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Searching for up to 100 curated homologs for BPHYT_RS10690 FitnessBrowser__BFirm:BPHYT_RS10690 (427 a.a.)

Found high-coverage hits (≥70%) to 92 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

iacC / B0FXI2 2-(3-hydroxy-2-oxo-1H-indol-3-yl)acetate dioxygenase IacC subunit from Pseudomonas putida (see 2 papers)
    62% identity, 95% coverage of query (536 bits)

tdnA1 / BAC82526.1 large subunit of terminal dioxygenase in aniline dioxygenase from Frateuria sp. ANA-18 (see 3 papers)
    34% identity, 96% coverage of query (219 bits)

ANTDA_ACIAD / O85673 Anthranilate 1,2-dioxygenase large subunit; EC 1.14.12.1 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see 3 papers)
antA / RF|YP_047246.1 anthranilate 1,2-dioxygenase, large subunit; EC 1.14.12.1 from Acinetobacter sp. ADP1 (see paper)
    33% identity, 89% coverage of query (204 bits)

PS417_23685 anthranilate 1,2-dioxygenase (deaminating, decarboxylating) large subunit [EC: 1.14.12.1] from Pseudomonas simiae WCS417
    32% identity, 89% coverage of query (201 bits)

A8I4E8 benzoate 4-monooxygenase (EC 1.14.14.92) from Chromohalobacter sp. (see paper)
    34% identity, 85% coverage of query (200 bits)

cmtAb / Q51974 p-cumate 2,3-dioxygenase system, large oxygenase component (EC 1.14.12.25) from Pseudomonas putida (see paper)
CMTAB_PSEPU / Q51974 p-cumate 2,3-dioxygenase system, large oxygenase component; Large terminal subunit of p-cumate dioxygenase; p-cumate 2,3-dioxygenase large subunit; p-cumate 2,3-dioxygenase subunit alpha; EC 1.14.12.25 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
Q51974 p-cumate 2,3-dioxygenase (subunit 3/4) (EC 1.14.12.25) from Pseudomonas putida (see paper)
cmtAb / AAB62285.1 p-cumate dioxygenase large subunit from Pseudomonas putida (see 3 papers)
    31% identity, 95% coverage of query (197 bits)

PfGW456L13_2740 Anthranilate 1,2-dioxygenase (deaminating, decarboxylating) (EC 1.14.12.1) from Pseudomonas fluorescens GW456-L13
    32% identity, 89% coverage of query (196 bits)

AO353_05950 Anthranilate 1,2-dioxygenase (deaminating, decarboxylating) (EC 1.14.12.1) from Pseudomonas fluorescens FW300-N2E3
    31% identity, 92% coverage of query (194 bits)

benA / AAC46436.2 BenA from Acinetobacter baylyi (see 8 papers)
    32% identity, 85% coverage of query (184 bits)

2xshA Crystal structure of p4 variant of biphenyl dioxygenase from burkholderia xenovorans lb400 in complex with 2,6 di chlorobiphenyl
    31% identity, 94% coverage of query (184 bits)

2yflA Crystal structure of biphenyl dioxygenase variant rr41 with 2-chloro dibenzofuran
    31% identity, 94% coverage of query (184 bits)

2yfjA Crystal structure of biphenyl dioxygenase variant rr41 with dibenzofuran
    31% identity, 94% coverage of query (184 bits)

2xrxA Crystal structure of biphenyl dioxygenase in complex with biphenyl from burkholderia xenovorans lb400
    31% identity, 94% coverage of query (182 bits)

5aeuA / P37333 Crystal structure of ii9 variant of biphenyl dioxygenase from burkholderia xenovorans lb400 (see paper)
    31% identity, 94% coverage of query (181 bits)

P37333 biphenyl 2,3-dioxygenase (EC 1.14.12.18) from Paraburkholderia xenovorans (see 2 papers)
bphA / GB|ABE37059.1 biphenyl 2,3-dioxygenase, alpha subunit; EC 1.14.12.18 from Burkholderia xenovorans LB400 (see paper)
    31% identity, 94% coverage of query (181 bits)

Build an alignment

Build an alignment for BPHYT_RS10690 and 15 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Q52438 biphenyl 2,3-dioxygenase (EC 1.14.12.18) from Pseudomonas sp. (see paper)
    29% identity, 97% coverage of query (176 bits)

7ylsB / C5CSP6 Structure of a bacteria protein complex
    31% identity, 97% coverage of query (175 bits)

8h2tB Cryo-em structure of iadd/e dioxygenase bound with iaa
    31% identity, 97% coverage of query (175 bits)

DigA / b2538 putative 3-phenylpropionate/cinnamate dioxygenase subunit α (EC 1.14.12.19) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
hcaE / P0ABR5 putative 3-phenylpropionate/cinnamate dioxygenase subunit α (EC 1.14.12.19) from Escherichia coli (strain K12) (see 2 papers)
HCAE_ECOLI / P0ABR5 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha; EC 1.14.12.19 from Escherichia coli (strain K12) (see paper)
hcaE / RF|NP_417033 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha; EC 1.14.12.19 from Escherichia coli K12 (see 5 papers)
    30% identity, 96% coverage of query (174 bits)

Q52028 biphenyl 2,3-dioxygenase (EC 1.14.12.18) from Pseudomonas oleovorans (see paper)
    30% identity, 94% coverage of query (171 bits)

tftA / Q51592 2,4,5-trichlorophenoxyacetate hydroxylase oxygenase component α subunit from Burkholderia cepacia (see 2 papers)
    32% identity, 84% coverage of query (170 bits)

nagG / O52379 salicylate-5-hydroxylase large subunit (EC 1.14.13.172) from Ralstonia sp. (see 2 papers)
NAGG_RALSP / O52379 Salicylate 5-hydroxylase, large oxygenase component; S5H large oxygenase component; Salicylate 5-hydroxylase, oxygenase component NagG; Salicylate 5-monooxygenase, hydroxylase large subunit; EC 1.14.13.172 from Ralstonia sp. (see 2 papers)
O52379 salicylate 5-hydroxylase (subunit 2/2) (EC 1.14.13.172) from Ralstonia sp. (see 2 papers)
    30% identity, 95% coverage of query (167 bits)

7c8zA / O52379 Crystal structure of salicylate 5-hydroxylase naggh (a rieske non-heme iron-dependent monooxgenase) (see paper)
    30% identity, 95% coverage of query (166 bits)

bpdC1 / AAB07750.1 terminal dioxygenase, large subunit from Rhodococcus sp. M5 (see paper)
    28% identity, 97% coverage of query (166 bits)

arhA1 / BAD34447.1 large subunit of PAH-dioxygenase from Sphingomonas sp. A4 (see paper)
    31% identity, 79% coverage of query (164 bits)

ANDAC_BURCE / Q84BZ3 Anthranilate 1,2-dioxygenase large subunit; EC 1.14.12.1 from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
Q84BZ3 anthranilate 1,2-dioxygenase (deaminating, decarboxylating) (EC 1.14.12.1) from Burkholderia cepacia (see paper)
    31% identity, 94% coverage of query (163 bits)

bphAa / BAK52803.1 biphenyl 2,3-dioxygenase, large subunit from Janibacter sp. TYM3221 (see paper)
bphAa / BAM76236.1 biphenyl 2,3-dioxygenase, large subunit from Janibacter sp. TYM3221 (see paper)
    29% identity, 99% coverage of query (163 bits)

1uliC / Q53122 Biphenyl dioxygenase (bpha1a2) derived from rhodococcus sp. Strain rha1 (see paper)
    28% identity, 95% coverage of query (162 bits)

1uljA Biphenyl dioxygenase (bpha1a2) in complex with the substrate
    28% identity, 95% coverage of query (162 bits)

dbfA1 / BAC75993.1 angular dioxygenase large subunit from Terrabacter sp. DBF63 (see paper)
    30% identity, 88% coverage of query (161 bits)

Q588I9 benzene 1,2-dioxygenase (EC 1.14.12.3) from Rhodococcus opacus (see paper)
    29% identity, 95% coverage of query (160 bits)

BPHA1_RHOJR / Q53122 Biphenyl 2,3-dioxygenase subunit alpha; Biphenyl dioxygenase system, oxygenase component subunit alpha; BDO, oxygenase component subunit alpha; Rieske dioxygenase; Terminal oxygenase component of biphenyl dioxygenase, large subunit; EC 1.14.12.18 from Rhodococcus jostii (strain RHA1) (see 4 papers)
bphA1 / BAA06868.1 biphenyl dioxygenase from Rhodococcus jostii RHA1 (see paper)
    29% identity, 95% coverage of query (160 bits)

A5W4F2 toluene dioxygenase (subunit 2/2) (EC 1.14.12.11) from Pseudomonas putida (see paper)
    28% identity, 98% coverage of query (159 bits)

phtA1 / BAC54156.1 oxygenase large subunit of phthalate dioxygenase from Terrabacter sp. DBF63 (see paper)
    30% identity, 85% coverage of query (159 bits)

3en1A / A5W4F2 Crystal structure of toluene 2,3-dioxygenase (see paper)
    29% identity, 98% coverage of query (159 bits)

1wqlA / Q51743 Cumene dioxygenase (cuma1a2) from pseudomonas fluorescens ip01 (see paper)
    28% identity, 94% coverage of query (158 bits)

Q52383 chlorobenzene dioxygenase (subunit 4/4) (EC 1.14.12.26) from Pseudomonas sp. P51 (see 2 papers)
tcbAa / AAC43632.1 chlorobenzene dioxygenase, large subunit of terminal oxygenase from Pseudomonas sp (see 3 papers)
    28% identity, 95% coverage of query (158 bits)

nahAc / BAE92156.1 iron sulfur protein large subunit NahAc of napthalene dioxygenase from Pseudomonas putida (see 2 papers)
nahAc / AAA25902.1 iron sulfur protein large subunit from Pseudomonas putida (see paper)
    28% identity, 86% coverage of query (157 bits)

bedC1 / Q07944 benzene 1,2 dioxygenase terminal oxygenase component α subunit from Pseudomonas putida (see paper)
bedC1 / AAA17758.1 BedC1 from Pseudomonas putida (see 3 papers)
    28% identity, 99% coverage of query (156 bits)

ndoB / P0A110 naphthalene 1,2-dioxygenase complex oxygenase component α subunit from Pseudomonas putida (see 2 papers)
NDOB_PSEPU / P0A110 Naphthalene 1,2-dioxygenase system, large oxygenase component; ISP NAP; Naphthalene 1,2-dioxygenase ISP alpha; Naphthalene 1,2-dioxygenase subunit alpha; ND subunit alpha; NDO subunit alpha; EC 1.14.12.12 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 6 papers)
NDOB_PSEU8 / P0A111 Naphthalene 1,2-dioxygenase system, large oxygenase component; ISP NAP; Naphthalene 1,2-dioxygenase ISP alpha; Naphthalene 1,2-dioxygenase subunit alpha; ND subunit alpha; NDO subunit alpha; EC 1.14.12.12 from Pseudomonas sp. (strain C18) (see 2 papers)
P0A110 naphthalene 1,2-dioxygenase (EC 1.14.12.12) from Pseudomonas putida (see 2 papers)
P0A111 naphthalene 1,2-dioxygenase (EC 1.14.12.12) from Pseudomonas sp. (see paper)
ndoB / GB|AAO64274.1 Naphthalene 1,2-dioxygenase subunit alpha; EC 1.14.12.12 from Pseudomonas putida (see 4 papers)
    28% identity, 86% coverage of query (155 bits)

1eg9A / P0A110 Naphthalene 1,2-dioxygenase with indole bound in the active site. (see paper)
    28% identity, 86% coverage of query (155 bits)

4hm0A Naphthalene 1,2-dioxygenase bound to indole-3-acetate
    28% identity, 86% coverage of query (155 bits)

1uuvA Naphthalene 1,2-dioxygenase with nitric oxide and indole bound in the active site.
    28% identity, 86% coverage of query (155 bits)

1o7pA Naphthalene 1,2-dioxygenase, product complex
    28% identity, 86% coverage of query (155 bits)

1o7mA Naphthalene 1,2-dioxygenase, binary complex with dioxygen
    28% identity, 86% coverage of query (155 bits)

1o7gA Naphthalene 1,2-dioxygenase with naphthalene bound in the active site.
    28% identity, 86% coverage of query (155 bits)

4hm8A Naphthalene 1,2-dioxygenase bound to thioanisole
    28% identity, 86% coverage of query (155 bits)

4hm7A Naphthalene 1,2-dioxygenase bound to styrene
    28% identity, 86% coverage of query (155 bits)

4hm6A Naphthalene 1,2-dioxygenase bound to phenetole
    28% identity, 86% coverage of query (155 bits)

4hm4A Naphthalene 1,2-dioxygenase bound to indan
    28% identity, 86% coverage of query (155 bits)

4hm3A Naphthalene 1,2-dioxygenase bound to ethylbenzene
    28% identity, 86% coverage of query (155 bits)

4hm2A Naphthalene 1,2-dioxygenase bound to ethylphenylsulfide
    28% identity, 86% coverage of query (155 bits)

4hm1A Naphthalene 1,2-dioxygenase bound to 1-indanone
    28% identity, 86% coverage of query (155 bits)

4hkvA Naphthalene 1,2-dioxygenase bound to benzamide
    28% identity, 86% coverage of query (155 bits)

4hjlA Naphthalene 1,2-dioxygenase bound to 1-chloronaphthalene
    28% identity, 86% coverage of query (155 bits)

2hmoA Crystal structure of naphthalene 1,2-dioxygenase bound to 3- nitrotoluene.
    28% identity, 86% coverage of query (155 bits)

2hmmA Crystal structure of naphthalene 1,2-dioxygenase bound to anthracene
    28% identity, 86% coverage of query (155 bits)

2hmkA Crystal structure of naphthalene 1,2-dioxygenase bound to phenanthrene
    28% identity, 86% coverage of query (155 bits)

3gzxA / Q46372 Crystal structure of the biphenyl dioxygenase in complex with biphenyl from comamonas testosteroni sp. Strain b-356 (see paper)
    29% identity, 94% coverage of query (154 bits)

Q46372 biphenyl 2,3-dioxygenase (EC 1.14.12.18) from Comamonas testosteroni (see 2 papers)
bphA / AAC44526.1 biphenyl dioxygenase terminal oxygenase alpha subunit from Pandoraea pnomenusa (see paper)
    29% identity, 94% coverage of query (154 bits)

TECA1_CUPXP / O24676 Chlorobenzene dioxygenase subunit alpha; EC 1.14.12.26 from Cupriavidus sp. (strain PS12) (see 3 papers)
    27% identity, 95% coverage of query (154 bits)

phnA1b / CAG17582.1 salicylate 1-hydroxylase alpha subunit from Sphingomonas sp. CHY-1 (see paper)
    30% identity, 83% coverage of query (153 bits)

F4Y9J0 nitroarene dioxygenase (subunit 2/4) (EC 1.14.12.23) from Pseudomonas stutzeri ZWLR2-1 (see paper)
    29% identity, 82% coverage of query (152 bits)

ntdAa / P95564 2-nitrotoluene dioxygenase complex ferredoxin reductase component (EC 1.14.12.23) from Pseudomonas sp. (see 3 papers)
    30% identity, 87% coverage of query (152 bits)

DNTAC_BURSR / Q45695 2,4-dinitrotoluene dioxygenase system, large oxygenase component; 2,4-dinitrotoluene dioxygenase ISP alpha; 2,4-dinitrotoluene dioxygenase subunit alpha; EC 1.14.12.24 from Burkholderia sp. (strain RASC) (see paper)
    32% identity, 80% coverage of query (152 bits)

M9PW10 nitroarene dioxygenase (subunit 3/4) (EC 1.14.12.23) from Diaphorobacter sp. DS2 (see paper)
    27% identity, 82% coverage of query (150 bits)

5xbpA / M9PW10 Oxygenase component of 3-nitrotoluene dioxygenase from diaphorobacter sp. Strain ds2 (see paper)
    27% identity, 82% coverage of query (150 bits)

NDOB_RALSP / O52382 Naphthalene 1,2-dioxygenase system, large oxygenase component; ISP NAP; Naphthalene 1,2-dioxygenase ISP alpha; Naphthalene 1,2-dioxygenase subunit alpha; ND subunit alpha; NDO subunit alpha; EC 1.14.12.12 from Ralstonia sp. (see 2 papers)
    27% identity, 86% coverage of query (148 bits)

2b1xA / Q9X3R9 Crystal structure of naphthalene 1,2-dioxygenase from rhodococcus sp. (see paper)
    29% identity, 84% coverage of query (148 bits)

XYLC1 / AAC44161.1 iron sulfur protein large subunit from Cycloclasticus oligotrophus (see paper)
    28% identity, 94% coverage of query (148 bits)

2b24A Crystal structure of naphthalene 1,2-dioxygenase from rhodococcus sp. Bound to indole
    29% identity, 84% coverage of query (148 bits)

7q05E / Q3C1D5 Crystal structure of tpado in complex with tpa (see paper)
    28% identity, 95% coverage of query (147 bits)

picB3 / A0A1X9WE59 6-hydroxypicolinate 3-monooxygenase subunit 3 from Alcaligenes faecalis (see paper)
    28% identity, 93% coverage of query (147 bits)

Q8RTL4 nitroarene dioxygenase (subunit 2/4) (EC 1.14.12.23) from Comamonas sp. (see paper)
    30% identity, 87% coverage of query (146 bits)

2bmoA / Q8RTL4 The crystal structure of nitrobenzene dioxygenase (see paper)
    31% identity, 81% coverage of query (146 bits)

7q06D Crystal structure of tpado in complex with 2-oh-tpa
    28% identity, 95% coverage of query (146 bits)

2bmrA The crystal structure of nitrobenzene dioxygenase in complex with 3- nitrotoluene
    31% identity, 81% coverage of query (146 bits)

2bmqA The crystal structure of nitrobenzene dioxygenase in complex with nitrobenzene
    31% identity, 81% coverage of query (146 bits)

TPDA1_COMSP / Q3C1E3 Terephthalate 1,2-dioxygenase, terminal oxygenase component subunit alpha 1; TPADO terminal oxygenase component; TER dioxygenase system; TERDOS; Terephthalate 1,2-dioxygenase large subunit 1; EC 1.14.12.15 from Comamonas sp. (see 3 papers)
    28% identity, 95% coverage of query (145 bits)

TPDA2_COMSP / Q3C1D5 Terephthalate 1,2-dioxygenase, terminal oxygenase component subunit alpha 2; TPADO terminal oxygenase component; TER dioxygenase system; TERDOS; Terephthalate 1,2-dioxygenase large subunit 2; EC 1.14.12.15 from Comamonas sp. (see 3 papers)
tphA2II / BAE47085.1 oxygenase large subunit of terephthalate 1,2-dioxygenase from Comamonas sp. E6 (see paper)
    28% identity, 95% coverage of query (145 bits)

G9IE62 naphthalene 1,2-dioxygenase (EC 1.14.12.12) from Comamonas sp. MQ (see paper)
    27% identity, 86% coverage of query (144 bits)

7vjuA Crystal structure of terephthalate dioxygenase from comamonas testosteroni kf1
    28% identity, 95% coverage of query (144 bits)

7q04D Crystal structure of tpado in a substrate-free state
    29% identity, 95% coverage of query (144 bits)

2gbwA / A2TC87 Crystal structure of biphenyl 2,3-dioxygenase from sphingomonas yanoikuyae b1 (see paper)
    29% identity, 80% coverage of query (141 bits)

2gbxA Crystal structure of biphenyl 2,3-dioxygenase from sphingomonas yanoikuyae b1 bound to biphenyl
    29% identity, 80% coverage of query (141 bits)

pdmA / S5RR11 N,N-dimethyl-phenylurea N demethylase oxygenase component α subunit (EC 1.14.15.38) from Sphingobium sp. (strain YBL2) (see paper)
PDMA_SPHYB / S5RR11 N,N-dimethyl phenylurea N-demethylase subunit alpha; EC 1.14.15.38 from Sphingobium sp. (strain YBL2) (see paper)
S5RR11 N,N-dimethyl phenylurea N-demethylase (subunit 2/2) (EC 1.14.15.38) from Sphingobium sp. YBL2 (see paper)
    29% identity, 86% coverage of query (140 bits)

phnA1a / CAG17576.1 ring-hydroxylating dioxygenase alpha subunit from Sphingomonas sp. CHY-1 (see paper)
    29% identity, 80% coverage of query (139 bits)

2ckfE / Q65AT1 Crystal structure of the terminal component of the pah- hydroxylating dioxygenase from sphingomonas sp chy-1 (see paper)
    30% identity, 80% coverage of query (137 bits)

ditA1 / AAD21063.1 dioxygenase DitA oxygenase component large subunit from Pseudomonas abietaniphila (see 4 papers)
    26% identity, 94% coverage of query (124 bits)

ABSAA_ALCSP / Q9RBG5 2-aminobenzenesulfonate 2,3-dioxygenase subunit alpha; 2-aminobenzenesulfonate dioxygenase large subunit; AbsAa; EC 1.14.12.14 from Alcaligenes sp. (see 2 papers)
Q9RBG5 2-aminobenzenesulfonate 2,3-dioxygenase (EC 1.14.12.14) from Alcaligenes sp. O-1 (see paper)
    25% identity, 94% coverage of query (123 bits)

A0A0D6JGB8 methanesulfonate monooxygenase (NADH) (EC 1.14.13.111) from Candidatus Filomicrobium marinum (see paper)
    27% identity, 94% coverage of query (117 bits)

msmA / Q9X404 methanesulfonate monooxygenase hydroxylase component α subunit from Methylosulfonomonas methylovora (see paper)
MSMA_METHY / Q9X404 Methanesulfonate monooxygenase hydroxylase subunit alpha; Methanesulfonic acid monooxygenase hydroxylase large subunit; Methanesulfonic acid monooxygenase hydroxylase subunit alpha; MSA monooxygenase hydroxylase subunit alpha; MSAMO hydroxylase subunit alpha; EC 1.14.13.111 from Methylosulfonomonas methylovora (see 4 papers)
Q9X404 methanesulfonate monooxygenase (NADH) (EC 1.14.13.111) from Methylosulfonomonas methylovora (see paper)
    27% identity, 95% coverage of query (114 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory