Searching for up to 100 curated homologs for BPHYT_RS10405 FitnessBrowser__BFirm:BPHYT_RS10405 (298 a.a.)
Found high-coverage hits (≥70%) to 78 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
SSUB_BACSU / P97027 Aliphatic sulfonates import ATP-binding protein SsuB; EC 7.6.2.14 from Bacillus subtilis (strain 168) (see paper)
49% identity, 79% coverage of query (236 bits)
TC 3.A.1.16.2 / O05347 CynD, component of Bispecific cyanate/nitrite transporter
50% identity, 72% coverage of query (225 bits)
Ac3H11_2560 ABC transporter for L-Histidine, ATPase component from Acidovorax sp. GW101-3H11
46% identity, 84% coverage of query (224 bits)
NRTC_SYNE7 / P38045 Nitrate import ATP-binding protein NrtC; EC 7.3.2.4 from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see 2 papers)
TC 3.A.1.16.1 / P38045 NrtC, component of Four component nitrate/nitrite porter (see paper)
50% identity, 79% coverage of query (224 bits)
CMPC_SYNE7 / Q55107 Bicarbonate transport ATP-binding protein CmpC; EC 7.6.2.- from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
TC 3.A.1.16.3 / Q55107 CmpC, component of Bicarbonate porter (activated by low [CO2] mediated by CmpR; (Nishimura et al., 2008)) (see 2 papers)
48% identity, 82% coverage of query (223 bits)
8wm7C / Q8YZ76 Cryo-em structure of cyanobacterial nitrate/nitrite transporter nrtbcd in complex with signalling protein pii (see paper)
47% identity, 81% coverage of query (218 bits)
8w9mC Cryo-em structure of the cyanobacterial nitrate transporter nrtbcd in complex with atp
47% identity, 81% coverage of query (217 bits)
NRTD_SYNE7 / P38046 Nitrate import ATP-binding protein NrtD; EC 7.3.2.4 from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
TC 3.A.1.16.1 / P38046 NrtD, component of Four component nitrate/nitrite porter (see paper)
45% identity, 85% coverage of query (216 bits)
TC 3.A.1.16.4 / Q8YRV8 Nitrate transport ATP-binding protein of ABC transporter, component of Nitrate uptake system, NrtABCD from Nostoc sp. (strain PCC 7120 / UTEX 2576) (see paper)
46% identity, 84% coverage of query (214 bits)
8wm7D / Q8YZ75 Cryo-em structure of cyanobacterial nitrate/nitrite transporter nrtbcd in complex with signalling protein pii (see paper)
46% identity, 83% coverage of query (212 bits)
CMPD_SYNE7 / Q55108 Bicarbonate transport ATP-binding protein CmpD; EC 7.6.2.- from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
TC 3.A.1.16.3 / Q55108 CmpD, component of Bicarbonate porter (activated by low [CO2] mediated by CmpR; (Nishimura et al., 2008)) (see 2 papers)
45% identity, 81% coverage of query (211 bits)
8w9mD Cryo-em structure of the cyanobacterial nitrate transporter nrtbcd in complex with atp
46% identity, 80% coverage of query (209 bits)
AZOBR_RS18550 ABC transporter for nitrate, ATPase component from Azospirillum brasilense Sp245
45% identity, 85% coverage of query (199 bits)
Q6RH47 taurine dehydrogenase (EC 1.4.99.2) from Paracoccus pantotrophus (see paper)
39% identity, 81% coverage of query (191 bits)
TC 3.A.1.17.5 / C0LZR9 OphH, component of The phthalate uptake system, OphFGH from Burkholderia cepacia
43% identity, 82% coverage of query (191 bits)
TC 3.A.1.17.4 / Q2BM69 Putative taurin uptake ABC transporter ATP-binding protein, component of The taurine uptake system, TauABC from Neptuniibacter caesariensis
40% identity, 77% coverage of query (187 bits)
TauB / b0366 taurine ABC transporter ATP binding subunit (EC 7.6.2.7) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TauB / Q47538 taurine ABC transporter ATP binding subunit (EC 7.6.2.7) from Escherichia coli (strain K12) (see 3 papers)
TAUB_ECOLI / Q47538 Taurine import ATP-binding protein TauB; EC 7.6.2.7 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.17.1 / Q47538 TauB aka SSIB aka B0366, component of Taurine (2-aminoethane sulfonate) porter from Escherichia coli (see 4 papers)
40% identity, 80% coverage of query (185 bits)
TC 3.A.1.17.2 / Q8KZQ6 Aliphatic sulfonates import ATP-binding protein SsuB, component of Aromatic sulfonate porter (see 3 papers)
43% identity, 79% coverage of query (173 bits)
SsuB / b0933 aliphatic sulfonate ABC transporter ATP binding subunit (EC 7.6.2.14) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
SsuB / P0AAI1 aliphatic sulfonate ABC transporter ATP binding subunit (EC 7.6.2.14) from Escherichia coli (strain K12) (see 3 papers)
SSUB_ECOLI / P0AAI1 Aliphatic sulfonates import ATP-binding protein SsuB; EC 7.6.2.14 from Escherichia coli (strain K12) (see paper)
TC 3.A.1.17.10 / B1X8N7 Aliphatic sulfonates import ATP-binding protein SsuB, component of Aliphatic sulfonate (alkanesulfonate) import permease, SsuABC (YcbOEM) and is regluated by the transcriptional activator, Cbl from Escherichia coli (strain K12 / DH10B)
40% identity, 84% coverage of query (164 bits)
PotG / b0855 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
PotG / P31134 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 2 papers)
POTG_ECOLI / P31134 Putrescine transport ATP-binding protein PotG; EC 7.6.2.16 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.11.2 / P31134 PotG aka B0855, component of Putrescine porter from Escherichia coli (see 4 papers)
41% identity, 72% coverage of query (160 bits)
1f3oA / Q58206 Crystal structure of mj0796 atp-binding cassette (see paper)
36% identity, 72% coverage of query (136 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
39% identity, 73% coverage of query (135 bits)
1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette
36% identity, 72% coverage of query (135 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
39% identity, 73% coverage of query (135 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
39% identity, 73% coverage of query (135 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
39% identity, 73% coverage of query (135 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
39% identity, 73% coverage of query (135 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
39% identity, 73% coverage of query (135 bits)
7ahhC Opua inhibited inward-facing, sbd docked
34% identity, 72% coverage of query (132 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
34% identity, 72% coverage of query (132 bits)
7ahdC Opua (e190q) occluded
34% identity, 72% coverage of query (130 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
39% identity, 71% coverage of query (124 bits)
FTSE_STRP2 / A0A0H2ZM82 Cell division ATP-binding protein FtsE from Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) (see 3 papers)
FTSE_STRR6 / Q8DQH4 Cell division ATP-binding protein FtsE from Streptococcus pneumoniae (strain ATCC BAA-255 / R6) (see paper)
6z4wA / Q8DQH4 Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
37% identity, 72% coverage of query (111 bits)
ECFA1_STRT2 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA 2, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
33% identity, 76% coverage of query (110 bits)
6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution
37% identity, 72% coverage of query (110 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
32% identity, 79% coverage of query (108 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
32% identity, 79% coverage of query (107 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
32% identity, 79% coverage of query (107 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
32% identity, 79% coverage of query (107 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
32% identity, 71% coverage of query (102 bits)
4hluA / Q9WY65 Structure of the ecfa-a' heterodimer bound to adp (see paper)
32% identity, 78% coverage of query (100 bits)
4zirA Crystal structure of ecfaa' heterodimer bound to amppnp
32% identity, 78% coverage of query (100 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
32% identity, 71% coverage of query (99.4 bits)
2awnA / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
33% identity, 73% coverage of query (97.1 bits)
6xgyA Crystal structure of e. Coli mlafb abc transport subunits in the dimeric state
32% identity, 74% coverage of query (92.4 bits)
7ch6C / P63386 Cryo-em structure of e.Coli mlafeb with amppnp (see paper)
32% identity, 74% coverage of query (92.4 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
31% identity, 71% coverage of query (91.3 bits)
7cgnB The overall structure of the mlafedb complex in atp-bound eqtall conformation (mutation of e170q on mlaf)
32% identity, 74% coverage of query (91.3 bits)
ABCG1_HUMAN / P45844 ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; White protein homolog; EC 7.6.2.- from Homo sapiens (Human) (see 11 papers)
TC 3.A.1.204.12 / P45844 The intracellular sterol transporter, ABCG1 from Homo sapiens (see 13 papers)
31% identity, 82% coverage of query (86.7 bits)
7oz1A Cryo-em structure of abcg1 e242q mutant with atp and cholesteryl hemisuccinate bound
30% identity, 72% coverage of query (83.2 bits)
7r8eA / P45844 The structure of human abcg1 e242q complexed with atp (see paper)
30% identity, 72% coverage of query (83.2 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
30% identity, 71% coverage of query (81.6 bits)
Build an alignment for BPHYT_RS10405 and 52 homologs with ≥ 30% identity
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8eopA / Q8IZY2 Cryo-em structure of nanodisc reconstituted human abca7 eq mutant in atp bound closed state (see paper)
28% identity, 80% coverage of query (79.7 bits)
ABCAD_MOUSE / Q5SSE9 ATP-binding cassette sub-family A member 13; EC 7.6.2.- from Mus musculus (Mouse) (see 3 papers)
25% identity, 72% coverage of query (73.9 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
26% identity, 72% coverage of query (73.2 bits)
2awnD / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
29% identity, 73% coverage of query (72.4 bits)
7r89B / Q9H221 The structure of human abcg5/abcg8 purified from yeast (see paper)
27% identity, 71% coverage of query (72.4 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
28% identity, 70% coverage of query (72.0 bits)
7y1lA Structure of sur2b in complex with mg-atp and repaglinide in the inward-facing conformation
28% identity, 74% coverage of query (72.0 bits)
7lkpA Structure of atp-free human abca4
28% identity, 71% coverage of query (71.6 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
28% identity, 71% coverage of query (71.6 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
28% identity, 71% coverage of query (71.6 bits)
ABCG8_HUMAN / Q9H221 ATP-binding cassette sub-family G member 8; Sterolin-2; EC 7.6.2.- from Homo sapiens (Human) (see 8 papers)
TC 3.A.1.204.5 / Q9H221 ABCG8 aka ATP-binding cassette sub-family G member 8, component of The ABCG5 (sterolin-1)/ABCG8 (sterolin-2) heterodimeric neutral sterol (cholesterol and plant sterols) (e.g., sitosterol) (phosphoryl donors ATP > CTP > GTP > UTP) exporter; present in the apical membranes of enterocytes and hepatocytes. Cholesteryl oleate, phosphatidyl choline and enantiomeric cholesterol are poorly transported (mutation of either ABCG5 or ABCG8 cause sitosterolemia and coronary atherosclerosis) (Zhang et al., 2006; Wang et al., 2006; 2011) from Homo sapiens (Human) (see 7 papers)
ABCG8 / RF|NP_071882.1 ATP-binding cassette sub-family G member 8 from Homo sapiens (see paper)
27% identity, 71% coverage of query (71.2 bits)
7lkzA Structure of atp-bound human abca4
28% identity, 71% coverage of query (70.5 bits)
7r8bB / Q9H221 The structure of human abcg5/abcg8 supplemented with cholesterol (see paper)
27% identity, 71% coverage of query (70.5 bits)
8pmjA / O95342 Vanadate-trapped bsep in nanodiscs (see paper)
30% identity, 74% coverage of query (69.3 bits)
7y1nA / Q63563 Structure of sur2b in complex with mg-atp, mg-adp, and repaglinide in the partially occluded state (see paper)
27% identity, 74% coverage of query (68.9 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
25% identity, 70% coverage of query (68.6 bits)
8jwfA / Q7K6A5 Cryo-em structure of plasmodium falciparum multidrug resistance protein 1 with h1 helix in complex with mfq (see paper)
27% identity, 71% coverage of query (68.2 bits)
8jwiA Cryo-em structure of the outward-facing plasmodium falciparum multidrug resistance protein 1
26% identity, 71% coverage of query (66.6 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
24% identity, 70% coverage of query (55.5 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
25% identity, 70% coverage of query (55.5 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
24% identity, 70% coverage of query (54.3 bits)
7mitE / Q63563 Vascular katp channel: kir6.1 sur2b propeller-like conformation 1 (see paper)
22% identity, 72% coverage of query (46.2 bits)
7vltA Structure of sur2b in complex with mg-atp/adp and levcromakalim
22% identity, 72% coverage of query (46.2 bits)
7vlsA Structure of sur2b in complex with mgatp/adp and p1075
22% identity, 72% coverage of query (46.2 bits)
7vlrA Structure of sur2b in complex with mg-atp/adp
22% identity, 72% coverage of query (46.2 bits)
7y1jA / Q63563 Structure of sur2a in complex with mg-atp and repaglinide in the inward-facing conformation. (see paper)
21% identity, 70% coverage of query (45.1 bits)
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