Searching for up to 100 curated homologs for BPHYT_RS13280 FitnessBrowser__BFirm:BPHYT_RS13280 (572 a.a.)
Found high-coverage hits (≥70%) to 35 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
leuA / CAA50295.1 2-isopropylmalate synthase from Corynebacterium glutamicum (see paper)
55% identity, 95% coverage of query (618 bits)
LEU1_CORGL / P42455 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
55% identity, 95% coverage of query (617 bits)
LEU1_MYCTO / P9WQB2 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (see paper)
LEU1_MYCTU / P9WQB3 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WQB3 2-isopropylmalate synthase (EC 2.3.3.13) from Mycobacterium tuberculosis (see 6 papers)
52% identity, 95% coverage of query (616 bits)
3hpzB Crystal structure of mycobacterium tuberculosis leua complexed with bromopyruvate
54% identity, 95% coverage of query (611 bits)
3figB / P9WQB3 Crystal structure of leucine-bound leua from mycobacterium tuberculosis (see paper)
54% identity, 95% coverage of query (610 bits)
3hq1A Crystal structure of mycobacterium tuberculosis leua complexed with citrate and mn2+
54% identity, 95% coverage of query (609 bits)
1sr9A Crystal structure of leua from mycobacterium tuberculosis
54% identity, 95% coverage of query (609 bits)
3hpsA Crystal structure of mycobacterium tuberculosis leua complexed with ketoisocaproate (kic)
54% identity, 95% coverage of query (607 bits)
CH_124190 2-isopropylmalate synthase 2 from Magnaporthe grisea 70-15 (see paper)
49% identity, 95% coverage of query (564 bits)
LEU4 putative 2-isopropylmalalate synthase from Candida albicans (see paper)
48% identity, 95% coverage of query (537 bits)
LEU9_YEAST / Q12166 2-isopropylmalate synthase 2, mitochondrial; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; Alpha-isopropylmalate synthase II; EC 2.3.3.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
47% identity, 95% coverage of query (528 bits)
LEU1_YEAST / P06208 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
46% identity, 95% coverage of query (525 bits)
GLOH_GLAL2 / S3D9F8 Isopropyl malate synthase gloH; L-homotyrosine biosynthesis sub-cluster protein gloH; Pneumocandin biosynthesis cluster protein H; EC 2.3.3.13 from Glarea lozoyensis (strain ATCC 20868 / MF5171) (see 5 papers)
39% identity, 94% coverage of query (429 bits)
AMT7_ALTAL / C9K7B8 Isopropyl malate synthase AMT7; AM-toxin biosynthesis protein 7; EC 2.3.3.13 from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
46% identity, 74% coverage of query (400 bits)
HtyA / K0E4E5 2-(4-hydroxybenzyl)-malate synthase from Aspergillus rugulosus (see paper)
HTYA_ASPRU / K0E4E5 Isopropyl malate synthase htyA; L-homotyrosine biosynthetic cluster protein A; EC 2.3.3.13 from Aspergillus rugulosus (Emericella rugulosa) (see paper)
41% identity, 95% coverage of query (397 bits)
Build an alignment for BPHYT_RS13280 and 15 homologs with ≥ 30% identity
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K4C627 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum (see paper)
25% identity, 96% coverage of query (142 bits)
LEU12_ARATH / Q9C550 2-isopropylmalate synthase 2, chloroplastic; 2-isopropylmalate synthase 1; Methylthioalkylmalate synthase-like 3; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9C550 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 2 papers)
24% identity, 89% coverage of query (137 bits)
LEU11_ARATH / Q9LPR4 2-isopropylmalate synthase 1, chloroplastic; Methylthioalkylmalate synthase-like 4; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LPR4 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 3 papers)
26% identity, 89% coverage of query (136 bits)
LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis (see 2 papers)
25% identity, 91% coverage of query (132 bits)
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus (see paper)
25% identity, 89% coverage of query (131 bits)
Q30DX9 2-isopropylmalate synthase (EC 2.3.3.13) from Brassica insularis (see paper)
25% identity, 89% coverage of query (130 bits)
LEU11_LEPIN / Q8F445 2-isopropylmalate synthase 1; Alpha-IPM synthase 1; Alpha-isopropylmalate synthase 1; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see paper)
26% identity, 89% coverage of query (130 bits)
Q2RAP8 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
26% identity, 90% coverage of query (127 bits)
Q2QXY9 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
26% identity, 90% coverage of query (126 bits)
BT1861 2-isopropylmalate synthase (EC 2.3.3.13) from Bacteroides thetaiotaomicron VPI-5482
24% identity, 89% coverage of query (119 bits)
LEU1_SALTY / P15875 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
26% identity, 91% coverage of query (118 bits)
LEU1_METJA / Q58595 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58595 2-isopropylmalate synthase (EC 2.3.3.13) from Methanocaldococcus jannaschii (see paper)
25% identity, 90% coverage of query (118 bits)
Q72JC9 2-isopropylmalate synthase (EC 2.3.3.13) from Thermus thermophilus (see 2 papers)
25% identity, 89% coverage of query (115 bits)
LeuA / b0074 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
leuA / P09151 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli (strain K12) (see 15 papers)
25% identity, 91% coverage of query (111 bits)
LEU1_SOYBN / Q39891 Probable 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; Late nodulin-56; N-56; EC 2.3.3.13 from Glycine max (Soybean) (Glycine hispida) (see paper)
24% identity, 90% coverage of query (108 bits)
AKSA_METJA / Q57926 Homocitrate synthase AksA; (R)-homo(2)citrate synthase; (R)-homo(3)citrate synthase; EC 2.3.3.14; EC 2.3.3.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
25% identity, 73% coverage of query (90.5 bits)
B0K6M2 (R)-citramalate synthase (EC 2.3.3.21) from Thermoanaerobacter sp. (see paper)
21% identity, 89% coverage of query (81.6 bits)
cimA / Q58787 (R)-citratemalate synthase subunit (EC 2.3.3.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
CIMA_METJA / Q58787 (R)-citramalate synthase CimA; EC 2.3.3.21 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58787 (R)-citramalate synthase (EC 2.3.3.21) from Methanocaldococcus jannaschii (see 2 papers)
24% identity, 89% coverage of query (77.8 bits)
cimA / Q74C76 (R)-citramalate synthase (EC 2.3.3.21) from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
CIMA_GEOSL / Q74C76 (R)-citramalate synthase; Citramalate synthase; EC 2.3.3.21 from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
Q74C76 (R)-citramalate synthase (EC 2.3.3.21) from Geobacter sulfurreducens (see paper)
22% identity, 89% coverage of query (59.7 bits)
hphA / B2J8P8 2-benzylmalate synthase from Nostoc punctiforme (strain ATCC 29133 / PCC 73102) (see paper)
23% identity, 71% coverage of query (59.7 bits)
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