Searching for up to 100 curated homologs for BPHYT_RS07250 FitnessBrowser__BFirm:BPHYT_RS07250 (347 a.a.)
Found high-coverage hits (≥70%) to 56 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
cmtG / Q51983 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
cmtG / AAB62295.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas putida (see 3 papers)
85% identity, 98% coverage of query (595 bits)
HOA_PSESP / Q9KWS0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Pseudomonas sp. (see paper)
83% identity, 98% coverage of query (591 bits)
carE / BAC41556.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas resinovorans (see 9 papers)
79% identity, 97% coverage of query (531 bits)
MhpE / b0352 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
mhpE / P51020 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli (strain K12) (see 3 papers)
HOA_ECOLI / P51020 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Escherichia coli (strain K12) (see 2 papers)
mhpE / GB|BAA13057.1 4-hydroxy-2-oxovalerate aldolase; EC 4.1.3.39 from Escherichia coli K12 (see 4 papers)
79% identity, 96% coverage of query (529 bits)
todH / P51018 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
77% identity, 97% coverage of query (526 bits)
todH / AAA61944.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas putida (see paper)
76% identity, 97% coverage of query (521 bits)
xylK / P51019 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (see 5 papers)
76% identity, 97% coverage of query (520 bits)
dmpG / P51016 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp. (strain CF600) (see paper)
HOA_PSEUF / P51016 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Pseudomonas sp. (strain CF600) (see 3 papers)
P51016 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp. (see paper)
dmpG / CAA43227.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas sp. CF600 (see paper)
76% identity, 97% coverage of query (510 bits)
1nvmA / P51016 Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate (see paper)
76% identity, 97% coverage of query (510 bits)
P51017 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (see paper)
nahM / AAA89107.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas putida (see paper)
56% identity, 98% coverage of query (399 bits)
nahM / BAE92172.1 4-hydroxy-2-oxovalerate aldolase NahM from Pseudomonas putida (see 2 papers)
55% identity, 100% coverage of query (398 bits)
tesG / Q83VZ3 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Comamonas testosteroni (see 2 papers)
55% identity, 100% coverage of query (379 bits)
HOA4_PARXL / P51015 4-hydroxy-2-oxovalerate aldolase 4; HOA 4; 4-hydroxy-2-keto-pentanoic acid aldolase 4; 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-oxopentanoate aldolase 4; EC 4.1.3.39; EC 4.1.3.43 from Paraburkholderia xenovorans (strain LB400) (see 3 papers)
P51015 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39); 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Paraburkholderia xenovorans LB400 (see 2 papers)
bphI / GB|ABE37049.1 4-hydroxy-2-oxovalerate aldolase; EC 4.1.3.39 from Burkholderia xenovorans LB400 (see paper)
57% identity, 98% coverage of query (377 bits)
bphI / CAA54036.1 4-hydroxy-2-oxovalerate aldolase from Paraburkholderia xenovorans LB400 (see paper)
56% identity, 98% coverage of query (375 bits)
HOA_THET8 / Q53WI0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39; EC 4.1.3.43 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
Q53WI0 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Thermus thermophilus (see paper)
54% identity, 97% coverage of query (345 bits)
hsaF / Q0S815 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Rhodococcus jostii (strain RHA1) (see paper)
51% identity, 97% coverage of query (343 bits)
4lrsA / D1A3K8 Crystal and solution structures of the bifunctional enzyme (aldolase/aldehyde dehydrogenase) from thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and coa accommodation whithin the shared cofactor-binding site
51% identity, 96% coverage of query (339 bits)
4jn6C / P9WMK5 Crystal structure of the aldolase-dehydrogenase complex from mycobacterium tuberculosis hrv37 (see paper)
50% identity, 96% coverage of query (333 bits)
hsaF / P9WMK5 4-hydroxy-2-oxohexanoate aldolase monomer (EC 4.1.3.43) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
HOA_MYCTU / P9WMK5 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; 4-hydroxy-2-oxovalerate aldolase; HOA; EC 4.1.3.43; EC 4.1.3.39 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WMK5 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Mycobacterium tuberculosis (see paper)
50% identity, 98% coverage of query (333 bits)
HOA_STRTE / Q9X9Q0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Streptomyces tendae (see paper)
38% identity, 98% coverage of query (210 bits)
OAADC_MYCTU / O06334 Oxaloacetate decarboxylase; OAA decarboxylase; EC 4.1.1.112 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
30% identity, 91% coverage of query (140 bits)
Build an alignment for BPHYT_RS07250 and 21 homologs with ≥ 30% identity
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rhiG / D4HRI4 rhiG aldolase subunit from Bacillus subtilis subsp. spizizenii ATCC 6633 (see paper)
26% identity, 90% coverage of query (98.2 bits)
LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis (see 2 papers)
26% identity, 80% coverage of query (73.2 bits)
3rmjB / Q9JZG1 Crystal structure of truncated alpha-isopropylmalate synthase from neisseria meningitidis (see paper)
25% identity, 79% coverage of query (70.1 bits)
B0K6M2 (R)-citramalate synthase (EC 2.3.3.21) from Thermoanaerobacter sp. (see paper)
25% identity, 73% coverage of query (63.9 bits)
P58637 homocitrate synthase (EC 2.3.3.14) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
27% identity, 75% coverage of query (62.8 bits)
HOSA_SULTO / Q971S5 Homocitrate synthase; HCS; EC 2.3.3.14 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
26% identity, 73% coverage of query (59.7 bits)
cimA / Q8F3Q1 (R)-citramalate synthase subunit (EC 2.3.3.21) from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see paper)
CIMA_LEPIN / Q8F3Q1 (R)-citramalate synthase CimA; LiCMS; EC 2.3.3.21 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see 3 papers)
25% identity, 71% coverage of query (59.7 bits)
A0A0S6UXF5 homocitrate synthase (EC 2.3.3.14) from Bradyrhizobium sp. DOA9 (see paper)
25% identity, 70% coverage of query (57.0 bits)
Q30DX9 2-isopropylmalate synthase (EC 2.3.3.13) from Brassica insularis (see paper)
26% identity, 71% coverage of query (54.3 bits)
LEU12_ARATH / Q9C550 2-isopropylmalate synthase 2, chloroplastic; 2-isopropylmalate synthase 1; Methylthioalkylmalate synthase-like 3; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9C550 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 2 papers)
26% identity, 71% coverage of query (53.9 bits)
BT1861 2-isopropylmalate synthase (EC 2.3.3.13) from Bacteroides thetaiotaomicron VPI-5482
25% identity, 79% coverage of query (52.8 bits)
LYS21 / Q12122 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
HOSM_YEAST / Q12122 Homocitrate synthase, mitochondrial; HCS; EC 2.3.3.14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
Q12122 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (see paper)
23% identity, 77% coverage of query (52.4 bits)
LEU11_ARATH / Q9LPR4 2-isopropylmalate synthase 1, chloroplastic; Methylthioalkylmalate synthase-like 4; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LPR4 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 3 papers)
26% identity, 71% coverage of query (52.0 bits)
6e1jA / C5J4P1 Crystal structure of methylthioalkylmalate synthase (bjumam1.1) from brassica juncea (see paper)
23% identity, 71% coverage of query (51.6 bits)
K4CJ56 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum (see paper)
24% identity, 71% coverage of query (51.6 bits)
LYS20 / P48570 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
HOSC_YEAST / P48570 Homocitrate synthase, cytosolic isozyme; HCS; EC 2.3.3.14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P48570 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (see 2 papers)
24% identity, 75% coverage of query (51.6 bits)
LEU1_SULAC / Q4JA78 2-isopropylmalate synthase; IPMS; Alpha-isopropylmalate synthase; Alpha-IPM synthase; EC 2.3.3.13 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
23% identity, 71% coverage of query (50.8 bits)
Q2RAP8 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
25% identity, 70% coverage of query (50.4 bits)
Q2QXY9 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
25% identity, 70% coverage of query (50.4 bits)
PYCB_METJA / Q58628 Pyruvate carboxylase subunit B; Pyruvic carboxylase B; EC 6.4.1.1 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
23% identity, 73% coverage of query (49.7 bits)
HMGCL_MOUSE / P38060 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Mus musculus (Mouse) (see paper)
24% identity, 77% coverage of query (49.3 bits)
LEU12_LEPIN / Q8F8T4 2-isopropylmalate synthase 2; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see 2 papers)
26% identity, 72% coverage of query (49.3 bits)
HOSA_SULAC / Q4J989 Homocitrate synthase; HCS; EC 2.3.3.14 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
Q4J989 homocitrate synthase (EC 2.3.3.14) from Sulfolobus acidocaldarius (see paper)
25% identity, 76% coverage of query (49.3 bits)
cimA / Q58787 (R)-citratemalate synthase subunit (EC 2.3.3.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
CIMA_METJA / Q58787 (R)-citramalate synthase CimA; EC 2.3.3.21 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58787 (R)-citramalate synthase (EC 2.3.3.21) from Methanocaldococcus jannaschii (see 2 papers)
24% identity, 72% coverage of query (48.5 bits)
6ktqA / Q4J989 Crystal structure of catalytic domain of homocitrate synthase from sulfolobus acidocaldarius (sahcs(dram)) in complex with alpha- ketoglutarate/zn2+/coa (see paper)
24% identity, 76% coverage of query (48.5 bits)
3ivsA Homocitrate synthase lys4
23% identity, 71% coverage of query (48.5 bits)
nifV / P05342 homocitrate synthase monomer (EC 2.3.3.14) from Azotobacter vinelandii (see paper)
NIFV_AZOVI / P05342 Homocitrate synthase; EC 2.3.3.14 from Azotobacter vinelandii (see paper)
23% identity, 72% coverage of query (47.8 bits)
HMGCL_RAT / P97519 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Rattus norvegicus (Rat) (see paper)
P97519 hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Rattus norvegicus (see paper)
22% identity, 77% coverage of query (46.6 bits)
3mi3A Homocitrate synthase lys4 bound to lysine
23% identity, 71% coverage of query (46.6 bits)
frbC / Q0ZQ46 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces rubellomurinus (strain ATCC 31215) (see 2 papers)
FRBC_STRR3 / Q0ZQ46 2-phosphonomethylmalate synthase; EC 2.3.3.19 from Streptomyces rubellomurinus (strain ATCC 31215) (see paper)
Q0ZQ46 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces rubellomurinus (see paper)
24% identity, 73% coverage of query (46.2 bits)
HMGCL / P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial (EC 4.1.3.4) from Homo sapiens (see 9 papers)
HMGCL_HUMAN / P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Homo sapiens (Human) (see 18 papers)
P35914 hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Homo sapiens (see 4 papers)
21% identity, 77% coverage of query (45.4 bits)
3mp3B Crystal structure of human lyase in complex with inhibitor hg-coa
21% identity, 77% coverage of query (45.4 bits)
2cw6A / P35914 Crystal structure of human hmg-coa lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria (see paper)
21% identity, 77% coverage of query (45.4 bits)
3ivtB / Q9Y823 Homocitrate synthase lys4 bound to 2-og (see paper)
23% identity, 71% coverage of query (45.4 bits)
HOSM_SCHPO / Q9Y823 Homocitrate synthase, mitochondrial; HCS; EC 2.3.3.14 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
lys4 / RF|NP_596458.1 homocitrate synthase (predicted); EC 2.3.3.14 from Schizosaccharomyces pombe (see 2 papers)
23% identity, 71% coverage of query (45.4 bits)
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Lawrence Berkeley National Laboratory