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Searching for up to 100 curated homologs for BPHYT_RS16030 FitnessBrowser__BFirm:BPHYT_RS16030 (416 a.a.)

Found high-coverage hits (≥70%) to 17 curated proteins.

Removed hits that are identical to the query, leaving 16

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

kyn / P83788 kynureninase subunit (EC 3.7.1.3) from Pseudomonas fluorescens (see 2 papers)
KYNU_PSEFL / P83788 Kynureninase; L-kynurenine hydrolase; EC 3.7.1.3 from Pseudomonas fluorescens (see paper)
    68% identity, 100% coverage of query (593 bits)

PfGW456L13_4288 Kynureninase (EC 3.7.1.3) from Pseudomonas fluorescens GW456-L13
    68% identity, 100% coverage of query (588 bits)

AO353_05935 Kynureninase (EC 3.7.1.3) from Pseudomonas fluorescens FW300-N2E3
    67% identity, 100% coverage of query (586 bits)

1qz9A / P83788 The three dimensional structure of kynureninase from pseudomonas fluorescens (see paper)
    69% identity, 96% coverage of query (585 bits)

PS417_23650 Kynureninase (EC 3.7.1.3) from Pseudomonas simiae WCS417
    66% identity, 100% coverage of query (582 bits)

RR42_RS15385 Kynureninase (EC 3.7.1.3) from Cupriavidus basilensis FW507-4G11
    68% identity, 99% coverage of query (577 bits)

acmH / D6R244 3-hydroxy-4-methyl-D-kynurenine hydrolase monomer from Streptomyces anulatus (see 4 papers)
    42% identity, 96% coverage of query (300 bits)

sibQ / C0LTN1 kynureninase (EC 3.7.1.3) from Streptosporangium sibiricum (see paper)
    42% identity, 93% coverage of query (280 bits)

B7XB98 kynureninase (EC 3.7.1.3) from Bombyx mori (see paper)
    33% identity, 95% coverage of query (232 bits)

KYNU_YEAST / Q05979 Kynureninase; Biosynthesis of nicotinic acid protein 5; L-kynurenine hydrolase; EC 3.7.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    31% identity, 95% coverage of query (163 bits)

Build an alignment

Build an alignment for BPHYT_RS16030 and 10 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

KYNU_CAEEL / Q18026 Kynureninase; Abnormal fluorescence under UV illumination; L-kynurenine hydrolase; EC 3.7.1.3 from Caenorhabditis elegans (see paper)
    28% identity, 95% coverage of query (159 bits)

2hzpA / Q16719 Crystal structure of homo sapiens kynureninase (see paper)
    29% identity, 94% coverage of query (156 bits)

KYNU_MOUSE / Q9CXF0 Kynureninase; L-kynurenine hydrolase; EC 3.7.1.3 from Mus musculus (Mouse) (see paper)
    28% identity, 94% coverage of query (155 bits)

3e9kA Crystal structure of homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex
    29% identity, 94% coverage of query (155 bits)

KYNU / Q16719 Kynureninase (EC 3.7.1.3) from Homo sapiens (see 5 papers)
KYNU_HUMAN / Q16719 Kynureninase; L-kynurenine hydrolase; EC 3.7.1.3 from Homo sapiens (Human) (see 6 papers)
Q16719 kynureninase (EC 3.7.1.3) from Homo sapiens (see 4 papers)
    29% identity, 94% coverage of query (154 bits)

Kynu / P70712 kynureninase subunit (EC 3.7.1.3) from Rattus norvegicus (see paper)
KYNU_RAT / P70712 Kynureninase; L-kynurenine hydrolase; EC 3.7.1.3 from Rattus norvegicus (Rat) (see paper)
    27% identity, 94% coverage of query (153 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory