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Searching for up to 100 curated homologs for BPHYT_RS21430 FitnessBrowser__BFirm:BPHYT_RS21430 (263 a.a.)

Found high-coverage hits (≥70%) to 88 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q13KT2 3-oxoadipate enol-lactonase (EC 3.1.1.24) from Paraburkholderia xenovorans (see 2 papers)
    94% identity, 100% coverage of query (513 bits)

2xuaH / Q13KT2 Crystal structure of the enol-lactonase from burkholderia xenovorans lb400 (see paper)
    93% identity, 99% coverage of query (508 bits)

AO353_17230 Beta-ketoadipate enol-lactone hydrolase (EC 3.1.1.24) from Pseudomonas fluorescens FW300-N2E3
    49% identity, 97% coverage of query (255 bits)

pcaD / Q88N36 subunit of 3-oxoadipate enol-lactone hydrolase (EC 3.1.1.24) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 5 papers)
Q88N36 3-oxoadipate enol-lactonase (EC 3.1.1.24) from Pseudomonas putida (see paper)
    47% identity, 95% coverage of query (233 bits)

catD / BAA75208.1 b-ketoadipate enol-lactone hydrolase from Frateuria sp. ANA-18 (see paper)
catD / BAC82535.1 b-ketoadipate enol-lactone hydrolase from Frateuria sp. ANA-18 (see 3 papers)
    44% identity, 95% coverage of query (216 bits)

catD / AAC46435.1 beta-ketoadipate enol-lactone hydrolase from Acinetobacter baylyi (see 8 papers)
    45% identity, 88% coverage of query (213 bits)

pcaL / AAC38246.1 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase from Rhodococcus opacus (see paper)
    42% identity, 92% coverage of query (187 bits)

Q0SH24 3-oxoadipate enol-lactonase (EC 3.1.1.24); 4-carboxymuconolactone decarboxylase (EC 4.1.1.44) from Rhodococcus jostii (see paper)
    42% identity, 92% coverage of query (182 bits)

pcaD / AAC37150.1 beta-ketoadipate enol-lactone hydrolase from Acinetobacter baylyi (see 11 papers)
    38% identity, 96% coverage of query (179 bits)

pcaD / AAF34270.1 beta-ketoadipate enol-lactone hydrolase from Agrobacterium tumefaciens (see 2 papers)
    35% identity, 98% coverage of query (160 bits)

Build an alignment

Build an alignment for BPHYT_RS21430 and 10 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

4uhfA / A0A0M3KKY6 Structural studies of a thermophilic esterase from thermogutta terrifontis (l37a mutant with butyrate bound) (see paper)
    29% identity, 89% coverage of query (102 bits)

4uhdA Structural studies of a thermophilic esterase from thermogutta terrifontis (acetate bound)
    29% identity, 89% coverage of query (102 bits)

4uheA Structural studies of a thermophilic esterase from thermogutta terrifontis (malate bound)
    29% identity, 89% coverage of query (102 bits)

bioH / BAB39459.1 BioH from Kurthia sp. 538-KA26 (see paper)
    29% identity, 98% coverage of query (101 bits)

6eb3B Structural and enzymatic characterization of an esterase from a metagenomic library
    30% identity, 100% coverage of query (97.4 bits)

6eb3A Structural and enzymatic characterization of an esterase from a metagenomic library
    30% identity, 100% coverage of query (95.9 bits)

6eb3C Structural and enzymatic characterization of an esterase from a metagenomic library
    30% identity, 100% coverage of query (95.1 bits)

Q8KT44 carboxylesterase (EC 3.1.1.1) from Lacticaseibacillus casei (see paper)
    27% identity, 94% coverage of query (90.5 bits)

2ocgA / Q86WA6 Crystal structure of human valacyclovir hydrolase (see paper)
    25% identity, 97% coverage of query (73.2 bits)

BPHL_HUMAN / Q86WA6 Valacyclovir hydrolase; VACVase; Valacyclovirase; Biphenyl hydrolase-like protein; Biphenyl hydrolase-related protein; Bph-rp; Breast epithelial mucin-associated antigen; MCNAA; EC 3.1.-.- from Homo sapiens (Human) (see 2 papers)
    25% identity, 97% coverage of query (73.2 bits)

2ociA Crystal structure of valacyclovir hydrolase complexed with a product analogue
    25% identity, 97% coverage of query (73.2 bits)

O73957 carboxylesterase (EC 3.1.1.1) from Sulfolobus acidocaldarius (see paper)
    26% identity, 98% coverage of query (72.4 bits)

EstN1 / K0IAM1 pimeloyl-[acyl-carrier protein] methyl ester esterase (EC 3.1.1.85) from Nitrososphaera gargensis (strain Ga9.2) (see paper)
    24% identity, 97% coverage of query (72.0 bits)

bphD / BAM76235.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Janibacter sp. TYM3221 (see paper)
    28% identity, 89% coverage of query (67.8 bits)

BPOC_MYCTU / P9WNH1 Putative non-heme bromoperoxidase BpoC from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    25% identity, 84% coverage of query (67.4 bits)

TGND_ACIAD / Q6F9F4 (E)-2-((N-methylformamido)methylene)succinate hydrolase; MFMS hydrolase; EC 3.5.1.- from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    25% identity, 89% coverage of query (67.0 bits)

P96965 2-hydroxymuconate-6-semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas fluorescens (see 2 papers)
cumD / BAA12150.1 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase from Pseudomonas fluorescens (see paper)
    27% identity, 85% coverage of query (66.6 bits)

2d0dA Crystal structure of a meta-cleavage product hydrolase (cumd) a129v mutant
    27% identity, 85% coverage of query (65.9 bits)

THAQ_BURTA / Q2T4P1 Polyketide synthase ThaQ from Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CCUG 48851 / CIP 106301 / E264) (see paper)
    27% identity, 92% coverage of query (65.5 bits)

1iunB / P96965 Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant hexagonal (see paper)
    27% identity, 85% coverage of query (65.5 bits)

1ukaA Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with (s)-2-methylbutyrate
    27% identity, 85% coverage of query (65.1 bits)

1uk9A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with isovalerate
    27% identity, 85% coverage of query (65.1 bits)

1uk8A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-valerate
    27% identity, 85% coverage of query (65.1 bits)

1uk7A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-butyrate
    27% identity, 85% coverage of query (65.1 bits)

1iupA Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant complexed with isobutyrates
    27% identity, 85% coverage of query (65.1 bits)

bphD / BAA25612.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Rhodococcus erythropolis (see paper)
    27% identity, 95% coverage of query (64.3 bits)

5z7wB / A0A0M4AV81 Crystal structure of striga hermonthica htl1 (shhtl1) (see paper)
    22% identity, 90% coverage of query (63.9 bits)

8agsAAA / A0A1U9WZ52 8agsAAA
    23% identity, 98% coverage of query (62.8 bits)

8agpAAA Alpha/beta epoxide hydrolase
    23% identity, 98% coverage of query (62.8 bits)

5ng7B Novel epoxide hydrolases belonging to the alpha/beta hydrolases superfamily in metagenomes from hot environments
    23% identity, 98% coverage of query (62.8 bits)

8agnAAA Alpha/beta epoxide hydrolase
    23% identity, 98% coverage of query (62.8 bits)

8agmAAA Alpha/beta epoxide hydrolase
    23% identity, 98% coverage of query (62.8 bits)

flnE / BAC75995.1 meta cleavage compound hydrolase from Terrabacter sp. DBF63 (see paper)
    26% identity, 94% coverage of query (62.0 bits)

PHAZ_PSEOL / P26495 Poly(3-hydroxyalkanoate) depolymerase; PHA depolymerase; ORF2; PHB depolymerase; EC 3.1.1.- from Pseudomonas oleovorans (see paper)
phaB / AAA25933.1 PHA-depolymerase from Pseudomonas oleovorans (see paper)
    25% identity, 90% coverage of query (62.0 bits)

Q5Y152 poly(3-hydroxyoctanoate) depolymerase (EC 3.1.1.76) from Pseudomonas putida (see paper)
    26% identity, 90% coverage of query (62.0 bits)

3heaA The l29p/l124i mutation of pseudomonas fluorescens esterase
    25% identity, 98% coverage of query (62.0 bits)

5z7xA / A0A0M4AMQ0 Crystal structure of striga hermonthica htl4 (shhtl4) (see paper)
    24% identity, 81% coverage of query (61.6 bits)

nahN / BAE92169.1 2-hydroxymuconic semialdehyde hydrolase NahN from Pseudomonas putida (see 2 papers)
    30% identity, 95% coverage of query (61.2 bits)

3hi4A Switching catalysis from hydrolysis to perhydrolysis in p. Fluorescens esterase
    25% identity, 98% coverage of query (61.2 bits)

bpdF / AAB17100.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Rhodococcus sp. M5 (see paper)
    27% identity, 95% coverage of query (60.8 bits)

phaZ / Q8KQ22 intracellular poly(3-hydroxyoctanoate) depolymerase (EC 3.1.1.76) from Pseudomonas putida (see 6 papers)
    26% identity, 90% coverage of query (60.8 bits)

3ia2A Pseudomonas fluorescens esterase complexed to the r-enantiomer of a sulfonate transition state analog
    25% identity, 98% coverage of query (60.8 bits)

ESTE_PSEFL / P22862 Arylesterase; Aryl-ester hydrolase; Carboxylic acid perhydrolase; PFE; Putative bromoperoxidase; EC 3.1.1.2; EC 1.-.-.- from Pseudomonas fluorescens (see 8 papers)
GI|951089 arylesterase; EC 1.-.-.-; EC 3.1.1.2 from Pseudomonas fluorescens (see 3 papers)
AAB60168.1 esterase from Pseudomonas fluorescens (see 2 papers)
    25% identity, 98% coverage of query (60.5 bits)

8pi1B / P22862 Bicyclic incypro pseudomonas fluorescens esterase (see paper)
    25% identity, 98% coverage of query (60.5 bits)

PFMAB_PESFW / W3XA95 Proline iminopeptidase PfmaB; PIP; Conidial pigment biosynthesis cluster protein B; EC 3.4.11.5 from Pestalotiopsis fici (strain W106-1 / CGMCC3.15140) (see 2 papers)
    23% identity, 97% coverage of query (58.5 bits)

5cbkA / A0A0M5I297 Crystal structure of the strigolactone receptor shhtl5 from striga hermonthica (see paper)
    23% identity, 81% coverage of query (58.2 bits)

G3KFX4 2-hydroxymuconate-6-semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas sp. (see paper)
    27% identity, 95% coverage of query (58.2 bits)

RutD / b1009 putative aminoacrylate hydrolase RutD from Escherichia coli K-12 substr. MG1655 (see 2 papers)
RUTD_ECOLI / P75895 Putative carbamate hydrolase RutD; Aminohydrolase; EC 3.5.1.- from Escherichia coli (strain K12) (see 5 papers)
    24% identity, 89% coverage of query (57.4 bits)

5h3hB / K0ACL0 Esterase (eaest) from exiguobacterium antarcticum (see paper)
    22% identity, 97% coverage of query (57.0 bits)

8dvcA Receptor shhtl5 from striga hermonthica in complex with strigolactone agonist gr24
    23% identity, 81% coverage of query (57.0 bits)

picE / A0A1X9WE55 N-formylmaleamate deformylase (EC 3.5.1.106) from Alcaligenes faecalis (see paper)
    23% identity, 97% coverage of query (55.8 bits)

xylF / P23106 2-hydroxymuconic semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas putida (see paper)
XYLF_PSEPU / P23106 2-hydroxymuconate semialdehyde hydrolase; HMSH; 2-hydroxymuconic semialdehyde hydrolase; EC 3.7.1.9 from Pseudomonas putida (Arthrobacter siderocapsulatus)
    28% identity, 82% coverage of query (55.8 bits)

5jz9A / P9WNH5 Crystal structure of hsad bound to 3,5-dichloro-4- hydroxybenzenesulphonic acid (see paper)
    27% identity, 95% coverage of query (55.5 bits)

hsaD / P9WNH5 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase monomer (EC 3.7.1.17) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
HSAD_MYCTU / P9WNH5 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; Meta-cleavage product hydrolase; MCP hydrolase; EC 3.7.1.17; EC 3.7.1.8 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WNH5 2,6-dioxo-6-phenylhexa-3-enoate hydrolase (EC 3.7.1.8) from Mycobacterium tuberculosis (see paper)
    27% identity, 95% coverage of query (55.5 bits)

7zm4A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclipostin-like inhibitor cyc31
    27% identity, 95% coverage of query (55.5 bits)

7zm3A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclipostin-like inhibitor cyc17
    27% identity, 95% coverage of query (55.5 bits)

7zm2A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclophostin-like inhibitor cyc8b
    27% identity, 95% coverage of query (55.5 bits)

7zm1A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclophostin-like inhibitor cyc7b
    27% identity, 95% coverage of query (55.5 bits)

5jzsB Hsad bound to 3,5-dichloro-4-hydroxybenzoic acid
    27% identity, 95% coverage of query (55.5 bits)

RSBQ_BACSU / O07015 Sigma factor SigB regulation protein RsbQ from Bacillus subtilis (strain 168) (see 2 papers)
    21% identity, 89% coverage of query (55.1 bits)

5jzbA Crystal structure of hsad bound to 3,5-dichlorobenzene sulphonamide
    27% identity, 95% coverage of query (55.1 bits)

2wugA Crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with hopda
    26% identity, 95% coverage of query (54.3 bits)

2wufB Crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with 4,9dsha
    26% identity, 95% coverage of query (54.3 bits)

2wueB Crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with hopoda
    26% identity, 95% coverage of query (54.3 bits)

7k38A Crystal structure of pisum sativum kai2 in complex with gr24-ent5ds product (see paper)
    20% identity, 88% coverage of query (52.4 bits)

6brtA / A0A0D9Z3K8 F-box protein cth with hydrolase (see paper)
    22% identity, 81% coverage of query (52.0 bits)

5zhtA Crystal structure of osd14 in complex with covalently bound kk073
    22% identity, 81% coverage of query (52.0 bits)

5zhrA Crystal structure of osd14 in complex with covalently bound kk094
    22% identity, 81% coverage of query (52.0 bits)

5yz7A Crystal structure of osd14 in complex with d-ring-opened 7'-carba-4bd
    22% identity, 81% coverage of query (52.0 bits)

5zhsA Crystal structure of osd14 in complex with covalently bound kk052
    22% identity, 81% coverage of query (51.6 bits)

7c8lA Hybrid designing of potent inhibitors of striga strigolactone receptor shhtl7
    21% identity, 81% coverage of query (51.6 bits)

6ap8A Crystal structure of rice d14 bound to 2-(2-methyl-3-nitroanilino) benzoic acid
    22% identity, 81% coverage of query (51.6 bits)

5dj5A Crystal structure of rice dwarf14 in complex with synthetic strigolactone gr24
    22% identity, 81% coverage of query (51.6 bits)

4ihaA Crystal structure of rice dwarf14 (d14) in complex with a gr24 hydrolysis intermediate
    22% identity, 81% coverage of query (51.6 bits)

7snuA / A0A0M3PNA2 Crystal structure of shhtl7 from striga hermonthica in complex with strigolactone antagonist rg6 (see paper)
    21% identity, 81% coverage of query (51.6 bits)

5z7yA Crystal structure of striga hermonthica htl7 (shhtl7)
    21% identity, 81% coverage of query (51.6 bits)

D14_ORYSJ / Q10QA5 Strigolactone esterase D14; Protein DWARF 14; Protein DWARF 88; Protein HIGH-TILLERING DWARF 2; EC 3.1.-.- from Oryza sativa subsp. japonica (Rice) (see 11 papers)
    22% identity, 81% coverage of query (51.6 bits)

5dnuA / A0A0M3PN85 Crystal structure of striga kai2-like protein in complex with karrikin (see paper)
    21% identity, 81% coverage of query (48.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory