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Searching for up to 100 curated homologs for BPHYT_RS12315 FitnessBrowser__BFirm:BPHYT_RS12315 (164 a.a.)

Found high-coverage hits (≥70%) to 7 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

RRAAH_THET8 / Q5SIP7 4-hydroxy-4-methyl-2-oxoglutarate aldolase; HMG aldolase; Oxaloacetate decarboxylase; OAA decarboxylase; Regulator of ribonuclease activity homolog; EC 4.1.3.17; EC 4.1.1.112 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    50% identity, 96% coverage of query (142 bits)

YiiV / b3929 ribonuclease E inhibitor protein A from Escherichia coli K-12 substr. MG1655 (see 20 papers)
RRAA_ECOLI / P0A8R0 Regulator of ribonuclease activity A from Escherichia coli (strain K12) (see 7 papers)
    41% identity, 100% coverage of query (125 bits)

1nxjA / P9WGY3 Structure of rv3853 from mycobacterium tuberculosis (see paper)
    43% identity, 96% coverage of query (124 bits)

2yjvC / P0A8R0 Crystal structure of e. Coli regulator of ribonuclease activity a (rraa) bound to fragment of dead-box protein rhlb (see paper)
    40% identity, 99% coverage of query (123 bits)

Build an alignment

Build an alignment for BPHYT_RS12315 and 4 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

LIGK_SPHSK / G2IQQ8 4-carboxy-4-hydroxy-2-oxoadipate aldolase; CHA aldolase; Oxaloacetate decarboxylase; OAA decarboxylase; EC 4.1.3.17; EC 4.1.1.112 from Sphingobium sp. (strain NBRC 103272 / SYK-6) (see 2 papers)
ligK / BAB88738.1 4-carboxy-4-hydroxy-2-oxoadipate aldolase from Sphingomonas paucimobilis (see 5 papers)
    29% identity, 98% coverage of query (52.0 bits)

pmdF / Q93PS8 HMG aldolase monomer (EC 4.1.3.17) from Comamonas testosteroni (see paper)
    26% identity, 92% coverage of query (46.2 bits)

proA / Q9AQI0 4-oxalocitramalate aldolase subunit (EC 4.1.1.112; EC 4.1.3.17) from Pseudomonas straminea (see 3 papers)
HMGA_PSEOC / Q9AQI0 4-hydroxy-4-methyl-2-oxoglutarate aldolase/4-carboxy-4-hydroxy-2-oxoadipate aldolase; HMG/CHA aldolase; 4-hydroxy-2-oxoglutarate aldolase; Oxaloacetate decarboxylase; OAA decarboxylase; EC 4.1.3.16; EC 4.1.3.17; EC 4.1.1.112 from Pseudomonas straminea (see 4 papers)
proA / BAB21456.3 4-Hydroxy-4-methyl-2-oxoglutarate aldolase from Pseudomonas straminea (see 2 papers)
    26% identity, 92% coverage of query (46.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory