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Searching for up to 100 curated homologs for BPHYT_RS07330 FitnessBrowser__BFirm:BPHYT_RS07330 (306 a.a.)

Found high-coverage hits (≥70%) to 20 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YISK_BACSU / O06724 Uncharacterized protein YisK from Bacillus subtilis (strain 168) (see paper)
    38% identity, 97% coverage of query (176 bits)

8skyB / A0A0D6X359 Crystal structure of yisk from bacillus subtilis in complex with oxalate (see paper)
    38% identity, 97% coverage of query (176 bits)

8sutA Crystal structure of yisk from bacillus subtilis in complex with reaction product 4-hydroxy-2-oxoglutaric acid
    38% identity, 97% coverage of query (176 bits)

BPHYT_RS34210 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-) from Burkholderia phytofirmans PsJN
    37% identity, 85% coverage of query (173 bits)

UGL_BURL3 / Q39BA7 Ureidoglycolate lyase; UGL; Ureidoglycolase; Ureidoglycolatase; Ureidoglycolate hydrolase; EC 4.3.2.3 from Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383) (see paper)
    39% identity, 79% coverage of query (171 bits)

Y2993_MYCTU / I6Y276 Protein Rv2993c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    39% identity, 72% coverage of query (155 bits)

6iymA / K0A9N9 Fumarylacetoacetate hydrolase (eafah) from psychrophilic exiguobacterium antarcticum (see paper)
    34% identity, 100% coverage of query (146 bits)

K0A9N9 fumarylacetoacetase (EC 3.7.1.2) from Exiguobacterium antarcticum (see paper)
    33% identity, 100% coverage of query (142 bits)

4dbhA / Q8NQY2 Crystal structure of cg1458 with inhibitor (see paper)
    37% identity, 74% coverage of query (139 bits)

6v77B / A0QTY3 Crystal structure of a putative hpce protein from mycobacterium smegmatis
    38% identity, 70% coverage of query (138 bits)

dntG / Q8VUC7 2,4-dihydroxy-5-methyl-6-oxohexa-2,4-dienoate isomerase from Burkholderia cepacia (see 2 papers)
    31% identity, 97% coverage of query (136 bits)

A0A1R4GQY2 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Corynebacterium glutamicum (see paper)
    37% identity, 70% coverage of query (132 bits)

6j5xA / Q8NLC0 Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
    37% identity, 70% coverage of query (132 bits)

6j5xB Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate
    37% identity, 70% coverage of query (132 bits)

3r6oA / B1MJ53 Crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7- dioateisomerase from mycobacterium abscessus (see paper)
    34% identity, 75% coverage of query (123 bits)

G2IPX5 maleylpyruvate hydrolase (EC 3.7.1.23) from Sphingobium sp. SYK-6 (see paper)
    36% identity, 71% coverage of query (123 bits)

6jvwB / G2IPX5 Crystal structure of maleylpyruvate hydrolase from sphingobium sp. Syk-6 in complex with manganese (ii) ion and pyruvate (see paper)
    33% identity, 81% coverage of query (111 bits)

Q4J7I6 2-dehydro-3-deoxy-D-arabinonate dehydratase (EC 4.2.1.141) from Sulfolobus acidocaldarius (see paper)
    30% identity, 72% coverage of query (71.6 bits)

Build an alignment

Build an alignment for BPHYT_RS07330 and 18 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

xacE / D4GP28 2-dehydro-3-deoxy-L-arabinonate dehydratase (EC 4.2.1.43; EC 4.2.1.141) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 3 papers)
KDXD_HALVD / D4GP28 Probable 2-keto-3-deoxyxylonate dehydratase; KDXD; EC 4.2.1.141 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 2 papers)
    27% identity, 76% coverage of query (54.7 bits)

SO1670 fumarylacetoacetate hydrolase (EC 3.7.1.2) from Shewanella oneidensis MR-1
    22% identity, 96% coverage of query (46.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory