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Searching for up to 100 curated homologs for BPHYT_RS21425 FitnessBrowser__BFirm:BPHYT_RS21425 (459 a.a.)

Found high-coverage hits (≥70%) to 36 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

RR42_RS32055 3-carboxymuconate cycloisomerase PcaB (EC 5.5.1.2) from Cupriavidus basilensis FW507-4G11
    62% identity, 92% coverage of query (453 bits)

pcaB / AAC37149.1 beta-carboxy-cis,cis-muconate cycloisomerase from Acinetobacter baylyi (see 11 papers)
    47% identity, 96% coverage of query (399 bits)

YBN5_SCHPO / O42889 Uncharacterized protein C8E4.05c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    41% identity, 95% coverage of query (345 bits)

pcaB2 / Q2HNY9 3-carboxymuconate lactonizing enzyme type 2 (EC 5.5.1.2) from Hydrogenophaga intermedia (see 2 papers)
    43% identity, 97% coverage of query (318 bits)

2SL_DICD3 / E0SKP1 N-acetyl-S-(2-succino)cysteine lyase; S-(2-succino) lyase; 2SL; EC 4.3.2.- from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see paper)
    39% identity, 95% coverage of query (308 bits)

TAD1 / A0A0U2UYC4 trans-aconitate decarboxylase (EC 4.1.1.113) from Ustilago maydis (see paper)
TAD1_USTMD / A0A0U2UYC4 Trans-aconitate decarboxylase 1; Itaconic acid/2-hydroxyparaconate biosynthesis cluster protein TAD1; EC 4.1.1.113 from Ustilago maydis (Corn smut fungus) (see 2 papers)
A0A0U2UYC4 trans-aconitate decarboxylase (EC 4.1.1.113) from Ustilago maydis (see paper)
    38% identity, 97% coverage of query (308 bits)

2SL_ENTI1 / E6LDH5 N-acetyl-S-(2-succino)cysteine lyase; S-(2-succino) lyase; 2SL; EC 4.3.2.- from Enterococcus italicus (strain DSM 15952 / CCUG 50447 / LMG 22039 / TP 1.5) (see paper)
    37% identity, 95% coverage of query (281 bits)

CREDH_STRDJ / K4R6W4 Nitrosuccinate lyase; EC 4.3.99.5 from Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768) (see paper)
    44% identity, 91% coverage of query (280 bits)

creD / A0A0K2JL82 nitrosuccinate lyase (EC 4.3.99.5) from Streptomyces cremeus (see paper)
CRED_STRCM / A0A0K2JL82 Nitrosuccinate lyase; EC 4.3.99.5 from Streptomyces cremeus (see 3 papers)
A0A0K2JL82 nitrosuccinate lyase (EC 4.3.99.5) from Streptomyces cremeus (see paper)
    44% identity, 94% coverage of query (271 bits)

5xnzA / A0A0K2JL82 Crystal structure of cred complex with fumarate (see paper)
    43% identity, 94% coverage of query (260 bits)

MJ0929 / Q58339 adenylosuccinate lyase (EC 4.3.2.2) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
    32% identity, 94% coverage of query (212 bits)

Q2HNZ1 3-Carboxy-cis,cis-muconate cycloisomerase (EC 5.5.1.2) from Agrobacterium tumefaciens (see paper)
    36% identity, 77% coverage of query (183 bits)

pcaB / AAF34266.1 3-carboxy-cis,cis-muconate cycloisomerase from Agrobacterium tumefaciens (see 2 papers)
    35% identity, 77% coverage of query (179 bits)

Build an alignment

Build an alignment for BPHYT_RS21425 and 13 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

PUR8_STAAW / Q7A0G9 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Staphylococcus aureus (strain MW2) (see paper)
Q7A0G9 adenylosuccinate lyase (EC 4.3.2.2) from Staphylococcus aureus (see paper)
    28% identity, 93% coverage of query (177 bits)

PUR8_THEMA / Q9X0I0 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    27% identity, 92% coverage of query (173 bits)

2x75A / Q7A0G9 Staphylococcus aureus adenylosuccinate lyase (see paper)
    28% identity, 93% coverage of query (172 bits)

PUR8_BACSU / P12047 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; Glutamyl--tRNA ligase regulatory factor; EC 4.3.2.2 from Bacillus subtilis (strain 168) (see 2 papers)
P12047 adenylosuccinate lyase (EC 4.3.2.2) from Bacillus subtilis (see paper)
purB / GI|143366 (glutamyl-trna synthetase regulatory factor); EC 4.3.2.2 from Bacillus subtilis (see 4 papers)
    30% identity, 90% coverage of query (167 bits)

toyF / B6CWI9 succinylo-toyocamycin phosphate lyase from Streptomyces rimosus (see paper)
    33% identity, 94% coverage of query (164 bits)

Q8ZY28 adenylosuccinate lyase (EC 4.3.2.2) from Pyrobaculum aerophilum (see paper)
    29% identity, 79% coverage of query (109 bits)

ADE13 enzyme of adenine biosynthesis from Candida albicans (see paper)
    27% identity, 73% coverage of query (87.0 bits)

ade13 / Q05911 Ade13 (EC 4.3.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
    25% identity, 74% coverage of query (83.2 bits)

Q05911 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    25% identity, 74% coverage of query (83.2 bits)

B2LS18 adenylosuccinate lyase (EC 4.3.2.2) from Ctenopharyngodon idella (see paper)
    28% identity, 74% coverage of query (81.6 bits)

PUR8_CHICK / P21265 Adenylosuccinate lyase; ADSL; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Gallus gallus (Chicken) (see paper)
    27% identity, 74% coverage of query (76.6 bits)

5vkwB / A0A1D8PT56 Crystal structure of adenylosuccinate lyase ade13 from candida albicans
    26% identity, 73% coverage of query (75.5 bits)

5eytA / G4VQX9 Crystal structure of adenylosuccinate lyase from schistosoma mansoni in complex with amp (see paper)
    27% identity, 76% coverage of query (75.5 bits)

5nx9D / A0A384E0N4 Crystal structure of neanderthal adenylosuccinate lyase (adsl) in complex with its products amp and fumarate (see paper)
    25% identity, 76% coverage of query (72.8 bits)

ade8 / RF|NP_596735.1 adenylosuccinate lyase Ade8; EC 4.3.2.2 from Schizosaccharomyces pombe (see paper)
    25% identity, 74% coverage of query (72.0 bits)

ADSL / P30566 adenylosuccinate lyase (EC 4.3.2.2) from Homo sapiens (see 3 papers)
PUR8_HUMAN / P30566 Adenylosuccinate lyase; ADSL; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Homo sapiens (Human) (see 14 papers)
P30566 adenylosuccinate lyase (EC 4.3.2.2) from Homo sapiens (see 5 papers)
    25% identity, 76% coverage of query (71.6 bits)

D3ZW08 adenylosuccinate lyase (EC 4.3.2.2) from Rattus norvegicus (see paper)
    25% identity, 74% coverage of query (70.5 bits)

5nxaB Crystal structure of neanderthal adenylosuccinate lyase (adsl)in complex with its products aicar and fumarate
    26% identity, 74% coverage of query (68.6 bits)

A0R4I6 adenylosuccinate lyase (EC 4.3.2.2) from Mycolicibacterium smegmatis (see paper)
    27% identity, 94% coverage of query (60.8 bits)

5nxaA Crystal structure of neanderthal adenylosuccinate lyase (adsl)in complex with its products aicar and fumarate
    24% identity, 76% coverage of query (54.3 bits)

3oceA / Q2YLW1 Crystal structure of fumarate lyase:delta crystallin from brucella melitensis bound to cobalt
    26% identity, 71% coverage of query (51.6 bits)

1tj7B / P11447 Structure determination and refinement at 2.44 a resolution of argininosuccinate lyase from e. Coli (see paper)
    26% identity, 73% coverage of query (50.4 bits)

5nx9C / A0A384E0N4 Crystal structure of neanderthal adenylosuccinate lyase (adsl) in complex with its products amp and fumarate (see paper)
    23% identity, 76% coverage of query (48.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory