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Searching for up to 100 curated homologs for BPHYT_RS11800 BPHYT_RS11800 acetate permease (528 a.a.)

Found high-coverage hits (≥70%) to 25 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PS417_08865 large component of pyruvate transporter (actP-like) from Pseudomonas simiae WCS417
    40% identity, 98% coverage of query (392 bits)

Pf1N1B4_3673 large component of pyruvate transporter (actP-like) from Pseudomonas fluorescens FW300-N1B4
    41% identity, 98% coverage of query (387 bits)

Pf6N2E2_5849 large component of pyruvate transporter (actP-like) from Pseudomonas fluorescens FW300-N2E2
    40% identity, 98% coverage of query (380 bits)

AZOBR_RS02940 large component of pyruvate transporter (actP-like) from Azospirillum brasilense Sp245
    40% identity, 98% coverage of query (377 bits)

YjcG / b4067 acetate/glycolate:cation symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
actP / P32705 acetate/glycolate:cation symporter from Escherichia coli (strain K12) (see 5 papers)
ACTP_ECOLI / P32705 Cation/acetate symporter ActP; Acetate permease; Acetate transporter ActP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.21.7.2 / P32705 Acetate/glyoxylate permease, ActP from Escherichia coli (see 6 papers)
    41% identity, 98% coverage of query (373 bits)

TC 2.A.21.7.1 / O50471 Phenylacetate permease, Ppa from Pseudomonas putida (see paper)
    41% identity, 97% coverage of query (370 bits)

TC 2.A.21.7.4 / D5AU53 Acetate uptake permease, ActP1; also takes up tellurite from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
    42% identity, 98% coverage of query (355 bits)

TC 2.A.21.7.5 / D5APM1 Acetate permease ActP-2/ActP2/ActP3 from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
    39% identity, 97% coverage of query (354 bits)

MCTC_CORGL / Q8NS49 Monocarboxylic acid transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
TC 2.A.21.7.3 / Q8NS49 Pyruvate/acetate/propionate: H+ symporter, MctC (DhlC; cg0953) from Corynebacterium glutamicum (see paper)
    41% identity, 98% coverage of query (350 bits)

Build an alignment

Build an alignment for BPHYT_RS11800 and 9 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Psest_0347 large component of pyruvate/D-alanine transporter (actP-like) from Pseudomonas stutzeri RCH2
    27% identity, 91% coverage of query (146 bits)

Shew_2371 actP-like component of L-lactate and L-malate uptake system from Shewanella loihica PV-4
    26% identity, 97% coverage of query (134 bits)

Sama_1523 actP-like component of lactate uptake system from Shewanella amazonensis SB2B
    26% identity, 82% coverage of query (129 bits)

PUTP_BACSU / P94392 High-affinity proline transporter PutP from Bacillus subtilis (strain 168) (see 3 papers)
TC 2.A.21.2.4 / J7JIE8 The high affinity nutritional proline uptake porter, PutP from Bacillus subtilis QB928
    24% identity, 79% coverage of query (84.3 bits)

OPUE_BACSU / O06493 Osmoregulated proline transporter OpuE; Osmoprotectant uptake; Proline uptake system from Bacillus subtilis (strain 168) (see 2 papers)
TC 2.A.21.2.5 / M1TZ79 Proline uptake porter, OpuE (YerK) from Bacillus subtilis subsp. subtilis 6051-HGW
opuE / AAB72182.1 OpuE from Bacillus subtilis (see paper)
    22% identity, 83% coverage of query (79.7 bits)

Psest_3078 L-proline:Na+ symporter from Pseudomonas stutzeri RCH2
    25% identity, 84% coverage of query (71.2 bits)

putP / AAA79365.1 proline permease homolog from Staphylococcus aureus (see paper)
    22% identity, 81% coverage of query (70.1 bits)

PUTP_STAA8 / Q2FWY7 Sodium/proline symporter; Proline permease from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 3 papers)
TC 2.A.21.2.2 / Q7A4Q7 Sodium/proline symporter (Proline permease) from Staphylococcus aureus (strain N315) (see paper)
    22% identity, 78% coverage of query (67.4 bits)

PanF / b3258 pantothenate:Na+ symporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
panF / P16256 pantothenate:Na+ symporter from Escherichia coli (strain K12) (see 3 papers)
PANF_ECOLI / P16256 Sodium/pantothenate symporter; Pantothenate permease from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.21.1.1 / P16256 Pantothenate:Na+ symporter, PanF from Escherichia coli (see 5 papers)
panF / GB|AAC76290.2 sodium/pantothenate symporter from Escherichia coli K12 (see 5 papers)
    24% identity, 79% coverage of query (62.8 bits)

TC 2.A.21.2.3 / Q9I5F5 L-proline uptake porter, PutP from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    26% identity, 84% coverage of query (62.0 bits)

TC 2.A.21.2.6 / O24896 High affinity proline-specific Na+:proline symporter, PutP (Rivera-Ordaz et al. 2013).  Proline is a preferred source of energy for this microaerophilic bacterium.  PutP is efficiently inhibited by the proline analogs, 3,4-dehydro-D,L-proline and L-azetidine-2-carboxylic acid from Helicobacter pylori (strain ATCC 700392 / 26695)
    22% identity, 79% coverage of query (62.0 bits)

PutC / b1015 proline:Na+ symporter from Escherichia coli K-12 substr. MG1655 (see 7 papers)
putP / P07117 proline:Na+ symporter from Escherichia coli (strain K12) (see 12 papers)
PUTP_ECOLI / P07117 Sodium/proline symporter; Proline carrier; Proline permease; Propionate transporter from Escherichia coli (strain K12) (see 9 papers)
TC 2.A.21.2.1 / P07117 Proline:Na+ symporter, PutP from Escherichia coli (see 12 papers)
    24% identity, 91% coverage of query (55.5 bits)

PUTP_SALTY / P10502 Sodium/proline symporter; Proline permease from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
    23% identity, 81% coverage of query (53.1 bits)

MCTP_RHIJ3 / Q1M7A2 Monocarboxylate transport permease protein from Rhizobium johnstonii (strain DSM 114642 / LMG 32736 / 3841) (Rhizobium leguminosarum bv. viciae) (see paper)
    22% identity, 77% coverage of query (50.1 bits)

TC 2.A.21.4.1 / Q8VM88 The monocarboxylate uptake (H+ symport?) permease, MctP (transports lactate (Km = 4.4 μM), pyruvate (Km = 3.8), propionate, butyrate (butanoic acid), α-hydroxybutyrate, L- and D-alanine (Km = 0.5 mM), and possibly cysteine and histidine) from Rhizobium leguminosarum (biovar viciae) (see paper)
mctP / CAD19128.1 monocarboxylic acid permease from Rhizobium leguminosarum bv. viciae (see paper)
    22% identity, 77% coverage of query (48.9 bits)

SC5A7_HUMAN / Q9GZV3 High affinity choline transporter 1; hCHT1; Hemicholinium-3-sensitive choline transporter; CHT; Solute carrier family 5 member 7 from Homo sapiens (Human) (see 10 papers)
TC 2.A.21.8.2 / Q9GZV3 High affinity choline transporter 1 (Hemicholinium-3-sensitive choline transporter) (CHT1) (Solute carrier family 5 member 7) from Homo sapiens (see 5 papers)
    22% identity, 74% coverage of query (43.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory