Searching for up to 100 curated homologs for BPHYT_RS04430 FitnessBrowser__BFirm:BPHYT_RS04430 (244 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
1ji0A / Q9X0M3 Crystal structure analysis of the abc transporter from thermotoga maritima
49% identity, 100% coverage of query (241 bits)
Ac3H11_1692 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, ATPase component 2 from Acidovorax sp. GW101-3H11
48% identity, 99% coverage of query (231 bits)
HSERO_RS00900 L-proline ABC transporter, ATPase component 2 from Herbaspirillum seropedicae SmR1
48% identity, 99% coverage of query (227 bits)
TC 3.A.1.4.10 / Q8DQH7 ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
47% identity, 99% coverage of query (226 bits)
TC 3.A.1.4.11 / Q6N8W2 Branched-chain amino acid transport system ATP-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
51% identity, 100% coverage of query (223 bits)
TC 3.A.1.4.6 / Q8YT15 NatE, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
47% identity, 99% coverage of query (215 bits)
LivF / b3454 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
LivF / P22731 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.4.1 / P22731 LivF aka B3454, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 4 papers)
livF / GB|AAC76479.2 high-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivF from Escherichia coli K12 (see 5 papers)
46% identity, 99% coverage of query (213 bits)
AZOBR_RS08250 L-proline and D-alanine ABC transporter, ATPase component 2 from Azospirillum brasilense Sp245
44% identity, 100% coverage of query (207 bits)
TC 3.A.1.4.8 / P21630 High-affinity branched-chain amino acid transport ATP-binding protein BraG, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
46% identity, 99% coverage of query (204 bits)
Pf6N2E2_2926 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, ATPase component 2 LivF from Pseudomonas fluorescens FW300-N2E2
46% identity, 99% coverage of query (202 bits)
braG / CAB75552.1 ATPase from Rhizobium leguminosarum bv. viciae (see 2 papers)
43% identity, 100% coverage of query (194 bits)
TC 3.A.1.4.9 / Q0S720 ABC branched-chain amino acid transporter, ATP-binding component, component of Uptake transporter, CamABCD of cholate (steroid) metabolites, 1β(2'-propanoate)-3aα-H-4α(3"(R)-hydroxy-3"-propanoate)-7aβ-methylhexahydro-5-indanone and a desaturated analog from Rhodococcus sp. (strain RHA1)
44% identity, 99% coverage of query (192 bits)
TC 3.A.1.4.2 / P73650 NatE aka LivF aka SLR1881, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
45% identity, 100% coverage of query (179 bits)
TC 3.A.1.4.7 / Q92TN4 Putative branched-chain amino acid uptake ABC transporter ATP-binding protein, component of The protocatechuate (3,4-dihydroxybenzoate) uptake porter, PcaMNVWX from Rhizobium meliloti (strain 1021)
42% identity, 98% coverage of query (168 bits)
TC 3.A.1.4.5 / Q8NRV7 UrtE, component of The high affinity urea/thiourea/hydroxyurea porter from Corynebacterium glutamicum (see paper)
36% identity, 97% coverage of query (150 bits)
TC 3.A.1.4.2 / Q55164 NatA aka BRAF aka SLR0467, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
33% identity, 100% coverage of query (136 bits)
E6MYT4 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Neisseria meningitidis serogroup B / serotype 15 (see 2 papers)
32% identity, 99% coverage of query (131 bits)
lptB / Q7CPN9 LPS export ABC transporter ATP-binding protein (EC 7.5.2.5) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 9 papers)
34% identity, 98% coverage of query (130 bits)
6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
33% identity, 99% coverage of query (129 bits)
AO356_00465 ABC transporter for D-Glucosamine, putative ATPase component from Pseudomonas fluorescens FW300-N2C3
36% identity, 96% coverage of query (128 bits)
Pf6N2E2_2925 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, ATPase component 1 LivG from Pseudomonas fluorescens FW300-N2E2
32% identity, 100% coverage of query (128 bits)
Pf6N2E2_2050 ABC transporter for D-Glucosamine, putative ATPase component from Pseudomonas fluorescens FW300-N2E2
36% identity, 96% coverage of query (128 bits)
TC 3.A.1.4.6 / Q7A2H0 NatA, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
32% identity, 99% coverage of query (127 bits)
BPHYT_RS07685 ABC transporter for L-Arginine, putative ATPase component from Burkholderia phytofirmans PsJN
33% identity, 95% coverage of query (127 bits)
AO353_21725 ABC transporter for D-glucosamine, ATPase component from Pseudomonas fluorescens FW300-N2E3
37% identity, 96% coverage of query (127 bits)
TC 3.A.1.4.8 / P21629 High-affinity branched-chain amino acid transport ATP-binding protein BraF, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
31% identity, 100% coverage of query (125 bits)
lptB / O25417 lipopolysaccharide transport system ATP-binding protein LptB (EC 7.5.2.5) from Helicobacter pylori (strain ATCC 700392 / 26695) (see paper)
31% identity, 100% coverage of query (125 bits)
Build an alignment for BPHYT_RS04430 and 27 homologs with ≥ 30% identity
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LivG / b3455 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivG (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
LivG / P0A9S7 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivG (EC 7.4.2.2) from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.4.1 / P0A9S7 High-affinity branched-chain amino acid transport ATP-binding protein LivG aka B3455, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 4 papers)
29% identity, 100% coverage of query (124 bits)
6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
33% identity, 98% coverage of query (124 bits)
6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
33% identity, 98% coverage of query (124 bits)
6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
33% identity, 98% coverage of query (124 bits)
LptB / b3201 lipopolysaccharide transport system ATP binding protein LptB (EC 7.5.2.5) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
LptB / P0A9V1 lipopolysaccharide transport system ATP binding protein LptB (EC 7.5.2.5) from Escherichia coli (strain K12) (see 10 papers)
LPTB_ECOLI / P0A9V1 Lipopolysaccharide export system ATP-binding protein LptB; EC 7.5.2.- from Escherichia coli (strain K12) (see 5 papers)
P0A9V1 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Escherichia coli (see 3 papers)
TC 1.B.42.1.2 / P0A9V1 Lipopolysaccharide export system ATP-binding protein LptB, component of LPS export porin complex, LptBCFG-A-DE, consists of LptD (Omp; OmpA; 784 aas)-LptE (RlpB; 193 aas; O.M. lipoprotein)-LptA (KdsD; YhbN; OstA small; 185 aas periplasmic chaparone protein)-LptB (KdsC; YhbG; 241 aas cytoplasmic ABC-type ATPase)-LptC (YrbK, 199aas;1 N-terminal TMS)- LptFG, part of the ABC transporter. LptDE (1:1 stoichiometry) comprise a two-protein β-barrel-lipoprotein complex in the outer membrane that assembles and exports LPS from Escherichia coli (strain K12)
lptB lipopolysaccharide ABC transporter, ATP-binding protein LptB; EC 3.6.3.- from Escherichia coli K12 (see 9 papers)
33% identity, 98% coverage of query (123 bits)
1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
30% identity, 99% coverage of query (123 bits)
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter
30% identity, 99% coverage of query (123 bits)
TC 3.A.1.4.3 / Q8VM83 BraF aka Bra2F, component of General L- (and D-)amino acid uptake porter (transports acidic, basic, polar, semipolar and hydrophobic amino acids). The amino and carboxyl groups do not need to be α since γ-aminobutyric acid (GABA) is a substrate. The system may function with additional binding proteins since L-alanine uptake is not dependent on BraC from Rhizobium leguminosarum (biovar viciae) (see paper)
33% identity, 99% coverage of query (122 bits)
6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
33% identity, 98% coverage of query (122 bits)
6b89A E. Coli lptb in complex with adp and novobiocin
33% identity, 98% coverage of query (121 bits)
4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
33% identity, 98% coverage of query (121 bits)
TC 3.A.1.3.23 / Q9HU32 Probable ATP-binding component of ABC transporter, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
34% identity, 100% coverage of query (120 bits)
A0A071L2Z5 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Pseudomonas aeruginosa (see paper)
TC 3.A.1.152.1 / Q9HVV6 Probable ATP-binding component of ABC transporter, component of LPS export system, LptF (M), LptG (M) and LptB (C) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
31% identity, 98% coverage of query (120 bits)
6b8bA E. Coli lptb in complex with adp and a novobiocin derivative
33% identity, 98% coverage of query (120 bits)
TC 3.A.1.3.6 / P35116 NocP aka ATU6028 aka AGR_PTI_69, component of Nopaline porter from Agrobacterium tumefaciens (see 3 papers)
32% identity, 95% coverage of query (118 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
27% identity, 94% coverage of query (106 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
30% identity, 96% coverage of query (105 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
30% identity, 96% coverage of query (105 bits)
2olkA Abc protein artp in complex with adp-beta-s
30% identity, 96% coverage of query (105 bits)
2oljA Abc protein artp in complex with adp/mg2+
30% identity, 96% coverage of query (105 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
32% identity, 96% coverage of query (103 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
29% identity, 96% coverage of query (99.0 bits)
6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp
29% identity, 100% coverage of query (97.8 bits)
7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
29% identity, 100% coverage of query (97.4 bits)
7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
29% identity, 100% coverage of query (97.4 bits)
ECSA_BACSU / P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.143.1 / P55339 ABC-type transporter ATP-binding protein EcsA, component of The exoprotein (including α-amylase) secretion system, EcsAB(C) (Leskelä et al., 1999). Also may play roles in sporulation, competence (Leskelä et al., 1996) and transformation using purified DNA (Takeno et al., 2011). An involvement of EcsC in transport is not established, but it is homologous to the C-terminus of the P-type ATPase, 3.A.3.31.2 from Bacillus subtilis (strain 168) (see 3 papers)
29% identity, 98% coverage of query (95.1 bits)
ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
27% identity, 94% coverage of query (93.6 bits)
5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
29% identity, 92% coverage of query (91.7 bits)
6xgyA Crystal structure of e. Coli mlafb abc transport subunits in the dimeric state
30% identity, 96% coverage of query (90.9 bits)
7ch6C / P63386 Cryo-em structure of e.Coli mlafeb with amppnp (see paper)
30% identity, 96% coverage of query (90.9 bits)
7cgnB The overall structure of the mlafedb complex in atp-bound eqtall conformation (mutation of e170q on mlaf)
30% identity, 96% coverage of query (89.4 bits)
7chaI / Q9HVW1 Cryo-em structure of p.Aeruginosa mlafebd with amppnp (see paper)
27% identity, 96% coverage of query (89.4 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
32% identity, 94% coverage of query (89.4 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
32% identity, 94% coverage of query (89.4 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
32% identity, 94% coverage of query (89.4 bits)
1b0uA / P02915 Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
31% identity, 95% coverage of query (87.4 bits)
HISP_SALTY / P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
31% identity, 95% coverage of query (87.4 bits)
CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
27% identity, 89% coverage of query (86.7 bits)
RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
25% identity, 97% coverage of query (85.9 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
28% identity, 99% coverage of query (83.2 bits)
P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
31% identity, 86% coverage of query (83.2 bits)
8hf4A / A0A0H2ZPI8 Cryo-em structure of nucleotide-bound coma at outward-facing state with ec gate closed conformation (see paper)
30% identity, 93% coverage of query (83.2 bits)
8i6rB / Q9I6C0 Cryo-em structure of pseudomonas aeruginosa ftse(e163q)x/envc complex with atp in peptidisc (see paper)
30% identity, 84% coverage of query (83.2 bits)
8hf7B Cryo-em structure of coma bound to its mature substrate csp peptide
30% identity, 93% coverage of query (82.4 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
24% identity, 95% coverage of query (82.4 bits)
8k7aA Cryo-em structure of nucleotide-bound coma e647q mutant with mg2+
29% identity, 93% coverage of query (81.6 bits)
8hf6A Cryo-em structure of nucleotide-bound coma e647q mutant
29% identity, 93% coverage of query (81.6 bits)
6fn1A Zosuquidar and uic2 fab complex of human-mouse chimeric abcb1 (abcb1hm)
29% identity, 89% coverage of query (81.6 bits)
4q9iA P-glycoprotein cocrystallised with qz-ala
29% identity, 89% coverage of query (81.3 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
24% identity, 95% coverage of query (80.9 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
24% identity, 95% coverage of query (80.9 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
24% identity, 95% coverage of query (80.9 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
29% identity, 89% coverage of query (80.9 bits)
1g291 / Q9YGA6 Malk (see paper)
29% identity, 95% coverage of query (80.9 bits)
4xwkA P-glycoprotein co-crystallized with bde-100
29% identity, 89% coverage of query (80.9 bits)
6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
29% identity, 89% coverage of query (80.9 bits)
3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
29% identity, 89% coverage of query (80.9 bits)
3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
29% identity, 89% coverage of query (80.9 bits)
7otgA Structure of abcb1/p-glycoprotein in the presence of the cftr potentiator ivacaftor
29% identity, 89% coverage of query (80.9 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
29% identity, 85% coverage of query (80.5 bits)
6qexA / P08183 Nanodisc reconstituted human abcb1 in complex with uic2 fab and taxol (see paper)
29% identity, 89% coverage of query (80.5 bits)
7a6fA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and zosuquidar
29% identity, 89% coverage of query (80.5 bits)
7a6eA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and tariquidar
29% identity, 89% coverage of query (80.5 bits)
7a6cA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and elacridar
29% identity, 89% coverage of query (80.5 bits)
7a69A Nanodisc reconstituted human abcb1 in complex with mrk16 fab and vincristine
29% identity, 89% coverage of query (80.5 bits)
MacB / b0879 ABC-type tripartite efflux pump ATP binding/membrane subunit from Escherichia coli K-12 substr. MG1655 (see 14 papers)
MacB / P75831 ABC-type tripartite efflux pump ATP binding/membrane subunit from Escherichia coli (strain K12) (see 16 papers)
MACB_ECOLI / P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.122.1 / P75831 MacB aka B0879, component of Macrolide (14- and 15- but not 16-membered lactone macrolides including erythromycin) exporter, MacAB (formerly YbjYZ). Both MacA and MacB are required for activity (Tikhonova et al., 2007). MacAB functions with TolC to export multiple drugs and heat-stable enterotoxin II (enterotoxin STII) (Yamanaka et al., 2008). The crystal structure of MacA is available (Yum et al., 2009). MacB is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA (Lin et al., 2009). Xu et al. (2009) have reported the crystal structure of the periplasmic region of MacB which they claim resembles the periplasmic domain of RND-type transporters such as AcrB (TC# 2.A.6.2.2). Also exports L-cysteine (Yamada et al., 2006). The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by the MacB transporter from Escherichia coli (see 5 papers)
macB / BAB64542.1 macrolide-specific ABC-type efflux carrier from Escherichia coli (see paper)
29% identity, 93% coverage of query (80.5 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
24% identity, 94% coverage of query (80.5 bits)
7o9wA Encequidar-bound human p-glycoprotein in complex with uic2-fab
29% identity, 89% coverage of query (80.5 bits)
7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
28% identity, 95% coverage of query (79.7 bits)
7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac
29% identity, 89% coverage of query (79.7 bits)
7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac
29% identity, 89% coverage of query (79.7 bits)
7zkaA Abcb1 v978c mutant (mabcb1) in the outward facing state bound to aac
29% identity, 89% coverage of query (79.7 bits)
7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
28% identity, 95% coverage of query (79.7 bits)
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Lawrence Berkeley National Laboratory