query (45.1 bits)
4gbyA / P0AGF4 The structure of the mfs (major facilitator superfamily) proton:xylose symporter xyle bound to d-xylose (see paper)
22% identity, 74% coverage of query (45.1 bits)
S22AE_HUMAN / Q9Y267 Solute carrier family 22 member 14; Organic cation transporter-like 4; ORCTL-4 from Homo sapiens (Human) (see 2 papers)
TC 2.A.1.19.22 / Q9Y267 solute carrier family 22, member 14, Slc22a14, is crucial for sperm motility and male fertility in mice. It is expressed specifically in male germ cells, and mice lacking the Slc22a14 gene show severe male infertility as well as sperm morphological changes from Homo sapiens (see 5 papers)
23% identity, 81% coverage of query (44.3 bits)
7zh6A Structure of human oct3 in complex with inhibitor corticosterone
25% identity, 79% coverage of query (43.9 bits)
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Lawrence Berkeley National Laboratory