Searching for up to 100 curated homologs for BPHYT_RS14820 FitnessBrowser__BFirm:BPHYT_RS14820 (344 a.a.)
Found high-coverage hits (≥70%) to 67 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
52% identity, 100% coverage of query (350 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
51% identity, 100% coverage of query (349 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
51% identity, 100% coverage of query (349 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
51% identity, 100% coverage of query (345 bits)
METN_BACSU / O32169 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.24.2 / O32169 MetN (C) (aka YusC), component of The L- and D-methionine porter (also transports methionine sulfoxide from Bacillus subtilis subsp. subtilis str. 168 (see 2 papers)
48% identity, 100% coverage of query (323 bits)
TC 3.A.1.24.5 / Q9HT70 Methionine import ATP-binding protein MetN 2, component of L-Histidine uptake porter, MetIQN from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
49% identity, 99% coverage of query (303 bits)
TC 3.A.1.24.3 / Q8K8K8 AtmD (MetN), component of The methionine porter, AtmBDE from Streptococcus pyogenes serotype M3 (see 2 papers)
45% identity, 98% coverage of query (288 bits)
TC 3.A.1.24.4 / Q8NSN2 Methionine import ATP-binding protein metN, component of L-Methionine uptake porter, MetQNI from Corynebacterium glutamicum (see paper)
44% identity, 94% coverage of query (270 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
46% identity, 71% coverage of query (202 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
43% identity, 71% coverage of query (197 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
43% identity, 71% coverage of query (197 bits)
2olkA Abc protein artp in complex with adp-beta-s
43% identity, 71% coverage of query (197 bits)
2oljA Abc protein artp in complex with adp/mg2+
43% identity, 71% coverage of query (197 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
41% identity, 71% coverage of query (194 bits)
TC 3.A.1.3.16 / A3ZI83 PEB1C, component of Uptake system for glutamate and aspartate from Campylobacter jejuni subsp. jejuni 84-25
40% identity, 71% coverage of query (187 bits)
GLUA_CORGL / P48243 Glutamate transport ATP-binding protein GluA; Glutamate uptake system protein GluA; EC 7.4.2.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
TC 3.A.1.3.9 / P48243 GluA aka CGL1950, component of Glutamate porter from Corynebacterium glutamicum (Brevibacterium flavum) (see 2 papers)
40% identity, 72% coverage of query (186 bits)
SMc02121 ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, ATPase component from Sinorhizobium meliloti 1021
40% identity, 71% coverage of query (186 bits)
TC 3.A.1.3.8 / Q52815 AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) from Rhizobium leguminosarum (biovar viciae) (see 2 papers)
aapP / CAA57936.1 general amino acid ABC type transporter from Rhizobium leguminosarum (see paper)
39% identity, 71% coverage of query (183 bits)
TcyN / b1917 cystine ABC transporter ATP binding subunit (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
tcyN / P37774 cystine ABC transporter ATP binding subunit (EC 7.4.2.12) from Escherichia coli (strain K12) (see 7 papers)
TCYN_ECOLI / P37774 L-cystine transport system ATP-binding protein TcyN; EC 7.4.2.12 from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.3.10 / P37774 YECC aka CysZ aka B1917, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 5 papers)
40% identity, 72% coverage of query (182 bits)
GLNQ_BACSU / O34677 Glutamine transport ATP-binding protein GlnQ; EC 7.4.2.- from Bacillus subtilis (strain 168) (see paper)
39% identity, 71% coverage of query (179 bits)
YhdZ / b3271 putative ABC transporter ATP-binding subunit YhdZ from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yhdZ / RF|NP_417737 uncharacterized amino-acid ABC transporter ATP-binding protein yhdZ from Escherichia coli K12 (see 3 papers)
39% identity, 71% coverage of query (177 bits)
TC 3.A.1.6.3 / P0A4W2 Sulfate/thiosulfate import ATP-binding protein CysA aka RV2397C aka MT2468 aka MTCY253.24, component of Sulfate porter from Mycobacterium tuberculosis (see 3 papers)
40% identity, 71% coverage of query (173 bits)
7ahhC Opua inhibited inward-facing, sbd docked
35% identity, 70% coverage of query (165 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
35% identity, 70% coverage of query (165 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
37% identity, 70% coverage of query (153 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
36% identity, 71% coverage of query (147 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
36% identity, 71% coverage of query (147 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
36% identity, 71% coverage of query (147 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
33% identity, 76% coverage of query (140 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
33% identity, 70% coverage of query (137 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
31% identity, 76% coverage of query (133 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
31% identity, 76% coverage of query (132 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
31% identity, 76% coverage of query (132 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
31% identity, 76% coverage of query (132 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
31% identity, 76% coverage of query (132 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
31% identity, 76% coverage of query (132 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
31% identity, 76% coverage of query (132 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
31% identity, 76% coverage of query (132 bits)
7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
33% identity, 72% coverage of query (129 bits)
7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
33% identity, 71% coverage of query (127 bits)
7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation
33% identity, 71% coverage of query (126 bits)
SapD / b1291 putrescine ABC exporter ATP binding protein SapD (EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
SapD / P0AAH4 putrescine ABC exporter ATP binding protein SapD (EC 7.6.2.16) from Escherichia coli (strain K12) (see 5 papers)
SAPD_ECOLI / P0AAH4 Putrescine export system ATP-binding protein SapD from Escherichia coli (strain K12) (see 2 papers)
31% identity, 70% coverage of query (120 bits)
7zkaA Abcb1 v978c mutant (mabcb1) in the outward facing state bound to aac
36% identity, 74% coverage of query (119 bits)
7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac
36% identity, 74% coverage of query (119 bits)
7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac
36% identity, 74% coverage of query (119 bits)
4xwkA P-glycoprotein co-crystallized with bde-100
35% identity, 74% coverage of query (117 bits)
6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
35% identity, 74% coverage of query (117 bits)
3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
35% identity, 74% coverage of query (117 bits)
3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
35% identity, 74% coverage of query (117 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
32% identity, 73% coverage of query (116 bits)
8hprC Lpqy-sugabc in state 4
32% identity, 73% coverage of query (116 bits)
8hprD Lpqy-sugabc in state 4
32% identity, 73% coverage of query (116 bits)
7zk4A The abcb1 l335c mutant (mabcb1) in the outward facing state
36% identity, 74% coverage of query (115 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
34% identity, 74% coverage of query (115 bits)
7otgA Structure of abcb1/p-glycoprotein in the presence of the cftr potentiator ivacaftor
36% identity, 74% coverage of query (115 bits)
2awnC / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
31% identity, 70% coverage of query (114 bits)
5koyA Mouse pgp 34 linker deleted bound with atp
36% identity, 74% coverage of query (114 bits)
DPPD_CALS4 / Q8RDH4 Dipeptide transport ATP-binding protein DppD; EC 7.4.2.9 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
32% identity, 72% coverage of query (109 bits)
4fwiB / Q8RDH4 Crystal structure of the nucleotide-binding domain of a dipeptide abc transporter (see paper)
32% identity, 71% coverage of query (107 bits)
7niwA / P21439 Nanodisc reconstituted human abcb4 in complex with 4b1-fab (posaconazole-bound, inward-open conformation) (see paper)
33% identity, 74% coverage of query (107 bits)
Build an alignment for BPHYT_RS14820 and 60 homologs with ≥ 30% identity
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7ch6C / P63386 Cryo-em structure of e.Coli mlafeb with amppnp (see paper)
28% identity, 70% coverage of query (106 bits)
6xgyA Crystal structure of e. Coli mlafb abc transport subunits in the dimeric state
28% identity, 70% coverage of query (106 bits)
7cgnB The overall structure of the mlafedb complex in atp-bound eqtall conformation (mutation of e170q on mlaf)
28% identity, 70% coverage of query (105 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
34% identity, 74% coverage of query (104 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
30% identity, 72% coverage of query (100 bits)
RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
27% identity, 85% coverage of query (95.9 bits)
8dneA Cryoem structure of the a.Aeolicus wzmwzt transporter bound to atp
27% identity, 73% coverage of query (93.2 bits)
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Lawrence Berkeley National Laboratory