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Searching for up to 100 curated homologs for BPHYT_RS13885 FitnessBrowser__BFirm:BPHYT_RS13885 (338 a.a.)

Found high-coverage hits (≥70%) to 68 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HSERO_RS12095 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Herbaspirillum seropedicae SmR1
    72% identity, 97% coverage of query (495 bits)

iolG / Q9WYP5 myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
IOLG_THEMA / Q9WYP5 Myo-inositol 2-dehydrogenase; EC 1.1.1.18 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
Q9WYP5 D-chiro-inositol 1-dehydrogenase (EC 1.1.1.369) from Thermotoga maritima (see paper)
    43% identity, 97% coverage of query (264 bits)

Q9EZV8 inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium fredii (see paper)
    45% identity, 97% coverage of query (254 bits)

SM_b20899 Inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium meliloti 1021
MI2D_RHIME / O68965 Inositol 2-dehydrogenase; Myo-inositol 2-dehydrogenase; MI-dehydrogenase; EC 1.1.1.18 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
O68965 inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium meliloti (see paper)
    47% identity, 97% coverage of query (252 bits)

iolX / P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (strain 168) (see paper)
IOLX_BACSU / P40332 scyllo-inositol 2-dehydrogenase (NAD(+)); EC 1.1.1.370 from Bacillus subtilis (strain 168) (see paper)
P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (see 2 papers)
    39% identity, 96% coverage of query (227 bits)

4n54A / A0A0J9X1Y7 Crystal structure of scyllo-inositol dehydrogenase from lactobacillus casei with bound cofactor NAD(h) and scyllo-inositol
    30% identity, 95% coverage of query (144 bits)

Build an alignment

Build an alignment for BPHYT_RS13885 and 6 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

E1U888 inositol 2-dehydrogenase (EC 1.1.1.18) from Lacticaseibacillus casei (see paper)
    29% identity, 95% coverage of query (142 bits)

3ceaA / F9ULF9 Crystal structure of myo-inositol 2-dehydrogenase (np_786804.1) from lactobacillus plantarum at 2.40 a resolution
    27% identity, 97% coverage of query (129 bits)

4minA / A0A0J9X1Y2 Crystal structure of myo-inositol dehydrogenase from lactobacillus casei with bound cofactor NAD
    29% identity, 98% coverage of query (120 bits)

E1U887 inositol 2-dehydrogenase (EC 1.1.1.18) from Lacticaseibacillus casei (see paper)
    29% identity, 98% coverage of query (120 bits)

4mjlD Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD and d-chiro-inositol
    29% identity, 98% coverage of query (120 bits)

4mioD Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD(h) and myo-inositol
    29% identity, 98% coverage of query (120 bits)

4mioA Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD(h) and myo-inositol
    29% identity, 98% coverage of query (120 bits)

iolG / P26935 inositol 2-dehydrogenase monomer (EC 1.1.1.18; EC 1.1.1.369) from Bacillus subtilis (strain 168) (see 5 papers)
IOLG_BACSU / P26935 Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; MI 2-dehydrogenase/DCI 3-dehydrogenase; EC 1.1.1.18; EC 1.1.1.369 from Bacillus subtilis (strain 168) (see 3 papers)
P26935 inositol 2-dehydrogenase (EC 1.1.1.18); D-chiro-inositol 1-dehydrogenase (EC 1.1.1.369) from Bacillus subtilis (see 7 papers)
    26% identity, 97% coverage of query (118 bits)

3nt5A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor and product inosose
    26% identity, 97% coverage of query (118 bits)

3nt4A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor nadh and inositol
    26% identity, 97% coverage of query (118 bits)

3nt2B Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor
    26% identity, 97% coverage of query (118 bits)

3nt2A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor
    26% identity, 97% coverage of query (118 bits)

4l8vA / P26935 Crystal structure of a12k/d35s mutant myo-inositol dehydrogenase from bacillus subtilis with bound cofactor NADP (see paper)
    26% identity, 97% coverage of query (117 bits)

PS417_11875 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas simiae WCS417
    30% identity, 91% coverage of query (116 bits)

BWI76_RS03095 Inositol 2-dehydrogenase (EC 1.1.1.18) from Klebsiella michiganensis M5al
    29% identity, 94% coverage of query (115 bits)

AO356_23190 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas fluorescens FW300-N2C3
    29% identity, 97% coverage of query (113 bits)

iolG / A0A0H3FQ94 myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56) (see 2 papers)
    29% identity, 94% coverage of query (111 bits)

AO353_21365 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas fluorescens FW300-N2E3
    29% identity, 91% coverage of query (111 bits)

mocA / GB|CAA55269.1 rhizopine catabolism protein MocA from Sinorhizobium meliloti (see paper)
    29% identity, 93% coverage of query (111 bits)

3ec7A / Q8ZK57 Crystal structure of putative dehydrogenase from salmonella typhimurium lt2
    28% identity, 96% coverage of query (110 bits)

6norA / Q70KD1 Crystal structure of gend2 from gentamicin a biosynthesis in complex with NAD (see paper)
    29% identity, 93% coverage of query (99.4 bits)

8qc6A / A0A1C9WRL0 Crystal structure of NAD-dependent glycoside hydrolase from arthrobacter sp. U41 in complex with NAD+ and sulfoquinovose (sq) (see paper)
    25% identity, 98% coverage of query (89.0 bits)

8qc8D Crystal structure of NAD-dependent glycoside hydrolase from flavobacterium sp. (Strain k172) in complex with co-factor NAD+ (see paper)
    24% identity, 97% coverage of query (87.8 bits)

8qc8B Crystal structure of NAD-dependent glycoside hydrolase from flavobacterium sp. (Strain k172) in complex with co-factor NAD+ (see paper)
    24% identity, 98% coverage of query (85.9 bits)

8qc2A Crystal structure of NAD-dependent glycoside hydrolase from flavobacterium sp. (Strain k172) in complex with co-factor NAD+ and sulfoquinovose (sq)
    24% identity, 98% coverage of query (85.9 bits)

2glxA / Q2I8V6 Crystal structure analysis of bacterial 1,5-af reductase (see paper)
    27% identity, 94% coverage of query (85.5 bits)

afr / Q2I8V6 1,5-anhydro-D-fructose reductase (EC 1.1.1.292) from Ensifer adhaerens (see 3 papers)
AFR_ENSAD / Q2I8V6 1,5-anhydro-D-fructose reductase; Anhydrofructose reductase; 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming); EC 1.1.1.292 from Ensifer adhaerens (Sinorhizobium morelense) (see 2 papers)
Q2I8V6 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Ensifer adhaerens (see 2 papers)
    27% identity, 94% coverage of query (85.5 bits)

UGNO_METMP / Q6M0B9 UDP-N-acetylglucosamine 3-dehydrogenase; UDP-GlcNAc oxidoreductase; UDP-N-acetyl-alpha-D-glucosamine:NAD(+) 3-oxidoreductase; EC 1.1.1.374 from Methanococcus maripaludis (strain S2 / LL) (see paper)
Q6M0B9 UDP-N-acetylglucosamine 3-dehydrogenase (EC 1.1.1.374) from Methanococcus maripaludis (see paper)
    24% identity, 94% coverage of query (82.0 bits)

6jw7A / Q6L737 The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin a (see paper)
    26% identity, 97% coverage of query (80.1 bits)

6jw8A The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin b
    26% identity, 97% coverage of query (80.1 bits)

6jw6A The crystal structure of kand2 in complex with NAD
    26% identity, 97% coverage of query (80.1 bits)

Q92KZ3 1,5-anhydro-D-fructose reductase (EC 1.1.1.263); 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Sinorhizobium meliloti (see paper)
4koaA / Q92KZ3 Crystal structure analysis of 1,5-anhydro-d-fructose reductase from sinorhizobium meliloti (see paper)
    26% identity, 94% coverage of query (76.3 bits)

1evjA Crystal structure of glucose-fructose oxidoreductase (gfor) delta1-22 s64d
    23% identity, 89% coverage of query (76.3 bits)

3q2kC / Q79H45 Crystal structure of the wlba dehydrogenase from bordetella pertussis in complex with nadh and udp-glcnaca (see paper)
    25% identity, 97% coverage of query (74.7 bits)

1h6dA / Q07982 Oxidized precursor form of glucose-fructose oxidoreductase from zymomonas mobilis complexed with glycerol (see paper)
    23% identity, 89% coverage of query (73.9 bits)

1rydA Crystal structure of glucose-fructose oxidoreductase from zymomonas mobilis
    23% identity, 89% coverage of query (73.9 bits)

gfo / Q07982 glucose-fructose oxidoreductase (EC 1.1.99.28) from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see paper)
Q07982 glucose-fructose oxidoreductase (EC 1.1.99.28) from Zymomonas mobilis (see 4 papers)
    23% identity, 89% coverage of query (73.6 bits)

orf19.6899 putative uncharacterized protein CaJ7.0133 from Candida albicans (see paper)
    23% identity, 97% coverage of query (72.4 bits)

APSD_PARG4 / B1G894 D-apiose dehydrogenase; EC 1.1.1.420 from Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M) (see paper)
    29% identity, 87% coverage of query (71.6 bits)

6a3iA Levoglucosan dehydrogenase, complex with nadh and levoglucosan
    26% identity, 73% coverage of query (70.1 bits)

apsD / B9JK80 D-apiose dehydrogenase (EC 1.1.1.420) from Agrobacterium radiobacter (strain K84 / ATCC BAA-868) (see paper)
APSD_RHIR8 / B9JK80 D-apiose dehydrogenase; EC 1.1.1.420 from Rhizobium rhizogenes (strain K84 / ATCC BAA-868) (Agrobacterium radiobacter) (see paper)
B9JK80 D-apiose dehydrogenase (EC 1.1.1.420) from Agrobacterium tumefaciens (see paper)
    26% identity, 78% coverage of query (68.6 bits)

5uhwA / B9JK80 Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+ and magnesium
    26% identity, 78% coverage of query (68.6 bits)

5uiaA Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, r-2,3-dihydroxyisovalerate and magnesium
    26% identity, 78% coverage of query (68.6 bits)

5ui9A Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, 2 -hydroxy-2-hydroxymethyl propanoic acid and magnesium
    26% identity, 78% coverage of query (68.6 bits)

5uhzA Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, d-apionate and magnesium
    26% identity, 78% coverage of query (68.6 bits)

6a3jC / F0M433 Levoglucosan dehydrogenase, complex with nadh and l-sorbose (see paper)
    26% identity, 73% coverage of query (67.4 bits)

3q2kK / Q79H45 Crystal structure of the wlba dehydrogenase from bordetella pertussis in complex with nadh and udp-glcnaca (see paper)
    25% identity, 97% coverage of query (67.4 bits)

A0A064C3N0 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Streptococcus pneumoniae (see paper)
    22% identity, 97% coverage of query (67.0 bits)

Asphe3_10730 / F0M433 levoglucosan dehydrogenase monomer (EC 1.1.1.425) from Pseudarthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3) (see 2 papers)
LGDH_PSEPM / F0M433 Levoglucosan dehydrogenase; LGDH; 1,6-anhydro-beta-D-glucose dehydrogenase; PpLGDH; EC 1.1.1.425 from Pseudarthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3) (Arthrobacter phenanthrenivorans) (see paper)
F0M433 levoglucosan dehydrogenase (EC 1.1.1.425) from Pseudarthrobacter phenanthrenivorans (see paper)
    25% identity, 73% coverage of query (64.3 bits)

5a03C / Q9A8X3 Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with xylose (see paper)
    25% identity, 84% coverage of query (63.5 bits)

5a05A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with maltotriose
    25% identity, 84% coverage of query (63.5 bits)

5a04A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with glucose
    25% identity, 84% coverage of query (63.5 bits)

5a03E Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with xylose
    25% identity, 84% coverage of query (63.5 bits)

5a02A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with glycerol
    25% identity, 84% coverage of query (63.5 bits)

5a06A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with sorbitol
    25% identity, 84% coverage of query (63.5 bits)

Q5KYQ3 inositol 2-dehydrogenase (EC 1.1.1.18) from Geobacillus kaustophilus (see paper)
    24% identity, 78% coverage of query (62.8 bits)

Q8NTY7 inositol 2-dehydrogenase (EC 1.1.1.18) from Corynebacterium glutamicum (see paper)
    23% identity, 88% coverage of query (61.6 bits)

NanY / b4280 KpLE2 phage-like element; 2,7-anhydro-N-acetylneuraminate hydratase from Escherichia coli K-12 substr. MG1655 (see 4 papers)
nanY / P39353 KpLE2 phage-like element; 2,7-anhydro-N-acetylneuraminate hydratase from Escherichia coli (strain K12) (see 6 papers)
NANY_ECOLI / P39353 2,7-anhydro-N-acetylneuraminate hydratase; EcNanOx; EC 4.2.1.- from Escherichia coli (strain K12) (see 4 papers)
    22% identity, 73% coverage of query (57.0 bits)

6o15A / P39353 Crystal structure of a putative oxidoreductase yjhc from escherichia coli in complex with NAD(h) (see paper)
    22% identity, 73% coverage of query (57.0 bits)

Q7NQL0 UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase (EC 1.1.1.335) from Chromobacterium violaceum (see paper)
    22% identity, 97% coverage of query (57.0 bits)

SM_b20330 glucoside 3-dehydrogenase; active on raffinose or trehalose (thuB) (EC 1.1.99.13) from Sinorhizobium meliloti 1021
    27% identity, 94% coverage of query (55.1 bits)

3q2iA / Q7NQL0 Crystal structure of the wlba dehydrognase from chromobactrium violaceum in complex with nadh and udp-glcnaca at 1.50 a resolution (see paper)
    23% identity, 97% coverage of query (55.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory